Bills vs Browns Prediction, Picks & Odds | 21 Dec 2025

NFL Betting Preview: Bills vs Browns

The Buffalo Bills face the Cleveland Browns at Huntington Bank Field, with kickoff scheduled for 13:00 on Sunday, December 21.

There could be plenty of points when the Browns clash with the Bills, with our prediction being Over 41.5 points in total. Odds of -105 look worth taking for this outcome.

Think the scoreboard’s going to light up? Claim the current BetMGM promo code and take a moment to browse our site review before you bet.

Buffalo Bills have triumphed in their previous three games. The latest was on the road where New England Patriots were beaten 35-31 at Gillette Stadium. The Bills finished with 349 total yards, made up of 181 through the air and 168 on the ground. The offense converted for 22 first downs along with 5 touchdowns.

Cleveland Browns have been defeated in their last three games. On the road, they recently suffered a 31-3 loss against Chicago Bears at Soldier Field. The Browns generated 192 yards, including 142 passing and 50 rushing yards. They produced 9 first downs and allowed 21.

Head-to-Head Statistics

The Bills won the last matchup between the pair. Enjoying a 31-23 triumph when facing the Browns at Ford Field.

Quarterbacks

Josh Allen

213.5 Passing Yards

Over -114

Under -114

Shedeur Sanders

177.5 Passing Yards

Over -114

Under -114

Bills vs Browns Prediction & Picks

We dive into the best Bills vs Browns betting angles, including an expert match prediction, correct score forecast, top player prop bets and a value-focused bet builder.

Game Prediction

We’re expecting Over 41.5 points to be scored by the two teams combined. There’s an attractive -105 for our pick and we’re anticipating that the scoreboard will tick over in this NFL matchup.

Team news plays a key role in our NFL predictions and we’re always tracking players with injury concerns. We also stay on top of the form guide, supported by detailed stats that help paint a clearer picture of what to expect.

Key Bills vs Browns stats:

• The 41.5 line has been covered in 8 of the last 10 Bills games.
• The 41.5 line has been covered in 4 of the last 5 Bills games.
• The 41.5 line has been covered in the last 2 Bills games.

Over 41.5 Probability

If you go by the best betting sites, our pick has a 51.3% chance of winning. Based on our cappers in-depth research, we calculate the actual probability to be 55-60%. This wager can therefore be backed with confidence.

The leading sportbooks allow you to shoot for a bigger price by moving the line on the Totals. Choose a number where you’re happy and get more juice.

Don’t miss out. Check our expert guide for the most rewarding betting offers, including top free bets and bonuses.

Our Game Prediction

Over 41.5 Points @ -105 Watch Live Bet Now

BetMGM Promo Up To $1500 in Bonus Bets Get Bonus T&C apply. Gamble responsibly 18+

Gamble responsibly 18+. All odds are correct at time of publishing and are subject to change. To use the Bookmaker Live Streaming services you will need to be logged in and have a funded account or to have placed a bet in the last 24 hours. Geo-restrictions apply.

Player Prop Picks

Top Pick: Shedeur Sanders Over 177.5 Passing Yards -114

Shedeur Sanders (Browns) is available at -114 to rack up over 177.5 passing yards. The line for him on the Overs is highly appealing, with QB Passing Yards bettors able to get plenty of juice.

Latest Shedeur Sanders Player Prop Odds

Touchdown

Anytime

+750

First

+3300

Passing Yards

Over 177.5

-114

Under 177.5

-114

Rushing Yards

Over 8.5

-114

Under 8.5

-114

---

Khalil Shakir Over 38.5 Receiving Yards -114

Khalil Shakir (Browns) is available at -114 to record more than 38.5 receiving yards. We’re happy to take him to cover the Player Receiving Yards line and bettors can place this wager with confidence.

Latest Khalil Shakir Player Prop Odds

Touchdown

Anytime

+250

First

+1000

Receiving Yards

Over 38.5

-114

Under 38.5

-114

Correct Score Prediction

Bills 28 - 23 Browns

The Bills might be able to claim a victory and we’re siding with a 28-23 scoreline in their favor. A small stake can provide a big return and there are monster odds available.

Bills vs Browns Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

The favorites are 87% likely to win according to the sportsbooks’ latest Moneyline odds, with Buffalo Bills priced at -667 to triumph in this game. Cleveland Browns are trading at bigger odds than their opponents and they can be backed at +480.

The spread currently stands at 10.5 and the total points line is 41.5. NFL bettors love the chance to get an alternative angle by going for a Total wager. If you’re going for Over 41.5, then the odds are -105.

National Football League fans are spoilt for choice thanks to the wide range of game lines and team props which are available for every game on the coupon. Visit the top betting apps and find the best value wagers.

Moneyline

Bills

-667

Browns

+480

Point Spread

Bills -10.5

-105

Browns +10.5

-115

Total Points

Under 41.5

-115

Over 41.5

-105

You will find James Cook at +400 to be First Touchdown Scorer which makes him the favorite. There’s the chance to get -125 that he scores a TD at anytime.

