NFL Betting Preview: Broncos vs Chargers

The Denver Broncos clash with the Los Angeles Chargers in this NFL matchup at SoFi Stadium, with kickoff scheduled for 16:05 on Sunday 21 September. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

High-Scoring Game is On the Cards

The Chargers and the Broncos should be able to accumulate enough points for our pick to win. We’re predicting Over 45.5 and odds of -115 are available for this outcome.

If you're liking our Totals play, grab the latest BetMGM promo code and check out our in-depth site review before placing your bet. It’s worth the read.

34-27 Chargers Victory in Previous H2H Meeting

Denver Broncos were defeated in their previous game. On the road, they suffered a 29-28 reverse against Indianapolis Colts at Lucas Oil Stadium. The Broncos recorded 324 yards, breaking down to 206 passing and 118 rushing yards. They picked up 23 first downs to go with 4 trips to the end zone.

Los Angeles Chargers made it back-to-back wins in their last game. It was a 20-9 road triumph at SoFi Stadium when meeting Las Vegas Raiders. The Chargers put up 317 total yards, made up of 236 through the air and 81 on the ground. They picked up 15 first downs and scored two touchdowns.

Head-to-Head Statistics

The Chargers have claimed victories in the last two matchups against the Broncos. At Empower Field at Mile High, the scoreline was 23-16 and then we saw 34-27 at SoFi Stadium. Both teams have won five games when it comes to the previous 10 H2H meetings.

Quarterbacks

Bo Nix

Justin Herbert

Broncos vs Chargers Prediction & Picks

Explore our best Broncos vs Chargers picks, including our main match prediction, correct score forecast, player performance props and a bet builder ready to use.

Game Prediction

Let’s go for Over 45.5 when these NFL teams lock horns. We think the line is too generous and we’re expecting the final total to be higher at -115.

Getting the lowdown on injuries and analyzing the form guide are key steps before making NFL picks. We also put strong emphasis on stats, where a data-led approach often leads to smarter predictions.

Key Broncos vs Chargers stats:

The 45.5 line has been covered in 4 of the last 5 Broncos games on the road.
The 45.5 line has been covered in 11 of the last 20 Broncos games on the road.
The 45.5 line has been covered in the last 5 Chargers games at home.
The 45.5 line has been covered in 6 of the last 10 Chargers games.

Over 45.5 Probability

The best sportsbooks are estimating that there is a 53.5% likelihood of this pick winning. However, our analysts research has found that the actual probability is closer to 60%. This is why we can recommend this wager.

Looking for Bigger Odds?

Want more juice from your Over bet on the Totals? Bigger odds can be found if you move the line and go for a riskier wager. You can choose from a wide range of options.

Find generous betting offers before placing your next wager. The latest free bets, promos, and welcome bonuses included.

Best Bet

Over 45.5 Points @ -115 Watch Live Bet Now

BetMGM Promo Up To $1500 in Bonus Bets Get Bonus T&C apply. Gamble responsibly 18+

Gamble responsibly 18+. All odds are correct at time of publishing and are subject to change. To use the Bookmaker Live Streaming services you will need to be logged in and have a funded account or to have placed a bet in the last 24 hours. Geo-restrictions apply.

Published 22:26, 19 September 2025

Player Prop Picks

Top Pick: Ladd McConkey Anytime TD +145

The odds for Ladd McConkey (Chargers) to hit the end zone are +145. The Anytime Touchdown Scorer odds look attractive based on the evidence, and we’ll back him to take it to the house.

Latest Ladd McConkey Player Prop Odds

Touchdown

Receiving Yards

Bo Nix Over 216.5 Passing Yards -114

The odds for Bo Nix (Broncos) to go over 216.5 passing yards stand at -114. The line for him on the Overs looks attractive and bettors can get plenty of juice from this QB Passing Yards wager.

Latest Bo Nix Player Prop Odds

Touchdown

Passing Yards

Rushing Yards

Same Game Parlay Picks

Totals Over 45.5

Spread Broncos +3

Anytime Touchdown Ladd McConkey

Our same game parlay pick is Over 45.5, Broncos +3 on the spread and Ladd McConkey (Chargers) scoring a touchdown.

A same game parlay allows football bettors to place a multiple wager on the same game. You can go through the available betting lines and select the outcomes that you think will happen. The odds for each pick are then combined together.

Bet Boosts

T&C apply. Gamble responsibly 18+

Correct Score Prediction

Broncos

27 - 24 Chargers logo

Chargers

For a fun wager, consider backing the Broncos to claim a 27-24 victory. Although it’s a speculative bet, we are expecting things to be close between the two teams.

Broncos vs Chargers Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Books Have Chargers as Favorites

The sportsbooks’ betting odds have Los Angeles Chargers as -154 favorites for this game, implying that they are 61% likely to win. If you’re looking for an alternative angle, Denver Broncos are trading at +130.

