Denver Broncos
American Football NFL SoFi Stadium Sun 21 Sep 16:05
Los Angeles Chargers
  1. Prediction
  2. SGP Picks
  3. Odds
  4. Player Props
  5. Stats
  6. Team News
  7. Lineups
  8. Injuries
  9. Standings

NFL Betting Preview: Broncos vs Chargers

The Denver Broncos clash with the Los Angeles Chargers in this NFL Week 3 matchup at SoFi Stadium, with kickoff scheduled for 16:05 on Sunday, September 21. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

High-Scoring Game is On the Cards

The Chargers and the Broncos should be able to accumulate enough points for our pick to win. We’re predicting Over 45.5 and odds of -115 are available for this outcome.

If you're liking our Totals play, grab the latest BetMGM promo code and check out our in-depth site review before placing your bet. It’s worth the read.

34-27 Chargers Victory in Previous H2H Meeting

Denver Broncos were defeated in their previous game. On the road, they suffered a 29-28 reverse against Indianapolis Colts at Lucas Oil Stadium. The Broncos recorded 324 yards, breaking down to 206 passing and 118 rushing yards. They picked up 23 first downs to go with 4 trips to the end zone.

Los Angeles Chargers made it back-to-back wins in their last game. It was a 20-9 road triumph at SoFi Stadium when meeting Las Vegas Raiders. The Chargers put up 317 total yards, made up of 236 through the air and 81 on the ground. They picked up 15 first downs and scored two touchdowns.

Head-to-Head Statistics

The Chargers have claimed victories in the last two matchups against the Broncos. At Empower Field at Mile High, the scoreline was 23-16 and then we saw 34-27 at SoFi Stadium. Both teams have won five games when it comes to the previous 10 H2H meetings.

Quarterbacks

Broncos vs Chargers Prediction & Picks

Explore our best Broncos vs Chargers picks, including our main match prediction, correct score forecast, player performance props and a bet builder ready to use.

Game Prediction

Let’s go for Over 45.5 when these NFL teams lock horns. We think the line is too generous and we’re expecting the final total to be higher at -115.

Getting the lowdown on injuries and analyzing the form guide are key steps before making NFL picks. We also put strong emphasis on stats, where a data-led approach often leads to smarter predictions.

Key Broncos vs Chargers stats:

  • The 45.5 line has been covered in 4 of the last 5 Broncos games on the road.
  • The 45.5 line has been covered in 11 of the last 20 Broncos games on the road.
  • The 45.5 line has been covered in the last 5 Chargers games at home.
  • The 45.5 line has been covered in 6 of the last 10 Chargers games.

Over 45.5 Probability

The best sportsbooks are estimating that there is a 53.5% likelihood of this pick winning. However, our analysts research has found that the actual probability is closer to 60%. This is why we can recommend this wager.

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Best Bet

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Published 22:26, 19 September 2025

Player Prop Picks

Top Pick: Ladd McConkey Anytime TD +145 BetMGM logo

The odds for Ladd McConkey (Chargers) to hit the end zone are +145. The Anytime Touchdown Scorer odds look attractive based on the evidence, and we’ll back him to take it to the house.

Latest Ladd McConkey Player Prop Odds

Bo Nix Over 216.5 Passing Yards -114 BetMGM logo

The odds for Bo Nix (Broncos) to go over 216.5 passing yards stand at -114. The line for him on the Overs looks attractive and bettors can get plenty of juice from this QB Passing Yards wager.

Latest Bo Nix Player Prop Odds

Same Game Parlay Picks

Totals Over 45.5
Spread Broncos +3
Anytime Touchdown Ladd McConkey

Our same game parlay pick is Over 45.5, Broncos +3 on the spread and Ladd McConkey (Chargers) scoring a touchdown.

A same game parlay allows football bettors to place a multiple wager on the same game. You can go through the available betting lines and select the outcomes that you think will happen. The odds for each pick are then combined together.

