NFL Betting Preview: Colts vs Rams

The Indianapolis Colts face off against the Los Angeles Rams in this NFL Week 4 matchup at SoFi Stadium, with kickoff scheduled for 16:05 on Sunday 28 September. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

Get With Rams to Cover the Line

We’re confident of backing the Rams to cover the -3.5 spread when playing the Colts. This is an appealing line and they look a great wager at odds of -108.

Feeling good about our spread pick? Don’t miss the new BetMGM promo code and our expert review as you get ready to make your move.

Overtime Joy for Rams in Previous H2H

Indianapolis Colts have triumphed in their previous three games. The latest was on the road where Tennessee Titans were beaten 41-20 at Nissan Stadium. The Colts finished with 365 yards, including 228 passing and 137 rushing yards. The offense generated 22 first downs and produced 5 touchdowns.

Los Angeles Rams were beaten last game and this was on the road at Lincoln Financial Field. Philadelphia Eagles claimed a 33-26 win. The Rams put up 356 total yards, made up of 196 through the air and 160 on the ground. The offense produced 22 first downs along with two touchdowns.

Head-to-Head Statistics

It was the Rams who came out on top when they last played the Colts. At Lucas Oil Stadium, a 29-23 (OT) win was recorded.

Quarterbacks

Daniel Jones

Matthew Stafford

Colts vs Rams Prediction & Picks

We dive into the best Colts vs Rams betting angles, including an expert match prediction, correct score forecast, top player prop bets and a value-focused bet builder.

Game Prediction

Our pick is for the Rams to cover the attractive -3.5 line in this NFL matchup. The favorites should be able to triumph by a more comfortable margin and -108 is available.

Incoming team news often impacts the betting lines and odds in significant ways. Our NFL handicappers factor this in alongside recent form, while key stats are also carefully weighed to strengthen each pick.

Key Colts vs Rams stats:

The -3.5 line has been covered by Rams in 6 of their last 10 games.
The -3.5 line has been covered by Rams in 3 of their last 5 games.
The -3.5 line has been covered by Rams in 2 consecutive games at home.

Rams -3.5 Probability

If you go by the best betting sites, our pick has a 51.8% chance of winning. Based on our cappers in-depth research, we calculate the actual probability to be 55-60%. This is why we can recommend this wager.

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Best Bet

Rams -3.5 @ -108 Watch Live Bet Now

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Published 22:26, 26 September 2025

Player Prop Picks

Top Pick: Puka Nacua Anytime TD -100

Puka Nacua (Rams) can be backed at -100 to reach the goal line. Based on all the information, we'll head to the Anytime Touchdown Scorer market where we can back him to punch it in at attractive odds.

Latest Puka Nacua Player Prop Odds

Touchdown

Receiving Yards

Daniel Jones Over 24.5 Rushing Yards -114

Daniel Jones (Colts) is available at -114 to go beyond over 24.5 rushing yards. We're confident in him covering the Player Rushing Yards line and hitting our Over bet.

Latest Daniel Jones Player Prop Odds

Touchdown

Passing Yards

Rushing Yards

Same Game Parlay Picks

Spread Rams -3.5

Totals Under 49.5

Anytime Touchdown Puka Nacua

We’ve loaded up a same game parlay with the combined picks of Rams -3.5, Under 49.5 and Puka Nacua (Rams) scoring a touchdown.

Should you want to back different outcomes for the same football game, then a same game parlay will suit your needs. The betting sites create this personalised wagering tool where you can hand-pick different outcomes and combine the odds together.

Bet Boosts

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Correct Score Prediction

Colts

20 - 27 Rams logo

Rams

Rather than betting on the Rams to win, there’s the option to try your luck when it comes to the correct score lines. Take a chance on a 27-20 victory in their favor.

Colts vs Rams Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Books Make Rams Likelier Winners

Los Angeles Rams have the shortest price to win this game, with the sportsbooks giving them a 65% probability due to their -185 Moneyline betting odds. If you’re looking for an alternative angle, Indianapolis Colts are trading at +156.

3.5 is where the spread lies, with total points being 49.5 right now. There is no denying the popularity of betting on the Totals. Those expecting a low total can back Under 49.5 at -108.

