Jaguars vs Cardinals Prediction, Picks & Odds | 23 Nov 2025

NFL Betting Preview: Jaguars vs Cardinals

The Jacksonville Jaguars square off against the Arizona Cardinals at State Farm Stadium, with kickoff scheduled for 16:05 on Sunday, November 23.

Over 47.5 points seems like a realistic outcome when the Cardinals go up against the Jaguars. We’re taking odds of -105 on the basis that the total line is too low.

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Jacksonville Jaguars won their previous game which was at home. It was a 35-6 triumph at EverBank Stadium against Los Angeles Chargers. The Jaguars moved the ball for 345 yards, with 153 through the air and 192 on the ground. They moved the chains 30 times and produced 5 touchdowns.

Arizona Cardinals were defeated last time, making it four home losses on the spin. State Farm Stadium saw them beaten 41-22 against San Francisco 49ers. The Cardinals put up 488 yards, split between 452 passing and 36 rushing yards. The offense managed 24 first downs and found the end zone 3 times.

Head-to-Head Statistics

These two teams last met at EverBank Stadium, with the Cardinals claiming the win. Beating the Jaguars by a 31-19 scoreline.

Quarterbacks

Trevor Lawrence

215.5 Passing Yards

Over -112

Under -112

Jacoby Brissett

247.5 Passing Yards

Over -112

Under -112

Jaguars vs Cardinals Prediction & Picks

Your complete Jaguars vs Cardinals betting guide is here, including our go-to match prediction, scoreline call, standout prop selections and a customized bet builder.

Game Prediction

We think the best betting angle can be found with the totals for this NFL battle. Our pick is that there will be Over 47.5 points and that is available at -105.

The formbook is always a smart starting point when making NFL picks. Up-to-date team news is just as important, while the stats we provide often reveal valuable insights.

Key Jaguars vs Cardinals stats:

• The 47.5 line has been covered in 4 of the last 5 Jaguars games on the road.
• The 47.5 line has been covered in 3 of the last 4 Jaguars games on the road this season.
• The 47.5 line has been covered in the last 2 Jaguars games on the road.
• The 47.5 line has been covered in 4 of the last 5 Cardinals games.
• The 47.5 line has been covered in 12 of the last 20 Cardinals games at home.
• The 47.5 line has been covered in the last 2 Cardinals games.

Over 47.5 Probability

If you go by the top betting sites, there’s a 51.3% likelihood of our pick landing a return. Based on our analysts in-depth research, we calculate the actual probability to be 55-60%. That means we are regarding it as a value wager.

In order to land bigger odds on your Overs wager, it’s possible to combine this with the winning franchise. The Result & Total lines can provide a larger potential payout.

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Our Game Prediction

Over 47.5 Points @ -105 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (22:25, 21 November 2025). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Trey McBride Anytime TD -120

You can place a bet on Trey McBride (Cardinals) to record a TD at -120. We believe there’s merit in backing him for an Anytime Touchdown Scorer prop wager, meaning we need him to punch it in.

Latest Trey McBride Player Prop Odds

Touchdown

Anytime

-115

First

+550

Receiving Yards

Over 75.5

-112

Under 75.5

-112

---

Michael Wilson Over 62.5 Receiving Yards -114

Michael Wilson (Jaguars) is priced at -114 to surpass 62.5 receiving yards. There’s an opportunity to place a Player Receiving Yards bet, with him capable of covering an appealing line.

Latest Michael Wilson Player Prop Odds

Touchdown

Anytime

+220

First

+1100

Receiving Yards

Over 60.5

-112

Under 60.5

-112

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Jaguars 31 - 21 Cardinals

The Jaguars might be able to claim a victory and we’re siding with a 31-21 scoreline in their favor. A small stake can provide a big return and there are monster odds available.

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Jaguars vs Cardinals Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

The Jacksonville Jaguars odds have been priced up by the sportsbooks and they are +130 betting favorites to land victory in this game which means a 43% chance of winning. Arizona Cardinals are trading at bigger odds than their opponents and they can be backed at -154.

The spread is calculated to be 3, while total points comes in at 47.5. Having a wager on the Totals is one of the most popular NFL bets. There’s an opportunity to bet Over 47.5 at -110.

Whether you are wagering pre-game or in-game on the National Football League, the best betting apps offer a wide range of game lines and team props. The selections are practically endless and it’s great to have so many different options.

Moneyline

Jaguars

+130

Cardinals

-154

Point Spread

Jaguars +3

-105

Cardinals -3

-115

Total Points

Under 47.5

-110

Over 47.5

-110

Travis Etienne Jr. is the market leader at +550 to be the First TD Scorer. Should you think he will score the final touchdown, then a similar price can be found.