T&C apply. Gamble responsibly 18+

Correct Score Prediction

Broncos Broncos logo 27 - 24 Chargers logo Chargers

For a fun wager, consider backing the Broncos to claim a 27-24 victory. Although it’s a speculative bet, we are expecting things to be close between the two teams.

Broncos vs Chargers Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Books Have Chargers as Favorites

The sportsbooks’ betting odds have Los Angeles Chargers as -147 favorites for this game, implying that they are 60% likely to win. If you’re looking for an alternative angle, Denver Broncos are trading at +124.

The spread is calculated to be 3, while total points comes in at 45.5. The Totals offers NFL fans an alternative way of getting involved. If you’re going for Over 45.5, then the odds are -110.

If you’re betting on the National Football League, we recommend visiting the top betting apps and scanning through the many team props and game lines. There’s the opportunity to wager pre-game and in-game.

Omarion Hampton Favorite to Score First Touchdown

Omarion Hampton can be backed to score a touchdown at anytime at +110. He is the favorite to score the first TD at odds of +600.

Touchdown

Omarion Hampton (Chargers)
First TD
+600
Anytime TD
+110
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J.K. Dobbins (Broncos)
First TD
+750
Anytime TD
+145
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Ladd McConkey (Chargers)
First TD
+800
Anytime TD
+150
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Courtland Sutton (Broncos)
First TD
+900
Anytime TD
+145
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Receiving Yards

Ladd McConkey (Chargers)
Over 65.5
-112
Under 65.5
-112
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Courtland Sutton (Broncos)
Over 54.5
-112
Under 54.5
-112
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Keenan Allen (Chargers)
Over 53.5
-112
Under 53.5
-112
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Troy Franklin (Broncos)
Over 44.5
-112
Under 44.5
-112
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Rushing Yards

J.K. Dobbins (Broncos)
Over 50.5
-112
Under 50.5
-112
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Omarion Hampton (Chargers)
Over 38.5
-112
Under 38.5
-112
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Najee Harris (Chargers)
Over 26.5
-112
Under 26.5
-112
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Justin Herbert (Chargers)
Over 24.5
-112
Under 24.5
-112
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Passing Yards

Micro Betting

Micro betting is something that’s really popular with bettors, with NFL fans essentially being able to wager in-game when it comes to score, player and team props. Sometimes these are two-way lines where you can bet on the Next Play or Next Drive.

Best Betting Offers
SoFi Stadium
SoFi Stadium

Chargers Have Picked Up Six Wins From Last Ten Home Games

The Chargers own a 6-4 mark in their past 10 home games, posting 23.20 points per contest while yielding 21.00.

The Broncos are on a skid of four consecutive road losses. They have a 4-6 record in their last 10 games on the road, averaging 20.80 points on offense and surrendering 22.60 on defense.

The most recent SoFi Stadium meeting saw the Chargers claim a 34-27 win over the Broncos. Over the last 5 head-to-head clashes at SoFi Stadium, the Chargers have recorded four wins, while the Broncos have one to their name.

Last 10 Games W-L P PF PA O45.5 U45.5
Chargers logo Chargers Home Stats 6-4 44.20 23.20 21.00 5 5
Broncos logo Broncos Away Stats 4-6 43.40 20.80 22.60 5 5
  • W-L = Wins-Losses
  • P = Avg. Points
  • PF = Avg. Points For
  • PA = Avg. Points Against
  • O45.5 = Games Over 45.5 Points
  • U45.5 = Games Under 45.5 Points
Team Stats

Latest regular season and playoff games stats.

