Panthers vs 49ers Prediction, Picks & Odds | 24 Nov 2025

NFL Betting Preview: Panthers vs Niners

The Carolina Panthers face the San Francisco 49ers in this Week 12 Monday Night Football matchup at Levi's Stadium, with kickoff scheduled for 20:15 on Monday, November 24.

Go for Under at -110. It might be defenses on top when the Niners clash with the Panthers, with the 49.5 points line looking on the high side when it comes to the totals.

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Carolina Panthers have triumphed in their previous three road games. The latest saw them beat Atlanta Falcons 30-27 (OT) at Mercedes-Benz Stadium. The Panthers recorded 486 yards, breaking down to 419 passing and 67 rushing yards. They picked up 22 first downs and managed 3 touchdowns, each one a passing score.

San Francisco 49ers got the win in their last game. A 41-22 triumph occurred on the road at State Farm Stadium when meeting Arizona Cardinals. The 49ers recorded 281 yards, with 186 through the air and 95 on the ground. The offense converted for 24 first downs and scored 5 TD's, including 3 passing scores and 2 rushing touchdowns.

Head-to-Head Statistics

The last matchup between the Niners and the Panthers saw the former win. It was a 37-15 scoreline at Bank of America Stadium.

Quarterbacks

Bryce Young

209.5 Passing Yards

Over -112

Under -112

Brock Purdy

256.5 Passing Yards

Over -112

Under -112

Panthers vs 49ers Prediction & Picks

Discover the top Panthers vs 49ers betting angles — from our trusted match prediction and likely score to the best prop plays and a customized bet builder.

Game Prediction

There’s every chance that the total won’t be as high as 49.5, so we’re prepared to take the -110 that the pair go under the line in this NFL matchup.

Our NFL predictions are built after tracking the latest team news and reviewing recent form. We also dive into up-to-date stats, which often serve as a solid barometer for how the action might unfold.

Key Panthers vs 49ers stats:

• The 49.5 line hasn’t been covered in 4 of the last 5 Panthers games.
• The 49.5 line hasn’t been covered in 4 of the last 6 Panthers games on the road this season.
• The 49.5 line hasn’t been covered in 3 of the last 4 49ers games at home this season.
• The 49.5 line hasn’t been covered in 8 of the last 11 49ers games this season.

Under 49.5 Probability

According to the top sportsbooks, there’s a 52.4% likelihood of our pick landing a return. Taking all factors into consideration, our analysts think there’s a stronger chance of success and have a probability interval between 55-60%. It’s why we think it’s worth placing this bet.

Bettors looking for more juice from their Unders wager can check out the Result & Total lines. Here you simply combine points with the franchise that will win.

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Our Game Prediction

Under 49.5 Points @ -110 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (02:25, 23 November 2025). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Tetairoa McMillan Anytime TD +145

The odds for Tetairoa McMillan (Panthers) to hit paydirt are +145. We think this is the pick of the player props, with generous odds available when it comes to backing him to score a touchdown at any time.

Latest Tetairoa McMillan Player Prop Odds

Touchdown

Anytime

+145

First

+950

Receiving Yards

Over 65.5

-112

Under 65.5

-112

---

Christian McCaffrey Under 71.5 Rushing Yards -114

You can back Christian McCaffrey (Panthers) at -114 to end with fewer than 71.5 rushing yards. The line looks too high and we’re confident he’ll fall short of the Player Rushing Yards total.

Latest Christian McCaffrey Player Prop Odds

Touchdown

Anytime

-345

First

+260

Receiving Yards

Over 47.5

-112

Under 47.5

-112

Rushing Yards

Over 68.5

-112

Under 68.5

-112

Correct Score Prediction

Panthers 21 - 24 49ers

We’ll throw a dart when it comes to the 49ers claiming a 24-21 victory. This correct score prediction is available at monster odds and could be an entertaining wager to place.

Panthers vs 49ers Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

The sportsbooks are taking no chances with their Moneyline odds of -294 about San Francisco 49ers which reflects they have a 75% chance of winning this game. Carolina Panthers are regarded as a long shot to win and you can currently back them at +240.

The spread is currently 7, with the total points line at 46.5. A Total bet is always available and can often provide value selections. If you fancy Under 46.5, then the odds are -110.

Consider every angle when placing your National Football League wagers. The top betting apps have a huge selection of game lines and team props and it’s all about finding a bet which matches your prediction of the game.

Moneyline

Panthers

+240

49ers

-294

Point Spread

Panthers +7

-115

49ers -7

-105

Total Points

Under 46.5

-110

Over 46.5

-110

There is -345 available that Christian McCaffrey scores a TD at any stage. He is available at +260 to record the first touchdown which makes him favorite.

