Jaguars vs Cardinals Prediction, Picks & Odds | 23 Nov 2025

NFL Betting Preview: Jaguars vs Cardinals

The Jacksonville Jaguars square off against the Arizona Cardinals at State Farm Stadium, with kickoff scheduled for 16:05 on Sunday, November 23.

Over 47.5 points seems like a realistic outcome when the Cardinals go up against the Jaguars. We’re taking odds of -105 on the basis that the total line is too low.

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Jacksonville Jaguars won their previous game which was at home. It was a 35-6 triumph at EverBank Stadium against Los Angeles Chargers. The Jaguars moved the ball for 345 yards, with 153 through the air and 192 on the ground. They moved the chains 30 times and produced 5 touchdowns.

Arizona Cardinals were defeated last time, making it four home losses on the spin. State Farm Stadium saw them beaten 41-22 against San Francisco 49ers. The Cardinals put up 488 yards, split between 452 passing and 36 rushing yards. The offense managed 24 first downs and found the end zone 3 times.

Head-to-Head Statistics

These two teams last met at EverBank Stadium, with the Cardinals claiming the win. Beating the Jaguars by a 31-19 scoreline.

Quarterbacks

Trevor Lawrence

214.5 Passing Yards

Over -114

Under -114

Jacoby Brissett

243.5 Passing Yards

Over -114

Under -114

Jaguars vs Cardinals Prediction & Picks

Your complete Jaguars vs Cardinals betting guide is here, including our go-to match prediction, scoreline call, standout prop selections and a customized bet builder.

Game Prediction

We think the best betting angle can be found with the totals for this NFL battle. Our pick is that there will be Over 47.5 points and that is available at -105.

The formbook is always a smart starting point when making NFL picks. Up-to-date team news is just as important, while the stats we provide often reveal valuable insights.

Key Jaguars vs Cardinals stats:

• The 47.5 line has been covered in 4 of the last 5 Jaguars games on the road.
• The 47.5 line has been covered in 3 of the last 4 Jaguars games on the road this season.
• The 47.5 line has been covered in the last 2 Jaguars games on the road.
• The 47.5 line has been covered in 4 of the last 5 Cardinals games.
• The 47.5 line has been covered in 12 of the last 20 Cardinals games at home.
• The 47.5 line has been covered in the last 2 Cardinals games.

Over 47.5 Probability

If you go by the top betting sites, there’s a 51.3% likelihood of our pick landing a return. Based on our analysts in-depth research, we calculate the actual probability to be 55-60%. That means we are regarding it as a value wager.

In order to land bigger odds on your Overs wager, it’s possible to combine this with the winning franchise. The Result & Total lines can provide a larger potential payout.

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Our Game Prediction

Over 47.5 Points @ -105 Bet Now

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Player Prop Picks

Top Pick: Trey McBride Anytime TD -120

You can place a bet on Trey McBride (Cardinals) to record a TD at -120. We believe there’s merit in backing him for an Anytime Touchdown Scorer prop wager, meaning we need him to punch it in.

Latest Trey McBride Player Prop Odds

Touchdown

Anytime

-120

First

+600

Receiving Yards

Over 75.5

-114

Under 75.5

-114

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Michael Wilson Over 62.5 Receiving Yards -114

Michael Wilson (Jaguars) is priced at -114 to surpass 62.5 receiving yards. There’s an opportunity to place a Player Receiving Yards bet, with him capable of covering an appealing line.

Latest Michael Wilson Player Prop Odds

Touchdown

Anytime

+210

First

+1100

Receiving Yards

Over 62.5

-114

Under 62.5

-114

Correct Score Prediction

Jaguars 31 - 21 Cardinals

The Jaguars might be able to claim a victory and we’re siding with a 31-21 scoreline in their favor. A small stake can provide a big return and there are monster odds available.

Jaguars vs Cardinals Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

The Jacksonville Jaguars odds have been priced up by the sportsbooks and they are -159 betting favorites to land victory in this game which means a 61% chance of winning. Arizona Cardinals are trading at bigger odds than their opponents and they can be backed at +134.

The spread is calculated to be 2.5, while total points comes in at 47.5. Having a wager on the Totals is one of the most popular NFL bets. There’s an opportunity to bet Over 47.5 at -105.

