Bills vs Browns Prediction, Picks & Odds | 21 Dec 2025

NFL Betting Preview: Bills vs Browns

The Buffalo Bills face the Cleveland Browns at Huntington Bank Field, with kickoff scheduled for 13:00 on Sunday, December 21.

There could be plenty of points when the Browns clash with the Bills, with our prediction being Over 41.5 points in total. Odds of -105 look worth taking for this outcome.

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Buffalo Bills have triumphed in their previous three games. The latest was on the road where New England Patriots were beaten 35-31 at Gillette Stadium. The Bills finished with 349 total yards, made up of 181 through the air and 168 on the ground. The offense converted for 22 first downs along with 5 touchdowns.

Cleveland Browns have been defeated in their last three games. On the road, they recently suffered a 31-3 loss against Chicago Bears at Soldier Field. The Browns generated 192 yards, including 142 passing and 50 rushing yards. They produced 9 first downs and allowed 21.

Head-to-Head Statistics

The Bills won the last matchup between the pair. Enjoying a 31-23 triumph when facing the Browns at Ford Field.

Quarterbacks

Josh Allen

205.5 Passing Yards

Over -112

Under -112

Shedeur Sanders

177.5 Passing Yards

Over -112

Under -112

Bills vs Browns Prediction & Picks

We dive into the best Bills vs Browns betting angles, including an expert match prediction, correct score forecast, top player prop bets and a value-focused bet builder.

Game Prediction

We’re expecting Over 41.5 points to be scored by the two teams combined. There’s an attractive -105 for our pick and we’re anticipating that the scoreboard will tick over in this NFL matchup.

Team news plays a key role in our NFL predictions and we’re always tracking players with injury concerns. We also stay on top of the form guide, supported by detailed stats that help paint a clearer picture of what to expect.

Key Bills vs Browns stats:

• The 41.5 line has been covered in 8 of the last 10 Bills games.
• The 41.5 line has been covered in 4 of the last 5 Bills games.
• The 41.5 line has been covered in the last 2 Bills games.

Over 41.5 Probability

If you go by the best betting sites, our pick has a 51.3% chance of winning. Based on our cappers in-depth research, we calculate the actual probability to be 55-60%. This wager can therefore be backed with confidence.

The leading sportbooks allow you to shoot for a bigger price by moving the line on the Totals. Choose a number where you’re happy and get more juice.

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Our Game Prediction

Over 41.5 Points @ -105 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (19:25, 19 December 2025). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Shedeur Sanders Over 177.5 Passing Yards -114

Shedeur Sanders (Browns) is available at -114 to rack up over 177.5 passing yards. The line for him on the Overs is highly appealing, with QB Passing Yards bettors able to get plenty of juice.

Latest Shedeur Sanders Player Prop Odds

Touchdown

Anytime

+900

First

+3500

Passing Yards

Over 177.5

-112

Under 177.5

-112

Rushing Yards

Over 10.5

-108

Under 10.5

-118

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Khalil Shakir Over 38.5 Receiving Yards -114

Khalil Shakir (Browns) is available at -114 to record more than 38.5 receiving yards. We’re happy to take him to cover the Player Receiving Yards line and bettors can place this wager with confidence.

Latest Khalil Shakir Player Prop Odds

Touchdown

Anytime

+270

First

+1000

Receiving Yards

Over 38.5

-112

Under 38.5

-112

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Bills 28 - 23 Browns

The Bills might be able to claim a victory and we’re siding with a 28-23 scoreline in their favor. A small stake can provide a big return and there are monster odds available.

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Bills vs Browns Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

The favorites are 79% likely to win according to the sportsbooks’ latest Moneyline odds, with Buffalo Bills priced at -385 to triumph in this game. Cleveland Browns are trading at bigger odds than their opponents and they can be backed at +300.

The spread currently stands at 8.5 and the total points line is 43.5. NFL bettors love the chance to get an alternative angle by going for a Total wager. If you’re going for Over 43.5, then the odds are -110.

National Football League fans are spoilt for choice thanks to the wide range of game lines and team props which are available for every game on the coupon. Visit the top betting apps and find the best value wagers.

Moneyline

Bills

-385

Browns

+300

Point Spread

Bills -8.5

-110

Browns +8.5

-110

Total Points

Under 43.5

-110

Over 43.5

-110

You will find James Cook at +400 to be First Touchdown Scorer which makes him the favorite. There’s the chance to get -120 that he scores a TD at anytime.

