Broncos vs Chargers Prediction, Picks & Odds | 21 Sep 2025

NFL Betting Preview: Broncos vs Chargers

The Denver Broncos clash with the Los Angeles Chargers in this NFL Week 3 matchup at SoFi Stadium, with kickoff scheduled for 16:05 on Sunday, September 21. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

The Chargers and the Broncos should be able to accumulate enough points for our pick to win. We’re predicting Over 45.5 and odds of -115 are available for this outcome.

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Denver Broncos were defeated in their previous game. On the road, they suffered a 29-28 reverse against Indianapolis Colts at Lucas Oil Stadium. The Broncos recorded 324 yards, breaking down to 206 passing and 118 rushing yards. They picked up 23 first downs to go with 4 trips to the end zone.

Los Angeles Chargers made it back-to-back wins in their last game. It was a 20-9 road triumph at SoFi Stadium when meeting Las Vegas Raiders. The Chargers put up 317 total yards, made up of 236 through the air and 81 on the ground. They picked up 15 first downs and scored two touchdowns.

Head-to-Head Statistics

The Chargers have claimed victories in the last two matchups against the Broncos. At Empower Field at Mile High, the scoreline was 23-16 and then we saw 34-27 at SoFi Stadium. Both teams have won five games when it comes to the previous 10 H2H meetings.

Quarterbacks

Bo Nix

223.5 Passing Yards

Over -112

Under -112

Justin Herbert

252.5 Passing Yards

Over -112

Under -112

Broncos vs Chargers Prediction & Picks

Explore our best Broncos vs Chargers picks, including our main match prediction, correct score forecast, player performance props and a bet builder ready to use.

Game Prediction

Let’s go for Over 45.5 when these NFL teams lock horns. We think the line is too generous and we’re expecting the final total to be higher at -115.

Getting the lowdown on injuries and analyzing the form guide are key steps before making NFL picks. We also put strong emphasis on stats, where a data-led approach often leads to smarter predictions.

Key Broncos vs Chargers stats:

• The 45.5 line has been covered in 4 of the last 5 Broncos games on the road.
• The 45.5 line has been covered in 11 of the last 20 Broncos games on the road.
• The 45.5 line has been covered in the last 5 Chargers games at home.
• The 45.5 line has been covered in 6 of the last 10 Chargers games.

Over 45.5 Probability

The best sportsbooks are estimating that there is a 53.5% likelihood of this pick winning. However, our analysts research has found that the actual probability is closer to 60%. This is why we can recommend this wager.

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Our Game Prediction

Over 45.5 Points @ -115 Bet Now

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Player Prop Picks

Top Pick: Ladd McConkey Anytime TD +145

The odds for Ladd McConkey (Chargers) to hit the end zone are +145. The Anytime Touchdown Scorer odds look attractive based on the evidence, and we’ll back him to take it to the house.

Latest Ladd McConkey Player Prop Odds

Touchdown

Anytime

+150

First

+800

Receiving Yards

Over 65.5

-112

Under 65.5

-112

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Bo Nix Over 216.5 Passing Yards -114

The odds for Bo Nix (Broncos) to go over 216.5 passing yards stand at -114. The line for him on the Overs looks attractive and bettors can get plenty of juice from this QB Passing Yards wager.

Latest Bo Nix Player Prop Odds

Touchdown

Anytime

+440

First

+1900

Passing Yards

Over 223.5

-112

Under 223.5

-112

Rushing Yards

Over 21.5

-112

Under 21.5

-112

Correct Score Prediction

Broncos 27 - 24 Chargers

For a fun wager, consider backing the Broncos to claim a 27-24 victory. Although it’s a speculative bet, we are expecting things to be close between the two teams.

Broncos vs Chargers Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

The sportsbooks’ betting odds have Los Angeles Chargers as -147 favorites for this game, implying that they are 60% likely to win. If you’re looking for an alternative angle, Denver Broncos are trading at +124.

The spread is calculated to be 3, while total points comes in at 45.5. The Totals offers NFL fans an alternative way of getting involved. If you’re going for Over 45.5, then the odds are -110.

If you’re betting on the National Football League, we recommend visiting the top betting apps and scanning through the many team props and game lines. There’s the opportunity to wager pre-game and in-game.

Moneyline

Broncos

+124

Chargers

-147

Point Spread

Broncos +3

-122

Chargers -3

-100

Total Points

Under 45.5

-110

Over 45.5

-110

Omarion Hampton can be backed to score a touchdown at anytime at +110. He is the favorite to score the first TD at odds of +600.

