Broncos vs Colts Prediction, Picks & Odds | 14 Sep 2025

NFL Betting Preview: Broncos vs Colts

The Denver Broncos go up against the Indianapolis Colts in this NFL Week 2 matchup at Lucas Oil Stadium, with kickoff scheduled for 16:05 on Sunday, September 14. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

We think that 43.5 is a generous total for Over backers when the Colts meet the Broncos. Take the -108 that we see the teams combine to good effect.

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Denver Broncos won their previous game, beating Tennessee Titans at home. It was a 20-12 win at Empower Field at Mile High. The Broncos recorded 317 yards, breaking down to 166 passing and 151 rushing yards. They produced 20 first downs and found the end zone on two occasions.

Indianapolis Colts won their last game which was at home. It was a 33-8 triumph at Lucas Oil Stadium against Miami Dolphins. The Colts finished with 418 total yards, made up of 262 through the air and 156 on the ground. The offense managed 27 first downs and found the end zone 3 times.

Head-to-Head Statistics

It was a 31-13 win for the Broncos at Empower Field at Mile High when they last played the Colts. It’s been two Colts wins in the past 3 games between these teams.

Quarterbacks

Bo Nix

228.5 Passing Yards

Over -112

Under -112

Daniel Jones

202.5 Passing Yards

Over -112

Under -112

Broncos vs Colts Prediction & Picks

Get set for Broncos vs Colts with our full betting breakdown, complete with an expert match prediction, a likely final score, top player prop picks and a value-driven bet builder.

Game Prediction

Let’s go for Over 43.5 when these NFL teams lock horns. We think the line is too generous and we’re expecting the final total to be higher at -108.

The NFL handicappers at Sportsgambler.com start by analyzing recent form and staying on top of injury news before making any predictions. From there, we interpret the story the stats are telling to help shape our picks.

Key Broncos vs Colts stats:

• The 43.5 line has been covered in 6 of the last 10 Broncos games.
• The 43.5 line has been covered in 3 of the last 5 Broncos games on the road.
• The 43.5 line has been covered in 4 of the last 5 Colts games.
• The 43.5 line has been covered in 7 of the last 10 Colts games.

Over 43.5 Probability

According to the top sportsbooks, our pick has a 51.8% chance of delivering a return. Based on our cappers in-depth research, we calculate the actual probability to be 55-60%. It's therefore regarded as a value wager.

There are many ways to increase the odds if you’re wanting to bet on Overs and one of them is wagering on the Result & Total lines where you also predict a franchise to win.

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Our Game Prediction

Over 43.5 Points @ -108 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (22:26, 12 September 2025). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: J.K. Dobbins Anytime TD +145

You can back J.K. Dobbins (Broncos) at +145 to break the plane of the end zone. Based on all the information, we'll head to the Anytime Touchdown Scorer market where we can back him to punch it in at attractive odds.

Latest J.K. Dobbins Player Prop Odds

Touchdown

Anytime

+150

First

+750

Receiving Yards

Over 10.5

-112

Under 10.5

-112

Rushing Yards

Over 47.5

-112

Under 47.5

-112

---

Daniel Jones Over 204.5 Passing Yards -114

Daniel Jones (Colts) can be backed at -114 to surpass 204.5 passing yards. We’re confident in taking him to cover the QB Passing Yards line and bettors can back this pick with conviction.

Latest Daniel Jones Player Prop Odds

Touchdown

Anytime

+250

First

+1100

Passing Yards

Over 202.5

-112

Under 202.5

-112

Rushing Yards

Over 28.5

-112

Under 28.5

-112

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Broncos 21 - 27 Colts

Should you want a bet that can land a monster return, then look no further than the correct score lines. Back the Colts to win 27-21 and leverage a huge payout if this happens.

T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Broncos vs Colts Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

The latest Moneyline odds are +110 that Indianapolis Colts win, while Denver Broncos have been chalked up at -130. There is a 48% chance of the hosts winning according to the top sportsbooks.

2.5 is where the spread lies, with total points being 43.5 right now. NFL fans regularly enjoy the opportunity to bet on the Totals. If you’re going for Over 43.5, then the odds are -108.

You can find a huge selection of game lines and team props for every National Football League showdown, with the top betting apps creating many different options. Check out the pre-game and in-game selections before placing your wagers.

Moneyline

Broncos

-130

Colts

+110

Point Spread

Broncos -2.5

-106

Colts +2.5

-114

Total Points

Under 43.5

-112

Over 43.5

-108

Jonathan Taylor is the First Touchdown Scorer favorite at +410. Alternatively, there’s the chance to simply back him to score a TD anytime at -135.

