Buffalo Bills
American Football NFL Bank of America Stadium Sun 26 Oct 12:00
Carolina Panthers
  1. Prediction
  2. SGP Picks
  3. Odds
  4. Player Props
  5. Stats
  6. Live Stream
  7. Team News
  8. Lineups
  9. Injuries
  10. Standings

NFL Betting Preview: Bills vs Panthers

The Buffalo Bills go up against the Carolina Panthers in this NFL Week 8 matchup at Bank of America Stadium, with kickoff scheduled for 12:00 on Sunday 26 October. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

Panthers to Give Bills a Tough Test

There’s a good opportunity to back the Panthers against the spread considering the underdogs should perform well against the Bills. Snap up the -120 when it comes to them covering the +7.5.

Like the look of our spread call? Grab the best BetMGM promo code and read our in-depth site review before you place your wager.

Bills Beat Panthers in their Last Clash

Buffalo Bills have been beaten in successive games and the latest was on the road at Mercedes-Benz Stadium. Atlanta Falcons claimed a 24-14 win. The Bills recorded 291 total yards, made up of 157 through the air and 134 on the ground. They managed 17 first downs and scored 2 touchdowns, both through the air.

Carolina Panthers won last time out by a 13-6 scoreline. On the road against New York Jets at MetLife Stadium, they made it three wins on the spin. The Panthers moved the ball for 302 yards, split between 177 passing and 125 rushing yards. They produced 17 first downs and scored one touchdown.

Head-to-Head Statistics

The Bills beat the Panthers in their last head-to-head matchup. It was a 31-14 scoreline at Highmark Stadium.

Quarterbacks

Bills vs Panthers Prediction & Picks

Our Bills vs Panthers tips include the main match prediction, a correct score forecast, bet builder advice and top player prop picks. Each section below offers expert insight into the key betting angles.

Game Prediction

We’re happy to get with the Panthers against the spread in this NFL battle. -120 is available that they are able to cover +7.5 and that looks more than reasonable.

We keep a close eye on team news and our expert NFL handicappers stay sharp by tracking the latest form and lineups. You’ll also find a full set of stats that offer valuable insight and help shape smarter predictions ahead of the action.

Key Bills vs Panthers stats:

  • The +7.5 line has been covered by Panthers in 4 consecutive games at home.
  • The +7.5 line has been covered by Panthers in 8 of their last 10 games at home.
  • The +7.5 line has been covered by Panthers in 5 of their last 7 games this season.
  • The -7.5 line hasn’t been covered by Bills in 4 of their last 5 games on the road.
  • The -7.5 line hasn’t been covered by Bills in 15 of their last 20 games on the road.
  • The -7.5 line hasn’t been covered by Bills in 2 consecutive games.

Panthers +7.5 Probability

The top betting sites imply that our pick has a 54.6% prospect of winning. After careful examination, our cappers have this probability close to 60%. This is why we regard this as a value bet.

Looking for Bigger Odds?

If the price on display doesn’t appeal, you can make the choice to secure bigger odds by moving the line for your selection. It’s a case of taking a view which you are happy with.

Before you place your bets, explore our updated guide packed with the latest free bets and betting bonuses.

Best Bet

Panthers +7.5 @ -120 Watch Live Bet Now BetMGM logo
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Published 18:26, 24 October 2025

Player Prop Picks

Top Pick: Andy Dalton Over 208.5 Passing Yards -114 BetMGM logo

Andy Dalton (Panthers) can be backed at -114 to go over 208.5 passing yards. We’re tempted to back him to cover the QB Passing Yards line, with plenty of juice on offer.

Latest Andy Dalton Player Prop Odds

Josh Allen Anytime TD +105 BetMGM logo

Josh Allen (Bills) is available at +105 to reach the goal line. The Anytime Touchdown Scorer odds are appealing from all angles and we’re willing to take a chance on him.

Latest Josh Allen Player Prop Odds

Same Game Parlay Picks

Spread Panthers +7.5
Totals Over 46.5
Passing Yards Andy Dalton Over 208.5

We’ve loaded up a same game parlay with the combined picks of Panthers +7.5, Over 46.5 and Andy Dalton (Panthers) to go Over 208.5 passing yards.

The betting sites now allow you to place a same game parlay on each individual game. It means that you can create a personalised football wager at bigger odds, with there generally being no limit as to the number of selections.

T&C apply. Gamble responsibly 18+

Correct Score Prediction

Bills Bills logo 28 - 23 Panthers logo Panthers

If you want to achieve a big return from your stake, then it’s worth checking out the correct score lines. The Bills to claim a 28-23 victory is available at huge odds.

