Denver Broncos
American Football NFL Lucas Oil Stadium Sun 14 Sep 16:05
Indianapolis Colts
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  9. Injuries
  10. Standings

NFL Betting Preview: Broncos vs Colts

The Denver Broncos go up against the Indianapolis Colts in this NFL Week 2 matchup at Lucas Oil Stadium, with kickoff scheduled for 16:05 on Sunday 14 September. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

Points on the Menu

We think that 43.5 is a generous total for Over backers when the Colts meet the Broncos. Take the -108 that we see the teams combine to good effect.

If you're backing our Totals call, take a minute to check out our BetMGM review, then grab the promo code before placing your bet.

Broncos Claimed 31-13 Victory in Last H2H

Denver Broncos won their previous game, beating Tennessee Titans at home. It was a 20-12 win at Empower Field at Mile High. The Broncos recorded 317 yards, breaking down to 166 passing and 151 rushing yards. They produced 20 first downs and found the end zone on two occasions.

Indianapolis Colts won their last game which was at home. It was a 33-8 triumph at Lucas Oil Stadium against Miami Dolphins. The Colts finished with 418 total yards, made up of 262 through the air and 156 on the ground. The offense managed 27 first downs and found the end zone 3 times.

Head-to-Head Statistics

It was a 31-13 win for the Broncos at Empower Field at Mile High when they last played the Colts. It’s been two Colts wins in the past 3 games between these teams.

Quarterbacks

Broncos vs Colts Prediction & Picks

Get set for Broncos vs Colts with our full betting breakdown, complete with an expert match prediction, a likely final score, top player prop picks and a value-driven bet builder.

Game Prediction

Let’s go for Over 43.5 when these NFL teams lock horns. We think the line is too generous and we’re expecting the final total to be higher at -108.

The NFL handicappers at Sportsgambler.com start by analyzing recent form and staying on top of injury news before making any predictions. From there, we interpret the story the stats are telling to help shape our picks.

Key Broncos vs Colts stats:

  • The 43.5 line has been covered in 6 of the last 10 Broncos games.
  • The 43.5 line has been covered in 3 of the last 5 Broncos games on the road.
  • The 43.5 line has been covered in 4 of the last 5 Colts games.
  • The 43.5 line has been covered in 7 of the last 10 Colts games.

Over 43.5 Probability

According to the top sportsbooks, our pick has a 51.8% chance of delivering a return. Based on our cappers in-depth research, we calculate the actual probability to be 55-60%. It's therefore regarded as a value wager.

Looking for Bigger Odds?

There are many ways to increase the odds if you’re wanting to bet on Overs and one of them is wagering on the Result & Total lines where you also predict a franchise to win.

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Best Bet

Over 43.5 Points @ -108 Watch Live Bet Now BetMGM logo
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Published 22:26, 12 September 2025

Player Prop Picks

Top Pick: J.K. Dobbins Anytime TD +145 BetMGM logo

You can back J.K. Dobbins (Broncos) at +145 to break the plane of the end zone. Based on all the information, we'll head to the Anytime Touchdown Scorer market where we can back him to punch it in at attractive odds.

Latest J.K. Dobbins Player Prop Odds

Daniel Jones Over 204.5 Passing Yards -114 BetMGM logo

Daniel Jones (Colts) can be backed at -114 to surpass 204.5 passing yards. We’re confident in taking him to cover the QB Passing Yards line and bettors can back this pick with conviction.

Latest Daniel Jones Player Prop Odds

Same Game Parlay Picks

Totals Over 43.5
Spread Colts +2.5
Anytime Touchdown J.K. Dobbins

We’ve loaded up a same game parlay with the combined picks of Over 43.5, Colts +2.5 and J.K. Dobbins (Broncos) to record a touchdown.

The betting sites now allow you to place a same game parlay on each individual game. It means that you can create a personalised football wager at bigger odds, with there generally being no limit as to the number of selections.

T&C apply. Gamble responsibly 18+

Correct Score Prediction

Broncos Broncos logo 21 - 27 Colts logo Colts

Should you want a bet that can land a monster return, then look no further than the correct score lines. Back the Colts to win 27-21 and leverage a huge payout if this happens.

Broncos vs Colts Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Tight Clash on the Cards According to the Books

The latest Moneyline odds are +104 that Indianapolis Colts win, while Denver Broncos have been chalked up at -122. There is a 49% chance of the hosts winning according to the top sportsbooks.

2.5 is where the spread lies, with total points being 43.5 right now. NFL fans regularly enjoy the opportunity to bet on the Totals. If you’re going for Over 43.5, then the odds are -108.