Touchdown

Travis Etienne Jr. (Jaguars)

First TD

+550

Anytime TD

-105

Trey McBride (Cardinals)

First TD

+550

Anytime TD

-115

Bam Knight (Cardinals)

First TD

+700

Anytime TD

+130

Bhayshul Tuten (Jaguars)

First TD

+950

Anytime TD

+155

Jakobi Meyers (Jaguars)

First TD

+950

Anytime TD

+190

Brian Thomas Jr (Jaguars)

First TD

+1000

Anytime TD

+160

Michael Wilson (Cardinals)

First TD

+1100

Anytime TD

+220

Parker Washington (Jaguars)

First TD

+1200

Anytime TD

+260

Brenton Strange (Jaguars)

First TD

+1500

Anytime TD

+300

Trevor Lawrence (Jaguars)

First TD

+1600

Anytime TD

+280

Greg Dortch (Cardinals)

First TD

+1700

Anytime TD

+350

Michael Carter (Cardinals)

First TD

+2000

Anytime TD

+280

Tim Patrick (Jaguars)

First TD

+2200

Anytime TD

+500

Hunter Long (Jaguars)

First TD

+2500

Anytime TD

+550

Jacoby Brissett (Cardinals)

First TD

+2500

Anytime TD

+500

Elijah Higgins (Cardinals)

First TD

+2500

Anytime TD

+500

Xavier Weaver (Cardinals)

First TD

+5000

Anytime TD

+500

Dyami Brown (Jaguars)

First TD

+6500

Anytime TD

+1100

Johnny Mundt (Jaguars)

First TD

+7000

Anytime TD

+1000

Quintin Morris (Jaguars)

First TD

+8000

Anytime TD

+1400

Andre Baccellia (Cardinals)

First TD

+10000

Anytime TD

+1600

Austin Trammell (Jaguars)

First TD

+10000

Anytime TD

+2700

Cody Schrader (Jaguars)

First TD

+10000

Anytime TD

+1500

Josiah Deguara (Cardinals)

First TD

+10000

Anytime TD

+1900

LeQuint Allen Jr. (Jaguars)

First TD

+10000

Anytime TD

+1500

Jermar Jefferson (Cardinals)

First TD

+10000

Anytime TD

+1700

Pharaoh Brown (Cardinals)

First TD

+10000

Anytime TD

+2700

Receiving Yards

Trey McBride (Cardinals)

Over 75.5

-112

Under 75.5

-112

Michael Wilson (Cardinals)

Over 60.5

-112

Under 60.5

-112

Jakobi Meyers (Jaguars)

Over 54.5

-112

Under 54.5

-112

Parker Washington (Jaguars)

Over 43.5

-112

Under 43.5

-112

Brenton Strange (Jaguars)

Over 28.5

-112

Under 28.5

-112

Greg Dortch (Cardinals)

Over 28.5

-112

Under 28.5

-112

Tim Patrick (Jaguars)

Over 19.5

-112

Under 19.5

-112

Travis Etienne Jr. (Jaguars)

Over 13.5

-112

Under 13.5

-112

Elijah Higgins (Cardinals)

Over 12.5

-112

Under 12.5

-112

Bam Knight (Cardinals)

Over 11.5

-112

Under 11.5

-112

Rushing Yards

Travis Etienne Jr. (Jaguars)

Over 46.5

-112

Under 46.5

-112

Bhayshul Tuten (Jaguars)

Over 45.5

-112

Under 45.5

-112

Bam Knight (Cardinals)

Over 42.5

-112

Under 42.5

-112

Michael Carter (Cardinals)

Over 18.5

-112

Under 18.5

-112

Trevor Lawrence (Jaguars)

Over 16.5

-112

Under 16.5

-112

Jacoby Brissett (Cardinals)

Over 12.5

-112

Under 12.5

-112

Passing Yards

Jacoby Brissett (Cardinals)

Over 247.5

-112

Under 247.5

-112

Trevor Lawrence (Jaguars)

Over 215.5

-112

Under 215.5

-112

It’s good to consider all wagering options when it comes to NFL and micro betting can be an exciting way to get involved in the action. When everything goes in-game, consider whether a player will make or miss a field goal.

Cardinals Have Been Beaten in Last Four at Home

The Cardinals have stumbled to four straight defeats at State Farm Stadium. They have five wins and five losses in the last 10 home games, averaging 26.80 points scored and 22.10 points allowed.

The Jaguars own a 3-7 mark in their past 10 road games, averaging 20.40 points on offense and surrendering 28.30 on defense.

Last 10 Games		W-L	P	PF	PA	O47.5	U47.5
Cardinals Home Stats		5-5	48.90	26.80	22.10	5	5
Jaguars Away Stats		3-7	48.70	20.40	28.30	7	3

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O47.5 = Games Over 47.5 Points
• U47.5 = Games Under 47.5 Points

Latest regular season and playoff games stats.

