NFL Betting Preview: Panthers vs Patriots

The Carolina Panthers battle the New England Patriots in this NFL Week 4 matchup at Gillette Stadium, with kickoff scheduled for 13:00 on Sunday 28 September. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

Points on the Menu

There’s juice available when it comes to backing Over 43.5 points between the Patriots and the Panthers. Our prediction is priced up at -105 which looks worth taking.

Think this one has the potential to go over? Get the latest BetMGM promo code and read our comprehensive site review before you make your selection.

Teams’ Previous H2H Saw 24-6 Patriots Victory

Carolina Panthers have experienced back-to-back road defeats. In their previous game, they beat Atlanta Falcons at home, winning 30-0 at Bank of America Stadium. The Panthers totaled 224 yards, split between 114 passing and 110 rushing yards. They generated 15 first downs to go with 3 trips to the end zone.

New England Patriots lost when they last took to the field. At Gillette Stadium, they were turned over 21-14 at home to Pittsburgh Steelers. The Patriots moved the ball for 369 yards, with 250 through the air and 119 on the ground. They produced 26 first downs and found the end zone on two occasions.

Head-to-Head Statistics

The Patriots triumphed 24-6 when they last played the Panthers. This head-to-head was played at Bank of America Stadium.

Quarterbacks

Bryce Young

Drake Maye

Panthers vs Patriots Prediction & Picks

Get fully prepped for Panthers vs Patriots with our betting guide, featuring our expert match pick, predicted scoreline, top player props and a value-focused bet builder.

Game Prediction

The two teams should be able to accumulate enough points for our pick to win. We’re predicting Over 43.5 and odds of -105 are available for this NFL battle.

Injuries can influence the outcome and our NFL handicappers factor that in alongside the latest form guide. We apply the same approach to the stats to build the clearest picture of how the game might unfold.

Key Panthers vs Patriots stats:

The 43.5 line has been covered in 7 of the last 10 Panthers games.
The 43.5 line has been covered in 14 of the last 20 Panthers games.
The 43.5 line has been covered in 7 of the last 10 Patriots games.

Over 43.5 Probability

According to the best NFL betting sites, there’s a 51.3% likelihood of our pick delivering a return. However, our cappers think that the probability sits between 55-60% taking all factors into consideration. This bet can therefore be backed with confidence.

Looking for Bigger Odds?

There are ways to get bigger odds by betting Over on the Totals. Bettors often look to move the line so they can land a more profitable return if the selection wins.

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Best Bet

Over 43.5 Points @ -105 Watch Live Bet Now

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Published 19:26, 26 September 2025

Player Prop Picks

Top Pick: Rico Dowdle Anytime TD +110

You can back Rico Dowdle (Panthers) at odds of +110 to score a TD. He looks like a value pick and we think that the odds offer plenty of appeal when it comes to wagering on Anytime Touchdown Scorer.

Latest Rico Dowdle Player Prop Odds

Touchdown

Chuba Hubbard Over 52.5 Rushing Yards -114

The odds for Chuba Hubbard (Panthers) to accumulate over 52.5 rushing yards are -114. He looks capable of covering the line and that leads us to taking this Player Rushing Yards bet.

Latest Chuba Hubbard Player Prop Odds

Touchdown

Receiving Yards

Rushing Yards

Same Game Parlay Picks

Totals Over 43.5

Spread Panthers +5.5

Anytime Touchdown Rico Dowdle

Get in the game with a same game parlay. Our picks are Over 43.5 on the total, Panthers to cover the +5.5 spread and Rico Dowdle (Panthers) among the touchdown scorers.

A same game parlay is a single event wager where you make predictions that are going to happen in a particular football game. Should a bettor get these selections correct, then they can achieve a good return from a small stake.

Bet Boosts

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Correct Score Prediction

Panthers

28 - 24 Patriots logo

Patriots

Don’t pass up the opportunity to have a speculative wager on the Panthers to claim a 28-24 victory. We don’t think that there will be too much between the teams.

Panthers vs Patriots Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Patriots Favorites to Win According to the Books

For this game, the sportsbooks’ Moneyline betting odds mean New England Patriots are -244 favorites to win and that means a 71% chance of landing a victory. Carolina Panthers are regarded as a long shot to win and you can currently back them at +198.

5.5 is where the spread lies, with total points being 43.5 right now. A Total wager relates to the number of points that will be scored overall. If you’re going for Over 43.5, then the odds are -105.

There are a wide range of game lines and team props when it comes to the National Football League and we recommend heading to the top betting apps to find the bet that matches your view on the matchup.