You can find a huge selection of game lines and team props for every National Football League showdown, with the top betting apps creating many different options. Check out the pre-game and in-game selections before placing your wagers.

Jonathan Taylor Favorite to Be First Touchdown Scorer

Jonathan Taylor is the First Touchdown Scorer favorite at +430. Alternatively, there’s the chance to simply back him to score a TD anytime at -141.

Touchdown

Jonathan Taylor (Colts)
First TD
+430
Anytime TD
-141
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J.K. Dobbins (Broncos)
First TD
+750
Anytime TD
+145
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Courtland Sutton (Broncos)
First TD
+850
Anytime TD
+150
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Michael Pittman Jr. (Colts)
First TD
+1100
Anytime TD
+230
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Receiving Yards

Courtland Sutton (Broncos)
Over 61.5
-114
Under 61.5
-114
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Michael Pittman Jr. (Colts)
Over 48.5
-114
Under 48.5
-114
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Rushing Yards

Passing Yards

Best Betting Offers
Lucas Oil Stadium
Lucas Oil Stadium

Colts Building a Fortress at Home

The Colts have won three straight at Lucas Oil Stadium. They have gone 6-4 across their last 10 home games, putting up 23.30 points on average and giving up 21.70.

The Broncos have endured three straight defeats on the road. They have four wins and six losses in the last 10 games away from home, posting 20.00 points per contest while yielding 22.30.

The Broncos beat the Colts 34-30 in their most recent meeting at Lucas Oil Stadium.

Last 10 Games W-L P PF PA O43.5 U43.5
Colts logo Colts Home Stats 6-4 45.00 23.30 21.70 5 5
Broncos logo Broncos Away Stats 4-6 42.30 20.00 22.30 5 5
  • W-L = Wins-Losses
  • P = Avg. Points
  • PF = Avg. Points For
  • PA = Avg. Points Against
  • O43.5 = Games Over 43.5 Points
  • U43.5 = Games Under 43.5 Points
Team Stats

Latest regular season and playoff games stats.

Denver Broncos logo Denver Broncos Stats
Indianapolis Colts logo Indianapolis Colts Stats
Moneyline
  • 6 wins and 4 defeats in the last 10 games
  • 4 wins and 6 defeats in the last 10 games on the road
Moneyline
  • 5 wins and 5 defeats in the last 10 games
  • 6 wins and 4 defeats in the last 10 home games
Point Spread
Point Spread
Total Points
Total Points
Game Stats
Last 10 Games
Game Stats
Last 10 Games
Last 10 Games on the Road
Last 10 Home Games

Live Streaming

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The leading betting apps stream many of the latest events across a wide range of sports and leagues.

Team News

Denver Broncos Injuries

Type
Name
Info
Nate Adkins
Ankle
Michael Burton
Hamstring
Nick Gargiulo
Knee
Dre Greenlaw
Quadriceps
Matt Henningsen
Achilles
Malcolm Roach
Calf
Drew Sanders
Foot
Johnny Walker
Undisclosed

Indianapolis Colts Injuries

Type
Name
Info
Salvon Ahmed
Ankle
Jaylon Carlies
Ankle
Blake Freeland
Leg
Tyler Goodson
Elbow
Jaylon Jones
Hamstring
Laiatu Latu
Hamstring
D.J. Montgomery
Undisclosed
Jacob Phillips
Biceps
Justin Walley
Knee - ACL
Charvarius Ward
Concussion
Jack Wilson
Undisclosed
Hunter Wohler
Foot

Previous Denver Broncos Lineups

07 Sep NFL
Titans 12-20 Broncos
12 Jan NFL Playoffs
Broncos 7-31 Bills
05 Jan NFL
Chiefs 0-38 Broncos
28 Dec NFL
Broncos 24-30 Bengals
19 Dec NFL
Broncos 27-34 Chargers
15 Dec NFL
Colts 13-31 Broncos
02 Dec NFL
Browns 32-41 Broncos
24 Nov NFL
Broncos 29-19 Raiders
17 Nov NFL
Falcons 6-38 Broncos
10 Nov NFL
Broncos 14-16 Chiefs

Previous Indianapolis Colts Lineups

07 Sep NFL
Dolphins 8-33 Colts
05 Jan NFL
Jaguars 23-26 Colts
29 Dec NFL
Colts 33-45 Giants
22 Dec NFL
Titans 30-38 Colts
15 Dec NFL
Colts 13-31 Broncos
01 Dec NFL
Colts 25-24 Patriots
24 Nov NFL
Lions 24-6 Colts
17 Nov NFL
Colts 28-27 Jets
10 Nov NFL
Bills 30-20 Colts
03 Nov NFL
Colts 13-21 Vikings

