Colts vs Titans Prediction, Picks & Odds | 21 Sep 2025

NFL Betting Preview: Colts vs Titans

The Indianapolis Colts face the Tennessee Titans in this NFL Week 3 matchup at Nissan Stadium, with kickoff scheduled for 13:00 on Sunday, September 21. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

Let’s go for Over 43.5 when the Titans face the Colts. We think the line is too generous and we’re expecting the final total to be higher at -106.

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Indianapolis Colts beat Denver Broncos in their previous game, making it back-to-back victories. It was a 29-28 home win at Lucas Oil Stadium. The Colts put up 473 total yards, made up of 306 through the air and 167 on the ground. The offense managed 26 first downs to go along with two touchdowns.

Tennessee Titans were defeated last time, making it back-to-back losses. Nissan Stadium saw them beaten 33-19 at home to Los Angeles Rams. The Titans moved the ball for 252 yards, including 143 passing and 109 rushing yards. They scored once through the air and picked up 18 first downs.

Head-to-Head Statistics

The Colts beat the Titans in their last head-to-head matchup. It was a 38-30 scoreline at Lucas Oil Stadium. Each franchise has landed five wins in the previous 10 games between these teams.

Quarterbacks

Daniel Jones

214.5 Passing Yards

Over -112

Under -112

Cam Ward

198.5 Passing Yards

Over -112

Under -112

Colts vs Titans Prediction & Picks

Our Colts vs Titans betting tips provide expert coverage of all major angles, including our main match prediction, top player prop picks, correct score recommendation and best bet builder insights.

Game Prediction

There’s juice available when it comes to backing Over 43.5 points in this NFL matchup and that’s the betting angle we’re pursuing. Our pick is priced up at -106 which looks worth taking.

We put solid research behind every NFL prediction, starting with recent form and a clear read on injuries. From there, key stats and advanced metrics help complete the picture and support smarter betting decisions.

Key Colts vs Titans stats:

• The 43.5 line has been covered in the last 4 Colts games on the road.
• The 43.5 line has been covered in 8 of the last 10 Colts games.
• The 43.5 line has been covered in 12 of the last 20 Colts games on the road.

Over 43.5 Probability

The best betting apps make it a 51.5% chance that our pick is settled as a winner. Based on our in-depth research, we calculate the actual probability to be 55-60%. That means we are regarding it as a value wager.

It’s possible to increase the odds on your Over wager by combining it with other picks. A Bet Builder allows you to place multiple bets from the same game into one single parlay.

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Our Game Prediction

Over 43.5 Points @ -106 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (19:27, 19 September 2025). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Cam Ward Over 198.5 Passing Yards -114

The odds for Cam Ward (Titans) to rack up over 198.5 passing yards stand at -114. The line for QB Passing Yards looks attractive and we’re confident of securing a return.

Latest Cam Ward Player Prop Odds

Touchdown

Anytime

+700

First

+3300

Passing Yards

Over 198.5

-112

Under 198.5

-112

Rushing Yards

Over 11.5

-112

Under 11.5

-112

---

Michael Pittman Jr. Over 44.5 Receiving Yards -114

The odds for Michael Pittman Jr. (Titans) to go beyond 44.5 receiving yards are -114. There’s an opportunity to place a Player Receiving Yards bet, with him capable of covering an appealing line.

Latest Michael Pittman Jr. Player Prop Odds

Touchdown

Anytime

+240

First

+1200

Receiving Yards

Over 44.5

-112

Under 44.5

-112

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Colts 27 - 21 Titans

The Colts might be able to claim a victory and we’re siding with a 27-21 scoreline in their favor. A small stake can provide a big return and there are monster odds available.

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Colts vs Titans Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

With a 70% chance of securing victory, Indianapolis Colts are favorites for this game and the sportsbooks have them at betting odds of -233. For those wanting to back Tennessee Titans, you will find +194 about the underdogs.

The spread is calculated to be 5.5, while total points comes in at 43.5. The Totals offers NFL fans an alternative way of getting involved. If you fancy Over 43.5, this outcome can be backed at -106.

If a National Football League wager is on your mind, visit the top sportsbooks and check out the huge selection of available game lines and team props. Find the betting odds and lines which are the most appealing.

Moneyline

Colts

-233

Titans

+194

Point Spread

Colts -5.5

-105

Titans +5.5

-115

Total Points

Under 43.5

-114

Over 43.5

-106

Jonathan Taylor is the First Touchdown Scorer favorite at +290. Alternatively, there’s the chance to simply back him to score a TD anytime at -222.