Moneyline

Point Spread

Total Points

Rico Dowdle Favorite to Be First TD Scorer

Rico Dowdle is the market leader at +650 to be the First TD Scorer. Should you think he will score the final touchdown, then a similar price can be found.

Touchdown

Rico Dowdle (Panthers)

Chuba Hubbard (Panthers)

TreVeyon Henderson (Patriots)

Rhamondre Stevenson (Patriots)

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Receiving Yards

Tetairoa McMillan (Panthers)

Hunter Henry (Patriots)

Stefon Diggs (Patriots)

Hunter Renfrow (Panthers)

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Rushing Yards

Chuba Hubbard (Panthers)

TreVeyon Henderson (Patriots)

Rhamondre Stevenson (Patriots)

Drake Maye (Patriots)

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Passing Yards

Drake Maye (Patriots)

Bryce Young (Panthers)

Best Betting Offers

Gillette Stadium

Patriots Hold Advantage in Recent Head-to-Head Meetings at Gillette Stadium

The Patriots are 2-8 in their last 10 home games, posting 17.90 points per contest while yielding 25.10.

The Panthers are 2-8 in their last 10 games on the road, posting 18.30 points per contest while yielding 33.40.

The last time these teams met at Gillette Stadium, the Patriots came out on top 17-3 against the Panthers. From 3 head-to-head games at Gillette Stadium, the Patriots have been victorious in all.

Last 10 Games		W-L	P	PF	PA	O43.5	U43.5
Patriots Home Stats		2-8	43.00	17.90	25.10	5	5
Panthers Away Stats		2-8	51.70	18.30	33.40	7	3

W-L = Wins-Losses
P = Avg. Points
PF = Avg. Points For
PA = Avg. Points Against
O43.5 = Games Over 43.5 Points
U43.5 = Games Under 43.5 Points

Last 5 & H2H

All
Home
Away

Last 5 Games

Panthers

NFL: 21/09 Falcons0 Panthers 30
NFL: 14/09 Panthers22 Cardinals 27
NFL: 07/09 Panthers10 Jaguars 26
NFL: 05/01 Panthers44 Falcons 38
NFL: 29/12 Panthers14 Buccaneers 48

Patriots

NFL: 21/09 Steelers21 Patriots 14
NFL: 14/09 Patriots33 Dolphins 27
NFL: 07/09 Raiders20 Patriots 13
NFL: 05/01 Bills16 Patriots 23
NFL: 28/12 Chargers40 Patriots 7

Head to Head

Panthers vs Patriots

NFL: 07/11 2021 Patriots 24 Panthers 6

Team Stats

Latest regular season and playoff games stats.

Carolina Panthers Stats

New England Patriots Stats

Moneyline

3 wins and 7 defeats in the last 10 games
2 wins and 8 defeats in the last 10 games on the road

Moneyline

2 wins and 8 defeats in the last 10 games
2 wins and 8 defeats in the last 10 home games

Point Spread

+5.5 Betting Line: Have covered the spread in 6 of the last 10 games
+5.5 Betting Line on the Road: Have covered the spread in 3 of the last 10 games on the road

Point Spread

-5.5 Betting Line: Have covered the spread in 2 of the last 10 games
-5.5 Betting Line at Home: Have covered the spread in 1 of the last 10 home games

Total Points

Game Totals: An average of 51.30 pts in the previous 10 games
Game Totals on the Road: An average of 51.70 pts in the previous 10 games on the road
Over 43.5: Covered in 7 of the previous 10 games
Over 43.5 on the Road: Covered in 7 of the previous 10 games on the road
Team Totals: Have scored an average of 23.60 pts and allowed 27.70 pts in the last 10 games
Team Totals on the Road: Have scored an average of 18.30 pts and allowed 33.40 pts in the last 10 games on the road

Total Points

Game Totals: An average of 45.40 pts in the previous 10 games
Game Totals at Home: An average of 43.00 pts in the previous 10 home games
Over 43.5: Covered in 7 of the previous 10 games
Over 43.5 at Home: Covered in 5 of the previous 10 home games
Team Totals: Have scored an average of 18.90 pts and allowed 26.50 pts in the last 10 games
Team Totals at Home: Have scored an average of 17.90 pts and allowed 25.10 pts in the last 10 home games