Touchdown

Omarion Hampton (Chargers)

First TD

+600

Anytime TD

+110

J.K. Dobbins (Broncos)

First TD

+750

Anytime TD

+145

Ladd McConkey (Chargers)

First TD

+800

Anytime TD

+150

Courtland Sutton (Broncos)

First TD

+900

Anytime TD

+145

Keenan Allen (Chargers)

First TD

+1100

Anytime TD

+220

Quentin Johnston (Chargers)

First TD

+1100

Anytime TD

+210

Najee Harris (Chargers)

First TD

+1400

Anytime TD

+260

RJ Harvey (Broncos)

First TD

+1500

Anytime TD

+270

Troy Franklin (Broncos)

First TD

+1600

Anytime TD

+280

Evan Engram (Broncos)

First TD

+1800

Anytime TD

+290

Marvin Mims Jr. (Broncos)

First TD

+1900

Anytime TD

+370

Bo Nix (Broncos)

First TD

+1900

Anytime TD

+440

Justin Herbert (Chargers)

First TD

+2000

Anytime TD

+430

Tyler Conklin (Chargers)

First TD

+2200

Anytime TD

+460

Adam Trautman (Broncos)

First TD

+3000

Anytime TD

+550

Will Dissly (Chargers)

First TD

+3300

Anytime TD

+650

Tre Harris (Chargers)

First TD

+4500

Anytime TD

+950

Tyler Badie (Broncos)

First TD

+5000

Anytime TD

+1000

Nate Adkins (Broncos)

First TD

+5000

Anytime TD

+1100

Lucas Krull (Broncos)

First TD

+5500

Anytime TD

+1300

Trent Sherfield Sr. (Broncos)

First TD

+6500

Anytime TD

+1300

Pat Bryant (Broncos)

First TD

+6500

Anytime TD

+1400

KeAndre Lambert-Smith (Chargers)

First TD

+8000

Anytime TD

+1600

Derius Davis (Chargers)

First TD

+8000

Anytime TD

+1700

Hassan Haskins (Chargers)

First TD

+10000

Anytime TD

+2000

Scott Matlock (Chargers)

First TD

+10000

Anytime TD

+5500

Oronde Gadsden II (Chargers)

First TD

+10000

Anytime TD

+3000

Tucker Fisk (Chargers)

First TD

+10000

Anytime TD

+2200

Adam Prentice (Broncos)

First TD

+10000

Anytime TD

+3300

Receiving Yards

Ladd McConkey (Chargers)

Over 65.5

-112

Under 65.5

-112

Courtland Sutton (Broncos)

Over 54.5

-112

Under 54.5

-112

Keenan Allen (Chargers)

Over 53.5

-112

Under 53.5

-112

Troy Franklin (Broncos)

Over 44.5

-112

Under 44.5

-112

Quentin Johnston (Chargers)

Over 44.5

-112

Under 44.5

-112

Marvin Mims Jr. (Broncos)

Over 26.5

-112

Under 26.5

-112

Tyler Conklin (Chargers)

Over 16.5

-112

Under 16.5

-112

Omarion Hampton (Chargers)

Over 11.5

-112

Under 11.5

-112

RJ Harvey (Broncos)

Over 9.5

-112

Under 9.5

-112

J.K. Dobbins (Broncos)

Over 7.5

-127

Under 7.5

-102

Rushing Yards

J.K. Dobbins (Broncos)

Over 50.5

-112

Under 50.5

-112

Omarion Hampton (Chargers)

Over 38.5

-112

Under 38.5

-112

Najee Harris (Chargers)

Over 26.5

-112

Under 26.5

-112

Justin Herbert (Chargers)

Over 24.5

-112

Under 24.5

-112

RJ Harvey (Broncos)

Over 21.5

-112

Under 21.5

-112

Bo Nix (Broncos)

Over 21.5

-112

Under 21.5

-112

Passing Yards

Justin Herbert (Chargers)

Over 252.5

-112

Under 252.5

-112

Bo Nix (Broncos)

Over 223.5

-112

Under 223.5

-112

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Chargers Have Picked Up Six Wins From Last Ten Home Games

The Chargers own a 6-4 mark in their past 10 home games, posting 23.20 points per contest while yielding 21.00.

The Broncos are on a skid of four consecutive road losses. They have a 4-6 record in their last 10 games on the road, averaging 20.80 points on offense and surrendering 22.60 on defense.

The most recent SoFi Stadium meeting saw the Chargers claim a 34-27 win over the Broncos. Over the last 5 head-to-head clashes at SoFi Stadium, the Chargers have recorded four wins, while the Broncos have one to their name.

Last 10 Games		W-L	P	PF	PA	O45.5	U45.5
Chargers Home Stats		6-4	44.20	23.20	21.00	5	5
Broncos Away Stats		4-6	43.40	20.80	22.60	5	5

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O45.5 = Games Over 45.5 Points
• U45.5 = Games Under 45.5 Points

Latest regular season and playoff games stats.

