Panthers vs Cardinals Prediction, Picks & Odds | 14 Sep 2025

NFL Betting Preview: Panthers vs Cardinals

The Carolina Panthers battle the Arizona Cardinals in this NFL Week 2 matchup at State Farm Stadium, with kickoff scheduled for 16:05 on Sunday, September 14. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

The Overs is sticking out like a sore thumb considering the line for the Cardinals and the Panthers is set at 44.5. We’re expecting a bigger total and -102 is available.

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Carolina Panthers were beaten in their previous game and this was on the road at EverBank Stadium. Jacksonville Jaguars claimed a 26-10 win. The Panthers finished with 255 yards, including 142 passing and 113 rushing yards. The offense picked up 15 first downs and scored a touchdown through the air.

Arizona Cardinals won last time out by a 20-13 scoreline. It was on the road against New Orleans Saints at Caesars Superdome. The Cardinals finished with 276 total yards, breaking down to 130 passing and 146 rushing yards. They picked up 19 first downs and scored two touchdowns.

Head-to-Head Statistics

It was a 36-30 (OT) win for the Panthers at Bank of America Stadium when they last played the Cardinals. The Panthers have won four of the past 5 games that these teams have played.

Quarterbacks

Bryce Young

203.5 Passing Yards

Over -112

Under -112

Kyler Murray

217.5 Passing Yards

Over -112

Under -112

Panthers vs Cardinals Prediction & Picks

We’ve lined up expert Panthers vs Cardinals betting tips, from our match prediction and correct score call to player prop picks and best bet builder advice. Read on for the full breakdown.

Game Prediction

There’s juice available when it comes to backing Over 44.5 points in this NFL matchup and that’s the betting angle we’re pursuing. Our pick is priced up at -102 which looks worth taking.

We use the latest team news and injury updates to help shape the best possible NFL picks. You’ll also notice we take a stats-led approach by factoring in the key numbers that truly make a difference.

Key Panthers vs Cardinals stats:

• The 44.5 line has been covered in 6 of the last 10 Panthers games.
• The 44.5 line has been covered in 12 of the last 20 Panthers games.
• The 44.5 line has been covered in the last 3 Cardinals games at home.
• The 44.5 line has been covered in 12 of the last 20 Cardinals games.

Over 44.5 Probability

According to the latest odds, there’s a 50.5% likelihood of our pick landing a return. However, our research has found that the actual probability is closer to 60%. This is why we regard this as a value wager.

If you want to go Over on the Totals at bigger odds, then you can combine this pick with other selections in a Bet Builder until you’re happy with the potential return.

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Our Game Prediction

Over 44.5 Points @ -102 Bet Now

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Player Prop Picks

Top Pick: James Conner Anytime TD -154

The odds for James Conner (Cardinals) to hit the end zone are -154. We're happy to back this Anytime Touchdown Scorer bet, as the odds offer value for him to take it to the house at least once.

Latest James Conner Player Prop Odds

Touchdown

Anytime

-154

First

+390

Receiving Yards

Over 14.5

-120

Under 14.5

-106

Rushing Yards

Over 69.5

-112

Under 69.5

-112

---

Kyler Murray Over 214.5 Passing Yards -114

You can place a bet on Kyler Murray (Cardinals) at -114 to rack up over 214.5 passing yards. We're confident in him covering the QB Passing Yards line and hitting our Over bet.

Latest Kyler Murray Player Prop Odds

Touchdown

Anytime

+210

First

+1100

Passing Yards

Over 217.5

-112

Under 217.5

-112

Rushing Yards

Over 28.5

-112

Under 28.5

-112

Correct Score Prediction

Panthers 17 - 31 Cardinals

There are a range of correct score lines to choose from and we’re taking a chance on the Cardinals to record a 31-17 victory. There’s a massive return if we get this right.

Panthers vs Cardinals Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

The sportsbooks’ betting odds have Arizona Cardinals as -333 favorites for this game, implying that they are 77% likely to win. If you’re looking for an alternative angle, Carolina Panthers are trading at +270.

There is a spread of 7 and total points has a line of 44.5. A bet on the Totals allows fans to use the latest NFL data to good effect. If you’re wanting to back Over 44.5, the odds are -110.

Every matchup offers a deep selection of team props and game lines and the top NFL betting sites deliver excellent pre-game and in-game wagering opportunities. It’s all about finding the bets that match your game plan.

Moneyline

Panthers

+270

Cardinals

-333

Point Spread

Panthers +7

-110

Cardinals -7

-110

Total Points

Under 44.5

-110

Over 44.5

-110

Those interested in favorite James Conner to score the first touchdown are able to get +390. If the Anytime TD angle makes appeal, then this is -154.

