Jaguars vs 49ers Prediction, Picks & Odds | 28 Sep 2025

NFL Betting Preview: Jaguars vs Niners

The Jacksonville Jaguars clash with the San Francisco 49ers in this NFL Week 4 matchup at Levi's Stadium, with kickoff scheduled for 16:05 on Sunday, September 28. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

Go for Under at -110. It might be defenses on top when the Niners clash with the Jaguars, with the 46.5 points line looking on the high side when it comes to the totals.

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Jacksonville Jaguars previous game saw them claim a 17-10 home win over Houston Texans at EverBank Stadium. The Jaguars generated 291 yards, including 205 passing and 86 rushing yards. The offense moved the chains 17 times along with two touchdowns.

San Francisco 49ers won their last game 16-15, making it three victories on the bounce. This was a home win at Levi's Stadium against Arizona Cardinals. The 49ers moved the ball for 355 yards, made up of 282 through the air and 73 on the ground. The offense moved the chains 19 times and reached the end zone once through the air.

Head-to-Head Statistics

The Niners won the last matchup between the pair. Enjoying a 34-3 triumph when facing the Jaguars at EverBank Stadium.

Quarterbacks

Trevor Lawrence

231.5 Passing Yards

Over -112

Under -112

Brock Purdy

244.5 Passing Yards

Over -112

Under -112

Jaguars vs 49ers Prediction & Picks

Approach Jaguars vs 49ers fully prepared with our expert match prediction, likely score outcome, standout player prop picks and a hand-picked bet builder.

Game Prediction

The Unders looks the way to go for this NFL matchup. The line looks too high at 46.5 and odds of -110 could favor bettors who go below that total.

Injuries can influence the outcome and our NFL handicappers factor that in alongside the latest form guide. We apply the same approach to the stats to build the clearest picture of how the game might unfold.

Key Jaguars vs 49ers stats:

• The 46.5 line hasn’t been covered in 2 of the last 3 Jaguars games this season.
• The 46.5 line hasn’t been covered in 6 of the last 10 Jaguars games.
• The 46.5 line hasn’t been covered in 2 of the last 3 49ers games this season.
• The 46.5 line hasn’t been covered in 3 of the last 5 49ers games at home.

Under 46.5 Probability

The best betting apps are estimating that there is a 52.4% likelihood of this pick winning. In the opinion of our analysts, there’s actually a probability of success between 55-60%. It’s why we think it’s worth placing this wager.

For a larger payout, many bettors will include their Under pick on the Totals with other selections. A Bet Builder is perfect for combining all your predictions.

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Our Game Prediction

Under 46.5 Points @ -110 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (22:26, 26 September 2025). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Trevor Lawrence Under 226.5 Passing Yards -114

You can place a bet on Trevor Lawrence (Jaguars) at -114 to finish with fewer than 226.5 passing yards. We’re confident he’ll fall short of the QB Passing Yards line, as the total looks too high.

Latest Trevor Lawrence Player Prop Odds

Touchdown

Anytime

+600

First

+2700

Passing Yards

Over 231.5

-112

Under 231.5

-112

Rushing Yards

Over 10.5

-112

Under 10.5

-112

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Bhayshul Tuten Under 23.5 Rushing Yards -114

You can place a bet on Bhayshul Tuten (Jaguars) at -114 to have less than 23.5 rushing yards. If you agree with our verdict that the line is too high, this Player Rushing Yards wager is worth backing.

Latest Bhayshul Tuten Player Prop Odds

Touchdown

Anytime

+320

First

+1600

Rushing Yards

Over 22.5

-112

Under 22.5

-112

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Jaguars 21 - 20 49ers

Don’t pass up the opportunity to have a speculative wager on the Jaguars to claim a 21-20 victory. We don’t think that there will be too much between the teams.

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Jaguars vs 49ers Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

The sportsbooks have San Francisco 49ers at -238 when it comes to the Moneyline betting, implying the market leaders are 70% likely to win this game according to the latest odds. Jacksonville Jaguars are trading at bigger odds than their opponents and they can be backed at +195.

The spread is currently 5.5, with the total points line at 48.5. The Totals offers NFL fans an alternative way of getting involved. Those expecting a low total can back Under 48.5 at -110.

If you're betting on the matchups, it's worth checking out the best NFL sportsbooks, where you'll find a massive range of game lines and team props. You can place your bets before kickoff or while the action is underway.

Moneyline

Jaguars

+195

49ers

-238

Point Spread

Jaguars +5.5

-110

49ers -5.5

-110

Total Points

Under 48.5

-110

Over 48.5

-110

Favorite Christian McCaffrey is available at +370 to be the First TD Scorer. Similar odds apply if you’re interested in this player to score the final touchdown.

