Browns vs Lions Prediction, Picks & Odds | 28 Sep 2025

NFL Betting Preview: Browns vs Lions

The Cleveland Browns face off against the Detroit Lions in this NFL Week 4 matchup at Ford Field, with kickoff scheduled for 13:00 on Sunday, September 28. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

Over 44.5 points are expected to be scored when the Lions and the Browns meet, with this prediction available at -110 and this looks like a value wager.

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Cleveland Browns won their previous game, beating Green Bay Packers at home. It was a 13-10 win at Huntington Bank Field. The Browns put up 221 yards, split between 125 passing and 96 rushing yards. The offense moved the chains 15 times and scored one rushing TD.

Detroit Lions have triumphed in back-to-back games. The latest of these was on the road where Baltimore Ravens were beaten 38-30 at M&T Bank Stadium. The Lions recorded 426 yards, with 202 through the air and 224 on the ground. They picked up 24 first downs to go with 5 trips to the end zone.

Head-to-Head Statistics

The Browns triumphed 13-10 when they last played the Lions. This head-to-head was played at Huntington Bank Field.

Quarterbacks

Joe Flacco

223.5 Passing Yards

Over -112

Under -112

Jared Goff

227.5 Passing Yards

Over -112

Under -112

Browns vs Lions Prediction & Picks

Take on Browns vs Lions with our in-depth betting analysis, featuring an expert match prediction, scoreline advice, key player props and a value-driven bet builder.

Game Prediction

We’re heading to the totals after finding that the line is set at a generous 44.5 points. Expect this number to be surpassed at -110 for this NFL battle.

To deliver the best possible NFL predictions, we start by locking in the team news and taking time to review the latest form. There’s also no shortage of data to crunch from the most up-to-date stats available.

Key Browns vs Lions stats:

• The 44.5 line has been covered in 12 of the last 20 Browns games on the road.
• The 44.5 line has been covered in 3 of the last 5 Browns games on the road.
• The 44.5 line has been covered in the last 2 Browns games on the road.
• The 44.5 line has been covered in 4 of the last 5 Lions games at home.
• The 44.5 line has been covered in 15 of the last 20 Lions games at home.
• The 44.5 line has been covered in the last 2 Lions games.

Over 44.5 Probability

The best betting apps are estimating that there is a 52.4% likelihood of this pick winning. However, our research has found that the actual probability is closer to 60%. This is why we regard this as a value bet.

There are ways to get bigger odds by betting Over on the Totals. Bettors often look to move the line so they can land a more profitable return if the selection wins.

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Our Game Prediction

Over 44.5 Points @ -110 Bet Now

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Player Prop Picks

Top Pick: Amon-Ra St. Brown Anytime TD -100

The odds for Amon-Ra St. Brown (Lions) to record a TD are -100. There are appealing odds on offer for this Anytime Touchdown Scorer pick, and we believe it's an attractive wager for him to punch it in.

Latest Amon-Ra St. Brown Player Prop Odds

Touchdown

Anytime

-100

First

+550

Receiving Yards

Over 67.5

-112

Under 67.5

-112

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David Njoku Over 39.5 Receiving Yards -114

The odds for David Njoku (Browns) to go accumulate over 39.5 receiving yards stand at -114. We can place a Player Receiving Yards bet with confidence, as we expect him to cover the line.

Latest David Njoku Player Prop Odds

Touchdown

Anytime

+330

First

+2000

Receiving Yards

Over 38.5

-112

Under 38.5

-112

Correct Score Prediction

Browns 17 - 34 Lions

Let’s roll the dice and try the Lions to enjoy a 34-17 winning scoreline here. There are massive odds for this potential outcome and it’s a fun type of wager to enjoy.

Browns vs Lions Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

According to the Moneyline betting odds, Detroit Lions are red-hot -588 favorites with the sportsbooks and that means a 85% chance of winning this game. Cleveland Browns are the underdogs at +430 and they’re regarded as least likely to win.

The spread currently stands at 9.5 and the total points line is 44.5. NFL fans regularly enjoy the opportunity to bet on the Totals. If you’re going for Over 44.5, then the odds are -110.

There’s a wide variety of game lines and team props available and we recommend checking out the best NFL betting sites to find the markets that align with your take on the matchup.

Moneyline

Browns

+430

Lions

-588

Point Spread

Browns +9.5

-102

Lions -9.5

-120

Total Points

Under 44.5

-110

Over 44.5

-110

Jahmyr Gibbs is the market leader to be First TD Scorer at +340. Alternatively, there’s the chance to back him to register a touchdown at any stage at -189.

