NFL Betting Preview: Panthers vs Cardinals

The Carolina Panthers battle the Arizona Cardinals in this NFL Week 2 matchup at State Farm Stadium, with kickoff scheduled for 16:05 on Sunday 14 September. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

Points the Play in Panthers at Cardinals

The Overs is sticking out like a sore thumb considering the line for the Cardinals and the Panthers is set at 44.5. We’re expecting a bigger total and -102 is available.

On board with our big-score prediction? Lock in the best BetMGM promo code and read our comprehensive review before placing your bet.

4 Panthers Victories in Last 5 H2H Battles

Carolina Panthers were beaten in their previous game and this was on the road at EverBank Stadium. Jacksonville Jaguars claimed a 26-10 win. The Panthers finished with 255 yards, including 142 passing and 113 rushing yards. The offense picked up 15 first downs and scored a touchdown through the air.

Arizona Cardinals won last time out by a 20-13 scoreline. It was on the road against New Orleans Saints at Caesars Superdome. The Cardinals finished with 276 total yards, breaking down to 130 passing and 146 rushing yards. They picked up 19 first downs and scored two touchdowns.

Head-to-Head Statistics

It was a 36-30 (OT) win for the Panthers at Bank of America Stadium when they last played the Cardinals. The Panthers have won four of the past 5 games that these teams have played.

Quarterbacks

Bryce Young

Kyler Murray

Panthers vs Cardinals Prediction & Picks

We’ve lined up expert Panthers vs Cardinals betting tips, from our match prediction and correct score call to player prop picks and best bet builder advice. Read on for the full breakdown.

Game Prediction

There’s juice available when it comes to backing Over 44.5 points in this NFL matchup and that’s the betting angle we’re pursuing. Our pick is priced up at -102 which looks worth taking.

We use the latest team news and injury updates to help shape the best possible NFL picks. You’ll also notice we take a stats-led approach by factoring in the key numbers that truly make a difference.

Key Panthers vs Cardinals stats:

The 44.5 line has been covered in 6 of the last 10 Panthers games.
The 44.5 line has been covered in 12 of the last 20 Panthers games.
The 44.5 line has been covered in the last 3 Cardinals games at home.
The 44.5 line has been covered in 12 of the last 20 Cardinals games.

Over 44.5 Probability

According to the latest odds, there’s a 50.5% likelihood of our pick landing a return. However, our research has found that the actual probability is closer to 60%. This is why we regard this as a value wager.

Looking for Bigger Odds?

If you want to go Over on the Totals at bigger odds, then you can combine this pick with other selections in a Bet Builder until you’re happy with the potential return.

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Best Bet

Over 44.5 Points @ -102 Bet Now

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Published 22:26, 12 September 2025

Player Prop Picks

Top Pick: James Conner Anytime TD -154

The odds for James Conner (Cardinals) to hit the end zone are -154. We're happy to back this Anytime Touchdown Scorer bet, as the odds offer value for him to take it to the house at least once.

Latest James Conner Player Prop Odds

Touchdown

Receiving Yards

Rushing Yards

Kyler Murray Over 214.5 Passing Yards -114

You can place a bet on Kyler Murray (Cardinals) at -114 to rack up over 214.5 passing yards. We're confident in him covering the QB Passing Yards line and hitting our Over bet.

Latest Kyler Murray Player Prop Odds

Touchdown

Passing Yards

Rushing Yards

Same Game Parlay Picks

Totals Over 44.5

Spread Cardinals -6.5

Anytime Touchdown James Conner

Take a same game parlay that incorporates Over 44.5 points followed by Cardinals to cover the -6.5 spread. Add in James Conner (Cardinals) as an anytime touchdown scorer.

There are lots of options when you place a same game parlay. You can go through the football lines and identify your favorite picks before combining the odds on the bet slip. Personalised wagering doesn’t come any better.

Bet Boosts

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Correct Score Prediction

Panthers

17 - 31 Cardinals logo

Cardinals

There are a range of correct score lines to choose from and we’re taking a chance on the Cardinals to record a 31-17 victory. There’s a massive return if we get this right.

Panthers vs Cardinals Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Books Make Cardinals Moneyline Favorites

The sportsbooks’ betting odds have Arizona Cardinals as -323 favorites for this game, implying that they are 76% likely to win. If you’re looking for an alternative angle, Carolina Panthers are trading at +260.

There is a spread of 6.5 and total points has a line of 44.5. A bet on the Totals allows fans to use the latest NFL data to good effect. If you’re wanting to back Over 44.5, the odds are -102.