Denver Broncos Stats

Los Angeles Chargers Stats

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 games on the road

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 6 wins and 4 defeats in the last 10 home games

Point Spread

• +3 Betting Line: Have covered the spread in 7 of the last 10 games
• +3 Betting Line on the Road: Have covered the spread in 6 of the last 10 games on the road

Point Spread

• -3 Betting Line: Have covered the spread in 6 of the last 10 games
• -3 Betting Line at Home: Have covered the spread in 6 of the last 10 home games

Total Points

• Game Totals: An average of 48.90 pts in the previous 10 games
• Game Totals on the Road: An average of 43.40 pts in the previous 10 games on the road
• Over 45.5: Covered in 5 of the previous 10 games
• Over 45.5 on the Road: Covered in 5 of the previous 10 games on the road
• Team Totals: Have scored an average of 28.30 pts and allowed 20.60 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 20.80 pts and allowed 22.60 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 45.90 pts in the previous 10 games
• Game Totals at Home: An average of 44.20 pts in the previous 10 home games
• Over 45.5: Covered in 6 of the previous 10 games
• Over 45.5 at Home: Covered in 5 of the previous 10 home games
• Team Totals: Have scored an average of 24.10 pts and allowed 21.80 pts in the last 10 games
• Team Totals at Home: Have scored an average of 23.20 pts and allowed 21.00 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 334.60 Yds. Allowed 351.10 Yds
• Rushing Yards: Gained 108.50 Yds. Allowed 105.20 Yds
• Passing Yards: Gained 226.10 Yds. Allowed 245.90 Yds
• Total Touchdowns: Scored 3.40 TD. Allowed 1.90 TD
• Rushing Touchdowns: Scored 0.70 TD. Allowed 0.50 TD
• Passing Touchdowns: Scored 2.40 TD. Allowed 1.30 TD
• Total 1st Downs: Picked up 19.90. Allowed 20.10
• Total Turnovers: Committed 1.10. Committed by opponents 1.50
• Total Penalties: Committed 5.60. Committed by opponents 6.20
• Penalty Yards: Lost 51.00 Yds. Gained 49.30 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 321.90 Yds. Allowed 333.70 Yds
• Rushing Yards: Gained 88.70 Yds. Allowed 122.60 Yds
• Passing Yards: Gained 233.20 Yds. Allowed 211.10 Yds
• Total Touchdowns: Scored 2.40 TD. Allowed 2.10 TD
• Rushing Touchdowns: Scored 0.60 TD. Allowed 0.60 TD
• Passing Touchdowns: Scored 1.60 TD. Allowed 1.40 TD
• Total 1st Downs: Picked up 19.30. Allowed 18.90
• Total Turnovers: Committed 0.90. Committed by opponents 1.40
• Total Penalties: Committed 5.70. Committed by opponents 6.70
• Penalty Yards: Lost 39.90 Yds. Gained 64.60 Yds

Last 10 Games on the Road

• Total Yards: Gained 306.30 Yds. Allowed 363.00 Yds
• Rushing Yards: Gained 118.00 Yds. Allowed 111.40 Yds
• Passing Yards: Gained 188.30 Yds. Allowed 251.60 Yds
• Total Touchdowns: Scored 2.20 TD. Allowed 2.20 TD
• Rushing Touchdowns: Scored 0.70 TD. Allowed 0.60 TD
• Passing Touchdowns: Scored 1.50 TD. Allowed 1.50 TD
• Total 1st Downs: Picked up 18.40. Allowed 22.20
• Total Turnovers: Committed 0.60. Committed by opponents 0.90
• Total Penalties: Committed 6.30. Committed by opponents 5.90
• Penalty Yards: Lost 54.20 Yds. Gained 38.70 Yds

Last 10 Home Games

• Total Yards: Gained 328.00 Yds. Allowed 359.70 Yds
• Rushing Yards: Gained 109.30 Yds. Allowed 129.70 Yds
• Passing Yards: Gained 218.70 Yds. Allowed 230.00 Yds
• Total Touchdowns: Scored 2.40 TD. Allowed 2.20 TD
• Rushing Touchdowns: Scored 0.90 TD. Allowed 0.50 TD
• Passing Touchdowns: Scored 1.40 TD. Allowed 1.60 TD
• Total 1st Downs: Picked up 18.90. Allowed 18.30
• Total Turnovers: Committed 0.50. Committed by opponents 0.80
• Total Penalties: Committed 5.30. Committed by opponents 6.80
• Penalty Yards: Lost 39.90 Yds. Gained 61.90 Yds

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