Touchdown

James Conner (Cardinals)

First TD

+390

Anytime TD

-154

Chuba Hubbard (Panthers)

First TD

+600

Anytime TD

-105

Marvin Harrison Jr. (Cardinals)

First TD

+850

Anytime TD

+150

Trey McBride (Cardinals)

First TD

+850

Anytime TD

+160

Trey Benson (Cardinals)

First TD

+1100

Anytime TD

+210

Kyler Murray (Cardinals)

First TD

+1100

Anytime TD

+210

Tetairoa McMillan (Panthers)

First TD

+1300

Anytime TD

+190

Michael Wilson (Cardinals)

First TD

+1800

Anytime TD

+390

Xavier Legette (Panthers)

First TD

+2200

Anytime TD

+410

Ja'Tavion Sanders (Panthers)

First TD

+2500

Anytime TD

+430

Hunter Renfrow (Panthers)

First TD

+2700

Anytime TD

+500

Zay Jones (Cardinals)

First TD

+3000

Anytime TD

+750

Rico Dowdle (Panthers)

First TD

+3000

Anytime TD

+500

Elijah Higgins (Cardinals)

First TD

+3300

Anytime TD

+950

Bryce Young (Panthers)

First TD

+3500

Anytime TD

+650

Greg Dortch (Cardinals)

First TD

+4500

Anytime TD

+1000

Tip Reiman (Cardinals)

First TD

+4500

Anytime TD

+1100

Emari Demercado (Cardinals)

First TD

+5500

Anytime TD

+1000

Tommy Tremble (Panthers)

First TD

+6500

Anytime TD

+1300

Trevor Etienne (Panthers)

First TD

+7500

Anytime TD

+1400

Travis Vokolek (Cardinals)

First TD

+8000

Anytime TD

+2000

Josiah Deguara (Cardinals)

First TD

+8000

Anytime TD

+2200

Simi Fehoko (Cardinals)

First TD

+8000

Anytime TD

+2200

James Mitchell (Panthers)

First TD

+10000

Anytime TD

+1700

Mitchell Evans (Panthers)

First TD

+10000

Anytime TD

+2500

Xavier Weaver (Cardinals)

First TD

+10000

Anytime TD

+2000

David Moore (Panthers)

First TD

+10000

Anytime TD

+2000

Brycen Tremayne (Panthers)

First TD

+10000

Anytime TD

+2500

Receiving Yards

Trey McBride (Cardinals)

Over 62.5

-112

Under 62.5

-112

Tetairoa McMillan (Panthers)

Over 60.5

-112

Under 60.5

-112

Marvin Harrison Jr. (Cardinals)

Over 55.5

-112

Under 55.5

-112

Xavier Legette (Panthers)

Over 28.5

-112

Under 28.5

-112

Hunter Renfrow (Panthers)

Over 24.5

-112

Under 24.5

-112

Michael Wilson (Cardinals)

Over 23.5

-112

Under 23.5

-112

Ja'Tavion Sanders (Panthers)

Over 20.5

-112

Under 20.5

-112

James Conner (Cardinals)

Over 14.5

-120

Under 14.5

-106

Chuba Hubbard (Panthers)

Over 13.5

-112

Under 13.5

-112

Rushing Yards

James Conner (Cardinals)

Over 69.5

-112

Under 69.5

-112

Chuba Hubbard (Panthers)

Over 62.5

-112

Under 62.5

-112

Trey Benson (Cardinals)

Over 34.5

-112

Under 34.5

-112

Kyler Murray (Cardinals)

Over 28.5

-112

Under 28.5

-112

Bryce Young (Panthers)

Over 15.5

-112

Under 15.5

-112

Passing Yards

Kyler Murray (Cardinals)

Over 217.5

-112

Under 217.5

-112

Bryce Young (Panthers)

Over 203.5

-112

Under 203.5

-112

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Cardinals With Six Wins in Past Ten Home Games

The Cardinals have a 6-4 record in their last 10 home games, posting 26.00 points per contest while yielding 19.40.

The Panthers have two wins and eight losses in the last 10 games away from home, putting up 16.10 points per contest and giving up 33.30.

The Panthers defeated the Cardinals 34-10 when the teams last met at State Farm Stadium.

Last 10 Games		W-L	P	PF	PA	O44.5	U44.5
Cardinals Home Stats		6-4	45.40	26.00	19.40	5	5
Panthers Away Stats		2-8	49.40	16.10	33.30	6	4

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O44.5 = Games Over 44.5 Points
• U44.5 = Games Under 44.5 Points

Latest regular season and playoff games stats.