Bills vs Panthers Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Bills Big Favorites According to Latest Odds

You might not get rich backing Buffalo Bills at -400. However, the sportsbooks’ betting odds imply a 80% chance of winning this game. If you’re looking for an alternative angle, Carolina Panthers are trading at +315.

The spread is currently 7.5, with the total points line at 46.5. A Total bet is always available and can often provide value selections. If you fancy Under 46.5, then the odds are -110.

The good news is that you can access a wide range of game lines and team props for every National Football League matchup. The best betting apps offer a great selection of pre-game and in-game wagering options.

James Cook Favorite to Score First TD

There’s the chance to back James Cook at +410 to be the First Touchdown Scorer. He’s the favorite and available at similar odds to record the last TD instead.

Touchdown

Receiving Yards

Tetairoa McMillan (Panthers)
Over 55.5
-114
Under 55.5
-114
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Khalil Shakir (Bills)
Over 48.5
-114
Under 48.5
-114
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Dalton Kincaid (Bills)
Over 40.5
-114
Under 40.5
-114
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Rushing Yards

Passing Yards

Best Betting Offers
Bank of America Stadium
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Will Panthers Extend Their Home Winning Streak?

The Panthers have reeled off four consecutive victories at Bank of America Stadium. They have a 5-5 record in their last 10 home games, posting 25.40 points per contest while yielding 26.10.

The Bills have five wins and five losses in the last 10 games on the road, putting up 28.30 points per contest and giving up 24.80.

The last time the teams met at Bank of America Stadium, the Panthers defeated the Bills 21-0.

Last 10 Games W-L P PF PA O46.5 U46.5
Panthers logo Panthers Home Stats 5-5 51.50 25.40 26.10 7 3
Bills logo Bills Away Stats 5-5 53.10 28.30 24.80 4 6
  • W-L = Wins-Losses
  • P = Avg. Points
  • PF = Avg. Points For
  • PA = Avg. Points Against
  • O46.5 = Games Over 46.5 Points
  • U46.5 = Games Under 46.5 Points
Team Stats

Latest regular season and playoff games stats.

Buffalo Bills logo Buffalo Bills Stats
Carolina Panthers logo Carolina Panthers Stats
Moneyline
  • 6 wins and 4 defeats in the last 10 games
  • 5 wins and 5 defeats in the last 10 games on the road
Moneyline
  • 6 wins and 4 defeats in the last 10 games
  • 6 wins and 4 defeats in the last 10 home games
Point Spread
Point Spread
Total Points
Total Points
Game Stats
Last 10 Games
Game Stats
Last 10 Games
Last 10 Games on the Road
Last 10 Home Games

Live Streaming

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Team News

Buffalo Bills Injuries

Type
Name
Info
Tyler Bass
Hip
Terrel Bernard
Ankle
DeWayne Carter
Achilles
Tylan Grable
Concussion
Maxwell Hairston
Knee
Damar Hamlin
Pectoral
Cameron Johnston
Foot
DaQuan Jones
Calf
Dalton Kincaid
Oblique
Matt Milano
Pectoral
Wande Owens
Undisclosed
Joshua Palmer
Knee
Taylor Rapp
Knee
T.J. Sanders
Knee
Dorian Strong
Neck

Carolina Panthers Injuries

Type
Name
Info
Popo Aumavae
Achilles
Jonathon Brooks
Knee - ACL
Robert Hunt
Biceps
Patrick Jones
Back
Damarri Mathis
Knee - ACL
David Moore
Elbow
Bryce Young
Ankle
Chandler Zavala
Knee

Previous Buffalo Bills Lineups

13 Oct NFL
Bills 14-24 Falcons
05 Oct NFL
Patriots 23-20 Bills
28 Sep NFL
Saints 19-31 Bills
18 Sep NFL
Dolphins 21-31 Bills
14 Sep NFL
Bills 30-10 Jets
07 Sep NFL
Ravens 40-41 Bills
26 Jan NFL Playoffs
Bills 29-32 Chiefs
19 Jan NFL Playoffs
Ravens 25-27 Bills
12 Jan NFL Playoffs
Broncos 7-31 Bills
05 Jan NFL
Bills 16-23 Patriots

