Bills vs Panthers Prediction, Picks & Odds | 26 Oct 2025

NFL Betting Preview: Bills vs Panthers

The Buffalo Bills go up against the Carolina Panthers in this NFL Week 8 matchup at Bank of America Stadium, with kickoff scheduled for 12:00 on Sunday, October 26. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

There’s a good opportunity to back the Panthers against the spread considering the underdogs should perform well against the Bills. Snap up the -120 when it comes to them covering the +7.5.

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Buffalo Bills have been beaten in successive games and the latest was on the road at Mercedes-Benz Stadium. Atlanta Falcons claimed a 24-14 win. The Bills recorded 291 total yards, made up of 157 through the air and 134 on the ground. They managed 17 first downs and scored 2 touchdowns, both through the air.

Carolina Panthers won last time out by a 13-6 scoreline. On the road against New York Jets at MetLife Stadium, they made it three wins on the spin. The Panthers moved the ball for 302 yards, split between 177 passing and 125 rushing yards. They produced 17 first downs and scored one touchdown.

Head-to-Head Statistics

The Bills beat the Panthers in their last head-to-head matchup. It was a 31-14 scoreline at Highmark Stadium.

Quarterbacks

Josh Allen

229.5 Passing Yards

Over -112

Under -112

Andy Dalton

209.5 Passing Yards

Over -112

Under -112

Bills vs Panthers Prediction & Picks

Our Bills vs Panthers tips include the main match prediction, a correct score forecast, bet builder advice and top player prop picks. Each section below offers expert insight into the key betting angles.

Game Prediction

We’re happy to get with the Panthers against the spread in this NFL battle. -120 is available that they are able to cover +7.5 and that looks more than reasonable.

We keep a close eye on team news and our expert NFL handicappers stay sharp by tracking the latest form and lineups. You’ll also find a full set of stats that offer valuable insight and help shape smarter predictions ahead of the action.

Key Bills vs Panthers stats:

• The +7.5 line has been covered by Panthers in 4 consecutive games at home.
• The +7.5 line has been covered by Panthers in 8 of their last 10 games at home.
• The +7.5 line has been covered by Panthers in 5 of their last 7 games this season.
• The -7.5 line hasn’t been covered by Bills in 4 of their last 5 games on the road.
• The -7.5 line hasn’t been covered by Bills in 15 of their last 20 games on the road.
• The -7.5 line hasn’t been covered by Bills in 2 consecutive games.

Panthers +7.5 Probability

The top betting sites imply that our pick has a 54.6% prospect of winning. After careful examination, our cappers have this probability close to 60%. This is why we regard this as a value bet.

If the price on display doesn’t appeal, you can make the choice to secure bigger odds by moving the line for your selection. It’s a case of taking a view which you are happy with.

Before you place your bets, explore our updated guide packed with the latest free bets and betting bonuses.

Our Game Prediction

Panthers +7.5 @ -120 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (18:26, 24 October 2025). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Andy Dalton Over 208.5 Passing Yards -114

Andy Dalton (Panthers) can be backed at -114 to go over 208.5 passing yards. We’re tempted to back him to cover the QB Passing Yards line, with plenty of juice on offer.

Latest Andy Dalton Player Prop Odds

Touchdown

Anytime

+1000

First

+5500

Passing Yards

Over 209.5

-112

Under 209.5

-112

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Josh Allen Anytime TD +105

Josh Allen (Bills) is available at +105 to reach the goal line. The Anytime Touchdown Scorer odds are appealing from all angles and we’re willing to take a chance on him.

Latest Josh Allen Player Prop Odds

Touchdown

Anytime

-100

First

+650

Passing Yards

Over 229.5

-112

Under 229.5

-112

Rushing Yards

Over 30.5

-112

Under 30.5

-112

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Bills 28 - 23 Panthers

If you want to achieve a big return from your stake, then it’s worth checking out the correct score lines. The Bills to claim a 28-23 victory is available at huge odds.

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Bills vs Panthers Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

You might not get rich backing Buffalo Bills at -303. However, the sportsbooks’ betting odds imply a 75% chance of winning this game. If you’re looking for an alternative angle, Carolina Panthers are trading at +245.

The spread is currently 7, with the total points line at 47.5. A Total bet is always available and can often provide value selections. If you fancy Under 47.5, then the odds are -110.

The good news is that you can access a wide range of game lines and team props for every National Football League matchup. The best betting apps offer a great selection of pre-game and in-game wagering options.

Moneyline

Bills

-303

Panthers

+245

Point Spread

Bills -7

-110

Panthers +7

-110

Total Points

Under 47.5

-110

Over 47.5

-110

There’s the chance to back James Cook at +400 to be the First Touchdown Scorer. He’s the favorite and available at similar odds to record the last TD instead.