NFL Standings Select Season

AFC East W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Bills 1 0 0 1.000 41 40 1 1-0-0 0-0-0 0-0-0 1-0-0 1-0-0 1W
Jets 0 1 0 0.000 32 34 -2 0-1-0 0-0-0 0-0-0 0-1-0 0-1-0 1L
Patriots 0 1 0 0.000 13 20 -7 0-1-0 0-0-0 0-0-0 0-1-0 0-1-0 1L
Dolphins 0 1 0 0.000 8 33 -25 0-0-0 0-1-0 0-0-0 0-1-0 0-1-0 1L
AFC North W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Bengals 1 0 0 1.000 17 16 1 0-0-0 1-0-0 1-0-0 1-0-0 1-0-0 1W
Steelers 1 0 0 1.000 34 32 2 0-0-0 1-0-0 0-0-0 1-0-0 1-0-0 1W
Ravens 0 1 0 0.000 40 41 -1 0-0-0 0-1-0 0-0-0 0-1-0 0-1-0 1L
Browns 0 1 0 0.000 16 17 -1 0-1-0 0-0-0 0-1-0 0-1-0 0-1-0 1L
AFC South W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Colts 1 0 0 1.000 33 8 25 1-0-0 0-0-0 0-0-0 1-0-0 1-0-0 1W
Jaguars 1 0 0 1.000 26 10 16 1-0-0 0-0-0 0-0-0 0-0-0 1-0-0 1W
Texans 0 1 0 0.000 9 14 -5 0-0-0 0-1-0 0-0-0 0-0-0 0-1-0 1L
Titans 0 1 0 0.000 12 20 -8 0-0-0 0-1-0 0-0-0 0-1-0 0-1-0 1L
AFC West W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Chargers 1 0 0 1.000 27 21 6 1-0-0 0-0-0 1-0-0 1-0-0 1-0-0 1W
Broncos 1 0 0 1.000 20 12 8 1-0-0 0-0-0 0-0-0 1-0-0 1-0-0 1W
Raiders 1 0 0 1.000 20 13 7 0-0-0 1-0-0 0-0-0 1-0-0 1-0-0 1W
Chiefs 0 1 0 0.000 21 27 -6 0-0-0 0-1-0 0-1-0 0-1-0 0-1-0 1L
NFC East W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Eagles 1 0 0 1.000 24 20 4 1-0-0 0-0-0 1-0-0 1-0-0 1-0-0 1W
Commanders 1 1 0 0.500 39 33 6 1-0-0 0-1-0 1-0-0 1-1-0 1-1-0 1L
Cowboys 0 1 0 0.000 20 24 -4 0-0-0 0-1-0 0-1-0 0-1-0 0-1-0 1L
Giants 0 1 0 0.000 6 21 -15 0-0-0 0-1-0 0-1-0 0-1-0 0-1-0 1L
NFC North W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Packers 2 0 0 1.000 54 31 23 2-0-0 0-0-0 1-0-0 2-0-0 2-0-0 2W
Vikings 1 0 0 1.000 27 24 3 0-0-0 1-0-0 1-0-0 1-0-0 1-0-0 1W
Bears 0 1 0 0.000 24 27 -3 0-1-0 0-0-0 0-1-0 0-1-0 0-1-0 1L
Lions 0 1 0 0.000 13 27 -14 0-0-0 0-1-0 0-1-0 0-1-0 0-1-0 1L
NFC South W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Buccaneers 1 0 0 1.000 23 20 3 0-0-0 1-0-0 1-0-0 1-0-0 1-0-0 1W
Falcons 0 1 0 0.000 20 23 -3 0-1-0 0-0-0 0-1-0 0-1-0 0-1-0 1L
Saints 0 1 0 0.000 13 20 -7 0-1-0 0-0-0 0-0-0 0-1-0 0-1-0 1L
Panthers 0 1 0 0.000 10 26 -16 0-0-0 0-1-0 0-0-0 0-0-0 0-1-0 1L