Touchdown

Christian McCaffrey (49ers)

First TD

+370

Anytime TD

-175

Travis Etienne Jr. (Jaguars)

First TD

+700

Anytime TD

+140

Brian Thomas Jr (Jaguars)

First TD

+850

Anytime TD

+155

Ricky Pearsall (49ers)

First TD

+1000

Anytime TD

+190

Jauan Jennings (49ers)

First TD

+1100

Anytime TD

+210

Travis Hunter (Jaguars)

First TD

+1500

Anytime TD

+280

Bhayshul Tuten (Jaguars)

First TD

+1600

Anytime TD

+320

Brenton Strange (Jaguars)

First TD

+1700

Anytime TD

+350

Jake Tonges (49ers)

First TD

+1800

Anytime TD

+370

Dyami Brown (Jaguars)

First TD

+1900

Anytime TD

+300

Parker Washington (Jaguars)

First TD

+2000

Anytime TD

+330

Brian Robinson Jr. (49ers)

First TD

+2500

Anytime TD

+500

Brock Purdy (49ers)

First TD

+2700

Anytime TD

+550

Trevor Lawrence (Jaguars)

First TD

+2700

Anytime TD

+600

Demarcus Robinson (49ers)

First TD

+3300

Anytime TD

+600

Kendrick Bourne (49ers)

First TD

+3300

Anytime TD

+650

Kyle Juszczyk (49ers)

First TD

+4000

Anytime TD

+700

Tim Patrick (Jaguars)

First TD

+4500

Anytime TD

+950

Luke Farrell (49ers)

First TD

+5000

Anytime TD

+1000

Russell Gage (49ers)

First TD

+6000

Anytime TD

+1200

LeQuint Allen Jr. (Jaguars)

First TD

+6500

Anytime TD

+1400

Skyy Moore (49ers)

First TD

+7000

Anytime TD

+1500

Johnny Mundt (Jaguars)

First TD

+7500

Anytime TD

+1400

Marquez Valdes-Scantling (49ers)

First TD

+8000

Anytime TD

+1400

Malik Turner (49ers)

First TD

+10000

Anytime TD

+3000

Isaac Guerendo (49ers)

First TD

+10000

Anytime TD

+2200

Brayden Willis (49ers)

First TD

+10000

Anytime TD

+2700

Quintin Morris (Jaguars)

First TD

+10000

Anytime TD

+3000

Hunter Long (Jaguars)

First TD

+10000

Anytime TD

+3000

Austin Trammell (Jaguars)

First TD

+10000

Anytime TD

+1900

Receiving Yards

Ricky Pearsall (49ers)

Over 60.5

-112

Under 60.5

-112

Brian Thomas Jr (Jaguars)

Over 59.5

-112

Under 59.5

-112

Christian McCaffrey (49ers)

Over 42.5

-112

Under 42.5

-112

Jauan Jennings (49ers)

Over 41.5

-112

Under 41.5

-112

Brenton Strange (Jaguars)

Over 32.5

-112

Under 32.5

-112

Travis Hunter (Jaguars)

Over 32.5

-112

Under 32.5

-112

Jake Tonges (49ers)

Over 20.5

-112

Under 20.5

-112

Travis Etienne Jr. (Jaguars)

Over 13.5

-112

Under 13.5

-112

Rushing Yards

Christian McCaffrey (49ers)

Over 72.5

-112

Under 72.5

-112

Travis Etienne Jr. (Jaguars)

Over 50.5

-112

Under 50.5

-112

Bhayshul Tuten (Jaguars)

Over 22.5

-112

Under 22.5

-112

Brian Robinson Jr. (49ers)

Over 19.5

-112

Under 19.5

-112

Brock Purdy (49ers)

Over 11.5

-112

Under 11.5

-112

Trevor Lawrence (Jaguars)

Over 10.5

-112

Under 10.5

-112

Passing Yards

Brock Purdy (49ers)

Over 244.5

-112

Under 244.5

-112

Trevor Lawrence (Jaguars)

Over 231.5

-112

Under 231.5

-112

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Last Ten Home Games Have Produced Five Wins for Niners

The Niners own a 5-5 mark in their past 10 home games, averaging 24.40 points scored and 20.80 points allowed.

The Jaguars have dropped three road games in a row. They are 1-9 in their last 10 road games, averaging 16.60 points on offense and surrendering 28.80 on defense.

Last 10 Games		W-L	P	PF	PA	O46.5	U46.5
49ers Home Stats		5-5	45.20	24.40	20.80	5	5
Jaguars Away Stats		1-9	45.40	16.60	28.80	6	4

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O46.5 = Games Over 46.5 Points
• U46.5 = Games Under 46.5 Points

Latest regular season and playoff games stats.