Denver Broncos logo Denver Broncos Stats
Los Angeles Chargers logo Los Angeles Chargers Stats
Moneyline
  • 6 wins and 4 defeats in the last 10 games
  • 4 wins and 6 defeats in the last 10 games on the road
Moneyline
  • 6 wins and 4 defeats in the last 10 games
  • 6 wins and 4 defeats in the last 10 home games
Point Spread
Point Spread
Total Points
Total Points
Game Stats
Last 10 Games
Game Stats
Last 10 Games
Last 10 Games on the Road
Last 10 Home Games

Team News

Denver Broncos @ Los Angeles Chargers Lineups

Denver Broncos Lineup

  • Head Coach Sean Payton

Los Angeles Chargers Lineup

  • Head Coach Sean McVay

Denver Broncos Injuries

Type
Name
Info
Michael Burton
Hamstring
Evan Engram
Back
Nick Gargiulo
Knee
Dre Greenlaw
Quadriceps
Matt Henningsen
Achilles
Malcolm Roach
Calf
Drew Sanders
Foot
Johnny Walker
Undisclosed

Los Angeles Chargers Injuries

Type
Name
Info
Junior Colson
Shoulder
Will Dissly
Knee
Josh Fuga
Undisclosed
Josh Harris
Undisclosed
Cam Hart
Hip
Daiyan Henley
Illness
Deane Leonard
Leg
Khalil Mack
Elbow
Elijah Molden
Hamstring
Jordan Oladokun
Undisclosed
Denzel Perryman
Ankle
Eric Rogers
Undisclosed
Rashawn Slater
Kneecap
Savion Washington
Undisclosed
Mike Williams
Undisclosed

Previous Denver Broncos Lineups

14 Sep NFL
Broncos 28-29 Colts
07 Sep NFL
Titans 12-20 Broncos
12 Jan NFL Playoffs
Broncos 7-31 Bills
05 Jan NFL
Chiefs 0-38 Broncos
28 Dec NFL
Broncos 24-30 Bengals
19 Dec NFL
Broncos 27-34 Chargers
15 Dec NFL
Colts 13-31 Broncos
02 Dec NFL
Browns 32-41 Broncos
24 Nov NFL
Broncos 29-19 Raiders
17 Nov NFL
Falcons 6-38 Broncos

Previous Los Angeles Chargers Lineups

15 Sep NFL
Chargers 20-9 Raiders
05 Sep NFL
Chiefs 21-27 Chargers
11 Jan NFL Playoffs
Chargers 12-32 Texans
05 Jan NFL
Chargers 34-20 Raiders
28 Dec NFL
Chargers 40-7 Patriots
19 Dec NFL
Broncos 27-34 Chargers
15 Dec NFL
Buccaneers 40-17 Chargers
08 Dec NFL
Chargers 17-19 Chiefs
01 Dec NFL
Chargers 17-13 Falcons
25 Nov NFL
Ravens 30-23 Chargers