Every matchup offers a deep selection of team props and game lines and the top NFL betting sites deliver excellent pre-game and in-game wagering opportunities. It’s all about finding the bets that match your game plan.

Moneyline

Point Spread

Total Points

James Conner Favorite to Be First TD Scorer

Those interested in favorite James Conner to score the first touchdown are able to get +420. If the Anytime TD angle makes appeal, then this is -154.

Touchdown

James Conner (Cardinals)

Chuba Hubbard (Panthers)

Marvin Harrison Jr. (Cardinals)

Trey McBride (Cardinals)

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Receiving Yards

Tetairoa McMillan (Panthers)

Trey McBride (Cardinals)

Marvin Harrison Jr. (Cardinals)

Xavier Legette (Panthers)

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Rushing Yards

James Conner (Cardinals)

Chuba Hubbard (Panthers)

Trey Benson (Cardinals)

Kyler Murray (Cardinals)

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Passing Yards

Kyler Murray (Cardinals)

Bryce Young (Panthers)

Best Betting Offers

State Farm Stadium

Cardinals With Six Wins in Past Ten Home Games

The Cardinals have a 6-4 record in their last 10 home games, posting 26.00 points per contest while yielding 19.40.

The Panthers have two wins and eight losses in the last 10 games away from home, putting up 16.10 points per contest and giving up 33.30.

The Panthers defeated the Cardinals 34-10 when the teams last met at State Farm Stadium.

Last 10 Games		W-L	P	PF	PA	O44.5	U44.5
Cardinals Home Stats		6-4	45.40	26.00	19.40	5	5
Panthers Away Stats		2-8	49.40	16.10	33.30	6	4

W-L = Wins-Losses
P = Avg. Points
PF = Avg. Points For
PA = Avg. Points Against
O44.5 = Games Over 44.5 Points
U44.5 = Games Under 44.5 Points

Last 5 & H2H

All
Home
Away

Last 5 Games

Panthers

NFL: 07/09 Panthers10 Jaguars 26
NFL: 05/01 Panthers44 Falcons 38
NFL: 29/12 Panthers14 Buccaneers 48
NFL: 22/12 Cardinals30 Panthers 36
NFL: 15/12 Cowboys30 Panthers 14

Cardinals

NFL: 07/09 Cardinals20 Saints 13
NFL: 05/01 49ers24 Cardinals 47
NFL: 29/12 Cardinals9 Rams 13
NFL: 22/12 Cardinals30 Panthers 36
NFL: 15/12 Patriots17 Cardinals 30

Head to Head

Panthers vs Cardinals

NFL: 22/12 2024 Cardinals 30 Panthers 36
NFL: 02/10 2022 Cardinals 26 Panthers 16
NFL: 14/11 2021 Panthers 34 Cardinals 10
NFL: 04/10 2020 Cardinals 21 Panthers 31
NFL: 22/09 2019 Panthers 38 Cardinals 20

Team Stats

Latest regular season and playoff games stats.

Carolina Panthers Stats

Arizona Cardinals Stats

Moneyline

4 wins and 6 defeats in the last 10 games
2 wins and 8 defeats in the last 10 games on the road

Moneyline

5 wins and 5 defeats in the last 10 games
6 wins and 4 defeats in the last 10 home games

Point Spread

+6.5 Betting Line: Have covered the spread in 7 of the last 10 games
+6.5 Betting Line on the Road: Have covered the spread in 3 of the last 10 games on the road

Point Spread

-6.5 Betting Line: Have covered the spread in 5 of the last 10 games
-6.5 Betting Line at Home: Have covered the spread in 5 of the last 10 home games

Total Points

Game Totals: An average of 51.60 pts in the previous 10 games
Game Totals on the Road: An average of 49.40 pts in the previous 10 games on the road
Over 44.5: Covered in 6 of the previous 10 games
Over 44.5 on the Road: Covered in 6 of the previous 10 games on the road
Team Totals: Have scored an average of 22.70 pts and allowed 28.90 pts in the last 10 games
Team Totals on the Road: Have scored an average of 16.10 pts and allowed 33.30 pts in the last 10 games on the road

Total Points

Game Totals: An average of 42.90 pts in the previous 10 games
Game Totals at Home: An average of 45.40 pts in the previous 10 home games
Over 44.5: Covered in 5 of the previous 10 games
Over 44.5 at Home: Covered in 5 of the previous 10 home games
Team Totals: Have scored an average of 24.20 pts and allowed 18.70 pts in the last 10 games
Team Totals at Home: Have scored an average of 26.00 pts and allowed 19.40 pts in the last 10 home games