The good news is that you can access a wide range of game lines and team props for every National Football League matchup. The best betting apps offer a great selection of pre-game and in-game wagering options.

Moneyline

Point Spread

Total Points

Jonathan Taylor Favorite to Be First TD Scorer

Jonathan Taylor can be backed to score a touchdown at anytime at -208. He is the favorite to score the first TD at odds of +360.

Touchdown

Jonathan Taylor (Colts)

Kyren Williams (Rams)

Puka Nacua (Rams)

Davante Adams (Rams)

View More View Less

Receiving Yards

Puka Nacua (Rams)

Davante Adams (Rams)

Michael Pittman Jr. (Colts)

Tyler Warren (Colts)

View More View Less

Rushing Yards

Jonathan Taylor (Colts)

Kyren Williams (Rams)

Daniel Jones (Colts)

Blake Corum (Rams)

Passing Yards

Matthew Stafford (Rams)

Daniel Jones (Colts)

Best Betting Offers

SoFi Stadium

Rams Have Collected Six Wins From Last Ten at Home

The Rams have six wins and four losses in the last 10 home games, posting 22.70 points per contest while yielding 23.30.

The Colts are 4-6 in their last 10 games away from home, putting up 23.70 points per contest and giving up 26.10.

Last 10 Games		W-L	P	PF	PA	O49.5	U49.5
Rams Home Stats		6-4	46.00	22.70	23.30	5	5
Colts Away Stats		4-6	49.80	23.70	26.10	4	6

W-L = Wins-Losses
P = Avg. Points
PF = Avg. Points For
PA = Avg. Points Against
O49.5 = Games Over 49.5 Points
U49.5 = Games Under 49.5 Points

Last 5 & H2H

All
Home
Away

Last 5 Games

Colts

NFL: 21/09 Colts41 Titans 20
NFL: 14/09 Broncos28 Colts 29
NFL: 07/09 Dolphins8 Colts 33
NFL: 05/01 Jaguars23 Colts 26
NFL: 29/12 Colts33 Giants 45

Rams

NFL: 21/09 Rams26 Eagles 33
NFL: 14/09 Rams33 Titans 19
NFL: 07/09 Texans9 Rams 14
NFL Playoffs: 19/01 Rams22 Eagles 28
NFL Playoffs: 14/01 Vikings9 Rams 27

Head to Head

Colts vs Rams

NFL: 01/10 2023 Rams 29 Colts 23
NFL: 19/09 2021 Rams 27 Colts 24

Team Stats

Latest regular season and playoff games stats.

Indianapolis Colts Stats

Los Angeles Rams Stats

Moneyline

7 wins and 3 defeats in the last 10 games
4 wins and 6 defeats in the last 10 games on the road

Moneyline

7 wins and 3 defeats in the last 10 games
6 wins and 4 defeats in the last 10 home games

Point Spread

+3.5 Betting Line: Have covered the spread in 7 of the last 10 games
+3.5 Betting Line on the Road: Have covered the spread in 6 of the last 10 games on the road

Point Spread

-3.5 Betting Line: Have covered the spread in 6 of the last 10 games
-3.5 Betting Line at Home: Have covered the spread in 5 of the last 10 home games

Total Points

Game Totals: An average of 53.20 pts in the previous 10 games
Game Totals on the Road: An average of 49.80 pts in the previous 10 games on the road
Over 49.5: Covered in 5 of the previous 10 games
Over 49.5 on the Road: Covered in 4 of the previous 10 games on the road
Team Totals: Have scored an average of 27.20 pts and allowed 26.00 pts in the last 10 games
Team Totals on the Road: Have scored an average of 23.70 pts and allowed 26.10 pts in the last 10 games on the road

Total Points

Game Totals: An average of 42.90 pts in the previous 10 games
Game Totals at Home: An average of 44.50 pts in the previous 10 home games
Over 49.5: Covered in 5 of the previous 10 games
Over 49.5 at Home: Covered in 4 of the previous 10 home games
Team Totals: Have scored an average of 23.50 pts and allowed 19.40 pts in the last 10 games
Team Totals at Home: Have scored an average of 22.70 pts and allowed 21.80 pts in the last 10 home games

