Colts vs Chargers Prediction, Picks & Odds | 19 Oct 2025

NFL Betting Preview: Colts vs Chargers

The Indianapolis Colts square off against the Los Angeles Chargers in this NFL Week 7 clash at SoFi Stadium, with kickoff scheduled for 16:05 on Sunday, October 19. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

We like the look of +112 when it comes to the road team. Our betting prediction is that the Colts will overcome the Chargers with something to spare.

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Indianapolis Colts claimed a home victory in their previous game. A 31-27 triumph against Arizona Cardinals at Lucas Oil Stadium made it back-to-back wins. The Colts finished with 355 total yards, made up of 205 through the air and 150 on the ground. They produced 25 first downs and scored 4 touchdowns, including 2 passing scores and 2 rushing TD's.

Los Angeles Chargers triumphed in their last game. It was on the road where Miami Dolphins were beaten 29-27 at Hard Rock Stadium. The Chargers moved the ball for 403 yards, made up of 263 through the air and 140 on the ground. They converted for 20 first downs and found the end zone twice.

Head-to-Head Statistics

The scoreline was 20-3 in favor of the Chargers when they last played the Colts, with the matchup taking place at Lucas Oil Stadium.

Quarterbacks

Daniel Jones

225.5 Passing Yards

Over -112

Under -112

Justin Herbert

256.5 Passing Yards

Over -112

Under -112

Colts vs Chargers Prediction & Picks

Our Colts vs Chargers tips include the main match prediction, a correct score forecast, bet builder advice and top player prop picks. Each section below offers expert insight into the key betting angles.

Game Prediction

We are eager to back the Colts to win this NFL matchup and that leads us to the Moneyline for our pick. It’s difficult to turn down the +112 that they claim the win.

Tracking injury updates is a big part of our analysis and team news plays a major role in shaping our NFL predictions. We combine this with recent form and the most important stats to get a complete picture.

Key Colts vs Chargers stats:

• Colts have won 5 of their last 6 games this season.
• Colts have won 4 of their last 5 games.
• Colts have won 2 consecutive games.
• Chargers have lost 11 of their last 20 games at home.

Colts Moneyline Probability

Based on the odds from the top NFL betting sites, there’s a 47.2% likelihood of our pick delivering a return. In the opinion of our analysts, there’s actually a probability of success between 50-55%. This bet can therefore be backed with confidence.

If you’re looking to squeeze more juice from the odds, consider the Colts on the spread. Those expecting this franchise to exceed expectations can bet them to cover the line.

Don’t miss out on extra value. Our comprehensive guide features a wide range of free bets and sign-up bonuses for new bettors.

Our Game Prediction

Colts Moneyline @ +112 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (22:26, 17 October 2025). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Michael Pittman Jr. Anytime TD +180

The odds for Michael Pittman Jr. (Colts) to make it to the end zone are +180. We’ll take a chance with this Anytime Touchdown Scorer wager as the betting odds look really appealing.

Latest Michael Pittman Jr. Player Prop Odds

Touchdown

Anytime

+200

First

+1200

Receiving Yards

Over 49.5

-112

Under 49.5

-112

---

Kimani Vidal Over 56.5 Rushing Yards -114

The odds for Kimani Vidal (Colts) to rack up over 56.5 rushing yards are -114. We believe it makes sense to stick with him on the Over and bettors can be confident in this Player Rushing Yards pick.

Latest Kimani Vidal Player Prop Odds

Touchdown

Anytime

+110

First

+650

Receiving Yards

Over 13.5

-112

Under 13.5

-112

Rushing Yards

Over 53.5

-112

Under 53.5

-112

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Colts 31 - 27 Chargers

We’ll throw a dart when it comes to the Colts claiming a 31-27 victory. This correct score prediction is available at monster odds and could be an entertaining wager to place.

T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Colts vs Chargers Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

You can choose Los Angeles Chargers at -244 or alternatively Indianapolis Colts who have betting odds of +200. If you want to know the probability of the road team winning this game, it’s 33% according to the most popular sportsbooks.

There is a spread of 6 and total points has a line of 45.5. NFL bettors love the chance to get an alternative angle by going for a Total wager. Those who wager Under 45.5 can get -110.

If a National Football League wager is on your mind, visit the top sportsbooks and check out the huge selection of available game lines and team props. Find the betting odds and lines which are the most appealing.

Moneyline

Colts

+200

Chargers

-244

Point Spread

Colts +6

-110

Chargers -6

-110

Total Points

Under 45.5

-110

Over 45.5

-110

Favorite Jonathan Taylor is priced at +420 to be the first player to score a touchdown. There’s also the opportunity to back him to score a TD at anytime at odds of -175.