Touchdown

Jonathan Taylor (Colts)

First TD

+290

Anytime TD

-222

Tony Pollard (Titans)

First TD

+600

Anytime TD

-105

Daniel Jones (Colts)

First TD

+900

Anytime TD

+195

Tyler Warren (Colts)

First TD

+1100

Anytime TD

+240

Michael Pittman Jr. (Colts)

First TD

+1200

Anytime TD

+240

Calvin Ridley (Titans)

First TD

+1300

Anytime TD

+210

Josh Downs (Colts)

First TD

+1500

Anytime TD

+320

Alec Pierce (Colts)

First TD

+1800

Anytime TD

+420

Elic Ayomanor (Titans)

First TD

+2000

Anytime TD

+350

Chigoziem Okonkwo (Titans)

First TD

+2000

Anytime TD

+360

Chimere Dike (Titans)

First TD

+2500

Anytime TD

+500

Cam Ward (Titans)

First TD

+3300

Anytime TD

+700

Tyler Lockett (Titans)

First TD

+3500

Anytime TD

+800

Adonai Mitchell (Colts)

First TD

+3500

Anytime TD

+1000

Ulysses Bentley IV (Colts)

First TD

+4000

Anytime TD

+750

Tyler Goodson (Colts)

First TD

+4000

Anytime TD

+900

Julius Chestnut (Titans)

First TD

+4500

Anytime TD

+1000

Mo Alie-Cox (Colts)

First TD

+5000

Anytime TD

+1300

Bryce Oliver (Titans)

First TD

+6000

Anytime TD

+1400

Van Jefferson (Titans)

First TD

+6000

Anytime TD

+1400

Gunnar Helm (Titans)

First TD

+6000

Anytime TD

+1300

Will Mallory (Colts)

First TD

+8000

Anytime TD

+2500

Drew Ogletree (Colts)

First TD

+8000

Anytime TD

+2500

DJ Giddens (Colts)

First TD

+8000

Anytime TD

+1600

David Martin-Robinson (Titans)

First TD

+10000

Anytime TD

+4000

Anthony Gould (Colts)

First TD

+10000

Anytime TD

+2500

Ashton Dulin (Colts)

First TD

+10000

Anytime TD

+3000

Jordan Mims (Titans)

First TD

+10000

Anytime TD

+2700

Kalel Mullings (Titans)

First TD

+10000

Anytime TD

+2000

Receiving Yards

Calvin Ridley (Titans)

Over 50.5

-112

Under 50.5

-112

Tyler Warren (Colts)

Over 46.5

-112

Under 46.5

-112

Michael Pittman Jr. (Colts)

Over 44.5

-112

Under 44.5

-112

Elic Ayomanor (Titans)

Over 40.5

-112

Under 40.5

-112

Josh Downs (Colts)

Over 37.5

-112

Under 37.5

-112

Chigoziem Okonkwo (Titans)

Over 32.5

-112

Under 32.5

-112

Alec Pierce (Colts)

Over 26.5

-112

Under 26.5

-112

Tony Pollard (Titans)

Over 13.5

-112

Under 13.5

-112

Jonathan Taylor (Colts)

Over 13.5

-112

Under 13.5

-112

Tyler Lockett (Titans)

Over 12.5

-112

Under 12.5

-112

Adonai Mitchell (Colts)

Over 9.5

-112

Under 9.5

-112

Rushing Yards

Jonathan Taylor (Colts)

Over 92.5

-112

Under 92.5

-112

Tony Pollard (Titans)

Over 70.5

-112

Under 70.5

-112

Daniel Jones (Colts)

Over 23.5

-112

Under 23.5

-112

Cam Ward (Titans)

Over 11.5

-112

Under 11.5

-112

Passing Yards

Daniel Jones (Colts)

Over 214.5

-112

Under 214.5

-112

Cam Ward (Titans)

Over 198.5

-112

Under 198.5

-112

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Titans With Five Consecutive Home Losses

The Titans have endured a run of five straight defeats at Nissan Stadium. They have a 2-8 record in their last 10 home games, putting up 17.50 points on average and giving up 23.70.

The Colts have a 3-7 record in their last 10 games on the road, averaging 20.60 points on offense and surrendering 27.00 on defense.

In their most recent matchup at Nissan Stadium, the Colts got the better of the Titans 20-17. Over the last 6 head-to-head clashes at Nissan Stadium, the Colts have secured four victories, as the Titans have picked up two.

Last 10 Games		W-L	P	PF	PA	O43.5	U43.5
Titans Home Stats		2-8	41.20	17.50	23.70	4	6
Colts Away Stats		3-7	47.60	20.60	27.00	5	5

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O43.5 = Games Over 43.5 Points
• U43.5 = Games Under 43.5 Points

Latest regular season and playoff games stats.