Touchdown

Jonathan Taylor (Colts)

First TD

+410

Anytime TD

-135

J.K. Dobbins (Broncos)

First TD

+750

Anytime TD

+150

Courtland Sutton (Broncos)

First TD

+850

Anytime TD

+155

Michael Pittman Jr. (Colts)

First TD

+1100

Anytime TD

+240

Daniel Jones (Colts)

First TD

+1100

Anytime TD

+250

RJ Harvey (Broncos)

First TD

+1200

Anytime TD

+230

Tyler Warren (Colts)

First TD

+1200

Anytime TD

+270

Evan Engram (Broncos)

First TD

+1400

Anytime TD

+280

Josh Downs (Colts)

First TD

+1700

Anytime TD

+370

Alec Pierce (Colts)

First TD

+2000

Anytime TD

+490

Marvin Mims Jr. (Broncos)

First TD

+2000

Anytime TD

+380

Troy Franklin (Broncos)

First TD

+2000

Anytime TD

+440

Bo Nix (Broncos)

First TD

+2000

Anytime TD

+420

Adam Trautman (Broncos)

First TD

+3500

Anytime TD

+700

DJ Giddens (Colts)

First TD

+5000

Anytime TD

+900

Adonai Mitchell (Colts)

First TD

+5000

Anytime TD

+950

Will Mallory (Colts)

First TD

+5000

Anytime TD

+900

Tyler Goodson (Colts)

First TD

+5000

Anytime TD

+800

Jaleel McLaughlin (Broncos)

First TD

+5500

Anytime TD

+1000

Tyler Badie (Broncos)

First TD

+5500

Anytime TD

+1100

Mo Alie-Cox (Colts)

First TD

+6000

Anytime TD

+1100

Trent Sherfield Sr. (Broncos)

First TD

+6500

Anytime TD

+1300

Lucas Krull (Broncos)

First TD

+8000

Anytime TD

+1700

Pat Bryant (Broncos)

First TD

+8000

Anytime TD

+2000

Drew Ogletree (Colts)

First TD

+10000

Anytime TD

+2500

Adam Prentice (Broncos)

First TD

+10000

Anytime TD

+3000

Ashton Dulin (Colts)

First TD

+10000

Anytime TD

+3000

Ulysses Bentley IV (Colts)

First TD

+10000

Anytime TD

+4000

Anthony Gould (Colts)

First TD

+10000

Anytime TD

+2500

Receiving Yards

Courtland Sutton (Broncos)

Over 61.5

-112

Under 61.5

-112

Michael Pittman Jr. (Colts)

Over 46.5

-108

Under 46.5

-118

Tyler Warren (Colts)

Over 44.5

-112

Under 44.5

-112

Josh Downs (Colts)

Over 36.5

-112

Under 36.5

-112

Marvin Mims Jr. (Broncos)

Over 31.5

-112

Under 31.5

-112

Troy Franklin (Broncos)

Over 29.5

-112

Under 29.5

-112

Evan Engram (Broncos)

Over 28.5

-112

Under 28.5

-112

Alec Pierce (Colts)

Over 21.5

-112

Under 21.5

-112

Jonathan Taylor (Colts)

Over 14.5

-112

Under 14.5

-112

J.K. Dobbins (Broncos)

Over 10.5

-112

Under 10.5

-112

Rushing Yards

Jonathan Taylor (Colts)

Over 76.5

-112

Under 76.5

-112

J.K. Dobbins (Broncos)

Over 47.5

-112

Under 47.5

-112

RJ Harvey (Broncos)

Over 30.5

-112

Under 30.5

-112

Daniel Jones (Colts)

Over 28.5

-112

Under 28.5

-112

Bo Nix (Broncos)

Over 19.5

-112

Under 19.5

-112

Passing Yards

Bo Nix (Broncos)

Over 228.5

-112

Under 228.5

-112

Daniel Jones (Colts)

Over 202.5

-112

Under 202.5

-112

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Colts Building a Fortress at Home

The Colts have won three straight at Lucas Oil Stadium. They have gone 6-4 across their last 10 home games, putting up 23.30 points on average and giving up 21.70.

The Broncos have endured three straight defeats on the road. They have four wins and six losses in the last 10 games away from home, posting 20.00 points per contest while yielding 22.30.

The Broncos beat the Colts 34-30 in their most recent meeting at Lucas Oil Stadium.

Last 10 Games		W-L	P	PF	PA	O43.5	U43.5
Colts Home Stats		6-4	45.00	23.30	21.70	5	5
Broncos Away Stats		4-6	42.30	20.00	22.30	5	5

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O43.5 = Games Over 43.5 Points
• U43.5 = Games Under 43.5 Points

Latest regular season and playoff games stats.

