Colts vs Chiefs Prediction, Picks & Odds | 23 Nov 2025

NFL Betting Preview: Colts vs Chiefs

The Indianapolis Colts battle the Kansas City Chiefs at GEHA Field at Arrowhead Stadium, with kickoff scheduled for 13:00 on Sunday, November 23.

The Chiefs really stand out on the spread. Back the favorites to beat the Colts with the confidence that KC can cover a generous -3.5 line at -104.

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Indianapolis Colts previous game saw them claim a 31-25 win over Atlanta Falcons at Olympiastadion. The Colts generated 519 yards, including 196 passing and 323 rushing yards. The offense scored 4 touchdowns and moved the chains 25 times.

Kansas City Chiefs have enjoyed four straight home wins. In their last game, they lost on the road to Denver Broncos 22-19 at Empower Field at Mile High. The Chiefs recorded 311 total yards, made up of 249 through the air and 62 on the ground. They produced 19 first downs and found the end zone on two occasions.

Head-to-Head Statistics

The Colts have beaten the Chiefs in the last two meetings. They won 19-13 at GEHA Field at Arrowhead Stadium and triumphed 20-17 at Lucas Oil Stadium. The Colts have won two of the past 3 games that these teams have played.

Quarterbacks

Daniel Jones

245.5 Passing Yards

Over -112

Under -112

Patrick Mahomes

271.5 Passing Yards

Over -112

Under -112

Colts vs Chiefs Prediction & Picks

Take in the full Colts vs Chiefs betting outlook — from our expert match prediction and correct score pick to player prop insights and a bet builder tailored for value.

Game Prediction

There’s a strong case for backing the Chiefs on the spread in this NFL showdown. The line looks really appealing considering you can get -104 when it comes to the favorites at -3.5.

We keep a close eye on team news and our expert NFL handicappers stay sharp by tracking the latest form and lineups. You’ll also find a full set of stats that offer valuable insight and help shape smarter predictions ahead of the action.

Key Colts vs Chiefs stats:

• The -3.5 line has been covered by Chiefs in 4 consecutive games at home.
• The -3.5 line has been covered by Chiefs in 6 of their last 10 games at home.
• The -3.5 line has been covered by Chiefs in 11 of their last 20 games at home.
• The +3.5 line hasn’t been covered by Colts in 3 of their last 5 games on the road.

Chiefs -3.5 Probability

Based on the betting odds from the top sportsbooks, our pick has a 51% chance of winning. However, we think that the probability is close to 60% taking all factors into consideration. This bet can therefore be backed with confidence.

Buying and selling points with a sportsbook gives you the opportunity to choose different lines. The former will mean shorter odds, while a sell leads to a bigger potential return.

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Our Game Prediction

Chiefs -3.5 @ -104 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (19:25, 21 November 2025). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Patrick Mahomes Over 271.5 Passing Yards -114

Patrick Mahomes (Chiefs) can be backed at -114 to accumulate over 271.5 passing yards. We’re confident in taking him to cover the QB Passing Yards line and bettors can back this pick with conviction.

Latest Patrick Mahomes Player Prop Odds

Touchdown

Anytime

+310

First

+1900

Passing Yards

Over 271.5

-112

Under 271.5

-112

Rushing Yards

Over 22.5

-112

Under 22.5

-112

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Daniel Jones Over 15.5 Rushing Yards -114

Daniel Jones (Colts) is available at -114 to go beyond over 15.5 rushing yards. We’re happy to take him to cover the Player Rushing Yards line and bettors can place this wager with confidence.

Latest Daniel Jones Player Prop Odds

Touchdown

Anytime

+370

First

+2000

Passing Yards

Over 245.5

-112

Under 245.5

-112

Rushing Yards

Over 15.5

-112

Under 15.5

-112

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Colts 17 - 28 Chiefs

For those wanting a big return from a small stake, consider the correct score lines. For example, the Chiefs can be backed to win 28-17 at huge betting odds.

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Colts vs Chiefs Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

Kansas City Chiefs are -417 favorites and that means a 81% chance of winning this game according to the Moneyline betting odds with the sportsbooks. Indianapolis Colts are regarded as a long shot to win and you can currently back the Shoe at +320.

The spread currently stands at 9.5 and the total points line is 45.5. There is no denying the popularity of betting on the Totals. There’s the chance to back Under 45.5 at -110.

National Football League fans are spoilt for choice thanks to the wide range of game lines and team props which are available for every game on the coupon. Visit the top betting apps and find the best value wagers.

Moneyline

Colts

+320

Chiefs

-417

Point Spread

Colts +9.5

-110

Chiefs -9.5

-110

Total Points

Under 45.5

-110

Over 45.5

-110

There is -222 available that Jonathan Taylor scores a TD at any stage. He is available at +330 to record the first touchdown which makes him favorite.

