Cowboys vs Panthers Prediction, Picks & Odds | 12 Oct 2025

NFL Betting Preview: Cowboys vs Panthers

The Dallas Cowboys go up against the Carolina Panthers in this NFL Week 6 matchup at Bank of America Stadium, with kickoff scheduled for 13:00 on Sunday, October 12. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

We’re confident that the Panthers can either win or suffer a narrow defeat. That makes the home team at +3 the best play when they battle with the Cowboys and odds of -105 are available.

Trusting our spread call? Learn more about BetMGM in our expert review, then unlock the best promo code before you make your move.

Dallas Cowboys triumphed in their previous game. It was on the road where New York Jets were beaten 37-22 at MetLife Stadium. The Cowboys recorded 416 yards, split between 236 passing and 180 rushing yards. The offense picked up 22 first downs and scored 5 touchdowns, with 4 through the air and one on the ground.

Carolina Panthers have enjoyed back-to-back home wins at Bank of America Stadium. Last time out, Miami Dolphins were beaten 27-24. The Panthers finished with 418 yards, including 179 passing and 239 rushing yards. They produced 26 first downs along with 3 touchdowns.

Head-to-Head Statistics

The last head-to-head saw the Cowboys claim a 30-14 win over the Panthers at Bank of America Stadium. It’s been a succession of Cowboys wins in the past 3 H2H meetings.

Quarterbacks

Dak Prescott

242.5 Passing Yards

Over -112

Under -112

Bryce Young

206.5 Passing Yards

Over -112

Under -112

Cowboys vs Panthers Prediction & Picks

From our main match prediction to correct score advice, must-watch player props and a custom bet builder — this Cowboys vs Panthers betting preview covers it all.

Game Prediction

We wouldn’t be surprised to see the Panthers win this NFL matchup. In terms of landing extra value, it makes sense to take +3 when it comes to the spread at -105.

The NFL handicappers at Sportsgambler.com stay on top of injuries and team form that could impact the outcome. We also leave no stone unturned when analyzing the latest stats to support every prediction.

Key Cowboys vs Panthers stats:

• The +3 line has been covered by Panthers in 4 of their last 5 games at home.
• The +3 line has been covered by Panthers in 7 of their last 10 games at home.
• The +3 line has been covered by Panthers in 3 consecutive games at home.
• The -3 line hasn’t been covered by Cowboys in 7 of their last 10 games.
• The -3 line hasn’t been covered by Cowboys in 2 of their last 3 games on the road this season.

Panthers +3 Probability

The top NFL sportsbooks make it a 51.3% chance that our pick is settled as a winner. After careful examination, our experts have this probability somewhere between 55-60%. This is why we can recommend this bet.

If you want an alternative to backing the Panthers against the spread, then the Winning Margin lines could be up your street. Choose from a wide range of options.

Make smarter bets by exploring our bonus guide full of updated betting offers, free bets, and exciting new promotions.

Our Game Prediction

Panthers +3 @ -105 Bet Now

BetMGM Promo Up To $1500 in Bonus Bets Get Bonus T&C apply. Gamble responsibly 18+

Gamble responsibly 18+. All odds are correct at time of publishing and are subject to change. To use the Bookmaker Live Streaming services you will need to be logged in and have a funded account or to have placed a bet in the last 24 hours. Geo-restrictions apply.

Player Prop Picks

Top Pick: Rico Dowdle Anytime TD -120

The odds for Rico Dowdle (Panthers) to record a TD are -120. He looks like an attractive wager to take it to the house and we recommend backing this Anytime Touchdown Scorer selection.

Latest Rico Dowdle Player Prop Odds

Touchdown

Anytime

-130

First

+500

Receiving Yards

Over 17.5

-112

Under 17.5

-112

Rushing Yards

Over 72.5

-112

Under 72.5

-112

---

Dak Prescott Over 247.5 Passing Yards -114

Dak Prescott (Cowboys) is available at -114 to rack up over 247.5 passing yards. We feel confident that he’ll cover the QB Passing Yards line, which looks generous.

Latest Dak Prescott Player Prop Odds

Touchdown

Anytime

+650

First

+3000

Passing Yards

Over 242.5

-112

Under 242.5

-112

Rushing Yards

Over 6.5

-112

Under 6.5

-112

Correct Score Prediction

Cowboys 28 - 30 Panthers

For a fun wager, consider backing the Panthers to claim a 30-28 victory. Although it’s a speculative bet, we are expecting things to be close between the two teams.

Cowboys vs Panthers Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

The sportsbooks have Dallas Cowboys at -122 when it comes to the Moneyline betting, implying the market leaders are 55% likely to win this game according to the latest odds. If you’re looking for an alternative angle, Carolina Panthers are trading at +102.

1.5 is the spread and 46.5 is the total points line. There are many ways to bet on the NFL including the Totals. If you’re going for Under 46.5, this outcome can be backed at -110.

There are hundreds of team props and game lines when it comes to wagering on the National Football League and we recommend visiting the best sportsbooks to find the bet that matches your view on the game.