The spread is calculated to be 3, while total points comes in at 45.5. The Totals offers NFL fans an alternative way of getting involved. If you’re going for Over 45.5, then the odds are -115.

If you’re betting on the National Football League, we recommend visiting the top betting apps and scanning through the many team props and game lines. There’s the opportunity to wager pre-game and in-game.

Moneyline

Point Spread

Total Points

Omarion Hampton Favorite to Score First Touchdown

Omarion Hampton can be backed to score a touchdown at anytime at -110. He is the favorite to score the first TD at odds of +550.

Touchdown

Omarion Hampton (Chargers)

J.K. Dobbins (Broncos)

Ladd McConkey (Chargers)

Courtland Sutton (Broncos)

View More View Less

Receiving Yards

Ladd McConkey (Chargers)

Courtland Sutton (Broncos)

Keenan Allen (Chargers)

Quentin Johnston (Chargers)

View More View Less

Rushing Yards

J.K. Dobbins (Broncos)

Omarion Hampton (Chargers)

Najee Harris (Chargers)

RJ Harvey (Broncos)

View More View Less

Passing Yards

Justin Herbert (Chargers)

Bo Nix (Broncos)

Best Betting Offers

SoFi Stadium

Chargers Have Picked Up Six Wins From Last Ten Home Games

The Chargers own a 6-4 mark in their past 10 home games, posting 23.20 points per contest while yielding 21.00.

The Broncos are on a skid of four consecutive road losses. They have a 4-6 record in their last 10 games on the road, averaging 20.80 points on offense and surrendering 22.60 on defense.

The most recent SoFi Stadium meeting saw the Chargers claim a 34-27 win over the Broncos. Over the last 5 head-to-head clashes at SoFi Stadium, the Chargers have recorded four wins, while the Broncos have one to their name.

Last 10 Games		W-L	P	PF	PA	O45.5	U45.5
Chargers Home Stats		6-4	44.20	23.20	21.00	5	5
Broncos Away Stats		4-6	43.40	20.80	22.60	5	5

W-L = Wins-Losses
P = Avg. Points
PF = Avg. Points For
PA = Avg. Points Against
O45.5 = Games Over 45.5 Points
U45.5 = Games Under 45.5 Points

Last 5 & H2H

All
Home
Away

Last 5 Games

Broncos

NFL: 14/09 Broncos28 Colts 29
NFL: 07/09 Titans12 Broncos 20
NFL Playoffs: 12/01 Broncos7 Bills 31
NFL: 05/01 Chiefs0 Broncos 38
NFL: 28/12 Broncos24 Bengals 30

Chargers

NFL: 16/09 Chargers20 Raiders 9
NFL: 06/09 Chiefs21 Chargers 27
NFL Playoffs: 11/01 Chargers12 Texans 32
NFL: 05/01 Chargers34 Raiders 20
NFL: 28/12 Chargers40 Patriots 7

Head to Head

Broncos vs Chargers

NFL: 20/12 2024 Broncos 27 Chargers 34
NFL: 13/10 2024 Chargers 23 Broncos 16
NFL: 31/12 2023 Chargers 9 Broncos 16
NFL: 10/12 2023 Broncos 24 Chargers 7
NFL: 08/01 2023 Chargers 28 Broncos 31
NFL: 18/10 2022 Broncos 16 Chargers 19
NFL: 02/01 2022 Broncos 13 Chargers 34
NFL: 28/11 2021 Chargers 13 Broncos 28
NFL: 27/12 2020 Broncos 16 Chargers 19
NFL: 01/11 2020 Chargers 30 Broncos 31

Team Stats

Latest regular season and playoff games stats.

Denver Broncos Stats

Los Angeles Chargers Stats

Moneyline

6 wins and 4 defeats in the last 10 games
4 wins and 6 defeats in the last 10 games on the road

Moneyline

6 wins and 4 defeats in the last 10 games
6 wins and 4 defeats in the last 10 home games

Point Spread

+3 Betting Line: Have covered the spread in 7 of the last 10 games
+3 Betting Line on the Road: Have covered the spread in 6 of the last 10 games on the road

Point Spread

-3 Betting Line: Have covered the spread in 6 of the last 10 games
-3 Betting Line at Home: Have covered the spread in 6 of the last 10 home games

Total Points

Game Totals: An average of 48.90 pts in the previous 10 games
Game Totals on the Road: An average of 43.40 pts in the previous 10 games on the road
Over 45.5: Covered in 5 of the previous 10 games
Over 45.5 on the Road: Covered in 5 of the previous 10 games on the road
Team Totals: Have scored an average of 28.30 pts and allowed 20.60 pts in the last 10 games
Team Totals on the Road: Have scored an average of 20.80 pts and allowed 22.60 pts in the last 10 games on the road

