NFL Betting Preview: Cardinals vs Niners

The Arizona Cardinals face the San Francisco 49ers in this NFL matchup at Levi's Stadium, with kickoff scheduled for 16:25 on Sunday 21 September. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

Cardinals Primed to Win This Matchup

The Cardinals should be able to outscore the Niners and our prediction is to side with them on the Moneyline. There is a tempting +110 should you wish to follow suit.

Confident in Cardinals to win? Unlock the best BetMGM promo code and read our in-depth expert review before placing your bet.

Teams’ Last Matchup Saw 47-24 Cardinals Win

Arizona Cardinals claimed a home victory in their previous game. A 27-22 triumph against Carolina Panthers at State Farm Stadium made it back-to-back wins. The Cardinals put up 293 yards, including 211 passing and 82 rushing yards. The offense managed 16 first downs and reached the end zone 3 times, 1 via the pass and 1 on the ground.

San Francisco 49ers have triumphed in back-to-back games. The latest of these was on the road where New Orleans Saints were beaten 26-21 at Caesars Superdome. The 49ers totaled 344 yards, with 267 through the air and 77 on the ground. They scored 3 touchdowns and picked up 23 first downs.

Head-to-Head Statistics

The Cardinals have beaten the Niners in the last two matchups. A 24-23 victory at Levi's Stadium was followed by a 47-24 win at State Farm Stadium. Both teams have won five games when it comes to the previous 10 H2H meetings.

Cardinals vs 49ers Prediction & Picks

The Cardinals vs 49ers betting tips feature sharp analysis across major markets, including a key match prediction, player prop bets, correct score guidance and a ready-made bet builder.

Game Prediction

We are eager to back the Cardinals to win this NFL matchup and that leads us to the Moneyline for our pick. It’s difficult to turn down the +110 that they claim the win.

The NFL handicappers at Sportsgambler.com start by analyzing recent form and staying on top of injury news before making any predictions. From there, we interpret the story the stats are telling to help shape our picks.

Key Cardinals vs 49ers stats:

Cardinals have won 3 consecutive games.
49ers have lost 7 of their last 10 games.
49ers have lost 12 of their last 20 games.
49ers have lost their last 2 games at home.
49ers have lost their last 2 games against Cardinals.

Cardinals Moneyline Probability

If you go by the top betting sites, there’s a 47.6% likelihood of our pick landing a return. In the opinion of our analysts, there’s actually a probability of success between 50-55%. It’s why we think it’s worth placing this bet.

Looking for Bigger Odds?

If you’re looking to squeeze more juice from the odds, consider the Cardinals on the spread. Those expecting this franchise to exceed expectations can bet them to cover the line.

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Best Bet

Cardinals Moneyline @ +110 Bet Now

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Published 22:26, 19 September 2025

Player Prop Picks

Top Pick: Kyler Murray Over 215.5 Passing Yards -114

Kyler Murray (Cardinals) can be backed at -114 to exceed 215.5 passing yards. The line for him on the Overs is highly appealing, with QB Passing Yards bettors able to get plenty of juice.

Latest Kyler Murray Player Prop Odds

Touchdown

Passing Yards

Rushing Yards

Trey McBride Anytime TD +200

The odds for Trey McBride (Cardinals) to hit paydirt are +200. We believe this is the best of the player props, with attractive odds available when it comes to betting him to score a touchdown at any time.

Latest Trey McBride Player Prop Odds

Touchdown

Receiving Yards

Same Game Parlay Picks

Moneyline Cardinals

Totals Over 44.5

Passing Yards Kyler Murray Over 215.5

The same game parlay pick is Cardinals on the moneyline, Over 44.5 on the total and Kyler Murray (Cardinals) to go Over 215.5 passing yards.

The betting sites now allow you to place a same game parlay on each individual game. It means that you can create a personalised football wager at bigger odds, with there generally being no limit as to the number of selections.

Bet Boosts

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Correct Score Prediction

Cardinals

31 - 23 49ers logo

49ers

For those looking to get more bang for their buck, consider a correct score bet on the Cardinals. Backing them to win 31-23 means you can land a potential monster return.

Cardinals vs 49ers Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Latest Odds Suggest a Close Contest

When you consider the latest Moneyline odds, you can find San Francisco 49ers at -135 whereas Arizona Cardinals are +116. This means the leading sportsbooks give the visiting team a 46% chance of success.

The spread currently stands at 2.5 and the total points line is 44.5. Having a wager on the Totals is one of the most popular NFL bets. There’s the chance to back Under 44.5 at -115.

The best NFL sportsbooks offer a wide range of team props and game lines for every matchup. Make sure you look through all the available options before deciding which bet to place.