Touchdown

Jahmyr Gibbs (Lions)

First TD

+340

Anytime TD

-189

David Montgomery (Lions)

First TD

+550

Anytime TD

-110

Amon-Ra St. Brown (Lions)

First TD

+550

Anytime TD

-100

Quinshon Judkins (Browns)

First TD

+850

Anytime TD

+155

Sam LaPorta (Lions)

First TD

+1000

Anytime TD

+210

Jameson Williams (Lions)

First TD

+1100

Anytime TD

+220

Jerry Jeudy (Browns)

First TD

+1600

Anytime TD

+260

Cedric Tillman (Browns)

First TD

+1900

Anytime TD

+310

David Njoku (Browns)

First TD

+2000

Anytime TD

+330

Harold Fannin Jr. (Browns)

First TD

+2200

Anytime TD

+400

Isaac TeSlaa (Lions)

First TD

+3000

Anytime TD

+750

Jerome Ford (Browns)

First TD

+3500

Anytime TD

+650

Kalif Raymond (Lions)

First TD

+5000

Anytime TD

+850

Isaiah Bond (Browns)

First TD

+5000

Anytime TD

+750

Dylan Sampson (Browns)

First TD

+5000

Anytime TD

+800

Brock Wright (Lions)

First TD

+6000

Anytime TD

+1100

Jared Goff (Lions)

First TD

+7500

Anytime TD

+1700

Jamari Thrash (Browns)

First TD

+10000

Anytime TD

+1400

Craig Reynolds (Lions)

First TD

+10000

Anytime TD

+2500

Dominic Lovett (Lions)

First TD

+10000

Anytime TD

+3000

Joe Flacco (Browns)

First TD

+10000

Anytime TD

+3000

DeAndre Carter (Browns)

First TD

+10000

Anytime TD

+4000

Blake Whiteheart (Browns)

First TD

+10000

Anytime TD

+3500

Jacob Saylors (Lions)

First TD

+10000

Anytime TD

+2200

Ross Dwelley (Lions)

First TD

+10000

Anytime TD

+3000

Receiving Yards

Amon-Ra St. Brown (Lions)

Over 67.5

-112

Under 67.5

-112

Jerry Jeudy (Browns)

Over 49.5

-112

Under 49.5

-112

Jameson Williams (Lions)

Over 43.5

-112

Under 43.5

-112

David Njoku (Browns)

Over 38.5

-112

Under 38.5

-112

Sam LaPorta (Lions)

Over 38.5

-112

Under 38.5

-112

Cedric Tillman (Browns)

Over 35.5

-112

Under 35.5

-112

Harold Fannin Jr. (Browns)

Over 31.5

-112

Under 31.5

-112

Jahmyr Gibbs (Lions)

Over 26.5

-112

Under 26.5

-112

Jerome Ford (Browns)

Over 11.5

-112

Under 11.5

-112

Quinshon Judkins (Browns)

Over 10.5

-108

Under 10.5

-118

David Montgomery (Lions)

Over 9.5

-112

Under 9.5

-112

Isaac TeSlaa (Lions)

Over 9.5

-112

Under 9.5

-112

Rushing Yards

Jahmyr Gibbs (Lions)

Over 63.5

-112

Under 63.5

-112

Quinshon Judkins (Browns)

Over 58.5

-112

Under 58.5

-112

David Montgomery (Lions)

Over 45.5

-112

Under 45.5

-112

Passing Yards

Jared Goff (Lions)

Over 227.5

-112

Under 227.5

-112

Joe Flacco (Browns)

Over 223.5

-112

Under 223.5

-112

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Lions Have Picked Up Seven Wins in Past Ten at Home

The Lions have seven wins and three losses in the last 10 home games, averaging 37.50 points on offense and surrendering 24.30 on defense.

The Browns have dropped nine road games in a row. They have one win and nine losses in the last 10 games on the road, posting 15.60 points per contest while yielding 29.00.

Last 10 Games		W-L	P	PF	PA	O44.5	U44.5
Lions Home Stats		7-3	61.80	37.50	24.30	7	3
Browns Away Stats		1-9	44.60	15.60	29.00	5	5

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O44.5 = Games Over 44.5 Points
• U44.5 = Games Under 44.5 Points

Latest regular season and playoff games stats.