Touchdown

James Cook (Bills)

First TD

+400

Anytime TD

-125

Josh Allen (Bills)

First TD

+500

Anytime TD

-120

Quinshon Judkins (Browns)

First TD

+650

Anytime TD

+105

Khalil Shakir (Bills)

First TD

+1000

Anytime TD

+250

Dalton Kincaid (Bills)

First TD

+1100

Anytime TD

+270

Dawson Knox (Bills)

First TD

+1500

Anytime TD

+400

Harold Fannin Jr. (Browns)

First TD

+1600

Anytime TD

+280

Jerry Jeudy (Browns)

First TD

+1800

Anytime TD

+360

Keon Coleman (Bills)

First TD

+1800

Anytime TD

+440

Joshua Palmer (Bills)

First TD

+1800

Anytime TD

+480

Gabe Davis (Bills)

First TD

+1800

Anytime TD

+480

Isaiah Bond (Browns)

First TD

+3000

Anytime TD

+600

David Njoku (Browns)

First TD

+3000

Anytime TD

+500

Ty Johnson (Bills)

First TD

+3000

Anytime TD

+550

Shedeur Sanders (Browns)

First TD

+3300

Anytime TD

+750

Brandin Cooks (Bills)

First TD

+4500

Anytime TD

+900

Tyrell Shavers (Bills)

First TD

+5000

Anytime TD

+1000

Cedric Tillman (Browns)

First TD

+5000

Anytime TD

+1200

Jamari Thrash (Browns)

First TD

+5000

Anytime TD

+1200

Jackson Hawes (Bills)

First TD

+5500

Anytime TD

+1200

Gage Larvadain (Browns)

First TD

+7000

Anytime TD

+1100

Ray Davis (Bills)

First TD

+8000

Anytime TD

+1000

Malachi Corley (Browns)

First TD

+8000

Anytime TD

+1300

Raheim Sanders (Browns)

First TD

+8000

Anytime TD

+1500

Trayveon Williams (Browns)

First TD

+8000

Anytime TD

+1500

Blake Whiteheart (Browns)

First TD

+10000

Anytime TD

+1600

Brenden Bates (Browns)

First TD

+10000

Anytime TD

+2000

Reggie Gilliam (Bills)

First TD

+10000

Anytime TD

+1700

Receiving Yards

Harold Fannin Jr. (Browns)

Over 53.5

-114

Under 53.5

-114

Khalil Shakir (Bills)

Over 38.5

-114

Under 38.5

-114

Dalton Kincaid (Bills)

Over 35.5

-114

Under 35.5

-114

Jerry Jeudy (Browns)

Over 29.5

-114

Under 29.5

-114

Dawson Knox (Bills)

Over 22.5

-114

Under 22.5

-114

Keon Coleman (Bills)

Over 17.5

-114

Under 17.5

-114

Joshua Palmer (Bills)

Over 16.5

-114

Under 16.5

-114

Isaiah Bond (Browns)

Over 15.5

-114

Under 15.5

-114

James Cook (Bills)

Over 13.5

-114

Under 13.5

-114

Ty Johnson (Bills)

Over 13.5

-114

Under 13.5

-114

Cedric Tillman (Browns)

Over 13.5

-114

Under 13.5

-114

Quinshon Judkins (Browns)

Over 12.5

-114

Under 12.5

-114

Rushing Yards

James Cook (Bills)

Over 87.5

-114

Under 87.5

-114

Quinshon Judkins (Browns)

Over 60.5

-114

Under 60.5

-114

Josh Allen (Bills)

Over 34.5

-114

Under 34.5

-114

Shedeur Sanders (Browns)

Over 8.5

-114

Under 8.5

-114

Passing Yards

Josh Allen (Bills)

Over 213.5

-114

Under 213.5

-114

Shedeur Sanders (Browns)

Over 177.5

-114

Under 177.5

-114

Browns Slide Includes Three Straight Defeats at Home

The Browns are riding a skid of three straight defeats at Huntington Bank Field. They have three wins and seven losses in the last 10 home games, putting up 15.70 points per contest and giving up 20.00.

The Bills have a 5-5 record in their last 10 games away from home, posting 27.00 points per contest while yielding 23.10.

The Browns earned a 19-16 win against the Bills in the teams’ last meeting at Huntington Bank Field.

Last 10 Games		W-L	P	PF	PA	O41.5	U41.5
Browns Home Stats		3-7	35.70	15.70	20.00	2	8
Bills Away Stats		5-5	50.10	27.00	23.10	6	4

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O41.5 = Games Over 41.5 Points
• U41.5 = Games Under 41.5 Points

Latest regular season and playoff games stats.