Previous Carolina Panthers Lineups

19 Oct NFL
Panthers 13-6 Jets
12 Oct NFL
Cowboys 27-30 Panthers
05 Oct NFL
Dolphins 24-27 Panthers
28 Sep NFL
Panthers 13-42 Patriots
21 Sep NFL
Falcons 0-30 Panthers
14 Sep NFL
Panthers 22-27 Cardinals
07 Sep NFL
Panthers 10-26 Jaguars
05 Jan NFL
Panthers 44-38 Falcons
29 Dec NFL
Panthers 14-48 Buccaneers
22 Dec NFL
Cardinals 30-36 Panthers

NFL Standings Select Season

AFC East W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Patriots 5 2 0 0.714 181 133 48 1-2-0 4-0-0 2-0-0 3-2-0 4-1-0 4W
Bills 4 2 0 0.667 167 137 30 3-1-0 1-1-0 2-1-0 3-1-0 3-2-0 2L
Dolphins 1 6 0 0.143 140 205 -65 1-2-0 0-4-0 1-2-0 1-5-0 1-4-0 3L
Jets 0 7 0 0.000 129 183 -54 0-5-0 0-2-0 0-2-0 0-4-0 0-5-0 7L
AFC North W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Steelers 4 2 0 0.667 150 140 10 2-1-0 2-1-0 1-1-0 3-1-0 3-2-0 1L
Bengals 3 4 0 0.429 136 214 -78 2-1-0 1-3-0 2-0-0 3-1-0 1-4-0 1W
Browns 2 5 0 0.286 113 152 -39 2-2-0 0-3-0 0-3-0 1-3-0 2-3-0 1W
Ravens 1 5 0 0.167 144 194 -50 1-3-0 0-2-0 1-0-0 1-3-0 1-4-0 4L
AFC South W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Colts 6 1 0 0.857 232 140 92 4-0-0 2-1-0 1-0-0 5-0-0 4-1-0 3W
Jaguars 4 3 0 0.571 146 155 -9 3-2-0 1-1-0 1-0-0 2-1-0 3-2-0 2L
Texans 2 4 0 0.333 127 88 39 1-1-0 1-3-0 1-1-0 2-1-0 2-3-0 1L
Titans 1 6 0 0.143 96 192 -96 0-3-0 1-3-0 0-2-0 0-5-0 1-4-0 2L
AFC West W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Broncos 5 2 0 0.714 163 127 36 3-0-0 2-2-0 0-1-0 3-2-0 4-1-0 4W
Chargers 5 3 0 0.625 188 173 15 3-2-0 2-1-0 3-0-0 4-1-0 2-3-0 1W
Chiefs 4 3 0 0.571 186 124 62 3-1-0 1-2-0 1-1-0 2-2-0 4-1-0 2W
Raiders 2 5 0 0.286 103 180 -77 1-2-0 1-3-0 0-2-0 2-3-0 1-4-0 1L
NFC East W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Eagles 5 2 0 0.714 170 165 5 2-1-0 3-1-0 1-1-0 4-1-0 3-2-0 1W
Cowboys 3 3 1 0.429 222 206 16 2-0-1 1-3-0 2-1-0 2-3-1 2-2-1 1W
Commanders 3 4 0 0.429 180 170 10 2-1-0 1-3-0 1-1-0 1-4-0 2-3-0 2L
Giants 2 5 0 0.286 153 177 -24 2-1-0 0-4-0 1-2-0 1-3-0 2-3-0 1L
NFC North W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Packers 4 1 1 0.667 158 125 33 3-0-0 1-1-1 1-0-0 3-0-1 3-1-1 2W
Lions 5 2 0 0.714 215 151 64 3-0-0 2-2-0 1-1-0 2-1-0 4-1-0 1W
Bears 4 2 0 0.667 152 155 -3 2-1-0 2-1-0 0-2-0 3-2-0 4-1-0 4W
Vikings 3 4 0 0.429 155 162 -7 1-2-0 2-2-0 1-0-0 1-2-0 2-3-0 2L
NFC South W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Buccaneers 5 2 0 0.714 174 175 -1 2-1-0 3-1-0 1-0-0 3-2-0 3-2-0 1L