Total Points

Game Totals: An average of 45.90 pts in the previous 10 games
Game Totals at Home: An average of 44.20 pts in the previous 10 home games
Over 45.5: Covered in 6 of the previous 10 games
Over 45.5 at Home: Covered in 5 of the previous 10 home games
Team Totals: Have scored an average of 24.10 pts and allowed 21.80 pts in the last 10 games
Team Totals at Home: Have scored an average of 23.20 pts and allowed 21.00 pts in the last 10 home games

Game Stats

Last 10 Games

Total Yards: Gained 334.60 Yds. Allowed 351.10 Yds
Rushing Yards: Gained 108.50 Yds. Allowed 105.20 Yds
Passing Yards: Gained 226.10 Yds. Allowed 245.90 Yds
Total Touchdowns: Scored 3.40 TD. Allowed 1.90 TD
Rushing Touchdowns: Scored 0.70 TD. Allowed 0.50 TD
Passing Touchdowns: Scored 2.40 TD. Allowed 1.30 TD
Total 1st Downs: Picked up 19.90. Allowed 20.10
Total Turnovers: Committed 1.10. Committed by opponents 1.50
Total Penalties: Committed 5.60. Committed by opponents 6.20
Penalty Yards: Lost 51.00 Yds. Gained 49.30 Yds

Game Stats

Last 10 Games

Total Yards: Gained 321.90 Yds. Allowed 333.70 Yds
Rushing Yards: Gained 88.70 Yds. Allowed 122.60 Yds
Passing Yards: Gained 233.20 Yds. Allowed 211.10 Yds
Total Touchdowns: Scored 2.40 TD. Allowed 2.10 TD
Rushing Touchdowns: Scored 0.60 TD. Allowed 0.60 TD
Passing Touchdowns: Scored 1.60 TD. Allowed 1.40 TD
Total 1st Downs: Picked up 19.30. Allowed 18.90
Total Turnovers: Committed 0.90. Committed by opponents 1.40
Total Penalties: Committed 5.70. Committed by opponents 6.70
Penalty Yards: Lost 39.90 Yds. Gained 64.60 Yds

Last 10 Games on the Road

Total Yards: Gained 306.30 Yds. Allowed 363.00 Yds
Rushing Yards: Gained 118.00 Yds. Allowed 111.40 Yds
Passing Yards: Gained 188.30 Yds. Allowed 251.60 Yds
Total Touchdowns: Scored 2.20 TD. Allowed 2.20 TD
Rushing Touchdowns: Scored 0.70 TD. Allowed 0.60 TD
Passing Touchdowns: Scored 1.50 TD. Allowed 1.50 TD
Total 1st Downs: Picked up 18.40. Allowed 22.20
Total Turnovers: Committed 0.60. Committed by opponents 0.90
Total Penalties: Committed 6.30. Committed by opponents 5.90
Penalty Yards: Lost 54.20 Yds. Gained 38.70 Yds

Last 10 Home Games

Total Yards: Gained 328.00 Yds. Allowed 359.70 Yds
Rushing Yards: Gained 109.30 Yds. Allowed 129.70 Yds
Passing Yards: Gained 218.70 Yds. Allowed 230.00 Yds
Total Touchdowns: Scored 2.40 TD. Allowed 2.20 TD
Rushing Touchdowns: Scored 0.90 TD. Allowed 0.50 TD
Passing Touchdowns: Scored 1.40 TD. Allowed 1.60 TD
Total 1st Downs: Picked up 18.90. Allowed 18.30
Total Turnovers: Committed 0.50. Committed by opponents 0.80
Total Penalties: Committed 5.30. Committed by opponents 6.80
Penalty Yards: Lost 39.90 Yds. Gained 61.90 Yds

Live Streaming

Watch NFL live streaming through your Android or Apple device simply by having a funded sportsbook account or placing a bet within the past 24 hours.

You can log into your betting account on a daily basis and enjoy the chance to access high quality streams.

Broncos vs Chargers Live Stream Watch Live Geo-restrictions apply. To use the services you need to be logged in, a funded account or to have placed a bet in the last 24 hours.

