Colts vs Rams Prediction, Picks & Odds | 28 Sep 2025

NFL Betting Preview: Colts vs Rams

The Indianapolis Colts face off against the Los Angeles Rams in this NFL Week 4 matchup at SoFi Stadium, with kickoff scheduled for 16:05 on Sunday, September 28. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

We’re confident of backing the Rams to cover the -3.5 spread when playing the Colts. This is an appealing line and they look a great wager at odds of -108.

Feeling good about our spread pick? Don’t miss the new BetMGM promo code and our expert review as you get ready to make your move.

Indianapolis Colts have triumphed in their previous three games. The latest was on the road where Tennessee Titans were beaten 41-20 at Nissan Stadium. The Colts finished with 365 yards, including 228 passing and 137 rushing yards. The offense generated 22 first downs and produced 5 touchdowns.

Los Angeles Rams were beaten last game and this was on the road at Lincoln Financial Field. Philadelphia Eagles claimed a 33-26 win. The Rams put up 356 total yards, made up of 196 through the air and 160 on the ground. The offense produced 22 first downs along with two touchdowns.

Head-to-Head Statistics

It was the Rams who came out on top when they last played the Colts. At Lucas Oil Stadium, a 29-23 (OT) win was recorded.

Quarterbacks

Daniel Jones

219.5 Passing Yards

Over -112

Under -112

Matthew Stafford

251.5 Passing Yards

Over -112

Under -112

Colts vs Rams Prediction & Picks

We dive into the best Colts vs Rams betting angles, including an expert match prediction, correct score forecast, top player prop bets and a value-focused bet builder.

Game Prediction

Our pick is for the Rams to cover the attractive -3.5 line in this NFL matchup. The favorites should be able to triumph by a more comfortable margin and -108 is available.

Incoming team news often impacts the betting lines and odds in significant ways. Our NFL handicappers factor this in alongside recent form, while key stats are also carefully weighed to strengthen each pick.

Key Colts vs Rams stats:

• The -3.5 line has been covered by Rams in 6 of their last 10 games.
• The -3.5 line has been covered by Rams in 3 of their last 5 games.
• The -3.5 line has been covered by Rams in 2 consecutive games at home.

Rams -3.5 Probability

If you go by the best betting sites, our pick has a 51.8% chance of winning. Based on our cappers in-depth research, we calculate the actual probability to be 55-60%. This is why we can recommend this wager.

There’s an opportunity to secure bigger odds and this can be achieved by moving the line. Squeeze more juice from your pick by taking an alternative wagering view.

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Our Game Prediction

Rams -3.5 @ -108 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (22:26, 26 September 2025). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Puka Nacua Anytime TD -100

Puka Nacua (Rams) can be backed at -100 to reach the goal line. Based on all the information, we'll head to the Anytime Touchdown Scorer market where we can back him to punch it in at attractive odds.

Latest Puka Nacua Player Prop Odds

Touchdown

Anytime

+105

First

+700

Receiving Yards

Over 90.5

-112

Under 90.5

-112

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Daniel Jones Over 24.5 Rushing Yards -114

Daniel Jones (Colts) is available at -114 to go beyond over 24.5 rushing yards. We're confident in him covering the Player Rushing Yards line and hitting our Over bet.

Latest Daniel Jones Player Prop Odds

Touchdown

Anytime

+175

First

+1000

Passing Yards

Over 219.5

-112

Under 219.5

-112

Rushing Yards

Over 25.5

-112

Under 25.5

-112

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Colts 20 - 27 Rams

Rather than betting on the Rams to win, there’s the option to try your luck when it comes to the correct score lines. Take a chance on a 27-20 victory in their favor.

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Colts vs Rams Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

Los Angeles Rams have the shortest price to win this game, with the sportsbooks giving them a 75% probability due to their -303 Moneyline betting odds. If you’re looking for an alternative angle, Indianapolis Colts are trading at +245.

6.5 is where the spread lies, with total points being 46.5 right now. There is no denying the popularity of betting on the Totals. Those expecting a low total can back Under 46.5 at -110.

The good news is that you can access a wide range of game lines and team props for every National Football League matchup. The best betting apps offer a great selection of pre-game and in-game wagering options.

Moneyline

Colts

+245

Rams

-303

Point Spread

Colts +6.5

-110

Rams -6.5

-110

Total Points

Under 46.5

-110

Over 46.5

-110

Jonathan Taylor can be backed to score a touchdown at anytime at -200. He is the favorite to score the first TD at odds of +370.