Game Stats

Last 10 Games

Total Yards: Gained 301.40 Yds. Allowed 415.40 Yds
Rushing Yards: Gained 110.30 Yds. Allowed 200.30 Yds
Passing Yards: Gained 191.10 Yds. Allowed 215.10 Yds
Total Touchdowns: Scored 2.70 TD. Allowed 3.20 TD
Rushing Touchdowns: Scored 1.30 TD. Allowed 1.10 TD
Passing Touchdowns: Scored 1.40 TD. Allowed 1.90 TD
Total 1st Downs: Picked up 17.90. Allowed 25.10
Total Turnovers: Committed 1.10. Committed by opponents 1.00
Total Penalties: Committed 6.60. Committed by opponents 8.30
Penalty Yards: Lost 52.40 Yds. Gained 66.90 Yds

Game Stats

Last 10 Games

Total Yards: Gained 365.50 Yds. Allowed 307.40 Yds
Rushing Yards: Gained 144.60 Yds. Allowed 107.30 Yds
Passing Yards: Gained 220.90 Yds. Allowed 200.10 Yds
Total Touchdowns: Scored 2.50 TD. Allowed 1.90 TD
Rushing Touchdowns: Scored 1.20 TD. Allowed 0.90 TD
Passing Touchdowns: Scored 1.20 TD. Allowed 1.00 TD
Total 1st Downs: Picked up 21.90. Allowed 18.30
Total Turnovers: Committed 1.10. Committed by opponents 0.70
Total Penalties: Committed 6.00. Committed by opponents 7.20
Penalty Yards: Lost 50.70 Yds. Gained 55.60 Yds

Last 10 Games on the Road

Total Yards: Gained 269.60 Yds. Allowed 403.20 Yds
Rushing Yards: Gained 95.50 Yds. Allowed 167.20 Yds
Passing Yards: Gained 174.10 Yds. Allowed 236.00 Yds
Total Touchdowns: Scored 2.00 TD. Allowed 3.90 TD
Rushing Touchdowns: Scored 0.80 TD. Allowed 1.50 TD
Passing Touchdowns: Scored 1.20 TD. Allowed 2.20 TD
Total 1st Downs: Picked up 15.50. Allowed 23.20
Total Turnovers: Committed 1.50. Committed by opponents 0.60
Total Penalties: Committed 5.10. Committed by opponents 6.40
Penalty Yards: Lost 41.90 Yds. Gained 53.60 Yds

Last 10 Home Games

Total Yards: Gained 375.20 Yds. Allowed 339.30 Yds
Rushing Yards: Gained 167.10 Yds. Allowed 123.20 Yds
Passing Yards: Gained 208.10 Yds. Allowed 216.10 Yds
Total Touchdowns: Scored 3.10 TD. Allowed 1.90 TD
Rushing Touchdowns: Scored 1.40 TD. Allowed 1.00 TD
Passing Touchdowns: Scored 1.40 TD. Allowed 0.90 TD
Total 1st Downs: Picked up 21.80. Allowed 19.80
Total Turnovers: Committed 0.80. Committed by opponents 1.00
Total Penalties: Committed 3.90. Committed by opponents 5.60
Penalty Yards: Lost 36.80 Yds. Gained 44.50 Yds

Team News

Carolina Panthers Injuries

Type

Name

Info

Popo Aumavae

Achilles

Jonathon Brooks

Knee - ACL

Jalen Coker

Quadriceps

Ikem Ekwonu

Appendix

Damarri Mathis

Knee - ACL

LaBryan Ray

Ankle

Tershawn Wharton

Hamstring

Arizona Cardinals Injuries

Type

Name

Info

Joey Blount

Neck

Hayden Conner

Knee

Blake Gillikin

Back

Will Hernandez

Knee - ACL

Trishton Jackson

Thumb

Christian Jones

Knee

Justin Jones

Knee

Sean Murphy-Bunting

Knee

Bilal Nichols

Neck

Walter Nolen

Calf

BJ Ojulari

Knee - ACL

Tip Reiman

Foot

J.J. Russell

Concussion

Valentin Senn

Undisclosed

Cody Simon

Concussion

Starling Thomas

Knee - ACL

Previous Carolina Panthers Lineups

07 Sep NFL

Panthers 10-26 Jaguars

AFC East	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Bills	1	0	1.000	41	40	1	1-0-0	0-0-0	0-0-0	1-0-0	1-0-0	1W
Jets	0	1	0.000	32	34	-2	0-1-0	0-0-0	0-0-0	0-1-0	0-1-0	1L
Patriots	0	1	0.000	13	20	-7	0-1-0	0-0-0	0-0-0	0-1-0	0-1-0	1L
Dolphins	0	1	0.000	8	33	-25	0-0-0	0-1-0	0-0-0	0-1-0	0-1-0	1L