Touchdown

James Cook (Bills)

First TD

+400

Anytime TD

-154

Josh Allen (Bills)

First TD

+650

Anytime TD

-100

Rico Dowdle (Panthers)

First TD

+900

Anytime TD

+140

Khalil Shakir (Bills)

First TD

+1000

Anytime TD

+210

Dalton Kincaid (Bills)

First TD

+1000

Anytime TD

+220

Keon Coleman (Bills)

First TD

+1100

Anytime TD

+230

Chuba Hubbard (Panthers)

First TD

+1200

Anytime TD

+210

Tetairoa McMillan (Panthers)

First TD

+1300

Anytime TD

+190

Xavier Legette (Panthers)

First TD

+2000

Anytime TD

+340

Dawson Knox (Bills)

First TD

+2200

Anytime TD

+380

Joshua Palmer (Bills)

First TD

+2500

Anytime TD

+500

Jalen Coker (Panthers)

First TD

+2700

Anytime TD

+500

Tyrell Shavers (Bills)

First TD

+3000

Anytime TD

+600

Ja'Tavion Sanders (Panthers)

First TD

+3500

Anytime TD

+650

Tommy Tremble (Panthers)

First TD

+3500

Anytime TD

+700

Elijah Moore (Bills)

First TD

+4000

Anytime TD

+850

Jackson Hawes (Bills)

First TD

+4000

Anytime TD

+800

Curtis Samuel (Bills)

First TD

+5500

Anytime TD

+900

Mitchell Evans (Panthers)

First TD

+5500

Anytime TD

+800

Andy Dalton (Panthers)

First TD

+5500

Anytime TD

+1000

Ty Johnson (Bills)

First TD

+6000

Anytime TD

+750

Jimmy Horn Jr. (Panthers)

First TD

+7500

Anytime TD

+1100

Hunter Renfrow (Panthers)

First TD

+7500

Anytime TD

+1100

Ray Davis (Bills)

First TD

+10000

Anytime TD

+1000

Brycen Tremayne (Panthers)

First TD

+10000

Anytime TD

+1600

Trevor Etienne (Panthers)

First TD

+10000

Anytime TD

+2200

James Mitchell (Panthers)

First TD

+10000

Anytime TD

+1600

Receiving Yards

Tetairoa McMillan (Panthers)

Over 57.5

-112

Under 57.5

-112

Khalil Shakir (Bills)

Over 48.5

-112

Under 48.5

-112

Keon Coleman (Bills)

Over 41.5

-112

Under 41.5

-112

Dalton Kincaid (Bills)

Over 39.5

-112

Under 39.5

-112

Xavier Legette (Panthers)

Over 32.5

-112

Under 32.5

-112

Jalen Coker (Panthers)

Over 24.5

-112

Under 24.5

-112

Ja'Tavion Sanders (Panthers)

Over 15.5

-112

Under 15.5

-112

Tyrell Shavers (Bills)

Over 14.5

-112

Under 14.5

-112

James Cook (Bills)

Over 13.5

-112

Under 13.5

-112

Chuba Hubbard (Panthers)

Over 11.5

-112

Under 11.5

-112

Tommy Tremble (Panthers)

Over 11.5

-112

Under 11.5

-112

Rico Dowdle (Panthers)

Over 10.5

-112

Under 10.5

-112

Rushing Yards

James Cook (Bills)

Over 71.5

-112

Under 71.5

-112

Rico Dowdle (Panthers)

Over 50.5

-112

Under 50.5

-112

Chuba Hubbard (Panthers)

Over 41.5

-112

Under 41.5

-112

Josh Allen (Bills)

Over 30.5

-112

Under 30.5

-112

Passing Yards

Josh Allen (Bills)

Over 229.5

-112

Under 229.5

-112

Andy Dalton (Panthers)

Over 209.5

-112

Under 209.5

-112

Among the various options for wagering on the NFL, you will find that micro betting is provided. It focuses on short-term in-game outcomes such as whether a touchdown will be scored within the next 10 minutes.

Will Panthers Extend Their Home Winning Streak?

The Panthers have reeled off four consecutive victories at Bank of America Stadium. They have a 5-5 record in their last 10 home games, posting 25.40 points per contest while yielding 26.10.

The Bills have five wins and five losses in the last 10 games on the road, putting up 28.30 points per contest and giving up 24.80.

The last time the teams met at Bank of America Stadium, the Panthers defeated the Bills 21-0.

Last 10 Games		W-L	P	PF	PA	O46.5	U46.5
Panthers Home Stats		5-5	51.50	25.40	26.10	7	3
Bills Away Stats		5-5	53.10	28.30	24.80	4	6

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O46.5 = Games Over 46.5 Points
• U46.5 = Games Under 46.5 Points

Latest regular season and playoff games stats.

