Bills vs Texans Prediction, Picks & Odds | 20 Nov 2025

NFL Betting Preview: Bills vs Texans

The Buffalo Bills battle the Houston Texans in this Week 12 Thursday Night Football matchup at NRG Stadium, with kickoff scheduled for 20:15 on Thursday, November 20.

The Texans at +5.5 looks a great number for the underdogs when they face the Bills. Take the odds of -100 that this line gets covered.

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Buffalo Bills claimed a victory in their previous game. A 44-32 home win occurred against Tampa Bay Buccaneers at Highmark Stadium. The Bills finished with 414 yards, including 317 passing and 97 rushing yards. The offense picked up 19 first downs and crossed the goal line 6 times.

Houston Texans have triumphed in back-to-back games. The latest of these was on the road where Tennessee Titans were beaten 16-13 at Nissan Stadium. The Texans moved the ball for 315 yards, with 240 through the air and 75 on the ground. The offense moved the chains 20 times and reached the end zone once through the air.

Head-to-Head Statistics

The scoreline was 23-20 in favor of the Texans when they last played the Bills, with the matchup taking place at NRG Stadium. The Texans have won two of the past 3 games that these teams have played.

Quarterbacks

Josh Allen

224.5 Passing Yards

Over -114

Under -114

Davis Mills

210.5 Passing Yards

Over -114

Under -114

Bills vs Texans Prediction & Picks

This Bills vs Texans betting guide features sharp analysis across major markets, including a match prediction, correct score bet, valuable player prop picks and a strategic bet builder.

Game Prediction

We’re making the Texans against the spread our pick for this NFL matchup. The line is favorably set at +5.5 and you can secure -100 that this happens.

It’s important to know which players are unavailable for the upcoming action along with the current form of each franchise. If you're after stats, you're in the right place because they form the foundation of our NFL picks.

Key Bills vs Texans stats:

• The +5.5 line has been covered by Texans in 6 consecutive games at home.
• The +5.5 line has been covered by Texans in 9 of their last 10 games at home.
• The +5.5 line has been covered by Texans in 18 of their last 20 games at home.
• The -5.5 line hasn’t been covered by Bills in 13 of their last 20 games on the road.
• The -5.5 line hasn’t been covered by Bills in 3 of their last 5 games on the road.
• The +5.5 line has been covered by Texans in 2 of their last 3 games against Bills.

Texans +5.5 Probability

According to the latest betting odds, our pick has a 50% chance of winning. Taking all factors into consideration, our analysts think there’s a stronger chance of success and have a probability interval between 55-60%. The wager can be recommended for this precise reason.

If you want to secure a bigger potential payout on your wager, there’s the option to move the betting line. Take a look at the various prices and see which spread you think will be covered.

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Our Game Prediction

Texans +5.5 @ -100 Watch Live Bet Now

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Player Prop Picks

Top Pick: Davis Mills Over 210.5 Passing Yards -114

Davis Mills (Texans) is priced at -114 to reach over 210.5 passing yards. The line for him on the Overs looks attractive and bettors can get plenty of juice from this QB Passing Yards wager.

Latest Davis Mills Player Prop Odds

Touchdown

Anytime

+1200

First

+5000

Passing Yards

Over 210.5

-114

Under 210.5

-114

Rushing Yards

Over 7.5

-114

Under 7.5

-114

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Nico Collins Over 74.5 Receiving Yards -114

You can place a bet on Nico Collins (Texans) at -114 to rack up over 74.5 receiving yards. We can back him in the Player Receiving Yards market and hope the Over hits.

Latest Nico Collins Player Prop Odds

Touchdown

Anytime

+135

First

+750

Receiving Yards

Over 74.5

-114

Under 74.5

-114

Correct Score Prediction

Bills 17 - 21 Texans

A close matchup could be on the cards. We’ll wager the Texans to secure a 21-17 win at massive odds and this correct score prediction should hopefully be a fun one.

Bills vs Texans Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Sportsbooks’ favorites Buffalo Bills are regarded as likeliest victors for this game and the -278 about them triumphing means a 74% chance based on their current Moneyline betting odds. Houston Texans are trading at bigger odds than their opponents and they can be backed at +225.

5.5 is the spread and 43.5 is the total points line. There are many ways to bet on the NFL including the Totals. There’s the chance to back Under 43.5 at -110.

There are hundreds of team props and game lines when it comes to wagering on the National Football League and we recommend visiting the best sportsbooks to find the bet that matches your view on the game.