Game Stats

Last 10 Games

Total Yards: Gained 303.80 Yds. Allowed 401.00 Yds
Rushing Yards: Gained 99.40 Yds. Allowed 185.20 Yds
Passing Yards: Gained 204.40 Yds. Allowed 215.80 Yds
Total Touchdowns: Scored 2.80 TD. Allowed 3.00 TD
Rushing Touchdowns: Scored 1.20 TD. Allowed 0.90 TD
Passing Touchdowns: Scored 1.50 TD. Allowed 1.90 TD
Total 1st Downs: Picked up 19.00. Allowed 23.40
Total Turnovers: Committed 1.20. Committed by opponents 1.10
Total Penalties: Committed 6.30. Committed by opponents 8.50
Penalty Yards: Lost 52.00 Yds. Gained 66.40 Yds

Game Stats

Last 10 Games

Total Yards: Gained 329.10 Yds. Allowed 338.40 Yds
Rushing Yards: Gained 112.70 Yds. Allowed 110.90 Yds
Passing Yards: Gained 216.40 Yds. Allowed 227.50 Yds
Total Touchdowns: Scored 2.10 TD. Allowed 3.10 TD
Rushing Touchdowns: Scored 0.50 TD. Allowed 0.80 TD
Passing Touchdowns: Scored 1.40 TD. Allowed 2.00 TD
Total 1st Downs: Picked up 20.00. Allowed 20.10
Total Turnovers: Committed 1.70. Committed by opponents 0.70
Total Penalties: Committed 7.50. Committed by opponents 6.80
Penalty Yards: Lost 60.50 Yds. Gained 50.50 Yds

Last 10 Games on the Road

Total Yards: Gained 292.40 Yds. Allowed 400.80 Yds
Rushing Yards: Gained 94.70 Yds. Allowed 159.90 Yds
Passing Yards: Gained 197.70 Yds. Allowed 240.90 Yds
Total Touchdowns: Scored 2.30 TD. Allowed 4.00 TD
Rushing Touchdowns: Scored 0.80 TD. Allowed 1.40 TD
Passing Touchdowns: Scored 1.50 TD. Allowed 2.30 TD
Total 1st Downs: Picked up 17.40. Allowed 23.20
Total Turnovers: Committed 1.60. Committed by opponents 0.70
Total Penalties: Committed 5.50. Committed by opponents 7.50
Penalty Yards: Lost 47.80 Yds. Gained 61.70 Yds

Last 10 Home Games

Total Yards: Gained 314.60 Yds. Allowed 336.80 Yds
Rushing Yards: Gained 120.60 Yds. Allowed 119.10 Yds
Passing Yards: Gained 194.00 Yds. Allowed 217.70 Yds
Total Touchdowns: Scored 1.90 TD. Allowed 2.90 TD
Rushing Touchdowns: Scored 0.70 TD. Allowed 1.00 TD
Passing Touchdowns: Scored 1.20 TD. Allowed 1.90 TD
Total 1st Downs: Picked up 19.30. Allowed 20.60
Total Turnovers: Committed 1.50. Committed by opponents 0.80
Total Penalties: Committed 7.30. Committed by opponents 6.20
Penalty Yards: Lost 62.30 Yds. Gained 50.70 Yds

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Team News

Carolina Panthers Injuries

Type

Name

Info

Popo Aumavae

Achilles

Jonathon Brooks

Knee - ACL

Jalen Coker

Quadriceps

Austin Corbett

Knee - MCL

Chuba Hubbard

Calf

Robert Hunt

Biceps

Patrick Jones

Hamstring

Xavier Legette

Hamstring

Damarri Mathis

Knee - ACL

Tetairoa McMillan

Calf

LaBryan Ray

Ankle

Ja'Tavion Sanders

Ankle

Tershawn Wharton

Hamstring

D.J. Wonnum

Hip

New England Patriots Injuries

Type

Name

Info

K'Lavon Chaisson

Knee

Marcellas Dial

Knee - ACL

Yasir Durant

Undisclosed

Christian Gonzalez

Hamstring

Isaiah Iton

Hip

Brock Lampe

Undisclosed

Lan Larison

Foot

Mike Onwenu

Shoulder

Deneric Prince

Undisclosed

Layden Robinson

Undisclosed

Jaquelin Roy

Undisclosed

Wes Schweitzer

Undisclosed

Jahlani Tavai

Undisclosed

Jared Wilson

Ankle

Previous Carolina Panthers Lineups

21 Sep NFL

Falcons 0-30 Panthers

AFC East	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Bills	3	0	1.000	102	71	31	2-0-0	1-0-0	2-0-0	3-0-0	3-0-0	3W
Patriots	1	2	0.333	60	68	-8	0-2-0	1-0-0	1-0-0	1-2-0	1-2-0	1L
Jets	0	3	0.000	69	93	-24	0-2-0	0-1-0	0-1-0	0-2-0	0-3-0	3L
Dolphins	0	3	0.000	56	97	-41	0-1-0	0-2-0	0-2-0	0-3-0	0-3-0	3L