Touchdown

Christian McCaffrey (49ers)

First TD

+260

Anytime TD

-345

Rico Dowdle (Panthers)

First TD

+550

Anytime TD

-141

George Kittle (49ers)

First TD

+700

Anytime TD

+125

Tetairoa McMillan (Panthers)

First TD

+950

Anytime TD

+145

Jauan Jennings (49ers)

First TD

+950

Anytime TD

+180

Ricky Pearsall (49ers)

First TD

+1000

Anytime TD

+200

Xavier Legette (Panthers)

First TD

+2200

Anytime TD

+390

Jalen Coker (Panthers)

First TD

+2200

Anytime TD

+400

Brian Robinson Jr. (49ers)

First TD

+2200

Anytime TD

+370

Ja'Tavion Sanders (Panthers)

First TD

+2700

Anytime TD

+480

Brock Purdy (49ers)

First TD

+2700

Anytime TD

+500

Demarcus Robinson (49ers)

First TD

+3000

Anytime TD

+650

Chuba Hubbard (Panthers)

First TD

+3000

Anytime TD

+550

Bryce Young (Panthers)

First TD

+4000

Anytime TD

+800

Tommy Tremble (Panthers)

First TD

+8000

Anytime TD

+750

Kyle Juszczyk (49ers)

First TD

+8000

Anytime TD

+700

Brycen Tremayne (Panthers)

First TD

+10000

Anytime TD

+1200

Jake Tonges (49ers)

First TD

+10000

Anytime TD

+1100

Kendrick Bourne (49ers)

First TD

+10000

Anytime TD

+1000

Skyy Moore (49ers)

First TD

+10000

Anytime TD

+1800

James Mitchell (Panthers)

First TD

+10000

Anytime TD

+1100

Mitchell Evans (Panthers)

First TD

+10000

Anytime TD

+1100

Luke Farrell (49ers)

First TD

+10000

Anytime TD

+1300

Hunter Renfrow (Panthers)

First TD

+10000

Anytime TD

+1700

Jimmy Horn Jr. (Panthers)

First TD

+10000

Anytime TD

+1700

Isaac Guerendo (49ers)

First TD

+10000

Anytime TD

+2200

Trevor Etienne (Panthers)

First TD

+10000

Anytime TD

+3000

Receiving Yards

Tetairoa McMillan (Panthers)

Over 65.5

-112

Under 65.5

-112

George Kittle (49ers)

Over 56.5

-112

Under 56.5

-112

Jauan Jennings (49ers)

Over 48.5

-112

Under 48.5

-112

Christian McCaffrey (49ers)

Over 47.5

-112

Under 47.5

-112

Ricky Pearsall (49ers)

Over 42.5

-112

Under 42.5

-112

Jalen Coker (Panthers)

Over 29.5

-112

Under 29.5

-112

Xavier Legette (Panthers)

Over 23.5

-112

Under 23.5

-112

Ja'Tavion Sanders (Panthers)

Over 17.5

-112

Under 17.5

-112

Rico Dowdle (Panthers)

Over 17.5

-112

Under 17.5

-112

Demarcus Robinson (49ers)

Over 11.5

-112

Under 11.5

-112

Rushing Yards

Rico Dowdle (Panthers)

Over 76.5

-112

Under 76.5

-112

Christian McCaffrey (49ers)

Over 68.5

-112

Under 68.5

-112

Brian Robinson Jr. (49ers)

Over 27.5

-112

Under 27.5

-112

Chuba Hubbard (Panthers)

Over 14.5

-112

Under 14.5

-112

Brock Purdy (49ers)

Over 9.5

-108

Under 9.5

-118

Bryce Young (Panthers)

Over 7.5

-112

Under 7.5

-112

Passing Yards

Brock Purdy (49ers)

Over 256.5

-112

Under 256.5

-112

Bryce Young (Panthers)

Over 209.5

-112

Under 209.5

-112

Instead of focusing on the overall outcome, some bettors prefer to look at the NFL micro betting lines. As the name suggests, it means placing short-term wagers and this might include the Next Play or Next Drive Result.

Niners Have Six Losses From Past Ten at Home

The Niners have a 4-6 record in their last 10 home games, scoring 22.60 points per contest and conceding 23.00.

The Panthers have posted three consecutive wins on the road. They own a 4-6 mark in their past 10 road games, posting 19.20 points per contest while yielding 27.70.

The Niners defeated the Panthers 51-13 the last time they played at Levi's Stadium.

Last 10 Games		W-L	P	PF	PA	O49.5	U49.5
49ers Home Stats		4-6	45.60	22.60	23.00	4	6
Panthers Away Stats		4-6	46.90	19.20	27.70	4	6

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O49.5 = Games Over 49.5 Points
• U49.5 = Games Under 49.5 Points

Latest regular season and playoff games stats.