Carolina Panthers Stats

Arizona Cardinals Stats

Moneyline

• 4 wins and 6 defeats in the last 10 games
• 2 wins and 8 defeats in the last 10 games on the road

Moneyline

• 5 wins and 5 defeats in the last 10 games
• 6 wins and 4 defeats in the last 10 home games

Point Spread

• +6.5 Betting Line: Have covered the spread in 7 of the last 10 games
• +6.5 Betting Line on the Road: Have covered the spread in 3 of the last 10 games on the road

Point Spread

• -6.5 Betting Line: Have covered the spread in 5 of the last 10 games
• -6.5 Betting Line at Home: Have covered the spread in 5 of the last 10 home games

Total Points

• Game Totals: An average of 51.60 pts in the previous 10 games
• Game Totals on the Road: An average of 49.40 pts in the previous 10 games on the road
• Over 44.5: Covered in 6 of the previous 10 games
• Over 44.5 on the Road: Covered in 6 of the previous 10 games on the road
• Team Totals: Have scored an average of 22.70 pts and allowed 28.90 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 16.10 pts and allowed 33.30 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 42.90 pts in the previous 10 games
• Game Totals at Home: An average of 45.40 pts in the previous 10 home games
• Over 44.5: Covered in 5 of the previous 10 games
• Over 44.5 at Home: Covered in 5 of the previous 10 home games
• Team Totals: Have scored an average of 24.20 pts and allowed 18.70 pts in the last 10 games
• Team Totals at Home: Have scored an average of 26.00 pts and allowed 19.40 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 301.40 Yds. Allowed 415.40 Yds
• Rushing Yards: Gained 110.30 Yds. Allowed 200.30 Yds
• Passing Yards: Gained 191.10 Yds. Allowed 215.10 Yds
• Total Touchdowns: Scored 2.70 TD. Allowed 3.20 TD
• Rushing Touchdowns: Scored 1.30 TD. Allowed 1.10 TD
• Passing Touchdowns: Scored 1.40 TD. Allowed 1.90 TD
• Total 1st Downs: Picked up 17.90. Allowed 25.10
• Total Turnovers: Committed 1.10. Committed by opponents 1.00
• Total Penalties: Committed 6.60. Committed by opponents 8.30
• Penalty Yards: Lost 52.40 Yds. Gained 66.90 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 365.50 Yds. Allowed 307.40 Yds
• Rushing Yards: Gained 144.60 Yds. Allowed 107.30 Yds
• Passing Yards: Gained 220.90 Yds. Allowed 200.10 Yds
• Total Touchdowns: Scored 2.50 TD. Allowed 1.90 TD
• Rushing Touchdowns: Scored 1.20 TD. Allowed 0.90 TD
• Passing Touchdowns: Scored 1.20 TD. Allowed 1.00 TD
• Total 1st Downs: Picked up 21.90. Allowed 18.30
• Total Turnovers: Committed 1.10. Committed by opponents 0.70
• Total Penalties: Committed 6.00. Committed by opponents 7.20
• Penalty Yards: Lost 50.70 Yds. Gained 55.60 Yds

Last 10 Games on the Road

• Total Yards: Gained 269.60 Yds. Allowed 403.20 Yds
• Rushing Yards: Gained 95.50 Yds. Allowed 167.20 Yds
• Passing Yards: Gained 174.10 Yds. Allowed 236.00 Yds
• Total Touchdowns: Scored 2.00 TD. Allowed 3.90 TD
• Rushing Touchdowns: Scored 0.80 TD. Allowed 1.50 TD
• Passing Touchdowns: Scored 1.20 TD. Allowed 2.20 TD
• Total 1st Downs: Picked up 15.50. Allowed 23.20
• Total Turnovers: Committed 1.50. Committed by opponents 0.60
• Total Penalties: Committed 5.10. Committed by opponents 6.40
• Penalty Yards: Lost 41.90 Yds. Gained 53.60 Yds

Last 10 Home Games

• Total Yards: Gained 375.20 Yds. Allowed 339.30 Yds
• Rushing Yards: Gained 167.10 Yds. Allowed 123.20 Yds
• Passing Yards: Gained 208.10 Yds. Allowed 216.10 Yds
• Total Touchdowns: Scored 3.10 TD. Allowed 1.90 TD
• Rushing Touchdowns: Scored 1.40 TD. Allowed 1.00 TD
• Passing Touchdowns: Scored 1.40 TD. Allowed 0.90 TD
• Total 1st Downs: Picked up 21.80. Allowed 19.80
• Total Turnovers: Committed 0.80. Committed by opponents 1.00
• Total Penalties: Committed 3.90. Committed by opponents 5.60
• Penalty Yards: Lost 36.80 Yds. Gained 44.50 Yds

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