Touchdown

Jonathan Taylor (Colts)

First TD

+420

Anytime TD

-175

Kimani Vidal (Chargers)

First TD

+650

Anytime TD

+110

Tyler Warren (Colts)

First TD

+1000

Anytime TD

+165

Quentin Johnston (Chargers)

First TD

+1000

Anytime TD

+185

Ladd McConkey (Chargers)

First TD

+1000

Anytime TD

+180

Keenan Allen (Chargers)

First TD

+1000

Anytime TD

+195

Michael Pittman Jr. (Colts)

First TD

+1200

Anytime TD

+200

Josh Downs (Colts)

First TD

+1600

Anytime TD

+260

Hassan Haskins (Chargers)

First TD

+1600

Anytime TD

+280

Daniel Jones (Colts)

First TD

+1600

Anytime TD

+270

Alec Pierce (Colts)

First TD

+1700

Anytime TD

+290

Oronde Gadsden II (Chargers)

First TD

+1800

Anytime TD

+340

Justin Herbert (Chargers)

First TD

+2000

Anytime TD

+430

Adonai Mitchell (Colts)

First TD

+2700

Anytime TD

+550

Ashton Dulin (Colts)

First TD

+3000

Anytime TD

+450

Tre Harris (Chargers)

First TD

+4500

Anytime TD

+750

KeAndre Lambert-Smith (Chargers)

First TD

+5500

Anytime TD

+850

Derius Davis (Chargers)

First TD

+5500

Anytime TD

+950

Mo Alie-Cox (Colts)

First TD

+7000

Anytime TD

+1100

Will Dissly (Chargers)

First TD

+7500

Anytime TD

+1200

Anthony Gould (Colts)

First TD

+8000

Anytime TD

+1600

Nyheim Hines (Chargers)

First TD

+8000

Anytime TD

+1600

Will Mallory (Colts)

First TD

+10000

Anytime TD

+2200

Ameer Abdullah (Colts)

First TD

+10000

Anytime TD

+1300

DJ Giddens (Colts)

First TD

+10000

Anytime TD

+1700

Drew Ogletree (Colts)

First TD

+10000

Anytime TD

+2200

Tyler Conklin (Chargers)

First TD

+10000

Anytime TD

+2700

Tucker Fisk (Chargers)

First TD

+10000

Anytime TD

+2700

Scott Matlock (Chargers)

First TD

+10000

Anytime TD

+3000

Laquon Treadwell (Colts)

First TD

+10000

Anytime TD

+1500

Receiving Yards

Ladd McConkey (Chargers)

Over 61.5

-112

Under 61.5

-112

Tyler Warren (Colts)

Over 55.5

-112

Under 55.5

-112

Quentin Johnston (Chargers)

Over 55.5

-112

Under 55.5

-112

Michael Pittman Jr. (Colts)

Over 49.5

-112

Under 49.5

-112

Keenan Allen (Chargers)

Over 47.5

-112

Under 47.5

-112

Alec Pierce (Colts)

Over 38.5

-112

Under 38.5

-112

Oronde Gadsden II (Chargers)

Over 27.5

-112

Under 27.5

-112

Adonai Mitchell (Colts)

Over 22.5

-112

Under 22.5

-112

Jonathan Taylor (Colts)

Over 18.5

-112

Under 18.5

-112

Kimani Vidal (Chargers)

Over 13.5

-112

Under 13.5

-112

Rushing Yards

Jonathan Taylor (Colts)

Over 88.5

-112

Under 88.5

-112

Kimani Vidal (Chargers)

Over 53.5

-112

Under 53.5

-112

Hassan Haskins (Chargers)

Over 17.5

-114

Under 17.5

-114

Justin Herbert (Chargers)

Over 15.5

-112

Under 15.5

-112

Daniel Jones (Colts)

Over 15.5

-112

Under 15.5

-112

Passing Yards

Justin Herbert (Chargers)

Over 256.5

-112

Under 256.5

-112

Daniel Jones (Colts)

Over 225.5

-112

Under 225.5

-112

It’s good to consider all wagering options when it comes to NFL and micro betting can be an exciting way to get involved in the action. When everything goes in-game, consider whether a player will make or miss a field goal.

Chargers Hold Six Wins in Previous Ten at Home

The Chargers have a 6-4 record in their last 10 home games, scoring 23.10 points per contest and conceding 23.40.

The Colts own a 4-6 mark in their past 10 games on the road, putting up 24.70 points on average and giving up 27.20.

The Chargers earned a 30-24 win over the Colts the last time they played at SoFi Stadium.

Last 10 Games		W-L	P	PF	PA	O48.5	U48.5
Chargers Home Stats		6-4	46.50	23.10	23.40	4	6
Colts Away Stats		4-6	51.90	24.70	27.20	5	5

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O48.5 = Games Over 48.5 Points
• U48.5 = Games Under 48.5 Points

Latest regular season and playoff games stats.

