Cardinals vs Saints Prediction, Picks & Odds | 07 Sep 2025

NFL Betting Preview: Cardinals vs Saints

The Arizona Cardinals face the New Orleans Saints in this NFL Week 1 matchup at Caesars Superdome, with kickoff scheduled for 13:00 on Sunday, September 7. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

There are reasons for anticipating that the Saints and the Cardinals points tally will be lower than the line. If you agree with our prediction of Under 42.5, you will find odds of -105 available.

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Arizona Cardinals won their previous game, beating San Francisco 49ers at home. It was a 47-24 win at State Farm Stadium. The Cardinals totaled 393 yards, with 242 through the air and 151 on the ground. The offense moved the chains 26 times and produced 6 touchdowns, including 4 passing scores and 2 rushing TD's.

New Orleans Saints lost on the road in their last game. Tampa Bay Buccaneers won 27-19 at Raymond James Stadium. The Saints recorded 292 total yards, made up of 228 through the air and 64 on the ground. The offense picked up 19 first downs and scored a touchdown through the air.

Head-to-Head Statistics

The Cardinals won the last matchup between the pair. Enjoying a 42-34 triumph when facing the Saints at State Farm Stadium.

Quarterbacks

Kyler Murray

222.5 Passing Yards

Over -114

Under -114

Spencer Rattler

199.5 Passing Yards

Over -114

Under -114

Cardinals vs Saints Prediction & Picks

Our Cardinals vs Saints betting guide delivers expert insight, including a main match pick, scoreline advice, standout player props and bet builder recommendations. Dive into each section below for more.

Game Prediction

We’re going for a modest total for this upcoming NFL matchup. Under 42.5 points could be on the money and our pick is currently available at odds of -105.

We put solid research behind every NFL prediction, starting with recent form and a clear read on injuries. From there, key stats and advanced metrics help complete the picture and support smarter betting decisions.

Key Cardinals vs Saints stats:

• The 42.5 line hasn’t been covered in 4 of the last 5 Saints games at home.
• The 42.5 line hasn’t been covered in 7 of the last 10 Saints games.
• The 42.5 line hasn’t been covered in the last 3 Saints games at home.

Under 42.5 Probability

When looking at the latest odds, our pick has a 51.3% chance of delivering a return. Taking all factors into consideration, our experts think there’s a stronger chance of success and have a probability interval between 55-60%. This wager can therefore be backed with confidence.

If you’re wanting to go Under a certain points total but fancy bigger odds, the Result & Total lines could be a good option. You need the two combinations to work in your favor.

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Our Game Prediction

Under 42.5 Points @ -105 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (19:26, 05 September 2025). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Kyler Murray Under 218.5 Passing Yards -114

You can back Kyler Murray (Cardinals) at -114 to finish with fewer than 218.5 passing yards. There’s no reason to doubt our instinct, so we’ll bet on him falling short of the QB Passing Yards line.

Latest Kyler Murray Player Prop Odds

Touchdown

Anytime

+190

First

+1000

Passing Yards

Over 222.5

-114

Under 222.5

-114

Rushing Yards

Over 26.5

-114

Under 26.5

-114

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Trey McBride Under 63.5 Receiving Yards -114

You can back Trey McBride (Saints) at -114 to end with fewer than 63.5 receiving yards. If you agree with our verdict that the line is too high, this Player Receiving Yards wager is worth backing.

Latest Trey McBride Player Prop Odds

Touchdown

Anytime

+190

First

+900

Receiving Yards

Over 64.5

-114

Under 64.5

-114

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Cardinals 21 - 17 Saints

There’s every chance that this is going to be a close battle and we’ll have a play on the Cardinals enjoying a 21-17 winning scoreline. Hopefully this can go close.

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Cardinals vs Saints Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

Arizona Cardinals are regarded as having a 72% chance of winning this game according to the latest betting odds. The sportsbooks have priced them up at -263. The market suggests that New Orleans Saints are least likely to win at +215.

The spread is calculated to be 6.5, while total points comes in at 44.5. A Total wager relates to the number of points that will be scored overall. Those who wager Under 44.5 can get -112.

If you’re betting on the National Football League, we recommend visiting the top betting apps and scanning through the many team props and game lines. There’s the opportunity to wager pre-game and in-game.

Moneyline

Cardinals

-263

Saints

+215

Point Spread

Cardinals -6.5

-102

Saints +6.5

-120

Total Points

Under 44.5

-112

Over 44.5

-108

The First Touchdown Scorer favorite is James Conner at +340. Similar odds can be found if you’re interested in this player to register the final TD.