Moneyline

Bills

-278

Texans

+225

Point Spread

Bills -5.5

-122

Texans +5.5

-100

Total Points

Under 43.5

-110

Over 43.5

-110

Favorite James Cook is available at +490 to be the First TD Scorer. Similar odds apply if you’re interested in this player to score the final touchdown.

Touchdown

James Cook (Bills)

First TD

+490

Anytime TD

-120

Josh Allen (Bills)

First TD

+500

Anytime TD

-125

Woody Marks (Texans)

First TD

+700

Anytime TD

+125

Nico Collins (Texans)

First TD

+750

Anytime TD

+135

Khalil Shakir (Bills)

First TD

+1200

Anytime TD

+260

Dalton Schultz (Texans)

First TD

+1600

Anytime TD

+310

Dawson Knox (Bills)

First TD

+1600

Anytime TD

+350

Keon Coleman (Bills)

First TD

+1600

Anytime TD

+370

Joshua Palmer (Bills)

First TD

+1900

Anytime TD

+400

Curtis Samuel (Bills)

First TD

+1900

Anytime TD

+400

Jayden Higgins (Texans)

First TD

+2200

Anytime TD

+500

Nick Chubb (Texans)

First TD

+2200

Anytime TD

+500

Tyrell Shavers (Bills)

First TD

+2500

Anytime TD

+550

Ty Johnson (Bills)

First TD

+3000

Anytime TD

+600

Jackson Hawes (Bills)

First TD

+3500

Anytime TD

+900

Christian Kirk (Texans)

First TD

+4000

Anytime TD

+750

Mecole Hardman (Bills)

First TD

+4000

Anytime TD

+850

Elijah Moore (Bills)

First TD

+4000

Anytime TD

+850

Xavier Hutchinson (Texans)

First TD

+4500

Anytime TD

+850

Davis Mills (Texans)

First TD

+5000

Anytime TD

+1200

Jaylin Noel (Texans)

First TD

+5500

Anytime TD

+1000

Cade Stover (Texans)

First TD

+6000

Anytime TD

+1100

Reggie Gilliam (Bills)

First TD

+10000

Anytime TD

+1700

Ray Davis (Bills)

First TD

+10000

Anytime TD

+1700

Dare Ogunbowale (Texans)

First TD

+10000

Anytime TD

+2200

Dameon Pierce (Texans)

First TD

+10000

Anytime TD

+2200

Jakob Johnson (Texans)

First TD

+10000

Anytime TD

+3000

Braxton Berrios (Texans)

First TD

+10000

Anytime TD

+3000

British Brooks (Texans)

First TD

+10000

Anytime TD

+3000

Receiving Yards

Nico Collins (Texans)

Over 74.5

-114

Under 74.5

-114

Khalil Shakir (Bills)

Over 43.5

-114

Under 43.5

-114

Dalton Schultz (Texans)

Over 38.5

-114

Under 38.5

-114

Jayden Higgins (Texans)

Over 27.5

-114

Under 27.5

-114

Dawson Knox (Bills)

Over 24.5

-114

Under 24.5

-114

Keon Coleman (Bills)

Over 22.5

-114

Under 22.5

-114

James Cook (Bills)

Over 14.5

-114

Under 14.5

-114

Woody Marks (Texans)

Over 11.5

-114

Under 11.5

-114

Rushing Yards

James Cook (Bills)

Over 73.5

-114

Under 73.5

-114

Woody Marks (Texans)

Over 63.5

-114

Under 63.5

-114

Josh Allen (Bills)

Over 33.5

-114

Under 33.5

-114

Nick Chubb (Texans)

Over 20.5

-114

Under 20.5

-114

Davis Mills (Texans)

Over 7.5

-114

Under 7.5

-114

Passing Yards

Josh Allen (Bills)

Over 224.5

-114

Under 224.5

-114

Davis Mills (Texans)

Over 210.5

-114

Under 210.5

-114

Texans Own Five Victories From Previous Ten at Home

The Texans have five wins and five losses in the last 10 games at home, averaging 22.60 points on offense and surrendering 19.50 on defense.

The Bills own a 5-5 mark in their past 10 games away from home, averaging 29.30 points scored and 24.40 points allowed.

The Texans beat the Bills 23-20 in their most recent meeting at NRG Stadium.

Last 10 Games		W-L	P	PF	PA	O43.5	U43.5
Texans Home Stats		5-5	42.10	22.60	19.50	4	6
Bills Away Stats		5-5	53.70	29.30	24.40	5	5

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O43.5 = Games Over 43.5 Points
• U43.5 = Games Under 43.5 Points

Latest regular season and playoff games stats.

