Indianapolis Colts
American Football NFL Nissan Stadium Sun 21 Sep 13:00
Tennessee Titans
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  9. Injuries
  10. Standings

NFL Betting Preview: Colts vs Titans

The Indianapolis Colts face the Tennessee Titans in this NFL matchup at Nissan Stadium, with kickoff scheduled for 13:00 on Sunday 21 September. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

A High-Scoring Game On the Cards?

Let’s go for Over 43.5 when the Titans face the Colts. We think the line is too generous and we’re expecting the final total to be higher at -106.

Expecting big plays all over the field? Grab the latest BetMGM promo code and check out our expert site review before locking in your pick.

Colts Beat Titans in Pair’s Last Matchup

Indianapolis Colts beat Denver Broncos in their previous game, making it back-to-back victories. It was a 29-28 home win at Lucas Oil Stadium. The Colts put up 473 total yards, made up of 306 through the air and 167 on the ground. The offense managed 26 first downs to go along with two touchdowns.

Tennessee Titans were defeated last time, making it back-to-back losses. Nissan Stadium saw them beaten 33-19 at home to Los Angeles Rams. The Titans moved the ball for 252 yards, including 143 passing and 109 rushing yards. They scored once through the air and picked up 18 first downs.

Head-to-Head Statistics

The Colts beat the Titans in their last head-to-head matchup. It was a 38-30 scoreline at Lucas Oil Stadium. Each franchise has landed five wins in the previous 10 games between these teams.

Quarterbacks

Colts vs Titans Prediction & Picks

Our Colts vs Titans betting tips provide expert coverage of all major angles, including our main match prediction, top player prop picks, correct score recommendation and best bet builder insights.

Game Prediction

There’s juice available when it comes to backing Over 43.5 points in this NFL matchup and that’s the betting angle we’re pursuing. Our pick is priced up at -106 which looks worth taking.

We put solid research behind every NFL prediction, starting with recent form and a clear read on injuries. From there, key stats and advanced metrics help complete the picture and support smarter betting decisions.

Key Colts vs Titans stats:

  • The 43.5 line has been covered in the last 4 Colts games on the road.
  • The 43.5 line has been covered in 8 of the last 10 Colts games.
  • The 43.5 line has been covered in 12 of the last 20 Colts games on the road.

Over 43.5 Probability

The best betting apps make it a 51.5% chance that our pick is settled as a winner. Based on our in-depth research, we calculate the actual probability to be 55-60%. That means we are regarding it as a value wager.

Looking for Bigger Odds?

It’s possible to increase the odds on your Over wager by combining it with other picks. A Bet Builder allows you to place multiple bets from the same game into one single parlay.

Getting ready to place a wager? Check our updated guide for the latest betting offers, including free bets and the newest promos codes.

Best Bet

Over 43.5 Points @ -106 Watch Live Bet Now BetMGM logo
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Published 19:27, 19 September 2025

Player Prop Picks

Top Pick: Cam Ward Over 198.5 Passing Yards -114 BetMGM logo

The odds for Cam Ward (Titans) to rack up over 198.5 passing yards stand at -114. The line for QB Passing Yards looks attractive and we’re confident of securing a return.

Latest Cam Ward Player Prop Odds

Michael Pittman Jr. Over 44.5 Receiving Yards -114 BetMGM logo

The odds for Michael Pittman Jr. (Titans) to go beyond 44.5 receiving yards are -114. There’s an opportunity to place a Player Receiving Yards bet, with him capable of covering an appealing line.

Latest Michael Pittman Jr. Player Prop Odds

Same Game Parlay Picks

Totals Over 43.5
Spread Colts -4.5
Passing Yards Cam Ward Over 198.5

Get in the game with a same game parlay. Our picks are Over 43.5 on the total, Colts to cover the -4.5 spread and Cam Ward (Titans) to go Over 198.5 passing yards.

We recommend a same game parlay as it’s an exciting way of wagering on a single event. Many bettors like to create a personalised football bet which reflects their predictions for how a game is going to play out.

T&C apply. Gamble responsibly 18+

Correct Score Prediction

Colts Colts logo 27 - 21 Titans logo Titans

The Colts might be able to claim a victory and we’re siding with a 27-21 scoreline in their favor. A small stake can provide a big return and there are monster odds available.

Colts vs Titans Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Books Make Colts Moneyline Favorites

With a 67% chance of securing victory, Indianapolis Colts are favorites for this game and the sportsbooks have them at betting odds of -204. For those wanting to back Tennessee Titans, you will find +172 about the underdogs.

