Arizona Cardinals
American Football NFL Caesars Superdome Sun 7 Sep 13:00
New Orleans Saints
  1. Prediction
  2. Bet Builder
  3. Odds
  4. Player Props
  5. Stats
  6. Team News
  7. Lineups
  8. Injuries
  9. Standings

NFL Betting Preview: Cardinals vs Saints

The Arizona Cardinals face the New Orleans Saints in this NFL Week 1 matchup at Caesars Superdome, with kickoff scheduled for 13:00 on Sunday 7 September. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

We’re Expecting a Low Points Total

There are reasons for anticipating that the Saints and the Cardinals points tally will be lower than the line. If you agree with our prediction of Under 42.5, you will find odds of -105 available.

Anticipating a defensive showcase? Secure the latest BetMGM promo code and check out our review before locking in your bet.

42-34 Victory for Cardinals in Previous H2H Clash

Arizona Cardinals won their previous game, beating San Francisco 49ers at home. It was a 47-24 win at State Farm Stadium. The Cardinals totaled 393 yards, with 242 through the air and 151 on the ground. The offense moved the chains 26 times and produced 6 touchdowns, including 4 passing scores and 2 rushing TD's.

New Orleans Saints lost on the road in their last game. Tampa Bay Buccaneers won 27-19 at Raymond James Stadium. The Saints recorded 292 total yards, made up of 228 through the air and 64 on the ground. The offense picked up 19 first downs and scored a touchdown through the air.

Head-to-Head Statistics

The Cardinals won the last matchup between the pair. Enjoying a 42-34 triumph when facing the Saints at State Farm Stadium.

Quarterbacks

Cardinals vs Saints Prediction & Picks

Our Cardinals vs Saints betting guide delivers expert insight, including a main match pick, scoreline advice, standout player props and bet builder recommendations. Dive into each section below for more.

Game Prediction

We’re going for a modest total for this upcoming NFL matchup. Under 42.5 points could be on the money and our pick is currently available at odds of -105.

We put solid research behind every NFL prediction, starting with recent form and a clear read on injuries. From there, key stats and advanced metrics help complete the picture and support smarter betting decisions.

Key Cardinals vs Saints stats:

  • The 42.5 line hasn’t been covered in 4 of the last 5 Saints games at home.
  • The 42.5 line hasn’t been covered in 7 of the last 10 Saints games.
  • The 42.5 line hasn’t been covered in the last 3 Saints games at home.

Under 42.5 Probability

When looking at the latest odds, our pick has a 51.3% chance of delivering a return. Taking all factors into consideration, our experts think there’s a stronger chance of success and have a probability interval between 55-60%. This wager can therefore be backed with confidence.

Looking for Bigger Odds?

If you’re wanting to go Under a certain points total but fancy bigger odds, the Result & Total lines could be a good option. You need the two combinations to work in your favor.

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Best Bet

Under 42.5 Points @ -105 Bet Now BetMGM logo
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Published 19:26, 05 September 2025

Player Prop Picks

Top Pick: Kyler Murray Under 218.5 Passing Yards -114 BetMGM logo

You can back Kyler Murray (Cardinals) at -114 to finish with fewer than 218.5 passing yards. There’s no reason to doubt our instinct, so we’ll bet on him falling short of the QB Passing Yards line.

Latest Kyler Murray Player Prop Odds

Trey McBride Under 63.5 Receiving Yards -114 BetMGM logo

You can back Trey McBride (Saints) at -114 to end with fewer than 63.5 receiving yards. If you agree with our verdict that the line is too high, this Player Receiving Yards wager is worth backing.

Latest Trey McBride Player Prop Odds

Same Game Parlay Picks

Totals Under 42.5
Spread Saints +6.5
Passing Yards Kyler Murray Under 218.5

We’ve compiled a same game parlay that includes Under 42.5, along with Saints +6.5 on the spread and Kyler Murray (Cardinals) to go Under 218.5 passing yards.

The same game parlay option allows you to combine different outcomes within the same football game. You need all your picks to be correct although bettors love to place a tailored wager on the clash which interests them most.

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Correct Score Prediction

Cardinals Cardinals logo 21 - 17 Saints logo Saints

There’s every chance that this is going to be a close battle and we’ll have a play on the Cardinals enjoying a 21-17 winning scoreline. Hopefully this can go close.