NFL Standings Select Season

AFC East W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Patriots 8 2 0 0.800 265 192 73 3-2-0 5-0-0 2-0-0 4-2-0 5-0-0 7W
Bills 6 3 0 0.667 248 197 51 4-1-0 2-2-0 2-2-0 4-2-0 2-3-0 1L
Dolphins 3 7 0 0.300 210 256 -46 2-3-0 1-4-0 2-2-0 2-6-0 2-3-0 1W
Jets 2 7 0 0.222 195 241 -46 1-5-0 1-2-0 0-2-0 2-4-0 2-3-0 2W
AFC North W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Steelers 5 4 0 0.556 212 220 -8 3-2-0 2-2-0 1-1-0 4-2-0 2-3-0 1L
Ravens 4 5 0 0.444 229 235 -6 2-3-0 2-2-0 1-0-0 2-3-0 3-2-0 3W
Bengals 3 6 0 0.333 216 300 -84 2-3-0 1-3-0 2-0-0 3-2-0 1-4-0 2L
Browns 2 7 0 0.222 146 211 -65 2-2-0 0-5-0 0-3-0 1-5-0 1-4-0 2L
AFC South W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Colts 8 2 0 0.800 321 206 115 6-0-0 2-2-0 2-0-0 6-1-0 4-1-0 1W
Jaguars 5 4 0 0.556 205 220 -15 3-2-0 2-2-0 1-1-0 3-2-0 2-3-0 1L
Texans 4 5 0 0.444 204 150 54 3-2-0 1-3-0 2-1-0 3-2-0 3-2-0 1W
Titans 1 8 0 0.111 130 257 -127 0-4-0 1-4-0 0-3-0 0-7-0 1-4-0 4L
AFC West W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Broncos 8 2 0 0.800 235 173 62 5-0-0 3-2-0 1-1-0 5-2-0 5-0-0 7W
Chargers 7 3 0 0.700 240 203 37 4-2-0 3-1-0 3-0-0 6-1-0 4-1-0 3W
Chiefs 5 4 0 0.556 235 159 76 4-1-0 1-3-0 1-1-0 2-3-0 3-2-0 1L
Raiders 2 7 0 0.222 139 220 -81 1-3-0 1-4-0 0-3-0 2-5-0 1-4-0 3L
NFC East W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Eagles 6 2 0 0.750 208 185 23 3-1-0 3-1-0 2-1-0 5-1-0 3-2-0 2W
Cowboys 3 5 1 0.333 263 277 -14 2-1-1 1-4-0 2-1-0 2-4-1 2-3-0 2L
Commanders 3 7 0 0.300 223 280 -57 2-3-0 1-4-0 1-1-0 1-6-0 0-5-0 5L
Giants 2 8 0 0.200 217 273 -56 2-2-0 0-6-0 1-3-0 1-6-0 1-4-0 4L
NFC North W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Packers 5 2 1 0.625 206 166 40 3-1-0 2-1-1 1-0-0 3-1-1 3-1-1 1L
Lions 6 3 0 0.667 283 200 83 3-1-0 3-2-0 1-2-0 3-2-0 3-2-0 1W
Bears 6 3 0 0.667 239 247 -8 3-1-0 3-2-0 0-2-0 4-2-0 4-1-0 2W
Vikings 4 5 0 0.444 201 213 -12 1-3-0 3-2-0 2-0-0 2-2-0 2-3-0 1L
NFC South W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Buccaneers 6 3 0 0.667 220 206 14 2-2-0 4-1-0 2-0-0 4-2-0 3-2-0 1L
Panthers 5 5 0 0.500 177 222 -45 3-2-0 2-3-0 1-1-0 3-2-0 3-2-0 1L
Falcons 3 6 0 0.333 168 209 -41 2-2-0 1-4-0 0-2-0 2-3-0 1-4-0 4L
Saints 2 8 0 0.200 155 250 -95 1-4-0 1-4-0 1-1-0 2-6-0 1-4-0 1W
