Cardinals vs Rams Prediction, Picks & Odds | 04 Jan 2026

NFL Betting Preview: Cardinals vs Rams

The Arizona Cardinals square off against the Los Angeles Rams at SoFi Stadium, with kickoff scheduled for 16:25 on Sunday, January 4.

You can get -115 that there are Over 45.5 points and there’s lots of juice in those odds. The Rams and the Cardinals should be able to keep the score ticking for our prediction to win.

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Arizona Cardinals have been defeated in their previous eight games. On the road, they recently suffered a 37-14 loss against Cincinnati Bengals at Paycor Stadium. The Cardinals recorded 233 yards, with 191 through the air and 42 on the ground. The offense scored two touchdowns and managed 12 first downs.

Los Angeles Rams have enjoyed four straight home wins. In their last game, they lost on the road to Atlanta Falcons 27-24 at Mercedes-Benz Stadium. The Rams moved the ball for 363 yards, breaking down to 248 passing and 115 rushing yards. The offense generated 16 first downs and produced 3 touchdowns.

Head-to-Head Statistics

The Rams have claimed back-to-back victories over the Cardinals. At SoFi Stadium they won 13-9 before winning 45-17 at State Farm Stadium. The Rams have won seven of the past 10 games that these teams have played.

Cardinals vs Rams Prediction & Picks

Approach Cardinals vs Rams fully prepared with our expert match prediction, likely correct score outcome and a hand-picked bet builder designed for value.

Game Prediction

We’re heading to the totals after finding that the line is set at a generous 45.5 points. Expect this number to be surpassed at -115 for this NFL battle.

Team news and current form always play a key role in shaping our expert NFL picks. We also dig into the latest stats and trends to help deliver the most accurate predictions possible.

Key Cardinals vs Rams stats:

• The 45.5 line has been covered in 7 of the last 10 Cardinals games.
• The 45.5 line has been covered in 12 of the last 20 Cardinals games.
• The 45.5 line has been covered in the last 2 Cardinals games on the road.
• The 45.5 line has been covered in the last 5 Rams games.
• The 45.5 line has been covered in 10 of the last 16 Rams games this season.
• The 45.5 line has been covered in 6 of the last 10 Rams games.

Over 45.5 Probability

According to the top sportsbooks, there’s a 53.5% likelihood of our pick landing a return. Taking all factors into consideration, our cappers think there’s a stronger chance of success and estimate the probability to be closer to 60%. This is why we can recommend this bet.

There’s a chance to secure larger odds when you bet on the Totals. The sportsbooks allow you to move the line for an Over pick until you’re happy with the potential return.

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Our Game Prediction

Over 45.5 Points @ -115 Bet Now

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Correct Score Prediction

Cardinals 20 - 35 Rams

For those looking to get more bang for their buck, consider a correct score bet on the Rams. Backing them to win 35-20 means you can land a potential monster return.

Cardinals vs Rams Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

With an estimated 81% chance of winning, the sportsbooks are taking no chances with their -417 betting odds about Los Angeles Rams triumphing in this game. Arizona Cardinals are the underdogs at +330 and they’re regarded as least likely to win.

The current spread is 8.5 and total points is 45.5. A Total bet is always available and can often provide value selections. The Over 45.5 selection is available to back at -115.

Every matchup offers a deep selection of team props and game lines and the top NFL betting sites deliver excellent pre-game and in-game wagering opportunities. It’s all about finding the bets that match your game plan.

Moneyline

Cardinals

+330

Rams

-417

Point Spread

Cardinals +8.5

-110

Rams -8.5

-110

Total Points

Under 45.5

-105

Over 45.5

-115

Prop bets don’t involve betting on a franchise to win and instead might look at a player’s individual performance. For example, the number of Passing Yards a quarterback might have or the number of Touchdowns a player might score.

Micro betting provides a rollercoaster ride for NFL bettors. It can be great to enjoy the live lines, with the opportunity to wager on the Next Scoring Play. Watch the live action before deciding which way to go.

Rams Keep Piling Up Home Wins

The Rams have rattled off four straight wins at SoFi Stadium. They have eight wins and two losses in the last 10 games at home, averaging 27.60 points scored and 20.60 points allowed.

The Cardinals have suffered four consecutive road defeats. They have a 2-8 record in their last 10 road games, putting up 20.10 points per contest and giving up 26.70.

In their last matchup at SoFi Stadium, the Rams came out on top 13-9 against the Cardinals. In their past 6 head-to-head matchups at SoFi Stadium, the Rams have recorded four victories, while the Cardinals have managed two.

Last 10 Games		W-L	P	PF	PA	O45.5	U45.5
Rams Home Stats		8-2	48.20	27.60	20.60	5	5
Cardinals Away Stats		2-8	46.80	20.10	26.70	5	5

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O45.5 = Games Over 45.5 Points
• U45.5 = Games Under 45.5 Points

Latest regular season and playoff games stats.