Moneyline

Point Spread

Total Points

Christian McCaffrey Favorite to Be First Touchdown Scorer

The First Touchdown Scorer favorite is Christian McCaffrey at +350. Similar odds can be found if you’re interested in this player to register the final TD.

Touchdown

Christian McCaffrey (49ers)

James Conner (Cardinals)

Marvin Harrison Jr. (Cardinals)

Jauan Jennings (49ers)

View More View Less

Receiving Yards

Trey McBride (Cardinals)

Marvin Harrison Jr. (Cardinals)

Christian McCaffrey (49ers)

Michael Wilson (Cardinals)

View More View Less

Rushing Yards

Christian McCaffrey (49ers)

James Conner (Cardinals)

Kyler Murray (Cardinals)

Trey Benson (Cardinals)

Best Betting Offers

Levi's Stadium

Niners Hold Five Wins in Previous Ten at Home

The Niners have a 5-5 record in their last 10 home games, scoring 26.20 points per contest and conceding 22.40.

The Cardinals own a 4-6 mark in their past 10 road games, averaging 21.50 points scored and 25.00 points allowed.

The last time the teams met at Levi's Stadium, the Cardinals defeated the Niners 24-23. The last 6 head-to-head matchups at Levi's Stadium have been split, with each team winning three times.

Last 10 Games		W-L	P	PF	PA	O44.5	U44.5
49ers Home Stats		5-5	48.60	26.20	22.40	7	3
Cardinals Away Stats		4-6	46.50	21.50	25.00	7	3

W-L = Wins-Losses
P = Avg. Points
PF = Avg. Points For
PA = Avg. Points Against
O44.5 = Games Over 44.5 Points
U44.5 = Games Under 44.5 Points

Last 5 & H2H

All
Home
Away

Last 5 Games

Cardinals

NFL: 14/09 Panthers22 Cardinals 27
NFL: 07/09 Cardinals20 Saints 13
NFL: 05/01 49ers24 Cardinals 47
NFL: 29/12 Cardinals9 Rams 13
NFL: 22/12 Cardinals30 Panthers 36

49ers

NFL: 14/09 49ers26 Saints 21
NFL: 07/09 49ers17 Seahawks 13
NFL: 05/01 49ers24 Cardinals 47
NFL: 31/12 Lions40 49ers 34
NFL: 22/12 49ers17 Dolphins 29

Head to Head

Cardinals vs 49ers

NFL: 05/01 2025 49ers 24 Cardinals 47
NFL: 06/10 2024 Cardinals 24 49ers 23
NFL: 17/12 2023 49ers 45 Cardinals 29
NFL: 01/10 2023 Cardinals 16 49ers 35
NFL: 08/01 2023 Cardinals 13 49ers 38
NFL: 22/11 2022 49ers 38 Cardinals 10
NFL: 07/11 2021 Cardinals 31 49ers 17
NFL: 10/10 2021 49ers 10 Cardinals 17
NFL: 26/12 2020 49ers 20 Cardinals 12
NFL: 13/09 2020 Cardinals 24 49ers 20

Team Stats

Latest regular season and playoff games stats.

Arizona Cardinals Stats

San Francisco 49ers Stats

Moneyline

5 wins and 5 defeats in the last 10 games
4 wins and 6 defeats in the last 10 games on the road

Moneyline

3 wins and 7 defeats in the last 10 games
5 wins and 5 defeats in the last 10 home games

Point Spread

+2.5 Betting Line: Have covered the spread in 6 of the last 10 games
+2.5 Betting Line on the Road: Have covered the spread in 5 of the last 10 games on the road

Point Spread

-2.5 Betting Line: Have covered the spread in 3 of the last 10 games
-2.5 Betting Line at Home: Have covered the spread in 5 of the last 10 home games

Total Points

Game Totals: An average of 44.00 pts in the previous 10 games
Game Totals on the Road: An average of 46.50 pts in the previous 10 games on the road
Over 44.5: Covered in 6 of the previous 10 games
Over 44.5 on the Road: Covered in 7 of the previous 10 games on the road
Team Totals: Have scored an average of 24.00 pts and allowed 20.00 pts in the last 10 games
Team Totals on the Road: Have scored an average of 21.50 pts and allowed 25.00 pts in the last 10 games on the road

Total Points

Game Totals: An average of 46.70 pts in the previous 10 games
Game Totals at Home: An average of 48.60 pts in the previous 10 home games
Over 44.5: Covered in 7 of the previous 10 games
Over 44.5 at Home: Covered in 7 of the previous 10 home games
Team Totals: Have scored an average of 19.90 pts and allowed 26.80 pts in the last 10 games
Team Totals at Home: Have scored an average of 26.20 pts and allowed 22.40 pts in the last 10 home games