Moneyline

Cowboys

-122

Panthers

+102

Point Spread

Cowboys -1.5

-108

Panthers +1.5

-112

Total Points

Under 46.5

-110

Over 46.5

-110

There’s the chance to back Javonte Williams at +430 to be the First Touchdown Scorer. He’s the favorite and available at similar odds to record the last TD instead.

Touchdown

Javonte Williams (Cowboys)

First TD

+430

Anytime TD

-164

Rico Dowdle (Panthers)

First TD

+500

Anytime TD

-130

CeeDee Lamb (Cowboys)

First TD

+700

Anytime TD

+115

George Pickens (Cowboys)

First TD

+750

Anytime TD

+120

Tetairoa McMillan (Panthers)

First TD

+900

Anytime TD

+150

Jake Ferguson (Cowboys)

First TD

+950

Anytime TD

+160

Xavier Legette (Panthers)

First TD

+1600

Anytime TD

+270

Ryan Flournoy (Cowboys)

First TD

+1700

Anytime TD

+320

Tommy Tremble (Panthers)

First TD

+1800

Anytime TD

+340

Jalen Tolbert (Cowboys)

First TD

+1900

Anytime TD

+370

Ja'Tavion Sanders (Panthers)

First TD

+2000

Anytime TD

+300

Jalen Coker (Panthers)

First TD

+2000

Anytime TD

+350

Jaydon Blue (Cowboys)

First TD

+2200

Anytime TD

+380

Hunter Renfrow (Panthers)

First TD

+2200

Anytime TD

+410

Miles Sanders (Cowboys)

First TD

+2500

Anytime TD

+360

Bryce Young (Panthers)

First TD

+2500

Anytime TD

+500

Dak Prescott (Cowboys)

First TD

+3000

Anytime TD

+650

Jimmy Horn Jr. (Panthers)

First TD

+3000

Anytime TD

+460

Trevor Etienne (Panthers)

First TD

+3300

Anytime TD

+650

Brycen Tremayne (Panthers)

First TD

+4500

Anytime TD

+800

Mitchell Evans (Panthers)

First TD

+5000

Anytime TD

+900

Luke Schoonmaker (Cowboys)

First TD

+7500

Anytime TD

+950

Hunter Luepke (Cowboys)

First TD

+10000

Anytime TD

+2000

Jalen Moreno-Cropper (Cowboys)

First TD

+10000

Anytime TD

+2200

Jalen Brooks (Cowboys)

First TD

+10000

Anytime TD

+2000

Brevyn Spann-Ford (Cowboys)

First TD

+10000

Anytime TD

+2000

James Mitchell (Panthers)

First TD

+10000

Anytime TD

+2700

Receiving Yards

Tetairoa McMillan (Panthers)

Over 70.5

-112

Under 70.5

-112

George Pickens (Cowboys)

Over 70.5

-112

Under 70.5

-112

Jake Ferguson (Cowboys)

Over 48.5

-112

Under 48.5

-112

Ryan Flournoy (Cowboys)

Over 32.5

-112

Under 32.5

-112

Jalen Tolbert (Cowboys)

Over 28.5

-112

Under 28.5

-112

Jalen Coker (Panthers)

Over 27.5

-114

Under 27.5

-114

Xavier Legette (Panthers)

Over 25.5

-112

Under 25.5

-112

Tommy Tremble (Panthers)

Over 19.5

-112

Under 19.5

-112

Rico Dowdle (Panthers)

Over 17.5

-112

Under 17.5

-112

Javonte Williams (Cowboys)

Over 15.5

-112

Under 15.5

-112

Hunter Renfrow (Panthers)

Over 14.5

-112

Under 14.5

-112

Rushing Yards

Javonte Williams (Cowboys)

Over 74.5

-112

Under 74.5

-112

Rico Dowdle (Panthers)

Over 72.5

-112

Under 72.5

-112

Jaydon Blue (Cowboys)

Over 18.5

-112

Under 18.5

-112

Bryce Young (Panthers)

Over 10.5

-112

Under 10.5

-112

Dak Prescott (Cowboys)

Over 6.5

-112

Under 6.5

-112

Passing Yards

Dak Prescott (Cowboys)

Over 242.5

-112

Under 242.5

-112

Bryce Young (Panthers)

Over 206.5

-112

Under 206.5

-112

Micro betting is something that’s really popular with bettors, with NFL fans essentially being able to wager in-game when it comes to score, player and team props. Sometimes these are two-way lines where you can bet on the Next Play or Next Drive.

Panthers Keep Delivering at Home

The Panthers have reeled off three in a row at Bank of America Stadium. They have four wins and six losses in the last 10 home games, putting up 22.70 points on average and giving up 26.00.

The Cowboys own a 5-5 mark in their past 10 games on the road, posting 22.70 points per contest while yielding 24.70.

When the teams last met at Bank of America Stadium, the Cowboys beat the Panthers 30-14.