Denver Broncos Stats

Indianapolis Colts Stats

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 games on the road

Moneyline

• 5 wins and 5 defeats in the last 10 games
• 6 wins and 4 defeats in the last 10 home games

Point Spread

• -2.5 Betting Line: Have covered the spread in 6 of the last 10 games
• -2.5 Betting Line on the Road: Have covered the spread in 3 of the last 10 games on the road

Point Spread

• +2.5 Betting Line: Have covered the spread in 5 of the last 10 games
• +2.5 Betting Line at Home: Have covered the spread in 7 of the last 10 home games

Total Points

• Game Totals: An average of 46.20 pts in the previous 10 games
• Game Totals on the Road: An average of 42.30 pts in the previous 10 games on the road
• Over 43.5: Covered in 6 of the previous 10 games
• Over 43.5 on the Road: Covered in 5 of the previous 10 games on the road
• Team Totals: Have scored an average of 26.90 pts and allowed 19.30 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 20.00 pts and allowed 22.30 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 49.80 pts in the previous 10 games
• Game Totals at Home: An average of 45.00 pts in the previous 10 home games
• Over 43.5: Covered in 7 of the previous 10 games
• Over 43.5 at Home: Covered in 5 of the previous 10 home games
• Team Totals: Have scored an average of 23.50 pts and allowed 26.30 pts in the last 10 games
• Team Totals at Home: Have scored an average of 23.30 pts and allowed 21.70 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 328.20 Yds. Allowed 333.80 Yds
• Rushing Yards: Gained 104.50 Yds. Allowed 94.20 Yds
• Passing Yards: Gained 223.70 Yds. Allowed 239.60 Yds
• Total Touchdowns: Scored 3.20 TD. Allowed 1.80 TD
• Rushing Touchdowns: Scored 0.60 TD. Allowed 0.40 TD
• Passing Touchdowns: Scored 2.30 TD. Allowed 1.30 TD
• Total 1st Downs: Picked up 19.20. Allowed 19.40
• Total Turnovers: Committed 1.00. Committed by opponents 1.50
• Total Penalties: Committed 5.40. Committed by opponents 5.40
• Penalty Yards: Lost 46.20 Yds. Gained 43.50 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 350.20 Yds. Allowed 331.40 Yds
• Rushing Yards: Gained 146.30 Yds. Allowed 110.40 Yds
• Passing Yards: Gained 203.90 Yds. Allowed 221.00 Yds
• Total Touchdowns: Scored 2.40 TD. Allowed 3.20 TD
• Rushing Touchdowns: Scored 1.30 TD. Allowed 1.10 TD
• Passing Touchdowns: Scored 1.00 TD. Allowed 1.70 TD
• Total 1st Downs: Picked up 19.40. Allowed 18.60
• Total Turnovers: Committed 1.80. Committed by opponents 1.60
• Total Penalties: Committed 5.40. Committed by opponents 4.90
• Penalty Yards: Lost 41.70 Yds. Gained 50.10 Yds

Last 10 Games on the Road

• Total Yards: Gained 297.00 Yds. Allowed 346.10 Yds
• Rushing Yards: Gained 116.10 Yds. Allowed 109.30 Yds
• Passing Yards: Gained 180.90 Yds. Allowed 236.80 Yds
• Total Touchdowns: Scored 1.90 TD. Allowed 2.30 TD
• Rushing Touchdowns: Scored 0.70 TD. Allowed 0.70 TD
• Passing Touchdowns: Scored 1.20 TD. Allowed 1.50 TD
• Total 1st Downs: Picked up 17.40. Allowed 21.50
• Total Turnovers: Committed 0.80. Committed by opponents 1.10
• Total Penalties: Committed 6.30. Committed by opponents 5.40
• Penalty Yards: Lost 51.90 Yds. Gained 36.00 Yds

Last 10 Home Games

• Total Yards: Gained 354.50 Yds. Allowed 350.10 Yds
• Rushing Yards: Gained 165.40 Yds. Allowed 117.40 Yds
• Passing Yards: Gained 189.10 Yds. Allowed 232.70 Yds
• Total Touchdowns: Scored 2.40 TD. Allowed 2.60 TD
• Rushing Touchdowns: Scored 1.50 TD. Allowed 1.20 TD
• Passing Touchdowns: Scored 0.90 TD. Allowed 1.20 TD
• Total 1st Downs: Picked up 18.80. Allowed 20.50
• Total Turnovers: Committed 1.00. Committed by opponents 1.60
• Total Penalties: Committed 5.30. Committed by opponents 5.60
• Penalty Yards: Lost 39.70 Yds. Gained 43.30 Yds

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