Buffalo Bills Stats

Houston Texans Stats

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 5 wins and 5 defeats in the last 10 games on the road

Moneyline

• 5 wins and 5 defeats in the last 10 games
• 5 wins and 5 defeats in the last 10 home games

Point Spread

• -5.5 Betting Line: Have covered the spread in 6 of the last 10 games
• -5.5 Betting Line on the Road: Have covered the spread in 5 of the last 10 games on the road

Point Spread

• +5.5 Betting Line: Have covered the spread in 8 of the last 10 games
• +5.5 Betting Line at Home: Have covered the spread in 9 of the last 10 home games

Total Points

• Game Totals: An average of 52.10 pts in the previous 10 games
• Game Totals on the Road: An average of 53.70 pts in the previous 10 games on the road
• Over 43.5: Covered in 6 of the previous 10 games
• Over 43.5 on the Road: Covered in 5 of the previous 10 games on the road
• Team Totals: Have scored an average of 29.20 pts and allowed 22.90 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 29.30 pts and allowed 24.40 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 38.30 pts in the previous 10 games
• Game Totals at Home: An average of 42.10 pts in the previous 10 home games
• Over 43.5: Covered in 3 of the previous 10 games
• Over 43.5 at Home: Covered in 4 of the previous 10 home games
• Team Totals: Have scored an average of 22.00 pts and allowed 16.30 pts in the last 10 games
• Team Totals at Home: Have scored an average of 22.60 pts and allowed 19.50 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 387.40 Yds. Allowed 322.80 Yds
• Rushing Yards: Gained 147.60 Yds. Allowed 153.00 Yds
• Passing Yards: Gained 239.80 Yds. Allowed 169.80 Yds
• Total Touchdowns: Scored 3.70 TD. Allowed 2.70 TD
• Rushing Touchdowns: Scored 1.90 TD. Allowed 1.70 TD
• Passing Touchdowns: Scored 1.80 TD. Allowed 0.90 TD
• Total 1st Downs: Picked up 22.40. Allowed 18.90
• Total Turnovers: Committed 1.20. Committed by opponents 1.30
• Total Penalties: Committed 6.80. Committed by opponents 5.00
• Penalty Yards: Lost 56.30 Yds. Gained 42.20 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 329.60 Yds. Allowed 258.00 Yds
• Rushing Yards: Gained 107.60 Yds. Allowed 87.10 Yds
• Passing Yards: Gained 222.00 Yds. Allowed 171.00 Yds
• Total Touchdowns: Scored 2.10 TD. Allowed 1.90 TD
• Rushing Touchdowns: Scored 0.40 TD. Allowed 0.70 TD
• Passing Touchdowns: Scored 1.40 TD. Allowed 1.00 TD
• Total 1st Downs: Picked up 19.30. Allowed 16.10
• Total Turnovers: Committed 0.90. Committed by opponents 1.50
• Total Penalties: Committed 7.20. Committed by opponents 7.40
• Penalty Yards: Lost 58.90 Yds. Gained 57.50 Yds

Last 10 Games on the Road

• Total Yards: Gained 397.70 Yds. Allowed 346.00 Yds
• Rushing Yards: Gained 156.60 Yds. Allowed 117.10 Yds
• Passing Yards: Gained 241.10 Yds. Allowed 228.90 Yds
• Total Touchdowns: Scored 3.70 TD. Allowed 3.00 TD
• Rushing Touchdowns: Scored 2.10 TD. Allowed 1.40 TD
• Passing Touchdowns: Scored 1.50 TD. Allowed 1.40 TD
• Total 1st Downs: Picked up 22.60. Allowed 21.20
• Total Turnovers: Committed 0.80. Committed by opponents 1.50
• Total Penalties: Committed 7.30. Committed by opponents 6.20
• Penalty Yards: Lost 59.00 Yds. Gained 45.20 Yds

Last 10 Home Games

• Total Yards: Gained 310.30 Yds. Allowed 287.20 Yds
• Rushing Yards: Gained 97.60 Yds. Allowed 108.30 Yds
• Passing Yards: Gained 212.70 Yds. Allowed 179.00 Yds
• Total Touchdowns: Scored 2.20 TD. Allowed 2.20 TD
• Rushing Touchdowns: Scored 0.60 TD. Allowed 0.60 TD
• Passing Touchdowns: Scored 1.30 TD. Allowed 1.50 TD
• Total 1st Downs: Picked up 16.70. Allowed 17.70
• Total Turnovers: Committed 1.20. Committed by opponents 2.10
• Total Penalties: Committed 7.00. Committed by opponents 5.10
• Penalty Yards: Lost 57.50 Yds. Gained 44.10 Yds

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