Touchdown

James Cook (Bills)

First TD

+400

Anytime TD

-120

Josh Allen (Bills)

First TD

+500

Anytime TD

-110

Quinshon Judkins (Browns)

First TD

+650

Anytime TD

+115

Khalil Shakir (Bills)

First TD

+1000

Anytime TD

+270

Dalton Kincaid (Bills)

First TD

+1100

Anytime TD

+280

Harold Fannin Jr. (Browns)

First TD

+1500

Anytime TD

+290

Dawson Knox (Bills)

First TD

+1500

Anytime TD

+380

Jerry Jeudy (Browns)

First TD

+1800

Anytime TD

+380

Keon Coleman (Bills)

First TD

+1800

Anytime TD

+450

Joshua Palmer (Bills)

First TD

+1900

Anytime TD

+550

Ty Johnson (Bills)

First TD

+2700

Anytime TD

+500

Isaiah Bond (Browns)

First TD

+3000

Anytime TD

+650

David Njoku (Browns)

First TD

+3000

Anytime TD

+500

Shedeur Sanders (Browns)

First TD

+3500

Anytime TD

+900

Jackson Hawes (Bills)

First TD

+3500

Anytime TD

+750

Gabe Davis (Bills)

First TD

+3500

Anytime TD

+750

Cedric Tillman (Browns)

First TD

+4000

Anytime TD

+1000

Jamari Thrash (Browns)

First TD

+4000

Anytime TD

+1000

Tyrell Shavers (Bills)

First TD

+5500

Anytime TD

+1300

Brandin Cooks (Bills)

First TD

+6000

Anytime TD

+1200

Mecole Hardman (Bills)

First TD

+6000

Anytime TD

+1200

Gage Larvadain (Browns)

First TD

+7500

Anytime TD

+1400

Ray Davis (Bills)

First TD

+8000

Anytime TD

+1100

Malachi Corley (Browns)

First TD

+8000

Anytime TD

+1600

Blake Whiteheart (Browns)

First TD

+8000

Anytime TD

+1600

Trayveon Williams (Browns)

First TD

+8000

Anytime TD

+1700

Raheim Sanders (Browns)

First TD

+10000

Anytime TD

+2700

Brenden Bates (Browns)

First TD

+10000

Anytime TD

+2700

Reggie Gilliam (Bills)

First TD

+10000

Anytime TD

+2000

Receiving Yards

Harold Fannin Jr. (Browns)

Over 53.5

-112

Under 53.5

-112

Khalil Shakir (Bills)

Over 38.5

-112

Under 38.5

-112

Dalton Kincaid (Bills)

Over 33.5

-112

Under 33.5

-112

Jerry Jeudy (Browns)

Over 29.5

-112

Under 29.5

-112

Dawson Knox (Bills)

Over 18.5

-112

Under 18.5

-112

Keon Coleman (Bills)

Over 17.5

-112

Under 17.5

-112

Joshua Palmer (Bills)

Over 15.5

-112

Under 15.5

-112

Isaiah Bond (Browns)

Over 15.5

-112

Under 15.5

-112

James Cook (Bills)

Over 13.5

-112

Under 13.5

-112

Cedric Tillman (Browns)

Over 13.5

-112

Under 13.5

-112

Quinshon Judkins (Browns)

Over 12.5

-112

Under 12.5

-112

Ty Johnson (Bills)

Over 11.5

-112

Under 11.5

-112

Rushing Yards

James Cook (Bills)

Over 89.5

-112

Under 89.5

-112

Quinshon Judkins (Browns)

Over 63.5

-112

Under 63.5

-112

Josh Allen (Bills)

Over 34.5

-112

Under 34.5

-112

Shedeur Sanders (Browns)

Over 10.5

-108

Under 10.5

-118

Passing Yards

Josh Allen (Bills)

Over 205.5

-112

Under 205.5

-112

Shedeur Sanders (Browns)

Over 177.5

-112

Under 177.5

-112

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Browns Slide Includes Three Straight Defeats at Home

The Browns are riding a skid of three straight defeats at Huntington Bank Field. They have three wins and seven losses in the last 10 home games, putting up 15.70 points per contest and giving up 20.00.

The Bills have a 5-5 record in their last 10 games away from home, posting 27.00 points per contest while yielding 23.10.

The Browns earned a 19-16 win against the Bills in the teams’ last meeting at Huntington Bank Field.

Last 10 Games		W-L	P	PF	PA	O41.5	U41.5
Browns Home Stats		3-7	35.70	15.70	20.00	2	8
Bills Away Stats		5-5	50.10	27.00	23.10	6	4

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O41.5 = Games Over 41.5 Points
• U41.5 = Games Under 41.5 Points

Latest regular season and playoff games stats.