Team News

Denver Broncos Injuries

Type

Name

Info

Michael Burton

Hamstring

Evan Engram

Back

Nick Gargiulo

Knee

Dre Greenlaw

Quadriceps

Matt Henningsen

Achilles

Malcolm Roach

Calf

Drew Sanders

Foot

Johnny Walker

Undisclosed

Los Angeles Chargers Injuries

Type

Name

Info

Junior Colson

Shoulder

Will Dissly

Knee

Josh Fuga

Undisclosed

Josh Harris

Undisclosed

Cam Hart

Hip

Daiyan Henley

Illness

Deane Leonard

Leg

Khalil Mack

Elbow

Elijah Molden

Hamstring

Jordan Oladokun

Undisclosed

Denzel Perryman

Ankle

Eric Rogers

Undisclosed

Rashawn Slater

Kneecap

Savion Washington

Undisclosed

Mike Williams

Undisclosed

Previous Denver Broncos Lineups

14 Sep NFL

Broncos 28-29 Colts

AFC East	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Bills	3	0	1.000	102	71	31	2-0-0	1-0-0	2-0-0	3-0-0	3-0-0	3W
Patriots	1	1	0.500	46	47	-1	0-1-0	1-0-0	1-0-0	1-1-0	1-1-0	1W
Jets	0	2	0.000	42	64	-22	0-2-0	0-0-0	0-1-0	0-2-0	0-2-0	2L
Dolphins	0	3	0.000	56	97	-41	0-1-0	0-2-0	0-2-0	0-3-0	0-3-0	3L

AFC North	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Bengals	2	0	1.000	48	43	5	1-0-0	1-0-0	1-0-0	2-0-0	2-0-0	2W
Ravens	1	1	0.500	81	58	23	1-0-0	0-1-0	1-0-0	1-1-0	1-1-0	1W
Steelers	1	1	0.500	51	63	-12	0-1-0	1-0-0	0-0-0	1-0-0	1-1-0	1L
Browns	0	2	0.000	33	58	-25	0-1-0	0-1-0	0-2-0	0-2-0	0-2-0	2L

AFC South	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Colts	2	0	1.000	62	36	26	2-0-0	0-0-0	0-0-0	2-0-0	2-0-0	2W
Jaguars	1	1	0.500	53	41	12	1-0-0	0-1-0	0-0-0	0-1-0	1-1-0	1L
Texans	0	2	0.000	28	34	-6	0-1-0	0-1-0	0-0-0	0-0-0	0-2-0	2L
Titans	0	2	0.000	31	53	-22	0-1-0	0-1-0	0-0-0	0-1-0	0-2-0	2L

NFC East	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Eagles	2	0	1.000	44	37	7	1-0-0	1-0-0	1-0-0	1-0-0	2-0-0	2W
Commanders	1	1	0.500	39	33	6	1-0-0	0-1-0	1-0-0	1-1-0	1-1-0	1L
Cowboys	1	1	0.500	60	61	-1	1-0-0	0-1-0	1-1-0	1-1-0	1-1-0	1W
Giants	0	2	0.000	43	61	-18	0-0-0	0-2-0	0-2-0	0-2-0	0-2-0	2L

NFC North	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Packers	2	0	1.000	54	31	23	2-0-0	0-0-0	1-0-0	2-0-0	2-0-0	2W
Vikings	1	1	0.500	33	46	-13	0-1-0	1-0-0	1-0-0	1-1-0	1-1-0	1L
Lions	1	1	0.500	65	48	17	1-0-0	0-1-0	1-1-0	1-1-0	1-1-0	1W
Bears	0	2	0.000	45	79	-34	0-1-0	0-1-0	0-2-0	0-2-0	0-2-0	2L

NFC South	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Buccaneers	2	0	1.000	43	39	4	0-0-0	2-0-0	1-0-0	1-0-0	2-0-0	2W
Falcons	1	1	0.500	42	29	13	0-1-0	1-0-0	0-1-0	1-1-0	1-1-0	1W
Saints	0	2	0.000	34	46	-12	0-2-0	0-0-0	0-0-0	0-2-0	0-2-0	2L
Panthers	0	2	0.000	32	53	-21	0-0-0	0-2-0	0-0-0	0-1-0	0-2-0	2L

NFC West	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
49ers	2	0	1.000	43	34	9	0-0-0	2-0-0	1-0-0	2-0-0	2-0-0	2W
Cardinals	2	0	1.000	47	35	12	1-0-0	1-0-0	0-0-0	2-0-0	2-0-0	2W
Rams	2	0	1.000	47	28	19	1-0-0	1-0-0	0-0-0	0-0-0	2-0-0	2W
Seahawks	1	1	0.500	44	34	10	0-1-0	1-0-0	0-1-0	0-1-0	1-1-0	1W

NFL Betting Preview: Broncos vs Chargers

Head-to-Head Statistics

Broncos vs Chargers Prediction & Picks

Game Prediction

Over 45.5 Probability

Best Bet

Player Prop Picks

Same Game Parlay Picks

Correct Score Prediction

Broncos vs Chargers Odds

Last 5 & H2H

Live Streaming

Team News

Denver Broncos Injuries

Los Angeles Chargers Injuries

Previous Denver Broncos Lineups

Previous Los Angeles Chargers Lineups

NFL Standings Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Get the Latest Betting Tips

NFL Standings Select Season