Game Stats

Last 10 Games

Total Yards: Gained 375.20 Yds. Allowed 309.00 Yds
Rushing Yards: Gained 157.80 Yds. Allowed 104.00 Yds
Passing Yards: Gained 217.40 Yds. Allowed 205.00 Yds
Total Touchdowns: Scored 2.80 TD. Allowed 3.20 TD
Rushing Touchdowns: Scored 1.70 TD. Allowed 1.10 TD
Passing Touchdowns: Scored 1.00 TD. Allowed 1.80 TD
Total 1st Downs: Picked up 21.00. Allowed 18.00
Total Turnovers: Committed 1.20. Committed by opponents 1.30
Total Penalties: Committed 5.70. Committed by opponents 5.40
Penalty Yards: Lost 43.30 Yds. Gained 55.70 Yds

Game Stats

Last 10 Games

Total Yards: Gained 344.60 Yds. Allowed 311.30 Yds
Rushing Yards: Gained 114.50 Yds. Allowed 118.00 Yds
Passing Yards: Gained 230.10 Yds. Allowed 193.30 Yds
Total Touchdowns: Scored 2.40 TD. Allowed 2.20 TD
Rushing Touchdowns: Scored 0.80 TD. Allowed 0.70 TD
Passing Touchdowns: Scored 1.40 TD. Allowed 1.40 TD
Total 1st Downs: Picked up 18.70. Allowed 18.60
Total Turnovers: Committed 0.70. Committed by opponents 1.10
Total Penalties: Committed 5.50. Committed by opponents 6.20
Penalty Yards: Lost 49.50 Yds. Gained 45.70 Yds

Last 10 Games on the Road

Total Yards: Gained 328.90 Yds. Allowed 343.80 Yds
Rushing Yards: Gained 119.70 Yds. Allowed 129.10 Yds
Passing Yards: Gained 209.20 Yds. Allowed 214.70 Yds
Total Touchdowns: Scored 2.60 TD. Allowed 2.90 TD
Rushing Touchdowns: Scored 1.10 TD. Allowed 0.80 TD
Passing Touchdowns: Scored 1.30 TD. Allowed 1.90 TD
Total 1st Downs: Picked up 19.70. Allowed 18.70
Total Turnovers: Committed 2.00. Committed by opponents 1.30
Total Penalties: Committed 5.10. Committed by opponents 5.80
Penalty Yards: Lost 36.90 Yds. Gained 58.10 Yds

Last 10 Home Games

Total Yards: Gained 333.70 Yds. Allowed 334.60 Yds
Rushing Yards: Gained 96.90 Yds. Allowed 125.50 Yds
Passing Yards: Gained 236.80 Yds. Allowed 209.10 Yds
Total Touchdowns: Scored 2.70 TD. Allowed 2.30 TD
Rushing Touchdowns: Scored 0.90 TD. Allowed 0.80 TD
Passing Touchdowns: Scored 1.40 TD. Allowed 1.50 TD
Total 1st Downs: Picked up 20.20. Allowed 20.00
Total Turnovers: Committed 0.90. Committed by opponents 1.30
Total Penalties: Committed 5.90. Committed by opponents 6.20
Penalty Yards: Lost 51.00 Yds. Gained 47.50 Yds

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Team News

Indianapolis Colts Injuries

Type

Name

Info

Salvon Ahmed

Ankle

DeForest Buckner

Back

Jaylon Carlies

Ankle

Blake Freeland

Leg

Matt Goncalves

Toe

Jaylon Jones

Hamstring

D.J. Montgomery

Undisclosed

Kenny Moore

Achilles

Jacob Phillips

Biceps

Alec Pierce

Concussion

Justin Walley

Knee - ACL

Jack Wilson

Undisclosed

Hunter Wohler

Foot

Los Angeles Rams Injuries

Type

Name

Info

Davante Adams

Hamstring

Rob Havenstein

Ankle

Tyler Higbee

Hip

Colby Parkinson

Shoulder

Keir Thomas

Undisclosed

Ahkello Witherspoon

Collarbone

Previous Indianapolis Colts Lineups

21 Sep NFL

Colts 41-20 Titans

AFC East	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Bills	3	0	1.000	102	71	31	2-0-0	1-0-0	2-0-0	3-0-0	3-0-0	3W
Patriots	1	2	0.333	60	68	-8	0-2-0	1-0-0	1-0-0	1-2-0	1-2-0	1L
Jets	0	3	0.000	69	93	-24	0-2-0	0-1-0	0-1-0	0-2-0	0-3-0	3L
Dolphins	0	3	0.000	56	97	-41	0-1-0	0-2-0	0-2-0	0-3-0	0-3-0	3L