NFC West W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
49ers 1 0 0 1.000 17 13 4 0-0-0 1-0-0 1-0-0 1-0-0 1-0-0 1W
Cardinals 1 0 0 1.000 20 13 7 0-0-0 1-0-0 0-0-0 1-0-0 1-0-0 1W
Rams 1 0 0 1.000 14 9 5 1-0-0 0-0-0 0-0-0 0-0-0 1-0-0 1W
Seahawks 0 1 0 0.000 13 17 -4 0-1-0 0-0-0 0-1-0 0-1-0 0-1-0 1L
AFC Conference W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Colts 1 0 0 1.000 33 8 25 1-0-0 0-0-0 0-0-0 1-0-0 1-0-0 1W
Bills 1 0 0 1.000 41 40 1 1-0-0 0-0-0 0-0-0 1-0-0 1-0-0 1W
Chargers 1 0 0 1.000 27 21 6 1-0-0 0-0-0 1-0-0 1-0-0 1-0-0 1W
Bengals 1 0 0 1.000 17 16 1 0-0-0 1-0-0 1-0-0 1-0-0 1-0-0 1W
Broncos 1 0 0 1.000 20 12 8 1-0-0 0-0-0 0-0-0 1-0-0 1-0-0 1W
Steelers 1 0 0 1.000 34 32 2 0-0-0 1-0-0 0-0-0 1-0-0 1-0-0 1W
Raiders 1 0 0 1.000 20 13 7 0-0-0 1-0-0 0-0-0 1-0-0 1-0-0 1W
Jaguars 1 0 0 1.000 26 10 16 1-0-0 0-0-0 0-0-0 0-0-0 1-0-0 1W
Dolphins 0 1 0 0.000 8 33 -25 0-0-0 0-1-0 0-0-0 0-1-0 0-1-0 1L
Browns 0 1 0 0.000 16 17 -1 0-1-0 0-0-0 0-1-0 0-1-0 0-1-0 1L
Patriots 0 1 0 0.000 13 20 -7 0-1-0 0-0-0 0-0-0 0-1-0 0-1-0 1L
Titans 0 1 0 0.000 12 20 -8 0-0-0 0-1-0 0-0-0 0-1-0 0-1-0 1L
Ravens 0 1 0 0.000 40 41 -1 0-0-0 0-1-0 0-0-0 0-1-0 0-1-0 1L
Chiefs 0 1 0 0.000 21 27 -6 0-0-0 0-1-0 0-1-0 0-1-0 0-1-0 1L
Jets 0 1 0 0.000 32 34 -2 0-1-0 0-0-0 0-0-0 0-1-0 0-1-0 1L
Texans 0 1 0 0.000 9 14 -5 0-0-0 0-1-0 0-0-0 0-0-0 0-1-0 1L
NFC Conference W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Packers 2 0 0 1.000 54 31 23 2-0-0 0-0-0 1-0-0 2-0-0 2-0-0 2W
Eagles 1 0 0 1.000 24 20 4 1-0-0 0-0-0 1-0-0 1-0-0 1-0-0 1W
Buccaneers 1 0 0 1.000 23 20 3 0-0-0 1-0-0 1-0-0 1-0-0 1-0-0 1W
49ers 1 0 0 1.000 17 13 4 0-0-0 1-0-0 1-0-0 1-0-0 1-0-0 1W
Cardinals 1 0 0 1.000 20 13 7 0-0-0 1-0-0 0-0-0 1-0-0 1-0-0 1W
Vikings 1 0 0 1.000 27 24 3 0-0-0 1-0-0 1-0-0 1-0-0 1-0-0 1W
Rams 1 0 0 1.000 14 9 5 1-0-0 0-0-0 0-0-0 0-0-0 1-0-0 1W
Commanders 1 1 0 0.500 39 33 6 1-0-0 0-1-0 1-0-0 1-1-0 1-1-0 1L
Panthers 0 1 0 0.000 10 26 -16 0-0-0 0-1-0 0-0-0 0-0-0 0-1-0 1L
Saints 0 1 0 0.000 13 20 -7 0-1-0 0-0-0 0-0-0 0-1-0 0-1-0 1L
Giants 0 1 0 0.000 6 21 -15 0-0-0 0-1-0 0-1-0 0-1-0 0-1-0 1L
Lions 0 1 0 0.000 13 27 -14 0-0-0 0-1-0 0-1-0 0-1-0 0-1-0 1L
Falcons 0 1 0 0.000 20 23 -3 0-1-0 0-0-0 0-1-0 0-1-0 0-1-0 1L