The spread is calculated to be 4.5, while total points comes in at 43.5. The Totals offers NFL fans an alternative way of getting involved. If you fancy Over 43.5, this outcome can be backed at -106.

If a National Football League wager is on your mind, visit the top sportsbooks and check out the huge selection of available game lines and team props. Find the betting odds and lines which are the most appealing.

Jonathan Taylor Favorite to Be First TD Scorer

Jonathan Taylor is the First Touchdown Scorer favorite at +310. Alternatively, there’s the chance to simply back him to score a TD anytime at -208.

Touchdown

Jonathan Taylor (Colts)
First TD
+310
Anytime TD
-208
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Tony Pollard (Titans)
First TD
+550
Anytime TD
-115
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Daniel Jones (Colts)
First TD
+950
Anytime TD
+195
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Receiving Yards

Calvin Ridley (Titans)
Over 52.5
-114
Under 52.5
-114
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Michael Pittman Jr. (Colts)
Over 44.5
-114
Under 44.5
-114
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Rushing Yards

Passing Yards

Best Betting Offers
Nissan Stadium
Nissan Stadium

Titans With Five Consecutive Home Losses

The Titans have endured a run of five straight defeats at Nissan Stadium. They have a 2-8 record in their last 10 home games, putting up 17.50 points on average and giving up 23.70.

The Colts have a 3-7 record in their last 10 games on the road, averaging 20.60 points on offense and surrendering 27.00 on defense.

In their most recent matchup at Nissan Stadium, the Colts got the better of the Titans 20-17. Over the last 6 head-to-head clashes at Nissan Stadium, the Colts have secured four victories, as the Titans have picked up two.

Last 10 Games W-L P PF PA O43.5 U43.5
Titans logo Titans Home Stats 2-8 41.20 17.50 23.70 4 6
Colts logo Colts Away Stats 3-7 47.60 20.60 27.00 5 5
  • W-L = Wins-Losses
  • P = Avg. Points
  • PF = Avg. Points For
  • PA = Avg. Points Against
  • O43.5 = Games Over 43.5 Points
  • U43.5 = Games Under 43.5 Points
Team Stats

Latest regular season and playoff games stats.

Indianapolis Colts logo Indianapolis Colts Stats
Tennessee Titans logo Tennessee Titans Stats
Moneyline
  • 6 wins and 4 defeats in the last 10 games
  • 3 wins and 7 defeats in the last 10 games on the road
Moneyline
  • 1 win and 9 defeats in the last 10 games
  • 2 wins and 8 defeats in the last 10 home games
Point Spread
Point Spread
Total Points
Total Points
Game Stats
Last 10 Games
Game Stats
Last 10 Games
Last 10 Games on the Road
Last 10 Home Games

Live Streaming

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It’s great to enjoy thousands of sporting events on an annual basis. Watch the action and get audio commentary too.

Team News

Indianapolis Colts Injuries

Type
Name
Info
Salvon Ahmed
Ankle
Joe Bachie
Quadriceps
Jaylon Carlies
Ankle
Blake Freeland
Leg
Jaylon Jones
Hamstring
D.J. Montgomery
Undisclosed
Jacob Phillips
Biceps
Bernhard Raimann
Illness
Justin Walley
Knee - ACL
Charvarius Ward
Concussion
Tyler Warren
Toe
Jack Wilson
Undisclosed
Hunter Wohler
Foot

Tennessee Titans Injuries

Type
Name
Info
Jarvis Brownlee
Ankle
Treylon Burks
Collarbone
JC Latham
Hip
Will Levis
Shoulder
Kalel Mullings
Ankle
Bryce Oliver
Knee
Anfernee Orji
Knee - ACL
L'Jarius Sneed
Back
Tyjae Spears
Ankle
T'Vondre Sweat
Ankle
Kevin Winston
Hamstring
Kevin Zeitler
Biceps

Previous Indianapolis Colts Lineups

14 Sep NFL
Broncos 28-29 Colts
07 Sep NFL
Dolphins 8-33 Colts
05 Jan NFL
Jaguars 23-26 Colts
29 Dec NFL
Colts 33-45 Giants
22 Dec NFL
Titans 30-38 Colts
15 Dec NFL
Colts 13-31 Broncos
01 Dec NFL
Colts 25-24 Patriots
24 Nov NFL
Lions 24-6 Colts
17 Nov NFL
Colts 28-27 Jets
10 Nov NFL
Bills 30-20 Colts