AFC North	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Bengals	1	0	1.000	17	16	1	0-0-0	1-0-0	1-0-0	1-0-0	1-0-0	1W
Steelers	1	0	1.000	34	32	2	0-0-0	1-0-0	0-0-0	1-0-0	1-0-0	1W
Ravens	0	1	0.000	40	41	-1	0-0-0	0-1-0	0-0-0	0-1-0	0-1-0	1L
Browns	0	1	0.000	16	17	-1	0-1-0	0-0-0	0-1-0	0-1-0	0-1-0	1L

AFC South	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Colts	1	0	1.000	33	8	25	1-0-0	0-0-0	0-0-0	1-0-0	1-0-0	1W
Jaguars	1	0	1.000	26	10	16	1-0-0	0-0-0	0-0-0	0-0-0	1-0-0	1W
Texans	0	1	0.000	9	14	-5	0-0-0	0-1-0	0-0-0	0-0-0	0-1-0	1L
Titans	0	1	0.000	12	20	-8	0-0-0	0-1-0	0-0-0	0-1-0	0-1-0	1L

AFC West	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Chargers	1	0	1.000	27	21	6	1-0-0	0-0-0	1-0-0	1-0-0	1-0-0	1W
Broncos	1	0	1.000	20	12	8	1-0-0	0-0-0	0-0-0	1-0-0	1-0-0	1W
Raiders	1	0	1.000	20	13	7	0-0-0	1-0-0	0-0-0	1-0-0	1-0-0	1W
Chiefs	0	1	0.000	21	27	-6	0-0-0	0-1-0	0-1-0	0-1-0	0-1-0	1L

NFC East	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Eagles	1	0	1.000	24	20	4	1-0-0	0-0-0	1-0-0	1-0-0	1-0-0	1W
Commanders	1	1	0.500	39	33	6	1-0-0	0-1-0	1-0-0	1-1-0	1-1-0	1L
Cowboys	0	1	0.000	20	24	-4	0-0-0	0-1-0	0-1-0	0-1-0	0-1-0	1L
Giants	0	1	0.000	6	21	-15	0-0-0	0-1-0	0-1-0	0-1-0	0-1-0	1L

NFC North	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Packers	2	0	1.000	54	31	23	2-0-0	0-0-0	1-0-0	2-0-0	2-0-0	2W
Vikings	1	0	1.000	27	24	3	0-0-0	1-0-0	1-0-0	1-0-0	1-0-0	1W
Bears	0	1	0.000	24	27	-3	0-1-0	0-0-0	0-1-0	0-1-0	0-1-0	1L
Lions	0	1	0.000	13	27	-14	0-0-0	0-1-0	0-1-0	0-1-0	0-1-0	1L

NFC South	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Buccaneers	1	0	1.000	23	20	3	0-0-0	1-0-0	1-0-0	1-0-0	1-0-0	1W
Falcons	0	1	0.000	20	23	-3	0-1-0	0-0-0	0-1-0	0-1-0	0-1-0	1L
Saints	0	1	0.000	13	20	-7	0-1-0	0-0-0	0-0-0	0-1-0	0-1-0	1L
Panthers	0	1	0.000	10	26	-16	0-0-0	0-1-0	0-0-0	0-0-0	0-1-0	1L

NFC West	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
49ers	1	0	1.000	17	13	4	0-0-0	1-0-0	1-0-0	1-0-0	1-0-0	1W
Cardinals	1	0	1.000	20	13	7	0-0-0	1-0-0	0-0-0	1-0-0	1-0-0	1W
Rams	1	0	1.000	14	9	5	1-0-0	0-0-0	0-0-0	0-0-0	1-0-0	1W
Seahawks	0	1	0.000	13	17	-4	0-1-0	0-0-0	0-1-0	0-1-0	0-1-0	1L

NFL Betting Preview: Panthers vs Cardinals

Head-to-Head Statistics

Panthers vs Cardinals Prediction & Picks

Game Prediction

Over 44.5 Probability

Best Bet

Player Prop Picks

Same Game Parlay Picks

Correct Score Prediction

Panthers vs Cardinals Odds

Last 5 & H2H

Team News

Carolina Panthers Injuries

Arizona Cardinals Injuries

Previous Carolina Panthers Lineups

Previous Arizona Cardinals Lineups

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