Indianapolis Colts Stats

Los Angeles Chargers Stats

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 games on the road

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 6 wins and 4 defeats in the last 10 home games

Point Spread

• +1.5 Betting Line: Have covered the spread in 7 of the last 10 games
• +1.5 Betting Line on the Road: Have covered the spread in 4 of the last 10 games on the road

Point Spread

• -1.5 Betting Line: Have covered the spread in 7 of the last 10 games
• -1.5 Betting Line at Home: Have covered the spread in 6 of the last 10 home games

Total Points

• Game Totals: An average of 54.90 pts in the previous 10 games
• Game Totals on the Road: An average of 51.90 pts in the previous 10 games on the road
• Over 48.5: Covered in 6 of the previous 10 games
• Over 48.5 on the Road: Covered in 5 of the previous 10 games on the road
• Team Totals: Have scored an average of 30.40 pts and allowed 24.50 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 24.70 pts and allowed 27.20 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 45.80 pts in the previous 10 games
• Game Totals at Home: An average of 46.50 pts in the previous 10 home games
• Over 48.5: Covered in 3 of the previous 10 games
• Over 48.5 at Home: Covered in 4 of the previous 10 home games
• Team Totals: Have scored an average of 24.70 pts and allowed 21.10 pts in the last 10 games
• Team Totals at Home: Have scored an average of 23.10 pts and allowed 23.40 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 390.40 Yds. Allowed 318.30 Yds
• Rushing Yards: Gained 157.80 Yds. Allowed 90.80 Yds
• Passing Yards: Gained 232.60 Yds. Allowed 227.50 Yds
• Total Touchdowns: Scored 3.40 TD. Allowed 2.90 TD
• Rushing Touchdowns: Scored 1.80 TD. Allowed 0.70 TD
• Passing Touchdowns: Scored 1.20 TD. Allowed 2.00 TD
• Total 1st Downs: Picked up 22.70. Allowed 19.20
• Total Turnovers: Committed 1.30. Committed by opponents 1.60
• Total Penalties: Committed 6.40. Committed by opponents 6.00
• Penalty Yards: Lost 50.80 Yds. Gained 60.30 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 370.60 Yds. Allowed 303.90 Yds
• Rushing Yards: Gained 117.50 Yds. Allowed 115.80 Yds
• Passing Yards: Gained 253.10 Yds. Allowed 188.10 Yds
• Total Touchdowns: Scored 2.40 TD. Allowed 2.10 TD
• Rushing Touchdowns: Scored 0.50 TD. Allowed 0.90 TD
• Passing Touchdowns: Scored 1.80 TD. Allowed 1.10 TD
• Total 1st Downs: Picked up 21.40. Allowed 17.20
• Total Turnovers: Committed 1.30. Committed by opponents 1.20
• Total Penalties: Committed 6.30. Committed by opponents 6.90
• Penalty Yards: Lost 45.60 Yds. Gained 57.90 Yds

Last 10 Games on the Road

• Total Yards: Gained 328.40 Yds. Allowed 351.70 Yds
• Rushing Yards: Gained 114.20 Yds. Allowed 113.20 Yds
• Passing Yards: Gained 214.20 Yds. Allowed 238.50 Yds
• Total Touchdowns: Scored 2.70 TD. Allowed 3.10 TD
• Rushing Touchdowns: Scored 1.20 TD. Allowed 0.80 TD
• Passing Touchdowns: Scored 1.30 TD. Allowed 2.10 TD
• Total 1st Downs: Picked up 19.50. Allowed 19.20
• Total Turnovers: Committed 2.00. Committed by opponents 1.30
• Total Penalties: Committed 5.90. Committed by opponents 5.90
• Penalty Yards: Lost 43.70 Yds. Gained 59.40 Yds

Last 10 Home Games

• Total Yards: Gained 332.30 Yds. Allowed 368.70 Yds
• Rushing Yards: Gained 106.00 Yds. Allowed 138.40 Yds
• Passing Yards: Gained 226.30 Yds. Allowed 230.30 Yds
• Total Touchdowns: Scored 2.50 TD. Allowed 2.50 TD
• Rushing Touchdowns: Scored 0.90 TD. Allowed 0.80 TD
• Passing Touchdowns: Scored 1.50 TD. Allowed 1.70 TD
• Total 1st Downs: Picked up 20.30. Allowed 18.80
• Total Turnovers: Committed 0.80. Committed by opponents 0.50
• Total Penalties: Committed 5.80. Committed by opponents 8.00
• Penalty Yards: Lost 45.40 Yds. Gained 68.50 Yds

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