Panthers vs Patriots Prediction, Picks & Odds | 28 Sep 2025

NFL Betting Preview: Panthers vs Patriots

The Carolina Panthers battle the New England Patriots in this NFL Week 4 matchup at Gillette Stadium, with kickoff scheduled for 13:00 on Sunday, September 28. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

There’s juice available when it comes to backing Over 43.5 points between the Patriots and the Panthers. Our prediction is priced up at -105 which looks worth taking.

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Carolina Panthers have experienced back-to-back road defeats. In their previous game, they beat Atlanta Falcons at home, winning 30-0 at Bank of America Stadium. The Panthers totaled 224 yards, split between 114 passing and 110 rushing yards. They generated 15 first downs to go with 3 trips to the end zone.

New England Patriots lost when they last took to the field. At Gillette Stadium, they were turned over 21-14 at home to Pittsburgh Steelers. The Patriots moved the ball for 369 yards, with 250 through the air and 119 on the ground. They produced 26 first downs and found the end zone on two occasions.

Head-to-Head Statistics

The Patriots triumphed 24-6 when they last played the Panthers. This head-to-head was played at Bank of America Stadium.

Quarterbacks

Bryce Young

202.5 Passing Yards

Over -112

Under -112

Drake Maye

212.5 Passing Yards

Over -112

Under -112

Panthers vs Patriots Prediction & Picks

Get fully prepped for Panthers vs Patriots with our betting guide, featuring our expert match pick, predicted scoreline, top player props and a value-focused bet builder.

Game Prediction

The two teams should be able to accumulate enough points for our pick to win. We’re predicting Over 43.5 and odds of -105 are available for this NFL battle.

Injuries can influence the outcome and our NFL handicappers factor that in alongside the latest form guide. We apply the same approach to the stats to build the clearest picture of how the game might unfold.

Key Panthers vs Patriots stats:

• The 43.5 line has been covered in 7 of the last 10 Panthers games.
• The 43.5 line has been covered in 14 of the last 20 Panthers games.
• The 43.5 line has been covered in 7 of the last 10 Patriots games.

Over 43.5 Probability

According to the best NFL betting sites, there’s a 51.3% likelihood of our pick delivering a return. However, our cappers think that the probability sits between 55-60% taking all factors into consideration. This bet can therefore be backed with confidence.

There are ways to get bigger odds by betting Over on the Totals. Bettors often look to move the line so they can land a more profitable return if the selection wins.

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Our Game Prediction

Over 43.5 Points @ -105 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (19:26, 26 September 2025). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Rico Dowdle Anytime TD +110

You can back Rico Dowdle (Panthers) at odds of +110 to score a TD. He looks like a value pick and we think that the odds offer plenty of appeal when it comes to wagering on Anytime Touchdown Scorer.

Latest Rico Dowdle Player Prop Odds

Touchdown

Anytime

+320

First

+1600

Rushing Yards

Over 22.5

-112

Under 22.5

-112

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Chuba Hubbard Over 52.5 Rushing Yards -114

The odds for Chuba Hubbard (Panthers) to accumulate over 52.5 rushing yards are -114. He looks capable of covering the line and that leads us to taking this Player Rushing Yards bet.

Latest Chuba Hubbard Player Prop Odds

Touchdown

Anytime

+135

First

+800

Receiving Yards

Over 16.5

-112

Under 16.5

-112

Rushing Yards

Over 49.5

-112

Under 49.5

-112

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Panthers 28 - 24 Patriots

Don’t pass up the opportunity to have a speculative wager on the Panthers to claim a 28-24 victory. We don’t think that there will be too much between the teams.

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Panthers vs Patriots Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

For this game, the sportsbooks’ Moneyline betting odds mean New England Patriots are -256 favorites to win and that means a 72% chance of landing a victory. Carolina Panthers are regarded as a long shot to win and you can currently back them at +210.

5.5 is where the spread lies, with total points being 43.5 right now. A Total wager relates to the number of points that will be scored overall. If you’re going for Over 43.5, then the odds are -105.

There are a wide range of game lines and team props when it comes to the National Football League and we recommend heading to the top betting apps to find the bet that matches your view on the matchup.

Moneyline

Panthers

+210

Patriots

-256

Point Spread

Panthers +5.5

-110

Patriots -5.5

-110

Total Points

Under 43.5

-115

Over 43.5

-105

TreVeyon Henderson is the market leader at +750 to be the First TD Scorer. Should you think he will score the final touchdown, then a similar price can be found.