Previous Tennessee Titans Lineups

14 Sep NFL
Rams 33-19 Titans
07 Sep NFL
Titans 12-20 Broncos
05 Jan NFL
Texans 23-14 Titans
29 Dec NFL
Titans 13-20 Jaguars
22 Dec NFL
Titans 30-38 Colts
15 Dec NFL
Bengals 37-27 Titans
08 Dec NFL
Jaguars 10-6 Titans
01 Dec NFL
Titans 19-42 Commanders
24 Nov NFL
Titans 32-27 Texans
17 Nov NFL
Vikings 23-13 Titans

NFL Standings Select Season

AFC East W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Bills 3 0 0 1.000 102 71 31 2-0-0 1-0-0 2-0-0 3-0-0 3-0-0 3W
Patriots 1 1 0 0.500 46 47 -1 0-1-0 1-0-0 1-0-0 1-1-0 1-1-0 1W
Jets 0 2 0 0.000 42 64 -22 0-2-0 0-0-0 0-1-0 0-2-0 0-2-0 2L
Dolphins 0 3 0 0.000 56 97 -41 0-1-0 0-2-0 0-2-0 0-3-0 0-3-0 3L
AFC North W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Bengals 2 0 0 1.000 48 43 5 1-0-0 1-0-0 1-0-0 2-0-0 2-0-0 2W
Ravens 1 1 0 0.500 81 58 23 1-0-0 0-1-0 1-0-0 1-1-0 1-1-0 1W
Steelers 1 1 0 0.500 51 63 -12 0-1-0 1-0-0 0-0-0 1-0-0 1-1-0 1L
Browns 0 2 0 0.000 33 58 -25 0-1-0 0-1-0 0-2-0 0-2-0 0-2-0 2L
AFC South W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Colts 2 0 0 1.000 62 36 26 2-0-0 0-0-0 0-0-0 2-0-0 2-0-0 2W
Jaguars 1 1 0 0.500 53 41 12 1-0-0 0-1-0 0-0-0 0-1-0 1-1-0 1L
Texans 0 2 0 0.000 28 34 -6 0-1-0 0-1-0 0-0-0 0-0-0 0-2-0 2L
Titans 0 2 0 0.000 31 53 -22 0-1-0 0-1-0 0-0-0 0-1-0 0-2-0 2L
AFC West W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Chargers 2 0 0 1.000 47 30 17 1-0-0 1-0-0 2-0-0 2-0-0 2-0-0 2W
Raiders 1 1 0 0.500 29 33 -4 0-1-0 1-0-0 0-1-0 1-1-0 1-1-0 1L
Broncos 1 1 0 0.500 48 41 7 1-0-0 0-1-0 0-0-0 1-1-0 1-1-0 1L
Chiefs 0 2 0 0.000 38 47 -9 0-1-0 0-1-0 0-1-0 0-1-0 0-2-0 2L
NFC East W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Eagles 2 0 0 1.000 44 37 7 1-0-0 1-0-0 1-0-0 1-0-0 2-0-0 2W
Commanders 1 1 0 0.500 39 33 6 1-0-0 0-1-0 1-0-0 1-1-0 1-1-0 1L
Cowboys 1 1 0 0.500 60 61 -1 1-0-0 0-1-0 1-1-0 1-1-0 1-1-0 1W
Giants 0 2 0 0.000 43 61 -18 0-0-0 0-2-0 0-2-0 0-2-0 0-2-0 2L
NFC North W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Packers 2 0 0 1.000 54 31 23 2-0-0 0-0-0 1-0-0 2-0-0 2-0-0 2W
Vikings 1 1 0 0.500 33 46 -13 0-1-0 1-0-0 1-0-0 1-1-0 1-1-0 1L
Lions 1 1 0 0.500 65 48 17 1-0-0 0-1-0 1-1-0 1-1-0 1-1-0 1W
Bears 0 2 0 0.000 45 79 -34 0-1-0 0-1-0 0-2-0 0-2-0 0-2-0 2L
NFC South W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Buccaneers 2 0 0 1.000 43 39 4 0-0-0 2-0-0 1-0-0 1-0-0 2-0-0 2W