Carolina Panthers Stats

San Francisco 49ers Stats

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 games on the road

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 home games

Point Spread

• +7.5 Betting Line: Have covered the spread in 7 of the last 10 games
• +7.5 Betting Line on the Road: Have covered the spread in 6 of the last 10 games on the road

Point Spread

• -7.5 Betting Line: Have covered the spread in 3 of the last 10 games
• -7.5 Betting Line at Home: Have covered the spread in 2 of the last 10 home games

Total Points

• Game Totals: An average of 42.00 pts in the previous 10 games
• Game Totals on the Road: An average of 46.90 pts in the previous 10 games on the road
• Over 49.5: Covered in 4 of the previous 10 games
• Over 49.5 on the Road: Covered in 4 of the previous 10 games on the road
• Team Totals: Have scored an average of 19.70 pts and allowed 22.30 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 19.20 pts and allowed 27.70 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 48.30 pts in the previous 10 games
• Game Totals at Home: An average of 45.60 pts in the previous 10 home games
• Over 49.5: Covered in 3 of the previous 10 games
• Over 49.5 at Home: Covered in 4 of the previous 10 home games
• Team Totals: Have scored an average of 24.40 pts and allowed 23.90 pts in the last 10 games
• Team Totals at Home: Have scored an average of 22.60 pts and allowed 23.00 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 320.20 Yds. Allowed 320.70 Yds
• Rushing Yards: Gained 128.50 Yds. Allowed 104.40 Yds
• Passing Yards: Gained 191.70 Yds. Allowed 216.30 Yds
• Total Touchdowns: Scored 2.20 TD. Allowed 2.50 TD
• Rushing Touchdowns: Scored 0.60 TD. Allowed 1.20 TD
• Passing Touchdowns: Scored 1.40 TD. Allowed 1.10 TD
• Total 1st Downs: Picked up 20.50. Allowed 17.40
• Total Turnovers: Committed 1.20. Committed by opponents 1.00
• Total Penalties: Committed 5.60. Committed by opponents 6.80
• Penalty Yards: Lost 42.80 Yds. Gained 50.60 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 345.90 Yds. Allowed 364.60 Yds
• Rushing Yards: Gained 92.40 Yds. Allowed 105.90 Yds
• Passing Yards: Gained 253.50 Yds. Allowed 258.70 Yds
• Total Touchdowns: Scored 2.60 TD. Allowed 2.90 TD
• Rushing Touchdowns: Scored 0.80 TD. Allowed 0.70 TD
• Passing Touchdowns: Scored 1.80 TD. Allowed 2.10 TD
• Total 1st Downs: Picked up 21.60. Allowed 21.70
• Total Turnovers: Committed 1.30. Committed by opponents 0.80
• Total Penalties: Committed 5.30. Committed by opponents 7.10
• Penalty Yards: Lost 42.10 Yds. Gained 48.30 Yds

Last 10 Games on the Road

• Total Yards: Gained 320.10 Yds. Allowed 369.70 Yds
• Rushing Yards: Gained 102.70 Yds. Allowed 143.60 Yds
• Passing Yards: Gained 217.40 Yds. Allowed 226.10 Yds
• Total Touchdowns: Scored 2.40 TD. Allowed 3.30 TD
• Rushing Touchdowns: Scored 0.60 TD. Allowed 1.40 TD
• Passing Touchdowns: Scored 1.80 TD. Allowed 1.60 TD
• Total 1st Downs: Picked up 19.40. Allowed 21.10
• Total Turnovers: Committed 0.90. Committed by opponents 1.00
• Total Penalties: Committed 5.60. Committed by opponents 7.10
• Penalty Yards: Lost 43.20 Yds. Gained 53.30 Yds

Last 10 Home Games

• Total Yards: Gained 363.50 Yds. Allowed 309.10 Yds
• Rushing Yards: Gained 112.80 Yds. Allowed 114.10 Yds
• Passing Yards: Gained 250.70 Yds. Allowed 195.00 Yds
• Total Touchdowns: Scored 2.60 TD. Allowed 2.70 TD
• Rushing Touchdowns: Scored 1.30 TD. Allowed 1.20 TD
• Passing Touchdowns: Scored 1.30 TD. Allowed 1.40 TD
• Total 1st Downs: Picked up 20.90. Allowed 19.40
• Total Turnovers: Committed 1.70. Committed by opponents 0.70
• Total Penalties: Committed 5.90. Committed by opponents 5.00
• Penalty Yards: Lost 44.60 Yds. Gained 38.80 Yds

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