Touchdown

James Conner (Cardinals)

First TD

+340

Anytime TD

-179

Alvin Kamara (Saints)

First TD

+500

Anytime TD

-130

Marvin Harrison Jr. (Cardinals)

First TD

+800

Anytime TD

+160

Trey McBride (Cardinals)

First TD

+900

Anytime TD

+190

Kyler Murray (Cardinals)

First TD

+1000

Anytime TD

+190

Chris Olave (Saints)

First TD

+1200

Anytime TD

+220

Michael Wilson (Cardinals)

First TD

+1700

Anytime TD

+390

Trey Benson (Cardinals)

First TD

+1800

Anytime TD

+360

Rashid Shaheed (Saints)

First TD

+1900

Anytime TD

+350

Juwan Johnson (Saints)

First TD

+2500

Anytime TD

+450

Spencer Rattler (Saints)

First TD

+2700

Anytime TD

+500

Kendre Miller (Saints)

First TD

+3000

Anytime TD

+500

Zay Jones (Cardinals)

First TD

+3300

Anytime TD

+900

Brandin Cooks (Saints)

First TD

+3500

Anytime TD

+850

Devaughn Vele (Saints)

First TD

+4500

Anytime TD

+650

Greg Dortch (Cardinals)

First TD

+5000

Anytime TD

+800

Elijah Higgins (Cardinals)

First TD

+8000

Anytime TD

+1400

Tip Reiman (Cardinals)

First TD

+8000

Anytime TD

+1700

Emari Demercado (Cardinals)

First TD

+8000

Anytime TD

+1300

Bam Knight (Cardinals)

First TD

+8000

Anytime TD

+1300

Mason Tipton (Saints)

First TD

+10000

Anytime TD

+2700

Xavier Weaver (Cardinals)

First TD

+10000

Anytime TD

+1900

Jack Stoll (Saints)

First TD

+10000

Anytime TD

+3000

Velus Jones Jr. (Saints)

First TD

+10000

Anytime TD

+3000

Trey Palmer (Saints)

First TD

+10000

Anytime TD

+2700

Travis Vokolek (Cardinals)

First TD

+10000

Anytime TD

+3500

Moliki Matavao (Saints)

First TD

+10000

Anytime TD

+5500

Receiving Yards

Trey McBride (Cardinals)

Over 64.5

-114

Under 64.5

-114

Marvin Harrison Jr. (Cardinals)

Over 58.5

-114

Under 58.5

-114

Chris Olave (Saints)

Over 51.5

-114

Under 51.5

-114

Rashid Shaheed (Saints)

Over 42.5

-114

Under 42.5

-114

Alvin Kamara (Saints)

Over 28.5

-106

Under 28.5

-120

Juwan Johnson (Saints)

Over 25.5

-114

Under 25.5

-114

Michael Wilson (Cardinals)

Over 24.5

-114

Under 24.5

-114

Brandin Cooks (Saints)

Over 17.5

-114

Under 17.5

-114

James Conner (Cardinals)

Over 14.5

-120

Under 14.5

-106

Zay Jones (Cardinals)

Over 13.5

-114

Under 13.5

-114

Rushing Yards

James Conner (Cardinals)

Over 72.5

-114

Under 72.5

-114

Alvin Kamara (Saints)

Over 61.5

-114

Under 61.5

-114

Kyler Murray (Cardinals)

Over 26.5

-114

Under 26.5

-114

Trey Benson (Cardinals)

Over 25.5

-114

Under 25.5

-114

Spencer Rattler (Saints)

Over 21.5

-114

Under 21.5

-114

Passing Yards

Kyler Murray (Cardinals)

Over 222.5

-114

Under 222.5

-114

Spencer Rattler (Saints)

Over 199.5

-114

Under 199.5

-114

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Saints Run Stands at Three Home Losses in Succession

The Saints have dropped three consecutive games at Caesars Superdome. They own a 4-6 mark in their past 10 home games, averaging 24.20 points on offense and surrendering 22.30 on defense.

The Cardinals have lost four consecutive road games. They have three wins and seven losses in the last 10 road games, putting up 21.10 points per matchup and giving up 26.40.

The Saints defeated the Cardinals 31-9 the last time they played at Caesars Superdome.

Last 10 Games		W-L	P	PF	PA	O42.5	U42.5
Saints Home Stats		4-6	46.50	24.20	22.30	5	5
Cardinals Away Stats		3-7	47.50	21.10	26.40	8	2

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O42.5 = Games Over 42.5 Points
• U42.5 = Games Under 42.5 Points

Latest regular season and playoff games stats.