Cardinals vs Saints Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Latest Odds Suggest Cardinals Win

Arizona Cardinals are regarded as having a 74% chance of winning this game according to the latest betting odds. The sportsbooks have priced them up at -278. The market suggests that New Orleans Saints are least likely to win at +225.

The spread is calculated to be 6.5, while total points comes in at 42.5. A Total wager relates to the number of points that will be scored overall. Those who wager Under 42.5 can get -105.

If you’re betting on the National Football League, we recommend visiting the top betting apps and scanning through the many team props and game lines. There’s the opportunity to wager pre-game and in-game.

James Conner Favorite to Score First TD

The First Touchdown Scorer favorite is James Conner at +350. Similar odds can be found if you’re interested in this player to register the final TD.

Touchdown

James Conner (Cardinals)
First TD
+350
Anytime TD
-164
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Alvin Kamara (Saints)
First TD
+550
Anytime TD
-110
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Marvin Harrison Jr. (Cardinals)
First TD
+750
Anytime TD
+145
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Trey McBride (Cardinals)
First TD
+850
Anytime TD
+185
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Receiving Yards

Trey McBride (Cardinals)
Over 63.5
-114
Under 63.5
-114
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Marvin Harrison Jr. (Cardinals)
Over 58.5
-114
Under 58.5
-114
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Rashid Shaheed (Saints)
Over 42.5
-114
Under 42.5
-114
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Rushing Yards

James Conner (Cardinals)
Over 72.5
-114
Under 72.5
-114
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Alvin Kamara (Saints)
Over 58.5
-114
Under 58.5
-114
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Kyler Murray (Cardinals)
Over 25.5
-114
Under 25.5
-114
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Trey Benson (Cardinals)
Over 25.5
-114
Under 25.5
-114
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Passing Yards

Kyler Murray (Cardinals)
Over 217.5
-114
Under 217.5
-114
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Spencer Rattler (Saints)
Over 197.5
-114
Under 197.5
-114
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Best Betting Offers
Caesars Superdome
Caesars Superdome

Saints Run Stands at Three Home Losses in Succession

The Saints have dropped three consecutive games at Caesars Superdome. They own a 4-6 mark in their past 10 home games, averaging 24.20 points on offense and surrendering 22.30 on defense.

The Cardinals have lost four consecutive road games. They have three wins and seven losses in the last 10 road games, putting up 21.10 points per matchup and giving up 26.40.

The Saints defeated the Cardinals 31-9 the last time they played at Caesars Superdome.

Last 10 Games W-L P PF PA O42.5 U42.5
Saints logo Saints Home Stats 4-6 46.50 24.20 22.30 5 5
Cardinals logo Cardinals Away Stats 3-7 47.50 21.10 26.40 8 2
  • W-L = Wins-Losses
  • P = Avg. Points
  • PF = Avg. Points For
  • PA = Avg. Points Against
  • O42.5 = Games Over 42.5 Points
  • U42.5 = Games Under 42.5 Points
Team Stats

Latest regular season and playoff games stats.

Arizona Cardinals logo Arizona Cardinals Stats
New Orleans Saints logo New Orleans Saints Stats
Moneyline
  • 5 wins and 5 defeats in the last 10 games
  • 3 wins and 7 defeats in the last 10 games on the road
Moneyline
  • 3 wins and 7 defeats in the last 10 games
  • 4 wins and 6 defeats in the last 10 home games
Point Spread
Point Spread
Total Points
Total Points
Game Stats
Last 10 Games
Game Stats
Last 10 Games
Last 10 Games on the Road
Last 10 Home Games

Team News

Arizona Cardinals Injuries

Type
Name
Info
Hayden Conner
Knee
Will Hernandez
Knee - ACL
Trishton Jackson
Thumb
Christian Jones
Knee
Justin Jones
Knee
Sean Murphy-Bunting
Knee
Bilal Nichols
Neck
Walter Nolen
Calf
BJ Ojulari
Knee - ACL
Owen Pappoe
Quadriceps
J.J. Russell
Concussion
Valentin Senn
Undisclosed
Dante Stills
Heel
Starling Thomas
Knee - ACL

New Orleans Saints Injuries

Type
Name
Info
Derek Carr
Shoulder
Will Clapp
Foot
Taysom Hill
Knee - ACL
Jordan Howden
Oblique
Tyrann Mathieu
Undisclosed
Bub Means
Lower Leg
Foster Moreau
Knee
Trevor Penning
Toe
Mason Pline
Upper Body
Ryan Ramczyk
Undisclosed
John Ridgeway
Pectoral
Nick Saldiveri
Knee
Barry Wesley
Undisclosed
Chase Young
Calf
Landon Young
Ankle