Arizona Cardinals Stats

Los Angeles Rams Stats

Moneyline

• 1 win and 9 defeats in the last 10 games
• 2 wins and 8 defeats in the last 10 games on the road

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 8 wins and 2 defeats in the last 10 home games

Point Spread

• +8.5 Betting Line: Have covered the spread in 5 of the last 10 games
• +8.5 Betting Line on the Road: Have covered the spread in 7 of the last 10 games on the road

Point Spread

• -8.5 Betting Line: Have covered the spread in 5 of the last 10 games
• -8.5 Betting Line at Home: Have covered the spread in 3 of the last 10 home games

Total Points

• Game Totals: An average of 52.90 pts in the previous 10 games
• Game Totals on the Road: An average of 46.80 pts in the previous 10 games on the road
• Over 45.5: Covered in 7 of the previous 10 games
• Over 45.5 on the Road: Covered in 5 of the previous 10 games on the road
• Team Totals: Have scored an average of 20.50 pts and allowed 32.40 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 20.10 pts and allowed 26.70 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 55.70 pts in the previous 10 games
• Game Totals at Home: An average of 43.20 pts in the previous 10 home games
• Over 45.5: Covered in 6 of the previous 10 games
• Over 45.5 at Home: Covered in 4 of the previous 10 home games
• Team Totals: Have scored an average of 34.10 pts and allowed 21.60 pts in the last 10 games
• Team Totals at Home: Have scored an average of 25.90 pts and allowed 17.30 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 337.90 Yds. Allowed 359.80 Yds
• Rushing Yards: Gained 82.50 Yds. Allowed 140.30 Yds
• Passing Yards: Gained 255.40 Yds. Allowed 219.50 Yds
• Total Touchdowns: Scored 2.40 TD. Allowed 3.80 TD
• Rushing Touchdowns: Scored 0.40 TD. Allowed 1.50 TD
• Passing Touchdowns: Scored 1.90 TD. Allowed 2.00 TD
• Total 1st Downs: Picked up 20.50. Allowed 22.40
• Total Turnovers: Committed 1.20. Committed by opponents 1.20
• Total Penalties: Committed 6.10. Committed by opponents 5.10
• Penalty Yards: Lost 45.90 Yds. Gained 41.20 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 406.40 Yds. Allowed 341.00 Yds
• Rushing Yards: Gained 137.40 Yds. Allowed 115.80 Yds
• Passing Yards: Gained 269.00 Yds. Allowed 225.20 Yds
• Total Touchdowns: Scored 4.50 TD. Allowed 2.60 TD
• Rushing Touchdowns: Scored 1.30 TD. Allowed 0.60 TD
• Passing Touchdowns: Scored 3.00 TD. Allowed 1.70 TD
• Total 1st Downs: Picked up 24.30. Allowed 18.70
• Total Turnovers: Committed 0.80. Committed by opponents 1.40
• Total Penalties: Committed 3.80. Committed by opponents 6.30
• Penalty Yards: Lost 28.40 Yds. Gained 47.30 Yds

Last 10 Games on the Road

• Total Yards: Gained 331.20 Yds. Allowed 343.40 Yds
• Rushing Yards: Gained 109.90 Yds. Allowed 126.40 Yds
• Passing Yards: Gained 221.30 Yds. Allowed 217.00 Yds
• Total Touchdowns: Scored 2.30 TD. Allowed 3.00 TD
• Rushing Touchdowns: Scored 0.50 TD. Allowed 1.40 TD
• Passing Touchdowns: Scored 1.80 TD. Allowed 1.30 TD
• Total 1st Downs: Picked up 20.60. Allowed 20.60
• Total Turnovers: Committed 1.10. Committed by opponents 0.80
• Total Penalties: Committed 5.80. Committed by opponents 6.30
• Penalty Yards: Lost 44.90 Yds. Gained 50.10 Yds

Last 10 Home Games

• Total Yards: Gained 370.50 Yds. Allowed 323.30 Yds
• Rushing Yards: Gained 101.30 Yds. Allowed 100.30 Yds
• Passing Yards: Gained 269.20 Yds. Allowed 223.00 Yds
• Total Touchdowns: Scored 3.10 TD. Allowed 1.70 TD
• Rushing Touchdowns: Scored 0.70 TD. Allowed 0.30 TD
• Passing Touchdowns: Scored 2.20 TD. Allowed 1.40 TD
• Total 1st Downs: Picked up 20.90. Allowed 19.50
• Total Turnovers: Committed 0.70. Committed by opponents 1.70
• Total Penalties: Committed 5.30. Committed by opponents 6.10
• Penalty Yards: Lost 42.50 Yds. Gained 43.20 Yds

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