Game Stats

Last 10 Games

Total Yards: Gained 359.80 Yds. Allowed 318.50 Yds
Rushing Yards: Gained 131.50 Yds. Allowed 105.30 Yds
Passing Yards: Gained 228.30 Yds. Allowed 213.20 Yds
Total Touchdowns: Scored 2.50 TD. Allowed 2.20 TD
Rushing Touchdowns: Scored 1.00 TD. Allowed 0.90 TD
Passing Touchdowns: Scored 1.30 TD. Allowed 1.30 TD
Total 1st Downs: Picked up 21.70. Allowed 19.30
Total Turnovers: Committed 1.00. Committed by opponents 0.90
Total Penalties: Committed 7.00. Committed by opponents 7.30
Penalty Yards: Lost 58.80 Yds. Gained 60.60 Yds

Game Stats

Last 10 Games

Total Yards: Gained 341.30 Yds. Allowed 319.20 Yds
Rushing Yards: Gained 101.20 Yds. Allowed 136.90 Yds
Passing Yards: Gained 240.10 Yds. Allowed 182.30 Yds
Total Touchdowns: Scored 2.40 TD. Allowed 3.10 TD
Rushing Touchdowns: Scored 0.80 TD. Allowed 1.40 TD
Passing Touchdowns: Scored 1.60 TD. Allowed 1.70 TD
Total 1st Downs: Picked up 20.20. Allowed 19.50
Total Turnovers: Committed 1.90. Committed by opponents 0.50
Total Penalties: Committed 7.30. Committed by opponents 4.40
Penalty Yards: Lost 50.30 Yds. Gained 34.70 Yds

Last 10 Games on the Road

Total Yards: Gained 352.40 Yds. Allowed 329.50 Yds
Rushing Yards: Gained 133.60 Yds. Allowed 119.80 Yds
Passing Yards: Gained 218.80 Yds. Allowed 209.70 Yds
Total Touchdowns: Scored 2.00 TD. Allowed 2.80 TD
Rushing Touchdowns: Scored 0.60 TD. Allowed 0.90 TD
Passing Touchdowns: Scored 1.30 TD. Allowed 1.70 TD
Total 1st Downs: Picked up 21.20. Allowed 20.00
Total Turnovers: Committed 1.30. Committed by opponents 0.80
Total Penalties: Committed 7.00. Committed by opponents 6.10
Penalty Yards: Lost 53.50 Yds. Gained 49.60 Yds

Last 10 Home Games

Total Yards: Gained 380.30 Yds. Allowed 309.50 Yds
Rushing Yards: Gained 136.00 Yds. Allowed 118.80 Yds
Passing Yards: Gained 244.30 Yds. Allowed 190.70 Yds
Total Touchdowns: Scored 2.80 TD. Allowed 2.60 TD
Rushing Touchdowns: Scored 1.60 TD. Allowed 1.40 TD
Passing Touchdowns: Scored 1.00 TD. Allowed 1.20 TD
Total 1st Downs: Picked up 20.90. Allowed 18.30
Total Turnovers: Committed 1.50. Committed by opponents 1.30
Total Penalties: Committed 5.60. Committed by opponents 3.50
Penalty Yards: Lost 37.70 Yds. Gained 27.50 Yds