Cleveland Browns Stats

Detroit Lions Stats

Moneyline

• 2 wins and 8 defeats in the last 10 games
• 1 win and 9 defeats in the last 10 games on the road

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 7 wins and 3 defeats in the last 10 home games

Point Spread

• +9.5 Betting Line: Have covered the spread in 4 of the last 10 games
• +9.5 Betting Line on the Road: Have covered the spread in 4 of the last 10 games on the road

Point Spread

• -9.5 Betting Line: Have covered the spread in 3 of the last 10 games
• -9.5 Betting Line at Home: Have covered the spread in 5 of the last 10 home games

Total Points

• Game Totals: An average of 39.70 pts in the previous 10 games
• Game Totals on the Road: An average of 44.60 pts in the previous 10 games on the road
• Over 44.5: Covered in 3 of the previous 10 games
• Over 44.5 on the Road: Covered in 5 of the previous 10 games on the road
• Team Totals: Have scored an average of 14.20 pts and allowed 25.50 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 15.60 pts and allowed 29.00 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 62.00 pts in the previous 10 games
• Game Totals at Home: An average of 61.80 pts in the previous 10 home games
• Over 44.5: Covered in 7 of the previous 10 games
• Over 44.5 at Home: Covered in 7 of the previous 10 home games
• Team Totals: Have scored an average of 33.80 pts and allowed 28.20 pts in the last 10 games
• Team Totals at Home: Have scored an average of 37.50 pts and allowed 24.30 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 307.10 Yds. Allowed 300.20 Yds
• Rushing Yards: Gained 98.30 Yds. Allowed 106.00 Yds
• Passing Yards: Gained 208.80 Yds. Allowed 194.20 Yds
• Total Touchdowns: Scored 1.70 TD. Allowed 3.10 TD
• Rushing Touchdowns: Scored 0.70 TD. Allowed 0.90 TD
• Passing Touchdowns: Scored 1.00 TD. Allowed 1.80 TD
• Total 1st Downs: Picked up 18.40. Allowed 16.70
• Total Turnovers: Committed 2.70. Committed by opponents 0.60
• Total Penalties: Committed 6.60. Committed by opponents 7.30
• Penalty Yards: Lost 55.00 Yds. Gained 53.50 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 432.90 Yds. Allowed 368.10 Yds
• Rushing Yards: Gained 147.70 Yds. Allowed 110.70 Yds
• Passing Yards: Gained 285.20 Yds. Allowed 257.40 Yds
• Total Touchdowns: Scored 4.20 TD. Allowed 3.60 TD
• Rushing Touchdowns: Scored 1.70 TD. Allowed 1.50 TD
• Passing Touchdowns: Scored 2.50 TD. Allowed 2.00 TD
• Total 1st Downs: Picked up 25.10. Allowed 20.50
• Total Turnovers: Committed 1.10. Committed by opponents 0.80
• Total Penalties: Committed 6.20. Committed by opponents 6.10
• Penalty Yards: Lost 50.30 Yds. Gained 44.10 Yds

Last 10 Games on the Road

• Total Yards: Gained 311.40 Yds. Allowed 354.20 Yds
• Rushing Yards: Gained 98.70 Yds. Allowed 143.10 Yds
• Passing Yards: Gained 212.70 Yds. Allowed 211.10 Yds
• Total Touchdowns: Scored 1.70 TD. Allowed 3.50 TD
• Rushing Touchdowns: Scored 0.20 TD. Allowed 1.40 TD
• Passing Touchdowns: Scored 1.30 TD. Allowed 1.70 TD
• Total 1st Downs: Picked up 17.70. Allowed 18.10
• Total Turnovers: Committed 1.50. Committed by opponents 0.90
• Total Penalties: Committed 6.50. Committed by opponents 5.80
• Penalty Yards: Lost 48.90 Yds. Gained 47.70 Yds

Last 10 Home Games

• Total Yards: Gained 446.50 Yds. Allowed 355.80 Yds
• Rushing Yards: Gained 152.40 Yds. Allowed 121.20 Yds
• Passing Yards: Gained 294.10 Yds. Allowed 234.60 Yds
• Total Touchdowns: Scored 4.80 TD. Allowed 3.00 TD
• Rushing Touchdowns: Scored 1.90 TD. Allowed 1.60 TD
• Passing Touchdowns: Scored 2.80 TD. Allowed 1.30 TD
• Total 1st Downs: Picked up 26.30. Allowed 20.70
• Total Turnovers: Committed 1.20. Committed by opponents 1.10
• Total Penalties: Committed 5.70. Committed by opponents 6.60
• Penalty Yards: Lost 53.00 Yds. Gained 49.60 Yds

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