Previous Arizona Cardinals Lineups

05 Jan NFL
49ers 24-47 Cardinals
28 Dec NFL
Cardinals 9-13 Rams
22 Dec NFL
Cardinals 30-36 Panthers
15 Dec NFL
Patriots 17-30 Cardinals
08 Dec NFL
Seahawks 30-18 Cardinals
01 Dec NFL
Cardinals 22-23 Vikings
24 Nov NFL
Cardinals 6-16 Seahawks
10 Nov NFL
Jets 6-31 Cardinals
03 Nov NFL
Bears 9-29 Cardinals
27 Oct NFL
Cardinals 28-27 Dolphins

Previous New Orleans Saints Lineups

05 Jan NFL
Saints 19-27 Buccaneers
29 Dec NFL
Raiders 25-10 Saints
23 Dec NFL
Saints 0-34 Packers
15 Dec NFL
Commanders 20-19 Saints
08 Dec NFL
Saints 14-11 Giants
01 Dec NFL
Rams 21-14 Saints
17 Nov NFL
Browns 14-35 Saints
10 Nov NFL
Falcons 17-20 Saints
03 Nov NFL
Saints 22-23 Panthers
27 Oct NFL
Saints 8-26 Chargers

NFL Standings Select Season

AFC East W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Bills 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Dolphins 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Patriots 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Jets 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
AFC North W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Ravens 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Bengals 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Browns 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Steelers 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
AFC South W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Texans 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Colts 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Jaguars 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Titans 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
AFC West W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Chargers 1 0 0 1.000 27 21 6 1-0-0 0-0-0 1-0-0 1-0-0 1-0-0 1W
Broncos 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Raiders 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Chiefs 0 1 0 0.000 21 27 -6 0-0-0 0-1-0 0-1-0 0-1-0 0-1-0 1L
NFC East W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Eagles 1 0 0 1.000 24 20 4 1-0-0 0-0-0 1-0-0 1-0-0 1-0-0 1W
Giants 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Commanders 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Cowboys 0 1 0 0.000 20 24 -4 0-0-0 0-1-0 0-1-0 0-1-0 0-1-0 1L
NFC North W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Bears 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Lions 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Packers 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Vikings 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
NFC South W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Falcons 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Panthers 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Saints 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Buccaneers 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
NFC West W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Cardinals 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Rams 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
49ers 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Seahawks 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
AFC Conference W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Chargers 1 0 0 1.000 27 21 6 1-0-0 0-0-0 1-0-0 1-0-0 1-0-0 1W
Bills 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Dolphins 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Patriots 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Jets 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Ravens 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Bengals 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Browns 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Steelers 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Texans 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Colts 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Jaguars 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Titans 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Broncos 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Raiders 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Chiefs 0 1 0 0.000 21 27 -6 0-0-0 0-1-0 0-1-0 0-1-0 0-1-0 1L
NFC Conference W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Eagles 1 0 0 1.000 24 20 4 1-0-0 0-0-0 1-0-0 1-0-0 1-0-0 1W
Giants 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Commanders 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Bears 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Lions 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Packers 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Vikings 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Falcons 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Panthers 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Saints 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Buccaneers 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Cardinals 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Rams 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
49ers 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Seahawks 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Cowboys 0 1 0 0.000 20 24 -4 0-0-0 0-1-0 0-1-0 0-1-0 0-1-0 1L
NFL Team W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Chargers 1 0 0 1.000 27 21 6 1-0-0 0-0-0 1-0-0 1-0-0 1-0-0 1W
Eagles 1 0 0 1.000 24 20 4 1-0-0 0-0-0 1-0-0 1-0-0 1-0-0 1W
Cardinals 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Falcons 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Ravens 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Bills 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Panthers 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Bears 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Bengals 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Browns 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Broncos 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Lions 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Packers 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Texans 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Colts 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Jaguars 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Raiders 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Rams 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Dolphins 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Vikings 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Patriots 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Saints 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Giants 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Jets 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Steelers 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
49ers 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Seahawks 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Buccaneers 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Titans 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Commanders 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Cowboys 0 1 0 0.000 20 24 -4 0-0-0 0-1-0 0-1-0 0-1-0 0-1-0 1L
Chiefs 0 1 0 0.000 21 27 -6 0-0-0 0-1-0 0-1-0 0-1-0 0-1-0 1L