Jacksonville Jaguars Stats

Arizona Cardinals Stats

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 3 wins and 7 defeats in the last 10 games on the road

Moneyline

• 3 wins and 7 defeats in the last 10 games
• 5 wins and 5 defeats in the last 10 home games

Point Spread

• -2.5 Betting Line: Have covered the spread in 5 of the last 10 games
• -2.5 Betting Line on the Road: Have covered the spread in 2 of the last 10 games on the road

Point Spread

• +2.5 Betting Line: Have covered the spread in 5 of the last 10 games
• +2.5 Betting Line at Home: Have covered the spread in 6 of the last 10 home games

Total Points

• Game Totals: An average of 46.60 pts in the previous 10 games
• Game Totals on the Road: An average of 48.70 pts in the previous 10 games on the road
• Over 47.5: Covered in 4 of the previous 10 games
• Over 47.5 on the Road: Covered in 7 of the previous 10 games on the road
• Team Totals: Have scored an average of 24.00 pts and allowed 22.60 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 20.40 pts and allowed 28.30 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 48.00 pts in the previous 10 games
• Game Totals at Home: An average of 48.90 pts in the previous 10 home games
• Over 47.5: Covered in 5 of the previous 10 games
• Over 47.5 at Home: Covered in 5 of the previous 10 home games
• Team Totals: Have scored an average of 22.40 pts and allowed 25.60 pts in the last 10 games
• Team Totals at Home: Have scored an average of 26.80 pts and allowed 22.10 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 329.10 Yds. Allowed 323.60 Yds
• Rushing Yards: Gained 129.80 Yds. Allowed 86.70 Yds
• Passing Yards: Gained 199.40 Yds. Allowed 236.90 Yds
• Total Touchdowns: Scored 2.80 TD. Allowed 2.80 TD
• Rushing Touchdowns: Scored 1.40 TD. Allowed 0.60 TD
• Passing Touchdowns: Scored 1.10 TD. Allowed 2.10 TD
• Total 1st Downs: Picked up 20.90. Allowed 19.90
• Total Turnovers: Committed 0.90. Committed by opponents 1.80
• Total Penalties: Committed 8.50. Committed by opponents 6.70
• Penalty Yards: Lost 70.30 Yds. Gained 60.00 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 333.50 Yds. Allowed 333.60 Yds
• Rushing Yards: Gained 105.70 Yds. Allowed 112.20 Yds
• Passing Yards: Gained 227.80 Yds. Allowed 221.40 Yds
• Total Touchdowns: Scored 2.50 TD. Allowed 2.80 TD
• Rushing Touchdowns: Scored 0.80 TD. Allowed 1.10 TD
• Passing Touchdowns: Scored 1.60 TD. Allowed 1.30 TD
• Total 1st Downs: Picked up 20.10. Allowed 21.80
• Total Turnovers: Committed 1.30. Committed by opponents 1.30
• Total Penalties: Committed 7.80. Committed by opponents 6.20
• Penalty Yards: Lost 57.00 Yds. Gained 57.40 Yds

Last 10 Games on the Road

• Total Yards: Gained 290.70 Yds. Allowed 396.20 Yds
• Rushing Yards: Gained 98.20 Yds. Allowed 127.50 Yds
• Passing Yards: Gained 192.60 Yds. Allowed 268.70 Yds
• Total Touchdowns: Scored 2.20 TD. Allowed 3.50 TD
• Rushing Touchdowns: Scored 1.00 TD. Allowed 1.20 TD
• Passing Touchdowns: Scored 0.90 TD. Allowed 2.20 TD
• Total 1st Downs: Picked up 17.50. Allowed 24.50
• Total Turnovers: Committed 1.50. Committed by opponents 1.20
• Total Penalties: Committed 7.20. Committed by opponents 5.40
• Penalty Yards: Lost 57.10 Yds. Gained 44.30 Yds

Last 10 Home Games

• Total Yards: Gained 362.40 Yds. Allowed 321.00 Yds
• Rushing Yards: Gained 126.40 Yds. Allowed 104.90 Yds
• Passing Yards: Gained 236.00 Yds. Allowed 216.10 Yds
• Total Touchdowns: Scored 3.10 TD. Allowed 2.30 TD
• Rushing Touchdowns: Scored 1.50 TD. Allowed 1.00 TD
• Passing Touchdowns: Scored 1.40 TD. Allowed 1.20 TD
• Total 1st Downs: Picked up 21.10. Allowed 20.30
• Total Turnovers: Committed 1.40. Committed by opponents 1.00
• Total Penalties: Committed 6.80. Committed by opponents 6.50
• Penalty Yards: Lost 53.60 Yds. Gained 55.10 Yds

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