Colts vs Chiefs Prediction, Picks & Odds | 23 Nov 2025

NFL Betting Preview: Colts vs Chiefs

The Indianapolis Colts battle the Kansas City Chiefs at GEHA Field at Arrowhead Stadium, with kickoff scheduled for 13:00 on Sunday, November 23.

The Chiefs really stand out on the spread. Back the favorites to beat the Colts with the confidence that they can cover a generous -3.5 line at -104.

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Indianapolis Colts previous game saw them claim a 31-25 win over Atlanta Falcons at Olympiastadion. The Colts generated 519 yards, including 196 passing and 323 rushing yards. The offense scored 4 touchdowns and moved the chains 25 times.

Kansas City Chiefs have enjoyed four straight home wins. In their last game, they lost on the road to Denver Broncos 22-19 at Empower Field at Mile High. The Chiefs recorded 311 total yards, made up of 249 through the air and 62 on the ground. They produced 19 first downs and found the end zone on two occasions.

Head-to-Head Statistics

The Colts have beaten the Chiefs in the last two meetings. They won 19-13 at GEHA Field at Arrowhead Stadium and triumphed 20-17 at Lucas Oil Stadium. The Colts have won two of the past 3 games that these teams have played.

Quarterbacks

Daniel Jones

241.5 Passing Yards

Over -114

Under -114

Patrick Mahomes

271.5 Passing Yards

Over -114

Under -114

Colts vs Chiefs Prediction & Picks

Take in the full Colts vs Chiefs betting outlook — from our expert match prediction and correct score pick to player prop insights and a bet builder tailored for value.

Game Prediction

There’s a strong case for backing the Chiefs on the spread in this NFL showdown. The line looks really appealing considering you can get -104 when it comes to the favorites at -3.5.

We keep a close eye on team news and our expert NFL handicappers stay sharp by tracking the latest form and lineups. You’ll also find a full set of stats that offer valuable insight and help shape smarter predictions ahead of the action.

Key Colts vs Chiefs stats:

• The -3.5 line has been covered by Chiefs in 4 consecutive games at home.
• The -3.5 line has been covered by Chiefs in 6 of their last 10 games at home.
• The -3.5 line has been covered by Chiefs in 11 of their last 20 games at home.
• The +3.5 line hasn’t been covered by Colts in 3 of their last 5 games on the road.

Chiefs -3.5 Probability

Based on the betting odds from the top sportsbooks, our pick has a 51% chance of winning. However, we think that the probability is close to 60% taking all factors into consideration. This bet can therefore be backed with confidence.

Buying and selling points with a sportsbook gives you the opportunity to choose different lines. The former will mean shorter odds, while a sell leads to a bigger potential return.

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Our Game Prediction

Chiefs -3.5 @ -104 Watch Live Bet Now

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Player Prop Picks

Top Pick: Patrick Mahomes Over 271.5 Passing Yards -114

Patrick Mahomes (Chiefs) can be backed at -114 to accumulate over 271.5 passing yards. We’re confident in taking him to cover the QB Passing Yards line and bettors can back this pick with conviction.

Latest Patrick Mahomes Player Prop Odds

Touchdown

Anytime

+290

First

+1800

Passing Yards

Over 271.5

-114

Under 271.5

-114

Rushing Yards

Over 22.5

-114

Under 22.5

-114

---

Daniel Jones Over 15.5 Rushing Yards -114

Daniel Jones (Colts) is available at -114 to go beyond over 15.5 rushing yards. We’re happy to take him to cover the Player Rushing Yards line and bettors can place this wager with confidence.

Latest Daniel Jones Player Prop Odds

Touchdown

Anytime

+360

First

+1800

Passing Yards

Over 241.5

-114

Under 241.5

-114

Rushing Yards

Over 15.5

-114

Under 15.5

-114

Correct Score Prediction

Colts 17 - 28 Chiefs

For those wanting a big return from a small stake, consider the correct score lines. For example, the Chiefs can be backed to win 28-17 at huge betting odds.

Colts vs Chiefs Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Kansas City Chiefs are -179 favorites and that means a 64% chance of winning this game according to the Moneyline betting odds with the sportsbooks. Indianapolis Colts are regarded as a long shot to win and you can currently back them at +152.

The spread currently stands at 3.5 and the total points line is 49.5. There is no denying the popularity of betting on the Totals. There’s the chance to back Under 49.5 at -105.

National Football League fans are spoilt for choice thanks to the wide range of game lines and team props which are available for every game on the coupon. Visit the top betting apps and find the best value wagers.

Moneyline

Colts

+152

Chiefs

-179

Point Spread

Colts +3.5

-118

Chiefs -3.5

-104

Total Points

Under 49.5

-105

Over 49.5

-115

There is -233 available that Jonathan Taylor scores a TD at any stage. He is available at +320 to record the first touchdown which makes him favorite.