Whether you are wagering pre-game or in-game on the National Football League, the best betting apps offer a wide range of game lines and team props. The selections are practically endless and it’s great to have so many different options.

Moneyline

Jaguars

-159

Cardinals

+134

Point Spread

Jaguars -2.5

-122

Cardinals +2.5

-100

Total Points

Under 47.5

-115

Over 47.5

-105

Bhayshul Tuten is the market leader at +420 to be the First TD Scorer. Should you think he will score the final touchdown, then a similar price can be found.

Touchdown

Bhayshul Tuten (Jaguars)

First TD

+420

Anytime TD

-185

Travis Etienne Jr. (Jaguars)

First TD

+420

Anytime TD

-185

Trey McBride (Cardinals)

First TD

+600

Anytime TD

-120

Bam Knight (Cardinals)

First TD

+850

Anytime TD

+135

Jakobi Meyers (Jaguars)

First TD

+1000

Anytime TD

+180

Brian Thomas Jr (Jaguars)

First TD

+1000

Anytime TD

+160

Trevor Lawrence (Jaguars)

First TD

+1100

Anytime TD

+200

Michael Wilson (Cardinals)

First TD

+1100

Anytime TD

+210

LeQuint Allen Jr. (Jaguars)

First TD

+1200

Anytime TD

+210

Parker Washington (Jaguars)

First TD

+1300

Anytime TD

+230

Michael Carter (Cardinals)

First TD

+1600

Anytime TD

+250

Brenton Strange (Jaguars)

First TD

+1800

Anytime TD

+330

Quintin Morris (Jaguars)

First TD

+1800

Anytime TD

+330

Hunter Long (Jaguars)

First TD

+2500

Anytime TD

+550

Greg Dortch (Cardinals)

First TD

+2500

Anytime TD

+340

Elijah Higgins (Cardinals)

First TD

+3000

Anytime TD

+410

Jacoby Brissett (Cardinals)

First TD

+3000

Anytime TD

+550

Tim Patrick (Jaguars)

First TD

+3000

Anytime TD

+650

Xavier Weaver (Cardinals)

First TD

+3500

Anytime TD

+600

Johnny Mundt (Jaguars)

First TD

+3500

Anytime TD

+750

Austin Trammell (Jaguars)

First TD

+5500

Anytime TD

+1300

Andre Baccellia (Cardinals)

First TD

+7000

Anytime TD

+1300

Cody Schrader (Jaguars)

First TD

+7500

Anytime TD

+1600

Josiah Deguara (Cardinals)

First TD

+8000

Anytime TD

+1600

Receiving Yards

Trey McBride (Cardinals)

Over 75.5

-114

Under 75.5

-114

Michael Wilson (Cardinals)

Over 62.5

-114

Under 62.5

-114

Passing Yards

Jacoby Brissett (Cardinals)

Over 243.5

-114

Under 243.5

-114

Trevor Lawrence (Jaguars)

Over 214.5

-114

Under 214.5

-114

Cardinals Have Been Beaten in Last Four at Home

The Cardinals have stumbled to four straight defeats at State Farm Stadium. They have five wins and five losses in the last 10 home games, averaging 26.80 points scored and 22.10 points allowed.

The Jaguars own a 3-7 mark in their past 10 road games, averaging 20.40 points on offense and surrendering 28.30 on defense.

Last 10 Games		W-L	P	PF	PA	O47.5	U47.5
Cardinals Home Stats		5-5	48.90	26.80	22.10	5	5
Jaguars Away Stats		3-7	48.70	20.40	28.30	7	3

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O47.5 = Games Over 47.5 Points
• U47.5 = Games Under 47.5 Points

Latest regular season and playoff games stats.