Jacksonville Jaguars Stats

San Francisco 49ers Stats

Moneyline

• 4 wins and 6 defeats in the last 10 games
• 1 win and 9 defeats in the last 10 games on the road

Moneyline

• 4 wins and 6 defeats in the last 10 games
• 5 wins and 5 defeats in the last 10 home games

Point Spread

• +3.5 Betting Line: Have covered the spread in 6 of the last 10 games
• +3.5 Betting Line on the Road: Have covered the spread in 3 of the last 10 games on the road

Point Spread

• -3.5 Betting Line: Have covered the spread in 3 of the last 10 games
• -3.5 Betting Line at Home: Have covered the spread in 4 of the last 10 home games

Total Points

• Game Totals: An average of 41.00 pts in the previous 10 games
• Game Totals on the Road: An average of 45.40 pts in the previous 10 games on the road
• Over 46.5: Covered in 4 of the previous 10 games
• Over 46.5 on the Road: Covered in 6 of the previous 10 games on the road
• Team Totals: Have scored an average of 18.80 pts and allowed 22.20 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 16.60 pts and allowed 28.80 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 46.10 pts in the previous 10 games
• Game Totals at Home: An average of 45.20 pts in the previous 10 home games
• Over 46.5: Covered in 5 of the previous 10 games
• Over 46.5 at Home: Covered in 5 of the previous 10 home games
• Team Totals: Have scored an average of 19.80 pts and allowed 26.30 pts in the last 10 games
• Team Totals at Home: Have scored an average of 24.40 pts and allowed 20.80 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 326.80 Yds. Allowed 359.90 Yds
• Rushing Yards: Gained 109.90 Yds. Allowed 120.80 Yds
• Passing Yards: Gained 216.90 Yds. Allowed 239.10 Yds
• Total Touchdowns: Scored 1.80 TD. Allowed 2.40 TD
• Rushing Touchdowns: Scored 0.60 TD. Allowed 0.90 TD
• Passing Touchdowns: Scored 1.20 TD. Allowed 1.50 TD
• Total 1st Downs: Picked up 18.10. Allowed 21.70
• Total Turnovers: Committed 1.30. Committed by opponents 1.00
• Total Penalties: Committed 6.80. Committed by opponents 4.80
• Penalty Yards: Lost 60.00 Yds. Gained 38.90 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 349.10 Yds. Allowed 316.30 Yds
• Rushing Yards: Gained 95.40 Yds. Allowed 138.10 Yds
• Passing Yards: Gained 253.70 Yds. Allowed 178.20 Yds
• Total Touchdowns: Scored 2.30 TD. Allowed 3.00 TD
• Rushing Touchdowns: Scored 0.70 TD. Allowed 1.20 TD
• Passing Touchdowns: Scored 1.60 TD. Allowed 1.80 TD
• Total 1st Downs: Picked up 20.00. Allowed 19.20
• Total Turnovers: Committed 1.80. Committed by opponents 0.40
• Total Penalties: Committed 7.00. Committed by opponents 4.50
• Penalty Yards: Lost 51.80 Yds. Gained 35.70 Yds

Last 10 Games on the Road

• Total Yards: Gained 282.20 Yds. Allowed 405.30 Yds
• Rushing Yards: Gained 96.40 Yds. Allowed 130.90 Yds
• Passing Yards: Gained 185.80 Yds. Allowed 274.40 Yds
• Total Touchdowns: Scored 1.80 TD. Allowed 3.50 TD
• Rushing Touchdowns: Scored 0.60 TD. Allowed 1.40 TD
• Passing Touchdowns: Scored 1.10 TD. Allowed 2.10 TD
• Total 1st Downs: Picked up 16.50. Allowed 23.90
• Total Turnovers: Committed 1.60. Committed by opponents 0.60
• Total Penalties: Committed 6.20. Committed by opponents 5.80
• Penalty Yards: Lost 47.20 Yds. Gained 49.70 Yds

Last 10 Home Games

• Total Yards: Gained 374.50 Yds. Allowed 291.30 Yds
• Rushing Yards: Gained 127.80 Yds. Allowed 111.20 Yds
• Passing Yards: Gained 246.70 Yds. Allowed 180.10 Yds
• Total Touchdowns: Scored 2.50 TD. Allowed 2.30 TD
• Rushing Touchdowns: Scored 1.30 TD. Allowed 1.10 TD
• Passing Touchdowns: Scored 1.00 TD. Allowed 1.20 TD
• Total 1st Downs: Picked up 20.50. Allowed 17.10
• Total Turnovers: Committed 1.50. Committed by opponents 1.20
• Total Penalties: Committed 5.80. Committed by opponents 3.80
• Penalty Yards: Lost 42.60 Yds. Gained 29.00 Yds

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