Team News

Arizona Cardinals Injuries

Type

Name

Info

Joey Blount

Neck

L.J. Collier

Knee

Hayden Conner

Knee

Will Hernandez

Knee - ACL

Trishton Jackson

Thumb

Paris Johnson

Knee

Will Johnson

Groin

Christian Jones

Knee

Justin Jones

Knee

Max Melton

Knee

Sean Murphy-Bunting

Knee

Bilal Nichols

Neck

Walter Nolen

Calf

BJ Ojulari

Knee - ACL

Tip Reiman

Foot

J.J. Russell

Concussion

Valentin Senn

Undisclosed

Starling Thomas

Knee - ACL

Garrett Williams

Knee

San Francisco 49ers Injuries

Type

Name

Info

Brandon Aiyuk

Knee - ACL + MCL

Isaac Alarcon

Suspension

Ben Bartch

Ankle

Spencer Burford

Knee

Connor Colby

Groin

Jacob Cowing

Hamstring

Kevin Givens

Pectoral

Tarron Jackson

Undisclosed

Jauan Jennings

Ankle

George Kittle

Hamstring

Malik Mustapha

Knee - ACL

Brock Purdy

Toe

Demarcus Robinson

Suspension

Jakob Robinson

Forearm

Kurtis Rourke

Knee

Patrick Taylor

Shoulder

Trent Taylor

Undisclosed

Tre Tomlinson

Undisclosed

Jordan Watkins

Calf

Previous Arizona Cardinals Lineups

14 Sep NFL

Panthers 22-27 Cardinals

AFC East	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Bills	3	0	1.000	102	71	31	2-0-0	1-0-0	2-0-0	3-0-0	3-0-0	3W
Patriots	1	1	0.500	46	47	-1	0-1-0	1-0-0	1-0-0	1-1-0	1-1-0	1W
Jets	0	2	0.000	42	64	-22	0-2-0	0-0-0	0-1-0	0-2-0	0-2-0	2L
Dolphins	0	3	0.000	56	97	-41	0-1-0	0-2-0	0-2-0	0-3-0	0-3-0	3L

AFC North	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Bengals	2	0	1.000	48	43	5	1-0-0	1-0-0	1-0-0	2-0-0	2-0-0	2W
Ravens	1	1	0.500	81	58	23	1-0-0	0-1-0	1-0-0	1-1-0	1-1-0	1W
Steelers	1	1	0.500	51	63	-12	0-1-0	1-0-0	0-0-0	1-0-0	1-1-0	1L
Browns	0	2	0.000	33	58	-25	0-1-0	0-1-0	0-2-0	0-2-0	0-2-0	2L

AFC South	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Colts	2	0	1.000	62	36	26	2-0-0	0-0-0	0-0-0	2-0-0	2-0-0	2W
Jaguars	1	1	0.500	53	41	12	1-0-0	0-1-0	0-0-0	0-1-0	1-1-0	1L
Texans	0	2	0.000	28	34	-6	0-1-0	0-1-0	0-0-0	0-0-0	0-2-0	2L
Titans	0	2	0.000	31	53	-22	0-1-0	0-1-0	0-0-0	0-1-0	0-2-0	2L

AFC West	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Chargers	2	0	1.000	47	30	17	1-0-0	1-0-0	2-0-0	2-0-0	2-0-0	2W
Raiders	1	1	0.500	29	33	-4	0-1-0	1-0-0	0-1-0	1-1-0	1-1-0	1L
Broncos	1	1	0.500	48	41	7	1-0-0	0-1-0	0-0-0	1-1-0	1-1-0	1L
Chiefs	0	2	0.000	38	47	-9	0-1-0	0-1-0	0-1-0	0-1-0	0-2-0	2L

NFC East	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Eagles	2	0	1.000	44	37	7	1-0-0	1-0-0	1-0-0	1-0-0	2-0-0	2W
Commanders	1	1	0.500	39	33	6	1-0-0	0-1-0	1-0-0	1-1-0	1-1-0	1L
Cowboys	1	1	0.500	60	61	-1	1-0-0	0-1-0	1-1-0	1-1-0	1-1-0	1W
Giants	0	2	0.000	43	61	-18	0-0-0	0-2-0	0-2-0	0-2-0	0-2-0	2L

NFC North	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Packers	2	0	1.000	54	31	23	2-0-0	0-0-0	1-0-0	2-0-0	2-0-0	2W
Vikings	1	1	0.500	33	46	-13	0-1-0	1-0-0	1-0-0	1-1-0	1-1-0	1L
Lions	1	1	0.500	65	48	17	1-0-0	0-1-0	1-1-0	1-1-0	1-1-0	1W
Bears	0	2	0.000	45	79	-34	0-1-0	0-1-0	0-2-0	0-2-0	0-2-0	2L

NFC South	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Buccaneers	2	0	1.000	43	39	4	0-0-0	2-0-0	1-0-0	1-0-0	2-0-0	2W
Falcons	1	1	0.500	42	29	13	0-1-0	1-0-0	0-1-0	1-1-0	1-1-0	1W
Saints	0	2	0.000	34	46	-12	0-2-0	0-0-0	0-0-0	0-2-0	0-2-0	2L
Panthers	0	2	0.000	32	53	-21	0-0-0	0-2-0	0-0-0	0-1-0	0-2-0	2L

NFL Betting Preview: Cardinals vs Niners

Head-to-Head Statistics

Cardinals vs 49ers Prediction & Picks

Game Prediction

Cardinals Moneyline Probability

Best Bet

Player Prop Picks

Same Game Parlay Picks

Correct Score Prediction

Cardinals vs 49ers Odds

Last 5 & H2H

Team News

Arizona Cardinals Injuries

San Francisco 49ers Injuries

Previous Arizona Cardinals Lineups

Previous San Francisco 49ers Lineups

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