Touchdown

Jonathan Taylor (Colts)

First TD

+330

Anytime TD

-222

Kareem Hunt (Chiefs)

First TD

+650

Anytime TD

-120

Rashee Rice (Chiefs)

First TD

+750

Anytime TD

+110

Isiah Pacheco (Chiefs)

First TD

+750

Anytime TD

-115

Travis Kelce (Chiefs)

First TD

+1000

Anytime TD

+150

Tyler Warren (Colts)

First TD

+1000

Anytime TD

+200

Xavier Worthy (Chiefs)

First TD

+1400

Anytime TD

+220

Michael Pittman Jr. (Colts)

First TD

+1400

Anytime TD

+270

Alec Pierce (Colts)

First TD

+1600

Anytime TD

+290

Josh Downs (Colts)

First TD

+1600

Anytime TD

+350

Patrick Mahomes (Chiefs)

First TD

+1900

Anytime TD

+310

Daniel Jones (Colts)

First TD

+2000

Anytime TD

+370

Marquise Brown (Chiefs)

First TD

+2200

Anytime TD

+420

Brashard Smith (Chiefs)

First TD

+3000

Anytime TD

+470

Noah Gray (Chiefs)

First TD

+3300

Anytime TD

+600

JuJu Smith-Schuster (Chiefs)

First TD

+5500

Anytime TD

+1100

Tyquan Thornton (Chiefs)

First TD

+10000

Anytime TD

+900

Ashton Dulin (Colts)

First TD

+10000

Anytime TD

+1100

Anthony Gould (Colts)

First TD

+10000

Anytime TD

+1100

Ameer Abdullah (Colts)

First TD

+10000

Anytime TD

+1300

Elijah Mitchell (Chiefs)

First TD

+10000

Anytime TD

+1400

DJ Giddens (Colts)

First TD

+10000

Anytime TD

+1900

Mo Alie-Cox (Colts)

First TD

+10000

Anytime TD

+1300

Nikko Remigio (Chiefs)

First TD

+10000

Anytime TD

+2500

Jalen Royals (Chiefs)

First TD

+10000

Anytime TD

+2500

Tyler Goodson (Colts)

First TD

+10000

Anytime TD

+1900

Drew Ogletree (Colts)

First TD

+10000

Anytime TD

+1900

Will Mallory (Colts)

First TD

+10000

Anytime TD

+1900

Robert Tonyan (Chiefs)

First TD

+10000

Anytime TD

+3500

Jared Wiley (Chiefs)

First TD

+10000

Anytime TD

+2500

Laquon Treadwell (Colts)

First TD

+10000

Anytime TD

+4000

Clyde Edwards-Helaire (Chiefs)

First TD

+10000

Anytime TD

+1400

Receiving Yards

Rashee Rice (Chiefs)

Over 71.5

-112

Under 71.5

-112

Travis Kelce (Chiefs)

Over 56.5

-112

Under 56.5

-112

Alec Pierce (Colts)

Over 56.5

-112

Under 56.5

-112

Tyler Warren (Colts)

Over 51.5

-112

Under 51.5

-112

Michael Pittman Jr. (Colts)

Over 49.5

-112

Under 49.5

-112

Xavier Worthy (Chiefs)

Over 40.5

-112

Under 40.5

-112

Josh Downs (Colts)

Over 33.5

-112

Under 33.5

-112

Marquise Brown (Chiefs)

Over 21.5

-112

Under 21.5

-112

Jonathan Taylor (Colts)

Over 19.5

-112

Under 19.5

-112

Brashard Smith (Chiefs)

Over 10.5

-112

Under 10.5

-112

Noah Gray (Chiefs)

Over 9.5

-112

Under 9.5

-112

Kareem Hunt (Chiefs)

Over 9.5

-112

Under 9.5

-112

JuJu Smith-Schuster (Chiefs)

Over 7.5

-112

Under 7.5

-112

Rushing Yards

Jonathan Taylor (Colts)

Over 85.5

-112

Under 85.5

-112

Kareem Hunt (Chiefs)

Over 52.5

-112

Under 52.5

-112

Patrick Mahomes (Chiefs)

Over 22.5

-112

Under 22.5

-112

Daniel Jones (Colts)

Over 15.5

-112

Under 15.5

-112

Passing Yards

Patrick Mahomes (Chiefs)

Over 271.5

-112

Under 271.5

-112

Daniel Jones (Colts)

Over 245.5

-112

Under 245.5

-112

There are lots of exciting NFL micro betting lines that are created and they are available in-game. Among them are whether a field goal will be scored and you simply bet whether the player will make it or miss.

Can Chiefs Continue Strong Home Form?

The Chiefs have strung together four in a row at GEHA Field at Arrowhead Stadium. They own a 9-1 mark in their past 10 home games, putting up 26.30 points per contest and giving up 16.00.

The Colts own a 4-6 mark in their past 10 road games, putting up 25.10 points on average and giving up 26.90.

The last time the Colts faced the Chiefs at GEHA Field at Arrowhead Stadium, they won 19-13.