NFC West W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Seahawks 7 2 0 0.778 275 172 103 3-2-0 4-0-0 2-1-0 4-2-0 4-1-0 4W
Rams 7 2 0 0.778 251 153 98 3-1-0 4-1-0 1-1-0 2-2-0 4-1-0 4W
49ers 6 4 0 0.600 220 230 -10 2-2-0 4-2-0 3-1-0 6-2-0 2-3-0 1L
Cardinals 3 6 0 0.333 202 215 -13 1-3-0 2-3-0 0-3-0 3-4-0 1-4-0 1L
AFC Conference W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Colts 8 2 0 0.800 321 206 115 6-0-0 2-2-0 2-0-0 6-1-0 4-1-0 1W
Broncos 8 2 0 0.800 235 173 62 5-0-0 3-2-0 1-1-0 5-2-0 5-0-0 7W
Patriots 8 2 0 0.800 265 192 73 3-2-0 5-0-0 2-0-0 4-2-0 5-0-0 7W
Steelers 5 4 0 0.556 212 220 -8 3-2-0 2-2-0 1-1-0 4-2-0 2-3-0 1L
Chargers 7 3 0 0.700 240 203 37 4-2-0 3-1-0 3-0-0 6-1-0 4-1-0 3W
Bills 6 3 0 0.667 248 197 51 4-1-0 2-2-0 2-2-0 4-2-0 2-3-0 1L
Jaguars 5 4 0 0.556 205 220 -15 3-2-0 2-2-0 1-1-0 3-2-0 2-3-0 1L
Chiefs 5 4 0 0.556 235 159 76 4-1-0 1-3-0 1-1-0 2-3-0 3-2-0 1L
Texans 4 5 0 0.444 204 150 54 3-2-0 1-3-0 2-1-0 3-2-0 3-2-0 1W
Ravens 4 5 0 0.444 229 235 -6 2-3-0 2-2-0 1-0-0 2-3-0 3-2-0 3W
Bengals 3 6 0 0.333 216 300 -84 2-3-0 1-3-0 2-0-0 3-2-0 1-4-0 2L
Dolphins 3 7 0 0.300 210 256 -46 2-3-0 1-4-0 2-2-0 2-6-0 2-3-0 1W
Jets 2 7 0 0.222 195 241 -46 1-5-0 1-2-0 0-2-0 2-4-0 2-3-0 2W
Raiders 2 7 0 0.222 139 220 -81 1-3-0 1-4-0 0-3-0 2-5-0 1-4-0 3L
Browns 2 7 0 0.222 146 211 -65 2-2-0 0-5-0 0-3-0 1-5-0 1-4-0 2L
Titans 1 8 0 0.111 130 257 -127 0-4-0 1-4-0 0-3-0 0-7-0 1-4-0 4L
NFC Conference W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Seahawks 7 2 0 0.778 275 172 103 3-2-0 4-0-0 2-1-0 4-2-0 4-1-0 4W
Eagles 6 2 0 0.750 208 185 23 3-1-0 3-1-0 2-1-0 5-1-0 3-2-0 2W
Packers 5 2 1 0.625 206 166 40 3-1-0 2-1-1 1-0-0 3-1-1 3-1-1 1L
Buccaneers 6 3 0 0.667 220 206 14 2-2-0 4-1-0 2-0-0 4-2-0 3-2-0 1L
Rams 7 2 0 0.778 251 153 98 3-1-0 4-1-0 1-1-0 2-2-0 4-1-0 4W
Lions 6 3 0 0.667 283 200 83 3-1-0 3-2-0 1-2-0 3-2-0 3-2-0 1W
Bears 6 3 0 0.667 239 247 -8 3-1-0 3-2-0 0-2-0 4-2-0 4-1-0 2W
49ers 6 4 0 0.600 220 230 -10 2-2-0 4-2-0 3-1-0 6-2-0 2-3-0 1L
Panthers 5 5 0 0.500 177 222 -45 3-2-0 2-3-0 1-1-0 3-2-0 3-2-0 1L
Vikings 4 5 0 0.444 201 213 -12 1-3-0 3-2-0 2-0-0 2-2-0 2-3-0 1L
Cowboys 3 5 1 0.333 263 277 -14 2-1-1 1-4-0 2-1-0 2-4-1 2-3-0 2L
Cardinals 3 6 0 0.333 202 215 -13 1-3-0 2-3-0 0-3-0 3-4-0 1-4-0 1L
Falcons 3 6 0 0.333 168 209 -41 2-2-0 1-4-0 0-2-0 2-3-0 1-4-0 4L