AFC North	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Bengals	2	1	0.667	58	91	-33	1-0-0	1-1-0	1-0-0	2-0-0	2-1-0	1L
Steelers	2	1	0.667	72	77	-5	0-1-0	2-0-0	0-0-0	2-0-0	2-1-0	1W
Ravens	1	2	0.333	111	96	15	1-1-0	0-1-0	1-0-0	1-1-0	1-2-0	1L
Browns	1	2	0.333	46	68	-22	1-1-0	0-1-0	0-2-0	0-2-0	1-2-0	1W

AFC South	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Colts	3	0	1.000	103	56	47	2-0-0	1-0-0	1-0-0	3-0-0	3-0-0	3W
Jaguars	2	1	0.667	70	51	19	2-0-0	0-1-0	1-0-0	1-1-0	2-1-0	1W
Texans	0	3	0.000	38	51	-13	0-1-0	0-2-0	0-1-0	0-1-0	0-3-0	3L
Titans	0	3	0.000	51	94	-43	0-2-0	0-1-0	0-1-0	0-2-0	0-3-0	3L

AFC West	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Chargers	3	0	1.000	70	50	20	2-0-0	1-0-0	3-0-0	3-0-0	3-0-0	3W
Raiders	1	2	0.333	53	74	-21	0-1-0	1-1-0	0-1-0	1-1-0	1-2-0	2L
Broncos	1	2	0.333	68	64	4	1-0-0	0-2-0	0-1-0	1-2-0	1-2-0	2L
Chiefs	1	2	0.333	60	56	4	0-1-0	1-1-0	0-1-0	0-1-0	1-2-0	1W

NFC East	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Eagles	3	0	1.000	77	63	14	2-0-0	1-0-0	1-0-0	2-0-0	3-0-0	3W
Commanders	2	1	0.667	80	57	23	2-0-0	0-1-0	1-0-0	1-1-0	2-1-0	1W
Cowboys	1	2	0.333	74	92	-18	1-0-0	0-2-0	1-1-0	1-2-0	1-2-0	1L
Giants	0	3	0.000	52	83	-31	0-1-0	0-2-0	0-2-0	0-2-0	0-3-0	3L

NFC North	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Packers	2	1	0.667	64	44	20	2-0-0	0-1-0	1-0-0	2-0-0	2-1-0	1L
Vikings	2	1	0.667	81	56	25	1-1-0	1-0-0	1-0-0	1-1-0	2-1-0	1W
Lions	2	1	0.667	103	78	25	1-0-0	1-1-0	1-1-0	1-1-0	2-1-0	2W
Bears	1	2	0.333	76	93	-17	1-1-0	0-1-0	0-2-0	1-2-0	1-2-0	1W

NFC South	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Buccaneers	3	0	1.000	72	66	6	1-0-0	2-0-0	1-0-0	1-0-0	3-0-0	3W
Panthers	1	2	0.333	62	53	9	1-0-0	0-2-0	1-0-0	1-1-0	1-2-0	1W
Falcons	1	2	0.333	42	59	-17	0-1-0	1-1-0	0-2-0	1-2-0	1-2-0	1L
Saints	0	3	0.000	47	90	-43	0-2-0	0-1-0	0-0-0	0-3-0	0-3-0	3L

NFC West	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
49ers	3	0	1.000	59	49	10	1-0-0	2-0-0	2-0-0	3-0-0	3-0-0	3W
Cardinals	2	2	0.500	82	74	8	1-1-0	1-1-0	0-2-0	2-2-0	2-2-0	2L
Seahawks	3	1	0.750	111	67	44	1-1-0	2-0-0	1-1-0	2-1-0	3-1-0	3W
Rams	2	1	0.667	73	61	12	1-0-0	1-1-0	0-0-0	0-1-0	2-1-0	1L

NFL Betting Preview: Panthers vs Patriots

Head-to-Head Statistics

Panthers vs Patriots Prediction & Picks

Game Prediction

Over 43.5 Probability

Best Bet

Player Prop Picks

Same Game Parlay Picks

Correct Score Prediction

Panthers vs Patriots Odds

Last 5 & H2H

Live Streaming

Team News

Carolina Panthers Injuries

New England Patriots Injuries

Previous Carolina Panthers Lineups

Previous New England Patriots Lineups

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