Buffalo Bills Stats

Cleveland Browns Stats

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 5 wins and 5 defeats in the last 10 games on the road

Moneyline

• 2 wins and 8 defeats in the last 10 games
• 3 wins and 7 defeats in the last 10 home games

Point Spread

• -10.5 Betting Line: Have covered the spread in 3 of the last 10 games
• -10.5 Betting Line on the Road: Have covered the spread in 3 of the last 10 games on the road

Point Spread

• +10.5 Betting Line: Have covered the spread in 6 of the last 10 games
• +10.5 Betting Line at Home: Have covered the spread in 7 of the last 10 home games

Total Points

• Game Totals: An average of 51.20 pts in the previous 10 games
• Game Totals on the Road: An average of 50.10 pts in the previous 10 games on the road
• Over 41.5: Covered in 8 of the previous 10 games
• Over 41.5 on the Road: Covered in 6 of the previous 10 games on the road
• Team Totals: Have scored an average of 27.80 pts and allowed 23.40 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 27.00 pts and allowed 23.10 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 40.00 pts in the previous 10 games
• Game Totals at Home: An average of 35.80 pts in the previous 10 home games
• Over 41.5: Covered in 3 of the previous 10 games
• Over 41.5 at Home: Covered in 2 of the previous 10 home games
• Team Totals: Have scored an average of 17.00 pts and allowed 23.00 pts in the last 10 games
• Team Totals at Home: Have scored an average of 16.40 pts and allowed 19.40 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 372.10 Yds. Allowed 321.70 Yds
• Rushing Yards: Gained 156.50 Yds. Allowed 134.70 Yds
• Passing Yards: Gained 215.60 Yds. Allowed 187.00 Yds
• Total Touchdowns: Scored 3.60 TD. Allowed 2.80 TD
• Rushing Touchdowns: Scored 1.60 TD. Allowed 1.80 TD
• Passing Touchdowns: Scored 1.80 TD. Allowed 0.80 TD
• Total 1st Downs: Picked up 21.10. Allowed 18.70
• Total Turnovers: Committed 1.70. Committed by opponents 1.40
• Total Penalties: Committed 6.50. Committed by opponents 4.90
• Penalty Yards: Lost 54.80 Yds. Gained 44.00 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 258.10 Yds. Allowed 274.80 Yds
• Rushing Yards: Gained 95.40 Yds. Allowed 111.30 Yds
• Passing Yards: Gained 162.70 Yds. Allowed 163.50 Yds
• Total Touchdowns: Scored 1.90 TD. Allowed 2.50 TD
• Rushing Touchdowns: Scored 0.60 TD. Allowed 0.90 TD
• Passing Touchdowns: Scored 1.10 TD. Allowed 1.40 TD
• Total 1st Downs: Picked up 15.40. Allowed 16.40
• Total Turnovers: Committed 1.20. Committed by opponents 1.40
• Total Penalties: Committed 6.60. Committed by opponents 7.70
• Penalty Yards: Lost 48.10 Yds. Gained 58.30 Yds

Last 10 Games on the Road

• Total Yards: Gained 371.90 Yds. Allowed 322.10 Yds
• Rushing Yards: Gained 172.40 Yds. Allowed 129.30 Yds
• Passing Yards: Gained 199.50 Yds. Allowed 192.80 Yds
• Total Touchdowns: Scored 3.40 TD. Allowed 2.80 TD
• Rushing Touchdowns: Scored 1.90 TD. Allowed 1.50 TD
• Passing Touchdowns: Scored 1.40 TD. Allowed 1.10 TD
• Total 1st Downs: Picked up 21.30. Allowed 19.20
• Total Turnovers: Committed 1.00. Committed by opponents 1.20
• Total Penalties: Committed 6.00. Committed by opponents 5.40
• Penalty Yards: Lost 50.60 Yds. Gained 41.80 Yds

Last 10 Home Games

• Total Yards: Gained 277.40 Yds. Allowed 252.30 Yds
• Rushing Yards: Gained 103.20 Yds. Allowed 96.00 Yds
• Passing Yards: Gained 174.20 Yds. Allowed 156.30 Yds
• Total Touchdowns: Scored 1.90 TD. Allowed 2.20 TD
• Rushing Touchdowns: Scored 1.00 TD. Allowed 1.10 TD
• Passing Touchdowns: Scored 0.70 TD. Allowed 1.10 TD
• Total 1st Downs: Picked up 16.70. Allowed 14.80
• Total Turnovers: Committed 1.90. Committed by opponents 1.20
• Total Penalties: Committed 6.90. Committed by opponents 7.80
• Penalty Yards: Lost 55.10 Yds. Gained 54.60 Yds

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