Falcons 1 1 0 0.500 42 29 13 0-1-0 1-0-0 0-1-0 1-1-0 1-1-0 1W
Saints 0 2 0 0.000 34 46 -12 0-2-0 0-0-0 0-0-0 0-2-0 0-2-0 2L
Panthers 0 2 0 0.000 32 53 -21 0-0-0 0-2-0 0-0-0 0-1-0 0-2-0 2L
NFC West W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
49ers 2 0 0 1.000 43 34 9 0-0-0 2-0-0 1-0-0 2-0-0 2-0-0 2W
Cardinals 2 0 0 1.000 47 35 12 1-0-0 1-0-0 0-0-0 2-0-0 2-0-0 2W
Rams 2 0 0 1.000 47 28 19 1-0-0 1-0-0 0-0-0 0-0-0 2-0-0 2W
Seahawks 1 1 0 0.500 44 34 10 0-1-0 1-0-0 0-1-0 0-1-0 1-1-0 1W
AFC Conference W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Bills 3 0 0 1.000 102 71 31 2-0-0 1-0-0 2-0-0 3-0-0 3-0-0 3W
Chargers 2 0 0 1.000 47 30 17 1-0-0 1-0-0 2-0-0 2-0-0 2-0-0 2W
Bengals 2 0 0 1.000 48 43 5 1-0-0 1-0-0 1-0-0 2-0-0 2-0-0 2W
Colts 2 0 0 1.000 62 36 26 2-0-0 0-0-0 0-0-0 2-0-0 2-0-0 2W
Raiders 1 1 0 0.500 29 33 -4 0-1-0 1-0-0 0-1-0 1-1-0 1-1-0 1L
Ravens 1 1 0 0.500 81 58 23 1-0-0 0-1-0 1-0-0 1-1-0 1-1-0 1W
Patriots 1 1 0 0.500 46 47 -1 0-1-0 1-0-0 1-0-0 1-1-0 1-1-0 1W
Steelers 1 1 0 0.500 51 63 -12 0-1-0 1-0-0 0-0-0 1-0-0 1-1-0 1L
Broncos 1 1 0 0.500 48 41 7 1-0-0 0-1-0 0-0-0 1-1-0 1-1-0 1L
Jaguars 1 1 0 0.500 53 41 12 1-0-0 0-1-0 0-0-0 0-1-0 1-1-0 1L
Titans 0 2 0 0.000 31 53 -22 0-1-0 0-1-0 0-0-0 0-1-0 0-2-0 2L
Chiefs 0 2 0 0.000 38 47 -9 0-1-0 0-1-0 0-1-0 0-1-0 0-2-0 2L
Jets 0 2 0 0.000 42 64 -22 0-2-0 0-0-0 0-1-0 0-2-0 0-2-0 2L
Browns 0 2 0 0.000 33 58 -25 0-1-0 0-1-0 0-2-0 0-2-0 0-2-0 2L
Texans 0 2 0 0.000 28 34 -6 0-1-0 0-1-0 0-0-0 0-0-0 0-2-0 2L
Dolphins 0 3 0 0.000 56 97 -41 0-1-0 0-2-0 0-2-0 0-3-0 0-3-0 3L
NFC Conference W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Packers 2 0 0 1.000 54 31 23 2-0-0 0-0-0 1-0-0 2-0-0 2-0-0 2W
Eagles 2 0 0 1.000 44 37 7 1-0-0 1-0-0 1-0-0 1-0-0 2-0-0 2W
Buccaneers 2 0 0 1.000 43 39 4 0-0-0 2-0-0 1-0-0 1-0-0 2-0-0 2W
49ers 2 0 0 1.000 43 34 9 0-0-0 2-0-0 1-0-0 2-0-0 2-0-0 2W
Cardinals 2 0 0 1.000 47 35 12 1-0-0 1-0-0 0-0-0 2-0-0 2-0-0 2W
Rams 2 0 0 1.000 47 28 19 1-0-0 1-0-0 0-0-0 0-0-0 2-0-0 2W
Falcons 1 1 0 0.500 42 29 13 0-1-0 1-0-0 0-1-0 1-1-0 1-1-0 1W
Commanders 1 1 0 0.500 39 33 6 1-0-0 0-1-0 1-0-0 1-1-0 1-1-0 1L
Vikings 1 1 0 0.500 33 46 -13 0-1-0 1-0-0 1-0-0 1-1-0 1-1-0 1L
Cowboys 1 1 0 0.500 60 61 -1 1-0-0 0-1-0 1-1-0 1-1-0 1-1-0 1W
Lions 1 1 0 0.500 65 48 17 1-0-0 0-1-0 1-1-0 1-1-0 1-1-0 1W