Panthers 4 3 0 0.571 145 152 -7 3-0-0 1-3-0 1-0-0 2-1-0 4-1-0 3W
Falcons 3 3 0 0.500 110 120 -10 2-1-0 1-2-0 0-2-0 2-3-0 3-2-0 1L
Saints 1 6 0 0.143 125 186 -61 1-3-0 0-3-0 0-0-0 1-4-0 1-4-0 2L
NFC West W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
49ers 5 2 0 0.714 145 138 7 2-1-0 3-1-0 3-0-0 5-1-0 3-2-0 1W
Seahawks 5 2 0 0.714 193 136 57 2-2-0 3-0-0 1-1-0 2-2-0 4-1-0 2W
Rams 5 2 0 0.714 175 117 58 2-1-0 3-1-0 0-1-0 0-2-0 3-2-0 2W
Cardinals 2 5 0 0.286 153 154 -1 1-3-0 1-2-0 0-2-0 2-3-0 0-5-0 5L
AFC Conference W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Colts 6 1 0 0.857 232 140 92 4-0-0 2-1-0 1-0-0 5-0-0 4-1-0 3W
Patriots 5 2 0 0.714 181 133 48 1-2-0 4-0-0 2-0-0 3-2-0 4-1-0 4W
Broncos 5 2 0 0.714 163 127 36 3-0-0 2-2-0 0-1-0 3-2-0 4-1-0 4W
Steelers 4 2 0 0.667 150 140 10 2-1-0 2-1-0 1-1-0 3-1-0 3-2-0 1L
Bills 4 2 0 0.667 167 137 30 3-1-0 1-1-0 2-1-0 3-1-0 3-2-0 2L
Chargers 5 3 0 0.625 188 173 15 3-2-0 2-1-0 3-0-0 4-1-0 2-3-0 1W
Jaguars 4 3 0 0.571 146 155 -9 3-2-0 1-1-0 1-0-0 2-1-0 3-2-0 2L
Chiefs 4 3 0 0.571 186 124 62 3-1-0 1-2-0 1-1-0 2-2-0 4-1-0 2W
Bengals 3 4 0 0.429 136 214 -78 2-1-0 1-3-0 2-0-0 3-1-0 1-4-0 1W
Texans 2 4 0 0.333 127 88 39 1-1-0 1-3-0 1-1-0 2-1-0 2-3-0 1L
Raiders 2 5 0 0.286 103 180 -77 1-2-0 1-3-0 0-2-0 2-3-0 1-4-0 1L
Browns 2 5 0 0.286 113 152 -39 2-2-0 0-3-0 0-3-0 1-3-0 2-3-0 1W
Ravens 1 5 0 0.167 144 194 -50 1-3-0 0-2-0 1-0-0 1-3-0 1-4-0 4L
Dolphins 1 6 0 0.143 140 205 -65 1-2-0 0-4-0 1-2-0 1-5-0 1-4-0 3L
Titans 1 6 0 0.143 96 192 -96 0-3-0 1-3-0 0-2-0 0-5-0 1-4-0 2L
Jets 0 7 0 0.000 129 183 -54 0-5-0 0-2-0 0-2-0 0-4-0 0-5-0 7L
NFC Conference W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Packers 4 1 1 0.667 158 125 33 3-0-0 1-1-1 1-0-0 3-0-1 3-1-1 2W
49ers 5 2 0 0.714 145 138 7 2-1-0 3-1-0 3-0-0 5-1-0 3-2-0 1W
Eagles 5 2 0 0.714 170 165 5 2-1-0 3-1-0 1-1-0 4-1-0 3-2-0 1W
Buccaneers 5 2 0 0.714 174 175 -1 2-1-0 3-1-0 1-0-0 3-2-0 3-2-0 1L
Lions 5 2 0 0.714 215 151 64 3-0-0 2-2-0 1-1-0 2-1-0 4-1-0 1W
Seahawks 5 2 0 0.714 193 136 57 2-2-0 3-0-0 1-1-0 2-2-0 4-1-0 2W
Rams 5 2 0 0.714 175 117 58 2-1-0 3-1-0 0-1-0 0-2-0 3-2-0 2W
Bears 4 2 0 0.667 152 155 -3 2-1-0 2-1-0 0-2-0 3-2-0 4-1-0 4W
Panthers 4 3 0 0.571 145 152 -7 3-0-0 1-3-0 1-0-0 2-1-0 4-1-0 3W
Cowboys 3 3 1 0.429 222 206 16 2-0-1 1-3-0 2-1-0 2-3-1 2-2-1 1W
Falcons 3 3 0 0.500 110 120 -10 2-1-0 1-2-0 0-2-0 2-3-0 3-2-0 1L
