Panthers vs Jaguars Prediction, Picks & Odds | 07 Sep 2025

NFL Betting Preview: Panthers vs Jaguars

The Carolina Panthers go up against the Jacksonville Jaguars in this NFL Week 1 matchup at EverBank Stadium, with kickoff scheduled for 13:00 on Sunday, September 7. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

Our betting prediction is that the Jaguars are going to cover the -3.5 on the spread. You can get -115 that there’s a bigger margin of victory against the Panthers.

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Carolina Panthers won their previous game 44-38. This was a road victory at Mercedes-Benz Stadium against Atlanta Falcons. The Panthers moved the ball for 425 yards, made up of 270 through the air and 155 on the ground. The offense converted for 25 first downs and scored 6 TD's, including 3 passing scores and 3 rushing touchdowns.

Jacksonville Jaguars were beaten last game and this was on the road at Lucas Oil Stadium. Indianapolis Colts claimed a 26-23 win. The Jaguars recorded 319 total yards, made up of 206 through the air and 113 on the ground. The offense managed 19 first downs and scored 2 touchdowns, one on the ground and one through the air.

Head-to-Head Statistics

The last matchup between the Jaguars and the Panthers saw the former win. It was a 26-0 scoreline at EverBank Stadium.

Quarterbacks

Bryce Young

212.5 Passing Yards

Over -114

Under -114

Trevor Lawrence

240.5 Passing Yards

Over -114

Under -114

Panthers vs Jaguars Prediction & Picks

Our Panthers vs Jaguars tips include the main match prediction, a correct score forecast, bet builder advice and top player prop picks. Each section below offers expert insight into the key betting angles.

Game Prediction

There’s a generous line of -3.5 when it comes to the Jaguars for this NFL showdown. The -115 that they cover the spread has plenty of juice and our pick is that the favorites will make it happen.

The NFL handicappers at Sportsgambler.com start by analyzing recent form and staying on top of injury news before making any predictions. From there, we interpret the story the stats are telling to help shape our picks.

Key Panthers vs Jaguars stats:

• The +3.5 line hasn’t been covered by Panthers in 8 of their last 10 games on the road.
• The +3.5 line hasn’t been covered by Panthers in 4 of their last 5 games on the road.

Jags -3.5 Probability

According to the best NFL sportsbooks, our pick has a 53.5% chance of winning. Based on our cappers in-depth research, we calculate the actual probability to be closer to 60%. This is why we can recommend this bet.

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Our Game Prediction

Jaguars -3.5 @ -115 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (19:26, 05 September 2025). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Trevor Lawrence Over 239.5 Passing Yards -114

Trevor Lawrence (Jaguars) can be backed at -114 to accumulate over 239.5 passing yards. We believe it makes sense to stick with him on the Over and bettors can be confident in this QB Passing Yards pick.

Latest Trevor Lawrence Player Prop Odds

Touchdown

Anytime

+420

First

+2000

Passing Yards

Over 240.5

-114

Under 240.5

-114

Rushing Yards

Over 17.5

-114

Under 17.5

-114

---

Rico Dowdle Over 24.5 Rushing Yards -114

You can back Rico Dowdle (Panthers) at -114 to accumulate over 24.5 rushing yards. With confidence, we can back him to cover the generous Player Rushing Yards line, as all the signs point to him reaching the expected total.

Latest Rico Dowdle Player Prop Odds

Touchdown

Anytime

+380

First

+2200

Rushing Yards

Over 24.5

-114

Under 24.5

-114

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Panthers 21 - 28 Jaguars

For those looking to get more bang for their buck, consider a correct score bet on the Jaguars. Backing them to win 28-21 means you can land a potential monster return.

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Panthers vs Jaguars Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

The Jacksonville Jaguars odds have been priced up by the sportsbooks and they are -208 betting favorites to land victory in this game which means a 68% chance of winning. Carolina Panthers are regarded as a long shot to win and you can currently back them at +176.

The spread is calculated to be 4.5, while total points comes in at 46.5. There are many ways to bet on the NFL including the Totals. If you’re going for Under 46.5, this outcome can be backed at -115.

You can find a huge selection of game lines and team props for every National Football League showdown, with the top betting apps creating many different options. Check out the pre-game and in-game selections before placing your wagers.

Moneyline

Panthers

+176

Jaguars

-208

Point Spread

Panthers +4.5

-115

Jaguars -4.5

-105

Total Points

Under 46.5

-115

Over 46.5

-105

Favorite Chuba Hubbard is priced at +600 to be the first player to score a touchdown. There’s also the opportunity to back him to score a TD at anytime at odds of -100.