Buffalo Bills Stats

Carolina Panthers Stats

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 5 wins and 5 defeats in the last 10 games on the road

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 6 wins and 4 defeats in the last 10 home games

Point Spread

• -7.5 Betting Line: Have covered the spread in 4 of the last 10 games
• -7.5 Betting Line on the Road: Have covered the spread in 3 of the last 10 games on the road

Point Spread

• +7.5 Betting Line: Have covered the spread in 7 of the last 10 games
• +7.5 Betting Line at Home: Have covered the spread in 8 of the last 10 home games

Total Points

• Game Totals: An average of 49.40 pts in the previous 10 games
• Game Totals on the Road: An average of 53.10 pts in the previous 10 games on the road
• Over 46.5: Covered in 5 of the previous 10 games
• Over 46.5 on the Road: Covered in 4 of the previous 10 games on the road
• Team Totals: Have scored an average of 27.00 pts and allowed 22.40 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 28.30 pts and allowed 24.80 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 50.70 pts in the previous 10 games
• Game Totals at Home: An average of 49.40 pts in the previous 10 home games
• Over 46.5: Covered in 7 of the previous 10 games
• Over 46.5 at Home: Covered in 6 of the previous 10 home games
• Team Totals: Have scored an average of 23.90 pts and allowed 26.80 pts in the last 10 games
• Team Totals at Home: Have scored an average of 25.00 pts and allowed 24.40 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 364.70 Yds. Allowed 325.90 Yds
• Rushing Yards: Gained 154.00 Yds. Allowed 140.50 Yds
• Passing Yards: Gained 210.70 Yds. Allowed 185.40 Yds
• Total Touchdowns: Scored 3.20 TD. Allowed 2.60 TD
• Rushing Touchdowns: Scored 1.60 TD. Allowed 1.40 TD
• Passing Touchdowns: Scored 1.60 TD. Allowed 1.20 TD
• Total 1st Downs: Picked up 22.30. Allowed 19.70
• Total Turnovers: Committed 0.60. Committed by opponents 1.00
• Total Penalties: Committed 6.40. Committed by opponents 5.60
• Penalty Yards: Lost 48.90 Yds. Gained 46.20 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 325.60 Yds. Allowed 353.90 Yds
• Rushing Yards: Gained 136.20 Yds. Allowed 126.60 Yds
• Passing Yards: Gained 189.40 Yds. Allowed 227.30 Yds
• Total Touchdowns: Scored 2.90 TD. Allowed 3.10 TD
• Rushing Touchdowns: Scored 0.80 TD. Allowed 1.00 TD
• Passing Touchdowns: Scored 1.90 TD. Allowed 1.80 TD
• Total 1st Downs: Picked up 20.50. Allowed 19.60
• Total Turnovers: Committed 0.90. Committed by opponents 1.00
• Total Penalties: Committed 5.70. Committed by opponents 7.40
• Penalty Yards: Lost 47.40 Yds. Gained 56.10 Yds

Last 10 Games on the Road

• Total Yards: Gained 382.60 Yds. Allowed 366.40 Yds
• Rushing Yards: Gained 153.30 Yds. Allowed 107.50 Yds
• Passing Yards: Gained 229.30 Yds. Allowed 258.90 Yds
• Total Touchdowns: Scored 3.50 TD. Allowed 2.90 TD
• Rushing Touchdowns: Scored 1.90 TD. Allowed 1.20 TD
• Passing Touchdowns: Scored 1.50 TD. Allowed 1.60 TD
• Total 1st Downs: Picked up 22.30. Allowed 21.20
• Total Turnovers: Committed 0.50. Committed by opponents 1.30
• Total Penalties: Committed 7.50. Committed by opponents 7.10
• Penalty Yards: Lost 58.20 Yds. Gained 57.20 Yds

Last 10 Home Games

• Total Yards: Gained 321.50 Yds. Allowed 368.90 Yds
• Rushing Yards: Gained 135.70 Yds. Allowed 154.40 Yds
• Passing Yards: Gained 185.80 Yds. Allowed 214.50 Yds
• Total Touchdowns: Scored 2.70 TD. Allowed 2.60 TD
• Rushing Touchdowns: Scored 1.10 TD. Allowed 0.90 TD
• Passing Touchdowns: Scored 1.40 TD. Allowed 1.60 TD
• Total 1st Downs: Picked up 19.50. Allowed 22.20
• Total Turnovers: Committed 1.30. Committed by opponents 1.20
• Total Penalties: Committed 7.90. Committed by opponents 7.60
• Penalty Yards: Lost 61.80 Yds. Gained 61.00 Yds

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