Touchdown

Jonathan Taylor (Colts)

First TD

+370

Anytime TD

-200

Kyren Williams (Rams)

First TD

+440

Anytime TD

-189

Puka Nacua (Rams)

First TD

+700

Anytime TD

+105

Davante Adams (Rams)

First TD

+750

Anytime TD

+115

Daniel Jones (Colts)

First TD

+1000

Anytime TD

+175

Tyler Warren (Colts)

First TD

+1400

Anytime TD

+240

Michael Pittman Jr. (Colts)

First TD

+1400

Anytime TD

+250

Blake Corum (Rams)

First TD

+1900

Anytime TD

+300

Alec Pierce (Colts)

First TD

+2000

Anytime TD

+350

Josh Downs (Colts)

First TD

+2000

Anytime TD

+370

Tyler Higbee (Rams)

First TD

+2200

Anytime TD

+450

Adonai Mitchell (Colts)

First TD

+2500

Anytime TD

+460

Tutu Atwell (Rams)

First TD

+3500

Anytime TD

+650

Jordan Whittington (Rams)

First TD

+4000

Anytime TD

+550

Konata Mumpfield (Rams)

First TD

+8000

Anytime TD

+1400

Terrance Ferguson (Rams)

First TD

+8000

Anytime TD

+1200

Matthew Stafford (Rams)

First TD

+8000

Anytime TD

+1600

Ashton Dulin (Colts)

First TD

+8000

Anytime TD

+1600

Davis Allen (Rams)

First TD

+8000

Anytime TD

+1100

Tyler Goodson (Colts)

First TD

+10000

Anytime TD

+1400

Colby Parkinson (Rams)

First TD

+10000

Anytime TD

+1500

Mo Alie-Cox (Colts)

First TD

+10000

Anytime TD

+1600

DJ Giddens (Colts)

First TD

+10000

Anytime TD

+1200

Will Mallory (Colts)

First TD

+10000

Anytime TD

+1700

Xavier Smith (Rams)

First TD

+10000

Anytime TD

+1800

Jarquez Hunter (Rams)

First TD

+10000

Anytime TD

+2000

Anthony Gould (Colts)

First TD

+10000

Anytime TD

+3000

Drew Ogletree (Colts)

First TD

+10000

Anytime TD

+2700

Receiving Yards

Puka Nacua (Rams)

Over 90.5

-112

Under 90.5

-112

Davante Adams (Rams)

Over 64.5

-112

Under 64.5

-112

Michael Pittman Jr. (Colts)

Over 53.5

-112

Under 53.5

-112

Tyler Warren (Colts)

Over 52.5

-112

Under 52.5

-112

Josh Downs (Colts)

Over 39.5

-112

Under 39.5

-112

Adonai Mitchell (Colts)

Over 31.5

-112

Under 31.5

-112

Jonathan Taylor (Colts)

Over 14.5

-112

Under 14.5

-112

Tyler Higbee (Rams)

Over 13.5

-112

Under 13.5

-112

Tutu Atwell (Rams)

Over 11.5

-112

Under 11.5

-112

Kyren Williams (Rams)

Over 9.5

-112

Under 9.5

-112

Rushing Yards

Jonathan Taylor (Colts)

Over 87.5

-112

Under 87.5

-112

Kyren Williams (Rams)

Over 70.5

-112

Under 70.5

-112

Daniel Jones (Colts)

Over 25.5

-112

Under 25.5

-112

Blake Corum (Rams)

Over 21.5

-112

Under 21.5

-112

Passing Yards

Matthew Stafford (Rams)

Over 251.5

-112

Under 251.5

-112

Daniel Jones (Colts)

Over 219.5

-112

Under 219.5

-112

There are lots of exciting NFL micro betting lines that are created and they are available in-game. Among them are whether a field goal will be scored and you simply bet whether the player will make it or miss.

Rams Have Collected Six Wins From Last Ten at Home

The Rams have six wins and four losses in the last 10 home games, posting 22.70 points per contest while yielding 23.30.

The Colts are 4-6 in their last 10 games away from home, putting up 23.70 points per contest and giving up 26.10.

Last 10 Games		W-L	P	PF	PA	O49.5	U49.5
Rams Home Stats		6-4	46.00	22.70	23.30	5	5
Colts Away Stats		4-6	49.80	23.70	26.10	4	6

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O49.5 = Games Over 49.5 Points
• U49.5 = Games Under 49.5 Points

Latest regular season and playoff games stats.