Indianapolis Colts Stats

Tennessee Titans Stats

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 3 wins and 7 defeats in the last 10 games on the road

Moneyline

• 1 win and 9 defeats in the last 10 games
• 2 wins and 8 defeats in the last 10 home games

Point Spread

• -4.5 Betting Line: Have covered the spread in 2 of the last 10 games
• -4.5 Betting Line on the Road: Have not covered the spread in any of the last 10 games on the road

Point Spread

• +4.5 Betting Line: Have covered the spread in 2 of the last 10 games
• +4.5 Betting Line at Home: Have covered the spread in 4 of the last 10 home games

Total Points

• Game Totals: An average of 52.10 pts in the previous 10 games
• Game Totals on the Road: An average of 47.60 pts in the previous 10 games on the road
• Over 43.5: Covered in 8 of the previous 10 games
• Over 43.5 on the Road: Covered in 5 of the previous 10 games on the road
• Team Totals: Have scored an average of 25.10 pts and allowed 27.00 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 20.60 pts and allowed 27.00 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 45.80 pts in the previous 10 games
• Game Totals at Home: An average of 41.20 pts in the previous 10 home games
• Over 43.5: Covered in 5 of the previous 10 games
• Over 43.5 at Home: Covered in 4 of the previous 10 home games
• Team Totals: Have scored an average of 18.50 pts and allowed 27.30 pts in the last 10 games
• Team Totals at Home: Have scored an average of 17.50 pts and allowed 23.70 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 374.80 Yds. Allowed 322.30 Yds
• Rushing Yards: Gained 156.20 Yds. Allowed 108.90 Yds
• Passing Yards: Gained 218.60 Yds. Allowed 213.40 Yds
• Total Touchdowns: Scored 2.50 TD. Allowed 3.30 TD
• Rushing Touchdowns: Scored 1.40 TD. Allowed 1.20 TD
• Passing Touchdowns: Scored 1.10 TD. Allowed 1.70 TD
• Total 1st Downs: Picked up 20.70. Allowed 18.00
• Total Turnovers: Committed 1.60. Committed by opponents 1.40
• Total Penalties: Committed 5.80. Committed by opponents 5.40
• Penalty Yards: Lost 43.50 Yds. Gained 54.30 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 289.70 Yds. Allowed 358.40 Yds
• Rushing Yards: Gained 89.80 Yds. Allowed 152.40 Yds
• Passing Yards: Gained 199.90 Yds. Allowed 206.00 Yds
• Total Touchdowns: Scored 1.70 TD. Allowed 3.40 TD
• Rushing Touchdowns: Scored 0.50 TD. Allowed 1.40 TD
• Passing Touchdowns: Scored 1.20 TD. Allowed 1.70 TD
• Total 1st Downs: Picked up 16.40. Allowed 20.20
• Total Turnovers: Committed 2.00. Committed by opponents 1.70
• Total Penalties: Committed 8.60. Committed by opponents 7.00
• Penalty Yards: Lost 68.40 Yds. Gained 56.70 Yds

Last 10 Games on the Road

• Total Yards: Gained 318.60 Yds. Allowed 356.20 Yds
• Rushing Yards: Gained 115.20 Yds. Allowed 138.20 Yds
• Passing Yards: Gained 203.40 Yds. Allowed 218.00 Yds
• Total Touchdowns: Scored 2.20 TD. Allowed 2.90 TD
• Rushing Touchdowns: Scored 0.90 TD. Allowed 0.80 TD
• Passing Touchdowns: Scored 1.20 TD. Allowed 1.90 TD
• Total 1st Downs: Picked up 19.50. Allowed 18.90
• Total Turnovers: Committed 2.10. Committed by opponents 1.20
• Total Penalties: Committed 5.10. Committed by opponents 5.40
• Penalty Yards: Lost 37.50 Yds. Gained 54.80 Yds

Last 10 Home Games

• Total Yards: Gained 301.10 Yds. Allowed 336.00 Yds
• Rushing Yards: Gained 108.70 Yds. Allowed 117.00 Yds
• Passing Yards: Gained 192.40 Yds. Allowed 219.00 Yds
• Total Touchdowns: Scored 1.90 TD. Allowed 2.80 TD
• Rushing Touchdowns: Scored 0.60 TD. Allowed 0.90 TD
• Passing Touchdowns: Scored 1.30 TD. Allowed 1.60 TD
• Total 1st Downs: Picked up 18.20. Allowed 19.60
• Total Turnovers: Committed 1.70. Committed by opponents 1.50
• Total Penalties: Committed 7.90. Committed by opponents 6.80
• Penalty Yards: Lost 62.50 Yds. Gained 54.70 Yds

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