Jacksonville Jaguars Stats

Arizona Cardinals Stats

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 3 wins and 7 defeats in the last 10 games on the road

Moneyline

• 3 wins and 7 defeats in the last 10 games
• 5 wins and 5 defeats in the last 10 home games

Point Spread

• -2.5 Betting Line: Have covered the spread in 5 of the last 10 games
• -2.5 Betting Line on the Road: Have covered the spread in 2 of the last 10 games on the road

Point Spread

• +2.5 Betting Line: Have covered the spread in 5 of the last 10 games
• +2.5 Betting Line at Home: Have covered the spread in 6 of the last 10 home games

Total Points

• Game Totals: An average of 46.60 pts in the previous 10 games
• Game Totals on the Road: An average of 48.70 pts in the previous 10 games on the road
• Over 47.5: Covered in 4 of the previous 10 games
• Over 47.5 on the Road: Covered in 7 of the previous 10 games on the road
• Team Totals: Have scored an average of 24.00 pts and allowed 22.60 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 20.40 pts and allowed 28.30 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 48.00 pts in the previous 10 games
• Game Totals at Home: An average of 48.90 pts in the previous 10 home games
• Over 47.5: Covered in 5 of the previous 10 games
• Over 47.5 at Home: Covered in 5 of the previous 10 home games
• Team Totals: Have scored an average of 22.40 pts and allowed 25.60 pts in the last 10 games
• Team Totals at Home: Have scored an average of 26.80 pts and allowed 22.10 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 329.10 Yds. Allowed 323.60 Yds
• Rushing Yards: Gained 129.80 Yds. Allowed 86.70 Yds
• Passing Yards: Gained 199.40 Yds. Allowed 236.90 Yds
• Total Touchdowns: Scored 2.80 TD. Allowed 2.80 TD
• Rushing Touchdowns: Scored 1.40 TD. Allowed 0.60 TD
• Passing Touchdowns: Scored 1.10 TD. Allowed 2.10 TD
• Total 1st Downs: Picked up 20.90. Allowed 19.90
• Total Turnovers: Committed 0.90. Committed by opponents 1.80
• Total Penalties: Committed 8.50. Committed by opponents 6.70
• Penalty Yards: Lost 70.30 Yds. Gained 60.00 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 333.50 Yds. Allowed 333.60 Yds
• Rushing Yards: Gained 105.70 Yds. Allowed 112.20 Yds
• Passing Yards: Gained 227.80 Yds. Allowed 221.40 Yds
• Total Touchdowns: Scored 2.50 TD. Allowed 2.80 TD
• Rushing Touchdowns: Scored 0.80 TD. Allowed 1.10 TD
• Passing Touchdowns: Scored 1.60 TD. Allowed 1.30 TD
• Total 1st Downs: Picked up 20.10. Allowed 21.80
• Total Turnovers: Committed 1.30. Committed by opponents 1.30
• Total Penalties: Committed 7.80. Committed by opponents 6.20
• Penalty Yards: Lost 57.00 Yds. Gained 57.40 Yds

Last 10 Games on the Road

• Total Yards: Gained 290.70 Yds. Allowed 396.20 Yds
• Rushing Yards: Gained 98.20 Yds. Allowed 127.50 Yds
• Passing Yards: Gained 192.60 Yds. Allowed 268.70 Yds
• Total Touchdowns: Scored 2.20 TD. Allowed 3.50 TD
• Rushing Touchdowns: Scored 1.00 TD. Allowed 1.20 TD
• Passing Touchdowns: Scored 0.90 TD. Allowed 2.20 TD
• Total 1st Downs: Picked up 17.50. Allowed 24.50
• Total Turnovers: Committed 1.50. Committed by opponents 1.20
• Total Penalties: Committed 7.20. Committed by opponents 5.40
• Penalty Yards: Lost 57.10 Yds. Gained 44.30 Yds

Last 10 Home Games

• Total Yards: Gained 362.40 Yds. Allowed 321.00 Yds
• Rushing Yards: Gained 126.40 Yds. Allowed 104.90 Yds
• Passing Yards: Gained 236.00 Yds. Allowed 216.10 Yds
• Total Touchdowns: Scored 3.10 TD. Allowed 2.30 TD
• Rushing Touchdowns: Scored 1.50 TD. Allowed 1.00 TD
• Passing Touchdowns: Scored 1.40 TD. Allowed 1.20 TD
• Total 1st Downs: Picked up 21.10. Allowed 20.30
• Total Turnovers: Committed 1.40. Committed by opponents 1.00
• Total Penalties: Committed 6.80. Committed by opponents 6.50
• Penalty Yards: Lost 53.60 Yds. Gained 55.10 Yds

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