Touchdown

Chuba Hubbard (Panthers)

First TD

+600

Anytime TD

-100

Brian Thomas Jr (Jaguars)

First TD

+700

Anytime TD

+125

Tank Bigsby (Jaguars)

First TD

+700

Anytime TD

+130

Travis Etienne Jr. (Jaguars)

First TD

+750

Anytime TD

+145

Travis Hunter (Jaguars)

First TD

+1000

Anytime TD

+185

Tetairoa McMillan (Panthers)

First TD

+1100

Anytime TD

+180

Jalen Coker (Panthers)

First TD

+1700

Anytime TD

+300

Brenton Strange (Jaguars)

First TD

+1700

Anytime TD

+400

Xavier Legette (Panthers)

First TD

+1800

Anytime TD

+280

Trevor Lawrence (Jaguars)

First TD

+2000

Anytime TD

+420

Rico Dowdle (Panthers)

First TD

+2200

Anytime TD

+380

Ja'Tavion Sanders (Panthers)

First TD

+2200

Anytime TD

+390

Dyami Brown (Jaguars)

First TD

+2200

Anytime TD

+500

Jacksonville Jaguars Defense (Jaguars)

First TD

+3000

Anytime TD

+650

Bryce Young (Panthers)

First TD

+3000

Anytime TD

+600

Parker Washington (Jaguars)

First TD

+3000

Anytime TD

+600

Bhayshul Tuten (Jaguars)

First TD

+3300

Anytime TD

+700

Tim Patrick (Jaguars)

First TD

+3500

Anytime TD

+650

Hunter Renfrow (Panthers)

First TD

+3500

Anytime TD

+700

Carolina Panthers Defense (Panthers)

First TD

+4000

Anytime TD

+800

Tommy Tremble (Panthers)

First TD

+4000

Anytime TD

+950

David Moore (Panthers)

First TD

+6000

Anytime TD

+900

Johnny Mundt (Jaguars)

First TD

+7000

Anytime TD

+1400

Trevor Etienne (Panthers)

First TD

+8000

Anytime TD

+1100

Jimmy Horn Jr. (Panthers)

First TD

+8000

Anytime TD

+1700

Hunter Long (Jaguars)

First TD

+10000

Anytime TD

+2000

Mitchell Evans (Panthers)

First TD

+10000

Anytime TD

+2000

James Mitchell (Panthers)

First TD

+10000

Anytime TD

+2000

Brycen Tremayne (Panthers)

First TD

+10000

Anytime TD

+3300

Receiving Yards

Brian Thomas Jr (Jaguars)

Over 72.5

-114

Under 72.5

-114

Tetairoa McMillan (Panthers)

Over 62.5

-114

Under 62.5

-114

Travis Hunter (Jaguars)

Over 48.5

-114

Under 48.5

-114

Xavier Legette (Panthers)

Over 36.5

-114

Under 36.5

-114

Jalen Coker (Panthers)

Over 36.5

-114

Under 36.5

-114

Brenton Strange (Jaguars)

Over 30.5

-114

Under 30.5

-114

Dyami Brown (Jaguars)

Over 23.5

-114

Under 23.5

-114

Ja'Tavion Sanders (Panthers)

Over 23.5

-114

Under 23.5

-114

Hunter Renfrow (Panthers)

Over 18.5

-114

Under 18.5

-114

Travis Etienne Jr. (Jaguars)

Over 14.5

-114

Under 14.5

-114

Parker Washington (Jaguars)

Over 11.5

-114

Under 11.5

-114

Chuba Hubbard (Panthers)

Over 9.5

-114

Under 9.5

-114

Tommy Tremble (Panthers)

Over 9.5

-114

Under 9.5

-114

Rushing Yards

Chuba Hubbard (Panthers)

Over 59.5

-114

Under 59.5

-114

Tank Bigsby (Jaguars)

Over 43.5

-114

Under 43.5

-114

Travis Etienne Jr. (Jaguars)

Over 37.5

-114

Under 37.5

-114

Rico Dowdle (Panthers)

Over 24.5

-114

Under 24.5

-114

Trevor Lawrence (Jaguars)

Over 17.5

-114

Under 17.5

-114

Bryce Young (Panthers)

Over 16.5

-114

Under 16.5

-114

Passing Yards

Trevor Lawrence (Jaguars)

Over 240.5

-114

Under 240.5

-114

Bryce Young (Panthers)

Over 212.5

-114

Under 212.5

-114

For those looking to enjoy a thrilling in-game wager, then NFL micro betting could be up your street. You are now able to wager on what will happen on the next snap by staking your money on the Next Play Result.

Jaguars Have Seven Home Defeats in Previous Ten Matches

The Jaguars own a 3-7 mark in their past 10 home games, scoring 21.30 points per contest and conceding 21.90.

The Panthers own a 2-8 mark in their past 10 games away from home, putting up 15.70 points per contest and giving up 33.50.

The last EverBank Stadium meeting saw the Jaguars beat the Panthers 26-0.