Arizona Cardinals Stats

New Orleans Saints Stats

Moneyline

• 5 wins and 5 defeats in the last 10 games
• 3 wins and 7 defeats in the last 10 games on the road

Moneyline

• 3 wins and 7 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 home games

Point Spread

• -6.5 Betting Line: Have covered the spread in 4 of the last 10 games
• -6.5 Betting Line on the Road: Have not covered the spread in any of the last 10 games on the road

Point Spread

• +6.5 Betting Line: Have covered the spread in 5 of the last 10 games
• +6.5 Betting Line at Home: Have covered the spread in 6 of the last 10 home games

Total Points

• Game Totals: An average of 45.10 pts in the previous 10 games
• Game Totals on the Road: An average of 47.50 pts in the previous 10 games on the road
• Over 42.5: Covered in 6 of the previous 10 games
• Over 42.5 on the Road: Covered in 8 of the previous 10 games on the road
• Team Totals: Have scored an average of 25.00 pts and allowed 20.10 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 21.10 pts and allowed 26.40 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 37.90 pts in the previous 10 games
• Game Totals at Home: An average of 46.50 pts in the previous 10 home games
• Over 42.5: Covered in 3 of the previous 10 games
• Over 42.5 at Home: Covered in 5 of the previous 10 home games
• Team Totals: Have scored an average of 16.10 pts and allowed 21.80 pts in the last 10 games
• Team Totals at Home: Have scored an average of 24.20 pts and allowed 22.30 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 376.80 Yds. Allowed 313.60 Yds
• Rushing Yards: Gained 138.20 Yds. Allowed 111.60 Yds
• Passing Yards: Gained 238.60 Yds. Allowed 202.00 Yds
• Total Touchdowns: Scored 2.60 TD. Allowed 2.10 TD
• Rushing Touchdowns: Scored 1.30 TD. Allowed 1.00 TD
• Passing Touchdowns: Scored 1.20 TD. Allowed 1.10 TD
• Total 1st Downs: Picked up 22.20. Allowed 18.40
• Total Turnovers: Committed 1.10. Committed by opponents 0.70
• Total Penalties: Committed 5.50. Committed by opponents 6.10
• Penalty Yards: Lost 48.20 Yds. Gained 48.20 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 325.20 Yds. Allowed 370.00 Yds
• Rushing Yards: Gained 114.00 Yds. Allowed 137.70 Yds
• Passing Yards: Gained 211.20 Yds. Allowed 231.80 Yds
• Total Touchdowns: Scored 1.70 TD. Allowed 2.50 TD
• Rushing Touchdowns: Scored 0.50 TD. Allowed 1.10 TD
• Passing Touchdowns: Scored 1.10 TD. Allowed 1.40 TD
• Total 1st Downs: Picked up 17.30. Allowed 20.80
• Total Turnovers: Committed 0.80. Committed by opponents 0.40
• Total Penalties: Committed 6.90. Committed by opponents 6.40
• Penalty Yards: Lost 60.80 Yds. Gained 54.40 Yds

Last 10 Games on the Road

• Total Yards: Gained 355.40 Yds. Allowed 340.00 Yds
• Rushing Yards: Gained 128.30 Yds. Allowed 134.10 Yds
• Passing Yards: Gained 227.10 Yds. Allowed 205.90 Yds
• Total Touchdowns: Scored 2.00 TD. Allowed 3.00 TD
• Rushing Touchdowns: Scored 0.60 TD. Allowed 1.00 TD
• Passing Touchdowns: Scored 1.30 TD. Allowed 1.80 TD
• Total 1st Downs: Picked up 20.90. Allowed 20.10
• Total Turnovers: Committed 1.30. Committed by opponents 0.90
• Total Penalties: Committed 6.30. Committed by opponents 5.30
• Penalty Yards: Lost 48.90 Yds. Gained 44.20 Yds

Last 10 Home Games

• Total Yards: Gained 325.10 Yds. Allowed 397.70 Yds
• Rushing Yards: Gained 120.40 Yds. Allowed 150.60 Yds
• Passing Yards: Gained 204.70 Yds. Allowed 246.60 Yds
• Total Touchdowns: Scored 2.70 TD. Allowed 2.60 TD
• Rushing Touchdowns: Scored 0.80 TD. Allowed 1.10 TD
• Passing Touchdowns: Scored 1.80 TD. Allowed 1.40 TD
• Total 1st Downs: Picked up 17.70. Allowed 21.20
• Total Turnovers: Committed 1.20. Committed by opponents 1.30
• Total Penalties: Committed 5.90. Committed by opponents 6.40
• Penalty Yards: Lost 51.60 Yds. Gained 52.60 Yds

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