Buffalo Bills Stats

Cleveland Browns Stats

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 5 wins and 5 defeats in the last 10 games on the road

Moneyline

• 2 wins and 8 defeats in the last 10 games
• 3 wins and 7 defeats in the last 10 home games

Point Spread

• -10.5 Betting Line: Have covered the spread in 3 of the last 10 games
• -10.5 Betting Line on the Road: Have covered the spread in 3 of the last 10 games on the road

Point Spread

• +10.5 Betting Line: Have covered the spread in 6 of the last 10 games
• +10.5 Betting Line at Home: Have covered the spread in 7 of the last 10 home games

Total Points

• Game Totals: An average of 51.20 pts in the previous 10 games
• Game Totals on the Road: An average of 50.10 pts in the previous 10 games on the road
• Over 41.5: Covered in 8 of the previous 10 games
• Over 41.5 on the Road: Covered in 6 of the previous 10 games on the road
• Team Totals: Have scored an average of 27.80 pts and allowed 23.40 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 27.00 pts and allowed 23.10 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 40.00 pts in the previous 10 games
• Game Totals at Home: An average of 35.80 pts in the previous 10 home games
• Over 41.5: Covered in 3 of the previous 10 games
• Over 41.5 at Home: Covered in 2 of the previous 10 home games
• Team Totals: Have scored an average of 17.00 pts and allowed 23.00 pts in the last 10 games
• Team Totals at Home: Have scored an average of 16.40 pts and allowed 19.40 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 372.10 Yds. Allowed 321.70 Yds
• Rushing Yards: Gained 156.50 Yds. Allowed 134.70 Yds
• Passing Yards: Gained 215.60 Yds. Allowed 187.00 Yds
• Total Touchdowns: Scored 3.60 TD. Allowed 2.80 TD
• Rushing Touchdowns: Scored 1.60 TD. Allowed 1.80 TD
• Passing Touchdowns: Scored 1.80 TD. Allowed 0.80 TD
• Total 1st Downs: Picked up 21.10. Allowed 18.70
• Total Turnovers: Committed 1.70. Committed by opponents 1.40
• Total Penalties: Committed 6.50. Committed by opponents 4.90
• Penalty Yards: Lost 54.80 Yds. Gained 44.00 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 258.10 Yds. Allowed 274.80 Yds
• Rushing Yards: Gained 95.40 Yds. Allowed 111.30 Yds
• Passing Yards: Gained 162.70 Yds. Allowed 163.50 Yds
• Total Touchdowns: Scored 1.90 TD. Allowed 2.50 TD
• Rushing Touchdowns: Scored 0.60 TD. Allowed 0.90 TD
• Passing Touchdowns: Scored 1.10 TD. Allowed 1.40 TD
• Total 1st Downs: Picked up 15.40. Allowed 16.40
• Total Turnovers: Committed 1.20. Committed by opponents 1.40
• Total Penalties: Committed 6.60. Committed by opponents 7.70
• Penalty Yards: Lost 48.10 Yds. Gained 58.30 Yds

Last 10 Games on the Road

• Total Yards: Gained 371.90 Yds. Allowed 322.10 Yds
• Rushing Yards: Gained 172.40 Yds. Allowed 129.30 Yds
• Passing Yards: Gained 199.50 Yds. Allowed 192.80 Yds
• Total Touchdowns: Scored 3.40 TD. Allowed 2.80 TD
• Rushing Touchdowns: Scored 1.90 TD. Allowed 1.50 TD
• Passing Touchdowns: Scored 1.40 TD. Allowed 1.10 TD
• Total 1st Downs: Picked up 21.30. Allowed 19.20
• Total Turnovers: Committed 1.00. Committed by opponents 1.20
• Total Penalties: Committed 6.00. Committed by opponents 5.40
• Penalty Yards: Lost 50.60 Yds. Gained 41.80 Yds

Last 10 Home Games

• Total Yards: Gained 277.40 Yds. Allowed 252.30 Yds
• Rushing Yards: Gained 103.20 Yds. Allowed 96.00 Yds
• Passing Yards: Gained 174.20 Yds. Allowed 156.30 Yds
• Total Touchdowns: Scored 1.90 TD. Allowed 2.20 TD
• Rushing Touchdowns: Scored 1.00 TD. Allowed 1.10 TD
• Passing Touchdowns: Scored 0.70 TD. Allowed 1.10 TD
• Total 1st Downs: Picked up 16.70. Allowed 14.80
• Total Turnovers: Committed 1.90. Committed by opponents 1.20
• Total Penalties: Committed 6.90. Committed by opponents 7.80
• Penalty Yards: Lost 55.10 Yds. Gained 54.60 Yds

Enjoy NFL live streaming on your mobile, laptop or tablet. It’s great to watch the latest games through your online sportsbook account, with customers able to access high definition streams.

Fans love the opportunity to watch thousands of sporting events per year with the best betting apps.

Bills vs Browns Live Stream Watch Live Geo-restrictions apply. To use the services you need to be logged in, a funded account or to have placed a bet in the last 24 hours.

Top American Football Pages