Touchdown

TreVeyon Henderson (Patriots)

First TD

+750

Anytime TD

+150

Chuba Hubbard (Panthers)

First TD

+800

Anytime TD

+135

Rhamondre Stevenson (Patriots)

First TD

+800

Anytime TD

+160

Hunter Henry (Patriots)

First TD

+1000

Anytime TD

+200

Stefon Diggs (Patriots)

First TD

+1100

Anytime TD

+240

Tetairoa McMillan (Panthers)

First TD

+1200

Anytime TD

+185

Drake Maye (Patriots)

First TD

+1200

Anytime TD

+280

Kayshon Boutte (Patriots)

First TD

+1300

Anytime TD

+270

Hunter Renfrow (Panthers)

First TD

+1600

Anytime TD

+300

Xavier Legette (Panthers)

First TD

+1600

Anytime TD

+280

Rico Dowdle (Panthers)

First TD

+1600

Anytime TD

+320

Mack Hollins (Patriots)

First TD

+1900

Anytime TD

+480

Antonio Gibson (Patriots)

First TD

+2200

Anytime TD

+500

Tommy Tremble (Panthers)

First TD

+2500

Anytime TD

+500

DeMario Douglas (Patriots)

First TD

+2500

Anytime TD

+650

Austin Hooper (Patriots)

First TD

+2700

Anytime TD

+650

Bryce Young (Panthers)

First TD

+3000

Anytime TD

+700

David Moore (Panthers)

First TD

+3000

Anytime TD

+700

Brycen Tremayne (Panthers)

First TD

+4500

Anytime TD

+1000

Mitchell Evans (Panthers)

First TD

+6000

Anytime TD

+1100

Kyle Williams (Patriots)

First TD

+6000

Anytime TD

+1500

Trevor Etienne (Panthers)

First TD

+6000

Anytime TD

+1100

Efton Chism III (Patriots)

First TD

+6000

Anytime TD

+1500

Jack Westover (Patriots)

First TD

+8000

Anytime TD

+3000

Dalevon Campbell (Panthers)

First TD

+10000

Anytime TD

+2200

Jimmy Horn Jr. (Panthers)

First TD

+10000

Anytime TD

+2200

James Mitchell (Panthers)

First TD

+10000

Anytime TD

+2200

Receiving Yards

Tetairoa McMillan (Panthers)

Over 63.5

-112

Under 63.5

-112

Hunter Henry (Patriots)

Over 40.5

-112

Under 40.5

-112

Stefon Diggs (Patriots)

Over 35.5

-112

Under 35.5

-112

Hunter Renfrow (Panthers)

Over 33.5

-112

Under 33.5

-112

Kayshon Boutte (Patriots)

Over 29.5

-112

Under 29.5

-112

Tommy Tremble (Panthers)

Over 20.5

-112

Under 20.5

-112

David Moore (Panthers)

Over 18.5

-112

Under 18.5

-112

TreVeyon Henderson (Patriots)

Over 16.5

-112

Under 16.5

-112

Chuba Hubbard (Panthers)

Over 16.5

-112

Under 16.5

-112

DeMario Douglas (Patriots)

Over 15.5

-112

Under 15.5

-112

Rhamondre Stevenson (Patriots)

Over 11.5

-112

Under 11.5

-112

Rushing Yards

Chuba Hubbard (Panthers)

Over 49.5

-112

Under 49.5

-112

TreVeyon Henderson (Patriots)

Over 38.5

-112

Under 38.5

-112

Rhamondre Stevenson (Patriots)

Over 31.5

-112

Under 31.5

-112

Drake Maye (Patriots)

Over 27.5

-112

Under 27.5

-112

Rico Dowdle (Panthers)

Over 22.5

-112

Under 22.5

-112

Bryce Young (Panthers)

Over 13.5

-112

Under 13.5

-112

Passing Yards

Drake Maye (Patriots)

Over 212.5

-112

Under 212.5

-112

Bryce Young (Panthers)

Over 202.5

-112

Under 202.5

-112

You don’t have to wait for the final outcome when it comes to NFL micro betting. Instead, there’s the opportunity to wager on live lines which tend to be settled in a shorter space of time and the in-game odds are always changing.

Patriots Hold Advantage in Recent Head-to-Head Meetings at Gillette Stadium

The Patriots are 2-8 in their last 10 home games, posting 17.90 points per contest while yielding 25.10.

The Panthers are 2-8 in their last 10 games on the road, posting 18.30 points per contest while yielding 33.40.

The last time these teams met at Gillette Stadium, the Patriots came out on top 17-3 against the Panthers. From 3 head-to-head games at Gillette Stadium, the Patriots have been victorious in all.

Last 10 Games		W-L	P	PF	PA	O43.5	U43.5
Patriots Home Stats		2-8	43.00	17.90	25.10	5	5
Panthers Away Stats		2-8	51.70	18.30	33.40	7	3

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O43.5 = Games Over 43.5 Points
• U43.5 = Games Under 43.5 Points

Latest regular season and playoff games stats.