Last 10 Games		W-L	P	PF	PA	O49.5	U49.5
Chiefs Home Stats		9-1	42.30	26.30	16.00	2	8
Colts Away Stats		4-6	52.00	25.10	26.90	4	6

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O49.5 = Games Over 49.5 Points
• U49.5 = Games Under 49.5 Points

Latest regular season and playoff games stats.

Indianapolis Colts Stats

Kansas City Chiefs Stats

Moneyline

• 8 wins and 2 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 games on the road

Moneyline

• 5 wins and 5 defeats in the last 10 games
• 9 wins and 1 defeat in the last 10 home games

Point Spread

• +3.5 Betting Line: Have covered the spread in 8 of the last 10 games
• +3.5 Betting Line on the Road: Have covered the spread in 5 of the last 10 games on the road

Point Spread

• -3.5 Betting Line: Have covered the spread in 5 of the last 10 games
• -3.5 Betting Line at Home: Have covered the spread in 6 of the last 10 home games

Total Points

• Game Totals: An average of 52.70 pts in the previous 10 games
• Game Totals on the Road: An average of 52.00 pts in the previous 10 games on the road
• Over 49.5: Covered in 6 of the previous 10 games
• Over 49.5 on the Road: Covered in 4 of the previous 10 games on the road
• Team Totals: Have scored an average of 32.10 pts and allowed 20.60 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 25.10 pts and allowed 26.90 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 43.50 pts in the previous 10 games
• Game Totals at Home: An average of 42.30 pts in the previous 10 home games
• Over 49.5: Covered in 2 of the previous 10 games
• Over 49.5 at Home: Covered in 2 of the previous 10 home games
• Team Totals: Have scored an average of 25.40 pts and allowed 18.10 pts in the last 10 games
• Team Totals at Home: Have scored an average of 26.30 pts and allowed 16.00 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 396.90 Yds. Allowed 327.60 Yds
• Rushing Yards: Gained 145.30 Yds. Allowed 92.30 Yds
• Passing Yards: Gained 251.60 Yds. Allowed 235.30 Yds
• Total Touchdowns: Scored 3.80 TD. Allowed 2.40 TD
• Rushing Touchdowns: Scored 1.90 TD. Allowed 0.80 TD
• Passing Touchdowns: Scored 1.50 TD. Allowed 1.60 TD
• Total 1st Downs: Picked up 23.70. Allowed 21.10
• Total Turnovers: Committed 1.20. Committed by opponents 1.40
• Total Penalties: Committed 6.10. Committed by opponents 5.90
• Penalty Yards: Lost 52.40 Yds. Gained 50.90 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 364.20 Yds. Allowed 296.80 Yds
• Rushing Yards: Gained 115.30 Yds. Allowed 100.00 Yds
• Passing Yards: Gained 248.90 Yds. Allowed 196.80 Yds
• Total Touchdowns: Scored 3.00 TD. Allowed 2.00 TD
• Rushing Touchdowns: Scored 1.20 TD. Allowed 1.00 TD
• Passing Touchdowns: Scored 1.80 TD. Allowed 0.90 TD
• Total 1st Downs: Picked up 22.40. Allowed 17.00
• Total Turnovers: Committed 0.60. Committed by opponents 0.90
• Total Penalties: Committed 6.90. Committed by opponents 5.80
• Penalty Yards: Lost 57.70 Yds. Gained 43.40 Yds

Last 10 Games on the Road

• Total Yards: Gained 333.80 Yds. Allowed 344.90 Yds
• Rushing Yards: Gained 113.80 Yds. Allowed 95.20 Yds
• Passing Yards: Gained 220.00 Yds. Allowed 249.70 Yds
• Total Touchdowns: Scored 2.80 TD. Allowed 3.10 TD
• Rushing Touchdowns: Scored 1.50 TD. Allowed 0.70 TD
• Passing Touchdowns: Scored 1.10 TD. Allowed 2.20 TD
• Total 1st Downs: Picked up 20.00. Allowed 19.80
• Total Turnovers: Committed 2.40. Committed by opponents 1.30
• Total Penalties: Committed 5.70. Committed by opponents 5.90
• Penalty Yards: Lost 45.80 Yds. Gained 53.70 Yds

Last 10 Home Games

• Total Yards: Gained 347.90 Yds. Allowed 297.10 Yds
• Rushing Yards: Gained 111.90 Yds. Allowed 106.10 Yds
• Passing Yards: Gained 236.00 Yds. Allowed 191.00 Yds
• Total Touchdowns: Scored 2.90 TD. Allowed 1.80 TD
• Rushing Touchdowns: Scored 1.00 TD. Allowed 0.70 TD
• Passing Touchdowns: Scored 1.90 TD. Allowed 1.10 TD
• Total 1st Downs: Picked up 22.80. Allowed 16.90
• Total Turnovers: Committed 0.40. Committed by opponents 0.80
• Total Penalties: Committed 5.10. Committed by opponents 6.30
• Penalty Yards: Lost 42.60 Yds. Gained 56.10 Yds

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