AFC North	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Bengals	2	1	0.667	58	91	-33	1-0-0	1-1-0	1-0-0	2-0-0	2-1-0	1L
Steelers	2	1	0.667	72	77	-5	0-1-0	2-0-0	0-0-0	2-0-0	2-1-0	1W
Ravens	1	2	0.333	111	96	15	1-1-0	0-1-0	1-0-0	1-1-0	1-2-0	1L
Browns	1	2	0.333	46	68	-22	1-1-0	0-1-0	0-2-0	0-2-0	1-2-0	1W

AFC West	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Chargers	3	0	1.000	70	50	20	2-0-0	1-0-0	3-0-0	3-0-0	3-0-0	3W
Raiders	1	2	0.333	53	74	-21	0-1-0	1-1-0	0-1-0	1-1-0	1-2-0	2L
Broncos	1	2	0.333	68	64	4	1-0-0	0-2-0	0-1-0	1-2-0	1-2-0	2L
Chiefs	1	2	0.333	60	56	4	0-1-0	1-1-0	0-1-0	0-1-0	1-2-0	1W

NFC East	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Eagles	3	0	1.000	77	63	14	2-0-0	1-0-0	1-0-0	2-0-0	3-0-0	3W
Commanders	2	1	0.667	80	57	23	2-0-0	0-1-0	1-0-0	1-1-0	2-1-0	1W
Cowboys	1	2	0.333	74	92	-18	1-0-0	0-2-0	1-1-0	1-2-0	1-2-0	1L
Giants	0	3	0.000	52	83	-31	0-1-0	0-2-0	0-2-0	0-2-0	0-3-0	3L

NFC North	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Packers	2	1	0.667	64	44	20	2-0-0	0-1-0	1-0-0	2-0-0	2-1-0	1L
Vikings	2	1	0.667	81	56	25	1-1-0	1-0-0	1-0-0	1-1-0	2-1-0	1W
Lions	2	1	0.667	103	78	25	1-0-0	1-1-0	1-1-0	1-1-0	2-1-0	2W
Bears	1	2	0.333	76	93	-17	1-1-0	0-1-0	0-2-0	1-2-0	1-2-0	1W

NFC South	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Buccaneers	3	0	1.000	72	66	6	1-0-0	2-0-0	1-0-0	1-0-0	3-0-0	3W
Panthers	1	2	0.333	62	53	9	1-0-0	0-2-0	1-0-0	1-1-0	1-2-0	1W
Falcons	1	2	0.333	42	59	-17	0-1-0	1-1-0	0-2-0	1-2-0	1-2-0	1L
Saints	0	3	0.000	47	90	-43	0-2-0	0-1-0	0-0-0	0-3-0	0-3-0	3L

NFC West	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
49ers	3	0	1.000	59	49	10	1-0-0	2-0-0	2-0-0	3-0-0	3-0-0	3W
Cardinals	2	2	0.500	82	74	8	1-1-0	1-1-0	0-2-0	2-2-0	2-2-0	2L
Seahawks	3	1	0.750	111	67	44	1-1-0	2-0-0	1-1-0	2-1-0	3-1-0	3W
Rams	2	1	0.667	73	61	12	1-0-0	1-1-0	0-0-0	0-1-0	2-1-0	1L

NFL Betting Preview: Colts vs Rams

Head-to-Head Statistics

Colts vs Rams Prediction & Picks

Game Prediction

Rams -3.5 Probability

Best Bet

Player Prop Picks

Same Game Parlay Picks

Correct Score Prediction

Colts vs Rams Odds

Last 5 & H2H

Live Streaming

Team News

Indianapolis Colts Injuries

Los Angeles Rams Injuries

Previous Indianapolis Colts Lineups

Previous Los Angeles Rams Lineups

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