Touchdown

Jonathan Taylor (Colts)

First TD

+320

Anytime TD

-233

Kareem Hunt (Chiefs)

First TD

+700

Anytime TD

-115

Isiah Pacheco (Chiefs)

First TD

+750

Anytime TD

-115

Rashee Rice (Chiefs)

First TD

+750

Anytime TD

+105

Travis Kelce (Chiefs)

First TD

+950

Anytime TD

+145

Tyler Warren (Colts)

First TD

+1100

Anytime TD

+190

Michael Pittman Jr. (Colts)

First TD

+1300

Anytime TD

+270

Xavier Worthy (Chiefs)

First TD

+1400

Anytime TD

+220

Alec Pierce (Colts)

First TD

+1600

Anytime TD

+280

Josh Downs (Colts)

First TD

+1600

Anytime TD

+350

Patrick Mahomes (Chiefs)

First TD

+1800

Anytime TD

+290

Daniel Jones (Colts)

First TD

+1800

Anytime TD

+360

Marquise Brown (Chiefs)

First TD

+2200

Anytime TD

+380

Noah Gray (Chiefs)

First TD

+3300

Anytime TD

+600

Brashard Smith (Chiefs)

First TD

+4500

Anytime TD

+500

JuJu Smith-Schuster (Chiefs)

First TD

+4500

Anytime TD

+1000

Tyquan Thornton (Chiefs)

First TD

+8000

Anytime TD

+750

Elijah Mitchell (Chiefs)

First TD

+8000

Anytime TD

+1200

Anthony Gould (Colts)

First TD

+10000

Anytime TD

+1100

Ameer Abdullah (Colts)

First TD

+10000

Anytime TD

+1300

Ashton Dulin (Colts)

First TD

+10000

Anytime TD

+1100

DJ Giddens (Colts)

First TD

+10000

Anytime TD

+1900

Mo Alie-Cox (Colts)

First TD

+10000

Anytime TD

+1300

Nikko Remigio (Chiefs)

First TD

+10000

Anytime TD

+2500

Jalen Royals (Chiefs)

First TD

+10000

Anytime TD

+2500

Tyler Goodson (Colts)

First TD

+10000

Anytime TD

+1900

Drew Ogletree (Colts)

First TD

+10000

Anytime TD

+2000

Will Mallory (Colts)

First TD

+10000

Anytime TD

+2000

Robert Tonyan (Chiefs)

First TD

+10000

Anytime TD

+3300

Jared Wiley (Chiefs)

First TD

+10000

Anytime TD

+2500

Laquon Treadwell (Colts)

First TD

+10000

Anytime TD

+3300

Receiving Yards

Rashee Rice (Chiefs)

Over 75.5

-114

Under 75.5

-114

Alec Pierce (Colts)

Over 55.5

-114

Under 55.5

-114

Travis Kelce (Chiefs)

Over 53.5

-114

Under 53.5

-114

Tyler Warren (Colts)

Over 51.5

-114

Under 51.5

-114

Michael Pittman Jr. (Colts)

Over 48.5

-114

Under 48.5

-114

Xavier Worthy (Chiefs)

Over 40.5

-114

Under 40.5

-114

Josh Downs (Colts)

Over 33.5

-114

Under 33.5

-114

Marquise Brown (Chiefs)

Over 21.5

-114

Under 21.5

-114

Jonathan Taylor (Colts)

Over 20.5

-114

Under 20.5

-114

Noah Gray (Chiefs)

Over 9.5

-114

Under 9.5

-114

JuJu Smith-Schuster (Chiefs)

Over 7.5

-114

Under 7.5

-114

Rushing Yards

Jonathan Taylor (Colts)

Over 90.5

-114

Under 90.5

-114

Kareem Hunt (Chiefs)

Over 54.5

-114

Under 54.5

-114

Patrick Mahomes (Chiefs)

Over 22.5

-114

Under 22.5

-114

Daniel Jones (Colts)

Over 15.5

-114

Under 15.5

-114

Passing Yards

Patrick Mahomes (Chiefs)

Over 271.5

-114

Under 271.5

-114

Daniel Jones (Colts)

Over 241.5

-114

Under 241.5

-114

Can Chiefs Continue Strong Home Form?

The Chiefs have strung together four in a row at GEHA Field at Arrowhead Stadium. They own a 9-1 mark in their past 10 home games, putting up 26.30 points per contest and giving up 16.00.

The Colts own a 4-6 mark in their past 10 road games, putting up 25.10 points on average and giving up 26.90.

The last time the Colts faced the Chiefs at GEHA Field at Arrowhead Stadium, they won 19-13.

Last 10 Games		W-L	P	PF	PA	O49.5	U49.5
Chiefs Home Stats		9-1	42.30	26.30	16.00	2	8
Colts Away Stats		4-6	52.00	25.10	26.90	4	6

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O49.5 = Games Over 49.5 Points
• U49.5 = Games Under 49.5 Points

Latest regular season and playoff games stats.