Vikings 3 4 0 0.429 155 162 -7 1-2-0 2-2-0 1-0-0 1-2-0 2-3-0 2L
Commanders 3 4 0 0.429 180 170 10 2-1-0 1-3-0 1-1-0 1-4-0 2-3-0 2L
Cardinals 2 5 0 0.286 153 154 -1 1-3-0 1-2-0 0-2-0 2-3-0 0-5-0 5L
Giants 2 5 0 0.286 153 177 -24 2-1-0 0-4-0 1-2-0 1-3-0 2-3-0 1L
Saints 1 6 0 0.143 125 186 -61 1-3-0 0-3-0 0-0-0 1-4-0 1-4-0 2L
NFL Team W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Colts 6 1 0 0.857 232 140 92 4-0-0 2-1-0 1-0-0 5-0-0 4-1-0 3W
Packers 4 1 1 0.667 158 125 33 3-0-0 1-1-1 1-0-0 3-0-1 3-1-1 2W
Broncos 5 2 0 0.714 163 127 36 3-0-0 2-2-0 0-1-0 3-2-0 4-1-0 4W
Lions 5 2 0 0.714 215 151 64 3-0-0 2-2-0 1-1-0 2-1-0 4-1-0 1W
Rams 5 2 0 0.714 175 117 58 2-1-0 3-1-0 0-1-0 0-2-0 3-2-0 2W
Patriots 5 2 0 0.714 181 133 48 1-2-0 4-0-0 2-0-0 3-2-0 4-1-0 4W
Eagles 5 2 0 0.714 170 165 5 2-1-0 3-1-0 1-1-0 4-1-0 3-2-0 1W
49ers 5 2 0 0.714 145 138 7 2-1-0 3-1-0 3-0-0 5-1-0 3-2-0 1W
Seahawks 5 2 0 0.714 193 136 57 2-2-0 3-0-0 1-1-0 2-2-0 4-1-0 2W
Buccaneers 5 2 0 0.714 174 175 -1 2-1-0 3-1-0 1-0-0 3-2-0 3-2-0 1L
Bills 4 2 0 0.667 167 137 30 3-1-0 1-1-0 2-1-0 3-1-0 3-2-0 2L
Bears 4 2 0 0.667 152 155 -3 2-1-0 2-1-0 0-2-0 3-2-0 4-1-0 4W
Steelers 4 2 0 0.667 150 140 10 2-1-0 2-1-0 1-1-0 3-1-0 3-2-0 1L
Chargers 5 3 0 0.625 188 173 15 3-2-0 2-1-0 3-0-0 4-1-0 2-3-0 1W
Panthers 4 3 0 0.571 145 152 -7 3-0-0 1-3-0 1-0-0 2-1-0 4-1-0 3W
Jaguars 4 3 0 0.571 146 155 -9 3-2-0 1-1-0 1-0-0 2-1-0 3-2-0 2L
Chiefs 4 3 0 0.571 186 124 62 3-1-0 1-2-0 1-1-0 2-2-0 4-1-0 2W
Falcons 3 3 0 0.500 110 120 -10 2-1-0 1-2-0 0-2-0 2-3-0 3-2-0 1L
Cowboys 3 3 1 0.429 222 206 16 2-0-1 1-3-0 2-1-0 2-3-1 2-2-1 1W
Bengals 3 4 0 0.429 136 214 -78 2-1-0 1-3-0 2-0-0 3-1-0 1-4-0 1W
Vikings 3 4 0 0.429 155 162 -7 1-2-0 2-2-0 1-0-0 1-2-0 2-3-0 2L
Commanders 3 4 0 0.429 180 170 10 2-1-0 1-3-0 1-1-0 1-4-0 2-3-0 2L
Texans 2 4 0 0.333 127 88 39 1-1-0 1-3-0 1-1-0 2-1-0 2-3-0 1L
Cardinals 2 5 0 0.286 153 154 -1 1-3-0 1-2-0 0-2-0 2-3-0 0-5-0 5L
Browns 2 5 0 0.286 113 152 -39 2-2-0 0-3-0 0-3-0 1-3-0 2-3-0 1W
Raiders 2 5 0 0.286 103 180 -77 1-2-0 1-3-0 0-2-0 2-3-0 1-4-0 1L
Giants 2 5 0 0.286 153 177 -24 2-1-0 0-4-0 1-2-0 1-3-0 2-3-0 1L
Ravens 1 5 0 0.167 144 194 -50 1-3-0 0-2-0 1-0-0 1-3-0 1-4-0 4L
Dolphins 1 6 0 0.143 140 205 -65 1-2-0 0-4-0 1-2-0 1-5-0 1-4-0 3L
Saints 1 6 0 0.143 125 186 -61 1-3-0 0-3-0 0-0-0 1-4-0 1-4-0 2L
Titans 1 6 0 0.143 96 192 -96 0-3-0 1-3-0 0-2-0 0-5-0 1-4-0 2L
Jets 0 7 0 0.000 129 183 -54 0-5-0 0-2-0 0-2-0 0-4-0 0-5-0 7L