Carolina Panthers Stats

New England Patriots Stats

Moneyline

• 3 wins and 7 defeats in the last 10 games
• 2 wins and 8 defeats in the last 10 games on the road

Moneyline

• 2 wins and 8 defeats in the last 10 games
• 2 wins and 8 defeats in the last 10 home games

Point Spread

• +5.5 Betting Line: Have covered the spread in 6 of the last 10 games
• +5.5 Betting Line on the Road: Have covered the spread in 3 of the last 10 games on the road

Point Spread

• -5.5 Betting Line: Have covered the spread in 2 of the last 10 games
• -5.5 Betting Line at Home: Have covered the spread in 1 of the last 10 home games

Total Points

• Game Totals: An average of 51.30 pts in the previous 10 games
• Game Totals on the Road: An average of 51.70 pts in the previous 10 games on the road
• Over 43.5: Covered in 7 of the previous 10 games
• Over 43.5 on the Road: Covered in 7 of the previous 10 games on the road
• Team Totals: Have scored an average of 23.60 pts and allowed 27.70 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 18.30 pts and allowed 33.40 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 45.40 pts in the previous 10 games
• Game Totals at Home: An average of 43.00 pts in the previous 10 home games
• Over 43.5: Covered in 7 of the previous 10 games
• Over 43.5 at Home: Covered in 5 of the previous 10 home games
• Team Totals: Have scored an average of 18.90 pts and allowed 26.50 pts in the last 10 games
• Team Totals at Home: Have scored an average of 17.90 pts and allowed 25.10 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 303.80 Yds. Allowed 401.00 Yds
• Rushing Yards: Gained 99.40 Yds. Allowed 185.20 Yds
• Passing Yards: Gained 204.40 Yds. Allowed 215.80 Yds
• Total Touchdowns: Scored 2.80 TD. Allowed 3.00 TD
• Rushing Touchdowns: Scored 1.20 TD. Allowed 0.90 TD
• Passing Touchdowns: Scored 1.50 TD. Allowed 1.90 TD
• Total 1st Downs: Picked up 19.00. Allowed 23.40
• Total Turnovers: Committed 1.20. Committed by opponents 1.10
• Total Penalties: Committed 6.30. Committed by opponents 8.50
• Penalty Yards: Lost 52.00 Yds. Gained 66.40 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 329.10 Yds. Allowed 338.40 Yds
• Rushing Yards: Gained 112.70 Yds. Allowed 110.90 Yds
• Passing Yards: Gained 216.40 Yds. Allowed 227.50 Yds
• Total Touchdowns: Scored 2.10 TD. Allowed 3.10 TD
• Rushing Touchdowns: Scored 0.50 TD. Allowed 0.80 TD
• Passing Touchdowns: Scored 1.40 TD. Allowed 2.00 TD
• Total 1st Downs: Picked up 20.00. Allowed 20.10
• Total Turnovers: Committed 1.70. Committed by opponents 0.70
• Total Penalties: Committed 7.50. Committed by opponents 6.80
• Penalty Yards: Lost 60.50 Yds. Gained 50.50 Yds

Last 10 Games on the Road

• Total Yards: Gained 292.40 Yds. Allowed 400.80 Yds
• Rushing Yards: Gained 94.70 Yds. Allowed 159.90 Yds
• Passing Yards: Gained 197.70 Yds. Allowed 240.90 Yds
• Total Touchdowns: Scored 2.30 TD. Allowed 4.00 TD
• Rushing Touchdowns: Scored 0.80 TD. Allowed 1.40 TD
• Passing Touchdowns: Scored 1.50 TD. Allowed 2.30 TD
• Total 1st Downs: Picked up 17.40. Allowed 23.20
• Total Turnovers: Committed 1.60. Committed by opponents 0.70
• Total Penalties: Committed 5.50. Committed by opponents 7.50
• Penalty Yards: Lost 47.80 Yds. Gained 61.70 Yds

Last 10 Home Games

• Total Yards: Gained 314.60 Yds. Allowed 336.80 Yds
• Rushing Yards: Gained 120.60 Yds. Allowed 119.10 Yds
• Passing Yards: Gained 194.00 Yds. Allowed 217.70 Yds
• Total Touchdowns: Scored 1.90 TD. Allowed 2.90 TD
• Rushing Touchdowns: Scored 0.70 TD. Allowed 1.00 TD
• Passing Touchdowns: Scored 1.20 TD. Allowed 1.90 TD
• Total 1st Downs: Picked up 19.30. Allowed 20.60
• Total Turnovers: Committed 1.50. Committed by opponents 0.80
• Total Penalties: Committed 7.30. Committed by opponents 6.20
• Penalty Yards: Lost 62.30 Yds. Gained 50.70 Yds

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