Indianapolis Colts Stats

Kansas City Chiefs Stats

Moneyline

• 8 wins and 2 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 games on the road

Moneyline

• 5 wins and 5 defeats in the last 10 games
• 9 wins and 1 defeat in the last 10 home games

Point Spread

• +3.5 Betting Line: Have covered the spread in 8 of the last 10 games
• +3.5 Betting Line on the Road: Have covered the spread in 5 of the last 10 games on the road

Point Spread

• -3.5 Betting Line: Have covered the spread in 5 of the last 10 games
• -3.5 Betting Line at Home: Have covered the spread in 6 of the last 10 home games

Total Points

• Game Totals: An average of 52.70 pts in the previous 10 games
• Game Totals on the Road: An average of 52.00 pts in the previous 10 games on the road
• Over 49.5: Covered in 6 of the previous 10 games
• Over 49.5 on the Road: Covered in 4 of the previous 10 games on the road
• Team Totals: Have scored an average of 32.10 pts and allowed 20.60 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 25.10 pts and allowed 26.90 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 43.50 pts in the previous 10 games
• Game Totals at Home: An average of 42.30 pts in the previous 10 home games
• Over 49.5: Covered in 2 of the previous 10 games
• Over 49.5 at Home: Covered in 2 of the previous 10 home games
• Team Totals: Have scored an average of 25.40 pts and allowed 18.10 pts in the last 10 games
• Team Totals at Home: Have scored an average of 26.30 pts and allowed 16.00 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 396.90 Yds. Allowed 327.60 Yds
• Rushing Yards: Gained 145.30 Yds. Allowed 92.30 Yds
• Passing Yards: Gained 251.60 Yds. Allowed 235.30 Yds
• Total Touchdowns: Scored 3.80 TD. Allowed 2.40 TD
• Rushing Touchdowns: Scored 1.90 TD. Allowed 0.80 TD
• Passing Touchdowns: Scored 1.50 TD. Allowed 1.60 TD
• Total 1st Downs: Picked up 23.70. Allowed 21.10
• Total Turnovers: Committed 1.20. Committed by opponents 1.40
• Total Penalties: Committed 6.10. Committed by opponents 5.90
• Penalty Yards: Lost 52.40 Yds. Gained 50.90 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 364.20 Yds. Allowed 296.80 Yds
• Rushing Yards: Gained 115.30 Yds. Allowed 100.00 Yds
• Passing Yards: Gained 248.90 Yds. Allowed 196.80 Yds
• Total Touchdowns: Scored 3.00 TD. Allowed 2.00 TD
• Rushing Touchdowns: Scored 1.20 TD. Allowed 1.00 TD
• Passing Touchdowns: Scored 1.80 TD. Allowed 0.90 TD
• Total 1st Downs: Picked up 22.40. Allowed 17.00
• Total Turnovers: Committed 0.60. Committed by opponents 0.90
• Total Penalties: Committed 6.90. Committed by opponents 5.80
• Penalty Yards: Lost 57.70 Yds. Gained 43.40 Yds

Last 10 Games on the Road

• Total Yards: Gained 333.80 Yds. Allowed 344.90 Yds
• Rushing Yards: Gained 113.80 Yds. Allowed 95.20 Yds
• Passing Yards: Gained 220.00 Yds. Allowed 249.70 Yds
• Total Touchdowns: Scored 2.80 TD. Allowed 3.10 TD
• Rushing Touchdowns: Scored 1.50 TD. Allowed 0.70 TD
• Passing Touchdowns: Scored 1.10 TD. Allowed 2.20 TD
• Total 1st Downs: Picked up 20.00. Allowed 19.80
• Total Turnovers: Committed 2.40. Committed by opponents 1.30
• Total Penalties: Committed 5.70. Committed by opponents 5.90
• Penalty Yards: Lost 45.80 Yds. Gained 53.70 Yds

Last 10 Home Games

• Total Yards: Gained 347.90 Yds. Allowed 297.10 Yds
• Rushing Yards: Gained 111.90 Yds. Allowed 106.10 Yds
• Passing Yards: Gained 236.00 Yds. Allowed 191.00 Yds
• Total Touchdowns: Scored 2.90 TD. Allowed 1.80 TD
• Rushing Touchdowns: Scored 1.00 TD. Allowed 0.70 TD
• Passing Touchdowns: Scored 1.90 TD. Allowed 1.10 TD
• Total 1st Downs: Picked up 22.80. Allowed 16.90
• Total Turnovers: Committed 0.40. Committed by opponents 0.80
• Total Penalties: Committed 5.10. Committed by opponents 6.30
• Penalty Yards: Lost 42.60 Yds. Gained 56.10 Yds

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