Seahawks 0 1 0 0.000 13 17 -4 0-1-0 0-0-0 0-1-0 0-1-0 0-1-0 1L
Bears 0 1 0 0.000 24 27 -3 0-1-0 0-0-0 0-1-0 0-1-0 0-1-0 1L
Cowboys 0 1 0 0.000 20 24 -4 0-0-0 0-1-0 0-1-0 0-1-0 0-1-0 1L
NFL Team W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Cardinals 1 0 0 1.000 20 13 7 0-0-0 1-0-0 0-0-0 1-0-0 1-0-0 1W
Bills 1 0 0 1.000 41 40 1 1-0-0 0-0-0 0-0-0 1-0-0 1-0-0 1W
Bengals 1 0 0 1.000 17 16 1 0-0-0 1-0-0 1-0-0 1-0-0 1-0-0 1W
Broncos 1 0 0 1.000 20 12 8 1-0-0 0-0-0 0-0-0 1-0-0 1-0-0 1W
Colts 1 0 0 1.000 33 8 25 1-0-0 0-0-0 0-0-0 1-0-0 1-0-0 1W
Jaguars 1 0 0 1.000 26 10 16 1-0-0 0-0-0 0-0-0 0-0-0 1-0-0 1W
Raiders 1 0 0 1.000 20 13 7 0-0-0 1-0-0 0-0-0 1-0-0 1-0-0 1W
Chargers 1 0 0 1.000 27 21 6 1-0-0 0-0-0 1-0-0 1-0-0 1-0-0 1W
Rams 1 0 0 1.000 14 9 5 1-0-0 0-0-0 0-0-0 0-0-0 1-0-0 1W
Vikings 1 0 0 1.000 27 24 3 0-0-0 1-0-0 1-0-0 1-0-0 1-0-0 1W
Eagles 1 0 0 1.000 24 20 4 1-0-0 0-0-0 1-0-0 1-0-0 1-0-0 1W
Steelers 1 0 0 1.000 34 32 2 0-0-0 1-0-0 0-0-0 1-0-0 1-0-0 1W
49ers 1 0 0 1.000 17 13 4 0-0-0 1-0-0 1-0-0 1-0-0 1-0-0 1W
Buccaneers 1 0 0 1.000 23 20 3 0-0-0 1-0-0 1-0-0 1-0-0 1-0-0 1W
Packers 2 0 0 1.000 54 31 23 2-0-0 0-0-0 1-0-0 2-0-0 2-0-0 2W
Commanders 1 1 0 0.500 39 33 6 1-0-0 0-1-0 1-0-0 1-1-0 1-1-0 1L
Falcons 0 1 0 0.000 20 23 -3 0-1-0 0-0-0 0-1-0 0-1-0 0-1-0 1L
Ravens 0 1 0 0.000 40 41 -1 0-0-0 0-1-0 0-0-0 0-1-0 0-1-0 1L
Panthers 0 1 0 0.000 10 26 -16 0-0-0 0-1-0 0-0-0 0-0-0 0-1-0 1L
Bears 0 1 0 0.000 24 27 -3 0-1-0 0-0-0 0-1-0 0-1-0 0-1-0 1L
Browns 0 1 0 0.000 16 17 -1 0-1-0 0-0-0 0-1-0 0-1-0 0-1-0 1L
Cowboys 0 1 0 0.000 20 24 -4 0-0-0 0-1-0 0-1-0 0-1-0 0-1-0 1L
Lions 0 1 0 0.000 13 27 -14 0-0-0 0-1-0 0-1-0 0-1-0 0-1-0 1L
Texans 0 1 0 0.000 9 14 -5 0-0-0 0-1-0 0-0-0 0-0-0 0-1-0 1L
Chiefs 0 1 0 0.000 21 27 -6 0-0-0 0-1-0 0-1-0 0-1-0 0-1-0 1L
Dolphins 0 1 0 0.000 8 33 -25 0-0-0 0-1-0 0-0-0 0-1-0 0-1-0 1L
Patriots 0 1 0 0.000 13 20 -7 0-1-0 0-0-0 0-0-0 0-1-0 0-1-0 1L
Saints 0 1 0 0.000 13 20 -7 0-1-0 0-0-0 0-0-0 0-1-0 0-1-0 1L
Giants 0 1 0 0.000 6 21 -15 0-0-0 0-1-0 0-1-0 0-1-0 0-1-0 1L
Jets 0 1 0 0.000 32 34 -2 0-1-0 0-0-0 0-0-0 0-1-0 0-1-0 1L
Seahawks 0 1 0 0.000 13 17 -4 0-1-0 0-0-0 0-1-0 0-1-0 0-1-0 1L
Titans 0 1 0 0.000 12 20 -8 0-0-0 0-1-0 0-0-0 0-1-0 0-1-0 1L