Indianapolis Colts Stats

Los Angeles Rams Stats

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 games on the road

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 6 wins and 4 defeats in the last 10 home games

Point Spread

• +3.5 Betting Line: Have covered the spread in 7 of the last 10 games
• +3.5 Betting Line on the Road: Have covered the spread in 6 of the last 10 games on the road

Point Spread

• -3.5 Betting Line: Have covered the spread in 6 of the last 10 games
• -3.5 Betting Line at Home: Have covered the spread in 5 of the last 10 home games

Total Points

• Game Totals: An average of 53.20 pts in the previous 10 games
• Game Totals on the Road: An average of 49.80 pts in the previous 10 games on the road
• Over 49.5: Covered in 5 of the previous 10 games
• Over 49.5 on the Road: Covered in 4 of the previous 10 games on the road
• Team Totals: Have scored an average of 27.20 pts and allowed 26.00 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 23.70 pts and allowed 26.10 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 42.90 pts in the previous 10 games
• Game Totals at Home: An average of 44.50 pts in the previous 10 home games
• Over 49.5: Covered in 5 of the previous 10 games
• Over 49.5 at Home: Covered in 4 of the previous 10 home games
• Team Totals: Have scored an average of 23.50 pts and allowed 19.40 pts in the last 10 games
• Team Totals at Home: Have scored an average of 22.70 pts and allowed 21.80 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 375.20 Yds. Allowed 309.00 Yds
• Rushing Yards: Gained 157.80 Yds. Allowed 104.00 Yds
• Passing Yards: Gained 217.40 Yds. Allowed 205.00 Yds
• Total Touchdowns: Scored 2.80 TD. Allowed 3.20 TD
• Rushing Touchdowns: Scored 1.70 TD. Allowed 1.10 TD
• Passing Touchdowns: Scored 1.00 TD. Allowed 1.80 TD
• Total 1st Downs: Picked up 21.00. Allowed 18.00
• Total Turnovers: Committed 1.20. Committed by opponents 1.30
• Total Penalties: Committed 5.70. Committed by opponents 5.40
• Penalty Yards: Lost 43.30 Yds. Gained 55.70 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 344.60 Yds. Allowed 311.30 Yds
• Rushing Yards: Gained 114.50 Yds. Allowed 118.00 Yds
• Passing Yards: Gained 230.10 Yds. Allowed 193.30 Yds
• Total Touchdowns: Scored 2.40 TD. Allowed 2.20 TD
• Rushing Touchdowns: Scored 0.80 TD. Allowed 0.70 TD
• Passing Touchdowns: Scored 1.40 TD. Allowed 1.40 TD
• Total 1st Downs: Picked up 18.70. Allowed 18.60
• Total Turnovers: Committed 0.70. Committed by opponents 1.10
• Total Penalties: Committed 5.50. Committed by opponents 6.20
• Penalty Yards: Lost 49.50 Yds. Gained 45.70 Yds

Last 10 Games on the Road

• Total Yards: Gained 328.90 Yds. Allowed 343.80 Yds
• Rushing Yards: Gained 119.70 Yds. Allowed 129.10 Yds
• Passing Yards: Gained 209.20 Yds. Allowed 214.70 Yds
• Total Touchdowns: Scored 2.60 TD. Allowed 2.90 TD
• Rushing Touchdowns: Scored 1.10 TD. Allowed 0.80 TD
• Passing Touchdowns: Scored 1.30 TD. Allowed 1.90 TD
• Total 1st Downs: Picked up 19.70. Allowed 18.70
• Total Turnovers: Committed 2.00. Committed by opponents 1.30
• Total Penalties: Committed 5.10. Committed by opponents 5.80
• Penalty Yards: Lost 36.90 Yds. Gained 58.10 Yds

Last 10 Home Games

• Total Yards: Gained 333.70 Yds. Allowed 334.60 Yds
• Rushing Yards: Gained 96.90 Yds. Allowed 125.50 Yds
• Passing Yards: Gained 236.80 Yds. Allowed 209.10 Yds
• Total Touchdowns: Scored 2.70 TD. Allowed 2.30 TD
• Rushing Touchdowns: Scored 0.90 TD. Allowed 0.80 TD
• Passing Touchdowns: Scored 1.40 TD. Allowed 1.50 TD
• Total 1st Downs: Picked up 20.20. Allowed 20.00
• Total Turnovers: Committed 0.90. Committed by opponents 1.30
• Total Penalties: Committed 5.90. Committed by opponents 6.20
• Penalty Yards: Lost 51.00 Yds. Gained 47.50 Yds

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