Last 10 Games		W-L	P	PF	PA	O46.5	U46.5
Jaguars Home Stats		3-7	43.20	21.30	21.90	4	6
Panthers Away Stats		2-8	49.20	15.70	33.50	5	5

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O46.5 = Games Over 46.5 Points
• U46.5 = Games Under 46.5 Points

Latest regular season and playoff games stats.

Carolina Panthers Stats

Jacksonville Jaguars Stats

Moneyline

• 4 wins and 6 defeats in the last 10 games
• 2 wins and 8 defeats in the last 10 games on the road

Moneyline

• 2 wins and 8 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 home games

Point Spread

• +3.5 Betting Line: Have covered the spread in 6 of the last 10 games
• +3.5 Betting Line on the Road: Have covered the spread in 2 of the last 10 games on the road

Point Spread

• -3.5 Betting Line: Have covered the spread in 2 of the last 10 games
• -3.5 Betting Line at Home: Have covered the spread in 3 of the last 10 home games

Total Points

• Game Totals: An average of 52.20 pts in the previous 10 games
• Game Totals on the Road: An average of 49.20 pts in the previous 10 games on the road
• Over 46.5: Covered in 5 of the previous 10 games
• Over 46.5 on the Road: Covered in 5 of the previous 10 games on the road
• Team Totals: Have scored an average of 23.10 pts and allowed 29.10 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 15.70 pts and allowed 33.50 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 41.60 pts in the previous 10 games
• Game Totals at Home: An average of 41.50 pts in the previous 10 home games
• Over 46.5: Covered in 5 of the previous 10 games
• Over 46.5 at Home: Covered in 4 of the previous 10 home games
• Team Totals: Have scored an average of 17.50 pts and allowed 24.10 pts in the last 10 games
• Team Totals at Home: Have scored an average of 21.40 pts and allowed 20.10 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 304.30 Yds. Allowed 417.60 Yds
• Rushing Yards: Gained 105.90 Yds. Allowed 190.50 Yds
• Passing Yards: Gained 198.40 Yds. Allowed 227.10 Yds
• Total Touchdowns: Scored 2.80 TD. Allowed 3.40 TD
• Rushing Touchdowns: Scored 1.30 TD. Allowed 1.10 TD
• Passing Touchdowns: Scored 1.50 TD. Allowed 2.10 TD
• Total 1st Downs: Picked up 18.00. Allowed 25.50
• Total Turnovers: Committed 1.00. Committed by opponents 1.10
• Total Penalties: Committed 7.00. Committed by opponents 7.60
• Penalty Yards: Lost 53.80 Yds. Gained 61.90 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 292.40 Yds. Allowed 399.40 Yds
• Rushing Yards: Gained 85.80 Yds. Allowed 153.60 Yds
• Passing Yards: Gained 206.60 Yds. Allowed 245.80 Yds
• Total Touchdowns: Scored 1.80 TD. Allowed 2.50 TD
• Rushing Touchdowns: Scored 0.70 TD. Allowed 1.20 TD
• Passing Touchdowns: Scored 1.00 TD. Allowed 1.30 TD
• Total 1st Downs: Picked up 16.70. Allowed 23.60
• Total Turnovers: Committed 1.70. Committed by opponents 0.60
• Total Penalties: Committed 5.70. Committed by opponents 5.10
• Penalty Yards: Lost 48.30 Yds. Gained 38.60 Yds

Last 10 Games on the Road

• Total Yards: Gained 274.40 Yds. Allowed 386.10 Yds
• Rushing Yards: Gained 104.60 Yds. Allowed 156.90 Yds
• Passing Yards: Gained 169.80 Yds. Allowed 229.20 Yds
• Total Touchdowns: Scored 1.90 TD. Allowed 4.10 TD
• Rushing Touchdowns: Scored 0.80 TD. Allowed 1.50 TD
• Passing Touchdowns: Scored 1.10 TD. Allowed 2.30 TD
• Total 1st Downs: Picked up 15.60. Allowed 22.70
• Total Turnovers: Committed 1.40. Committed by opponents 0.60
• Total Penalties: Committed 5.10. Committed by opponents 5.60
• Penalty Yards: Lost 41.10 Yds. Gained 47.30 Yds

Last 10 Home Games

• Total Yards: Gained 345.60 Yds. Allowed 344.50 Yds
• Rushing Yards: Gained 115.60 Yds. Allowed 130.10 Yds
• Passing Yards: Gained 230.00 Yds. Allowed 214.40 Yds
• Total Touchdowns: Scored 2.20 TD. Allowed 1.90 TD
• Rushing Touchdowns: Scored 0.90 TD. Allowed 0.70 TD
• Passing Touchdowns: Scored 1.20 TD. Allowed 1.20 TD
• Total 1st Downs: Picked up 18.60. Allowed 20.60
• Total Turnovers: Committed 1.20. Committed by opponents 0.80
• Total Penalties: Committed 5.00. Committed by opponents 5.90
• Penalty Yards: Lost 43.30 Yds. Gained 41.80 Yds

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