Commanders 3 7 0 0.300 223 280 -57 2-3-0 1-4-0 1-1-0 1-6-0 0-5-0 5L
Saints 2 8 0 0.200 155 250 -95 1-4-0 1-4-0 1-1-0 2-6-0 1-4-0 1W
Giants 2 8 0 0.200 217 273 -56 2-2-0 0-6-0 1-3-0 1-6-0 1-4-0 4L
NFL Team W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Broncos 8 2 0 0.800 235 173 62 5-0-0 3-2-0 1-1-0 5-2-0 5-0-0 7W
Colts 8 2 0 0.800 321 206 115 6-0-0 2-2-0 2-0-0 6-1-0 4-1-0 1W
Patriots 8 2 0 0.800 265 192 73 3-2-0 5-0-0 2-0-0 4-2-0 5-0-0 7W
Rams 7 2 0 0.778 251 153 98 3-1-0 4-1-0 1-1-0 2-2-0 4-1-0 4W
Seahawks 7 2 0 0.778 275 172 103 3-2-0 4-0-0 2-1-0 4-2-0 4-1-0 4W
Eagles 6 2 0 0.750 208 185 23 3-1-0 3-1-0 2-1-0 5-1-0 3-2-0 2W
Chargers 7 3 0 0.700 240 203 37 4-2-0 3-1-0 3-0-0 6-1-0 4-1-0 3W
Packers 5 2 1 0.625 206 166 40 3-1-0 2-1-1 1-0-0 3-1-1 3-1-1 1L
Bills 6 3 0 0.667 248 197 51 4-1-0 2-2-0 2-2-0 4-2-0 2-3-0 1L
Bears 6 3 0 0.667 239 247 -8 3-1-0 3-2-0 0-2-0 4-2-0 4-1-0 2W
Lions 6 3 0 0.667 283 200 83 3-1-0 3-2-0 1-2-0 3-2-0 3-2-0 1W
Buccaneers 6 3 0 0.667 220 206 14 2-2-0 4-1-0 2-0-0 4-2-0 3-2-0 1L
49ers 6 4 0 0.600 220 230 -10 2-2-0 4-2-0 3-1-0 6-2-0 2-3-0 1L
Jaguars 5 4 0 0.556 205 220 -15 3-2-0 2-2-0 1-1-0 3-2-0 2-3-0 1L
Chiefs 5 4 0 0.556 235 159 76 4-1-0 1-3-0 1-1-0 2-3-0 3-2-0 1L
Steelers 5 4 0 0.556 212 220 -8 3-2-0 2-2-0 1-1-0 4-2-0 2-3-0 1L
Panthers 5 5 0 0.500 177 222 -45 3-2-0 2-3-0 1-1-0 3-2-0 3-2-0 1L
Ravens 4 5 0 0.444 229 235 -6 2-3-0 2-2-0 1-0-0 2-3-0 3-2-0 3W
Texans 4 5 0 0.444 204 150 54 3-2-0 1-3-0 2-1-0 3-2-0 3-2-0 1W
Vikings 4 5 0 0.444 201 213 -12 1-3-0 3-2-0 2-0-0 2-2-0 2-3-0 1L
Cowboys 3 5 1 0.333 263 277 -14 2-1-1 1-4-0 2-1-0 2-4-1 2-3-0 2L
Cardinals 3 6 0 0.333 202 215 -13 1-3-0 2-3-0 0-3-0 3-4-0 1-4-0 1L
Falcons 3 6 0 0.333 168 209 -41 2-2-0 1-4-0 0-2-0 2-3-0 1-4-0 4L
Bengals 3 6 0 0.333 216 300 -84 2-3-0 1-3-0 2-0-0 3-2-0 1-4-0 2L
Dolphins 3 7 0 0.300 210 256 -46 2-3-0 1-4-0 2-2-0 2-6-0 2-3-0 1W
Commanders 3 7 0 0.300 223 280 -57 2-3-0 1-4-0 1-1-0 1-6-0 0-5-0 5L
Browns 2 7 0 0.222 146 211 -65 2-2-0 0-5-0 0-3-0 1-5-0 1-4-0 2L
Raiders 2 7 0 0.222 139 220 -81 1-3-0 1-4-0 0-3-0 2-5-0 1-4-0 3L
Jets 2 7 0 0.222 195 241 -46 1-5-0 1-2-0 0-2-0 2-4-0 2-3-0 2W
Saints 2 8 0 0.200 155 250 -95 1-4-0 1-4-0 1-1-0 2-6-0 1-4-0 1W
Giants 2 8 0 0.200 217 273 -56 2-2-0 0-6-0 1-3-0 1-6-0 1-4-0 4L
Titans 1 8 0 0.111 130 257 -127 0-4-0 1-4-0 0-3-0 0-7-0 1-4-0 4L