Last 10 Games		W-L	P	PF	PA	O49.5	U49.5
Panthers Home Stats		4-6	48.70	22.70	26.00	5	5
Cowboys Away Stats		5-5	47.40	22.70	24.70	3	7

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O49.5 = Games Over 49.5 Points
• U49.5 = Games Under 49.5 Points

Latest regular season and playoff games stats.

Dallas Cowboys Stats

Carolina Panthers Stats

Moneyline

• 4 wins, 5 defeats and 1 draw in the last 10 games
• 5 wins and 5 defeats in the last 10 games on the road

Moneyline

• 4 wins and 6 defeats in the last 10 games
• 5 wins and 5 defeats in the last 10 home games

Point Spread

• -3 Betting Line: Have covered the spread in 3 of the last 10 games
• -3 Betting Line on the Road: Have covered the spread in 5 of the last 10 games on the road

Point Spread

• +3 Betting Line: Have covered the spread in 4 of the last 10 games
• +3 Betting Line at Home: Have covered the spread in 7 of the last 10 home games

Total Points

• Game Totals: An average of 53.60 pts in the previous 10 games
• Game Totals on the Road: An average of 47.40 pts in the previous 10 games on the road
• Over 49.5: Covered in 4 of the previous 10 games
• Over 49.5 on the Road: Covered in 3 of the previous 10 games on the road
• Team Totals: Have scored an average of 25.30 pts and allowed 28.30 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 22.70 pts and allowed 24.70 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 51.30 pts in the previous 10 games
• Game Totals at Home: An average of 49.50 pts in the previous 10 home games
• Over 49.5: Covered in 5 of the previous 10 games
• Over 49.5 at Home: Covered in 5 of the previous 10 home games
• Team Totals: Have scored an average of 22.60 pts and allowed 28.70 pts in the last 10 games
• Team Totals at Home: Have scored an average of 24.40 pts and allowed 25.10 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 372.80 Yds. Allowed 378.40 Yds
• Rushing Yards: Gained 134.70 Yds. Allowed 119.70 Yds
• Passing Yards: Gained 238.10 Yds. Allowed 258.70 Yds
• Total Touchdowns: Scored 2.60 TD. Allowed 3.40 TD
• Rushing Touchdowns: Scored 0.90 TD. Allowed 1.00 TD
• Passing Touchdowns: Scored 1.70 TD. Allowed 2.30 TD
• Total 1st Downs: Picked up 21.90. Allowed 22.00
• Total Turnovers: Committed 1.30. Committed by opponents 1.10
• Total Penalties: Committed 8.40. Committed by opponents 7.90
• Penalty Yards: Lost 66.10 Yds. Gained 69.40 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 308.10 Yds. Allowed 372.90 Yds
• Rushing Yards: Gained 119.90 Yds. Allowed 157.40 Yds
• Passing Yards: Gained 188.20 Yds. Allowed 215.50 Yds
• Total Touchdowns: Scored 2.90 TD. Allowed 3.40 TD
• Rushing Touchdowns: Scored 1.00 TD. Allowed 1.10 TD
• Passing Touchdowns: Scored 1.70 TD. Allowed 2.00 TD
• Total 1st Downs: Picked up 19.70. Allowed 21.10
• Total Turnovers: Committed 1.30. Committed by opponents 0.90
• Total Penalties: Committed 6.00. Committed by opponents 8.40
• Penalty Yards: Lost 48.00 Yds. Gained 63.70 Yds

Last 10 Games on the Road

• Total Yards: Gained 353.70 Yds. Allowed 339.60 Yds
• Rushing Yards: Gained 123.10 Yds. Allowed 121.40 Yds
• Passing Yards: Gained 230.60 Yds. Allowed 218.20 Yds
• Total Touchdowns: Scored 2.50 TD. Allowed 2.80 TD
• Rushing Touchdowns: Scored 0.40 TD. Allowed 0.90 TD
• Passing Touchdowns: Scored 1.90 TD. Allowed 1.80 TD
• Total 1st Downs: Picked up 20.50. Allowed 18.80
• Total Turnovers: Committed 1.60. Committed by opponents 1.10
• Total Penalties: Committed 8.20. Committed by opponents 7.00
• Penalty Yards: Lost 60.70 Yds. Gained 56.40 Yds

Last 10 Home Games

• Total Yards: Gained 318.00 Yds. Allowed 377.00 Yds
• Rushing Yards: Gained 129.60 Yds. Allowed 165.40 Yds
• Passing Yards: Gained 188.40 Yds. Allowed 211.60 Yds
• Total Touchdowns: Scored 2.70 TD. Allowed 2.70 TD
• Rushing Touchdowns: Scored 1.20 TD. Allowed 1.10 TD
• Passing Touchdowns: Scored 1.30 TD. Allowed 1.50 TD
• Total 1st Downs: Picked up 19.20. Allowed 23.10
• Total Turnovers: Committed 1.30. Committed by opponents 1.30
• Total Penalties: Committed 7.90. Committed by opponents 7.50
• Penalty Yards: Lost 59.80 Yds. Gained 61.20 Yds

Top American Football Pages