Seahawks 1 1 0 0.500 44 34 10 0-1-0 1-0-0 0-1-0 0-1-0 1-1-0 1W
Panthers 0 2 0 0.000 32 53 -21 0-0-0 0-2-0 0-0-0 0-1-0 0-2-0 2L
Bears 0 2 0 0.000 45 79 -34 0-1-0 0-1-0 0-2-0 0-2-0 0-2-0 2L
Saints 0 2 0 0.000 34 46 -12 0-2-0 0-0-0 0-0-0 0-2-0 0-2-0 2L
Giants 0 2 0 0.000 43 61 -18 0-0-0 0-2-0 0-2-0 0-2-0 0-2-0 2L
NFL Team W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Cardinals 2 0 0 1.000 47 35 12 1-0-0 1-0-0 0-0-0 2-0-0 2-0-0 2W
Bengals 2 0 0 1.000 48 43 5 1-0-0 1-0-0 1-0-0 2-0-0 2-0-0 2W
Packers 2 0 0 1.000 54 31 23 2-0-0 0-0-0 1-0-0 2-0-0 2-0-0 2W
Colts 2 0 0 1.000 62 36 26 2-0-0 0-0-0 0-0-0 2-0-0 2-0-0 2W
Chargers 2 0 0 1.000 47 30 17 1-0-0 1-0-0 2-0-0 2-0-0 2-0-0 2W
Rams 2 0 0 1.000 47 28 19 1-0-0 1-0-0 0-0-0 0-0-0 2-0-0 2W
Eagles 2 0 0 1.000 44 37 7 1-0-0 1-0-0 1-0-0 1-0-0 2-0-0 2W
49ers 2 0 0 1.000 43 34 9 0-0-0 2-0-0 1-0-0 2-0-0 2-0-0 2W
Buccaneers 2 0 0 1.000 43 39 4 0-0-0 2-0-0 1-0-0 1-0-0 2-0-0 2W
Bills 3 0 0 1.000 102 71 31 2-0-0 1-0-0 2-0-0 3-0-0 3-0-0 3W
Falcons 1 1 0 0.500 42 29 13 0-1-0 1-0-0 0-1-0 1-1-0 1-1-0 1W
Ravens 1 1 0 0.500 81 58 23 1-0-0 0-1-0 1-0-0 1-1-0 1-1-0 1W
Cowboys 1 1 0 0.500 60 61 -1 1-0-0 0-1-0 1-1-0 1-1-0 1-1-0 1W
Broncos 1 1 0 0.500 48 41 7 1-0-0 0-1-0 0-0-0 1-1-0 1-1-0 1L
Lions 1 1 0 0.500 65 48 17 1-0-0 0-1-0 1-1-0 1-1-0 1-1-0 1W
Jaguars 1 1 0 0.500 53 41 12 1-0-0 0-1-0 0-0-0 0-1-0 1-1-0 1L
Raiders 1 1 0 0.500 29 33 -4 0-1-0 1-0-0 0-1-0 1-1-0 1-1-0 1L
Vikings 1 1 0 0.500 33 46 -13 0-1-0 1-0-0 1-0-0 1-1-0 1-1-0 1L
Patriots 1 1 0 0.500 46 47 -1 0-1-0 1-0-0 1-0-0 1-1-0 1-1-0 1W
Steelers 1 1 0 0.500 51 63 -12 0-1-0 1-0-0 0-0-0 1-0-0 1-1-0 1L
Seahawks 1 1 0 0.500 44 34 10 0-1-0 1-0-0 0-1-0 0-1-0 1-1-0 1W
Commanders 1 1 0 0.500 39 33 6 1-0-0 0-1-0 1-0-0 1-1-0 1-1-0 1L
Panthers 0 2 0 0.000 32 53 -21 0-0-0 0-2-0 0-0-0 0-1-0 0-2-0 2L
Bears 0 2 0 0.000 45 79 -34 0-1-0 0-1-0 0-2-0 0-2-0 0-2-0 2L
Browns 0 2 0 0.000 33 58 -25 0-1-0 0-1-0 0-2-0 0-2-0 0-2-0 2L
Texans 0 2 0 0.000 28 34 -6 0-1-0 0-1-0 0-0-0 0-0-0 0-2-0 2L
Chiefs 0 2 0 0.000 38 47 -9 0-1-0 0-1-0 0-1-0 0-1-0 0-2-0 2L
Dolphins 0 3 0 0.000 56 97 -41 0-1-0 0-2-0 0-2-0 0-3-0 0-3-0 3L
Saints 0 2 0 0.000 34 46 -12 0-2-0 0-0-0 0-0-0 0-2-0 0-2-0 2L
Giants 0 2 0 0.000 43 61 -18 0-0-0 0-2-0 0-2-0 0-2-0 0-2-0 2L
Jets 0 2 0 0.000 42 64 -22 0-2-0 0-0-0 0-1-0 0-2-0 0-2-0 2L
Titans 0 2 0 0.000 31 53 -22 0-1-0 0-1-0 0-0-0 0-1-0 0-2-0 2L