Jacksonville Jaguars
American Football NFL Levi's Stadium Sun 28 Sep 16:05
San Francisco 49ers
  1. Prediction
  2. Bet Builder
  3. Odds
  4. Player Props
  5. Stats
  6. Live Stream
  7. Team News
  8. Lineups
  9. Injuries
  10. Standings

NFL Betting Preview: Jaguars vs Niners

The Jacksonville Jaguars clash with the San Francisco 49ers in this NFL Week 4 matchup at Levi's Stadium, with kickoff scheduled for 16:05 on Sunday 28 September. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

Points Look in Short Supply

Go for Under at -110. It might be defenses on top when the Niners clash with the Jaguars, with the 46.5 points line looking on the high side when it comes to the totals.

Think the defenses are gonna control this one? Make sure you’ve got the latest BetMGM promo code and check out our comprehensive review to make your bet go further.

Niners Beat Jaguars in Pair’s Last Meeting

Jacksonville Jaguars previous game saw them claim a 17-10 home win over Houston Texans at EverBank Stadium. The Jaguars generated 291 yards, including 205 passing and 86 rushing yards. The offense moved the chains 17 times along with two touchdowns.

San Francisco 49ers won their last game 16-15, making it three victories on the bounce. This was a home win at Levi's Stadium against Arizona Cardinals. The 49ers moved the ball for 355 yards, made up of 282 through the air and 73 on the ground. The offense moved the chains 19 times and reached the end zone once through the air.

Head-to-Head Statistics

The Niners won the last matchup between the pair. Enjoying a 34-3 triumph when facing the Jaguars at EverBank Stadium.

Quarterbacks

Jaguars vs 49ers Prediction & Picks

Approach Jaguars vs 49ers fully prepared with our expert match prediction, likely score outcome, standout player prop picks and a hand-picked bet builder.

Game Prediction

The Unders looks the way to go for this NFL matchup. The line looks too high at 46.5 and odds of -110 could favor bettors who go below that total.

Injuries can influence the outcome and our NFL handicappers factor that in alongside the latest form guide. We apply the same approach to the stats to build the clearest picture of how the game might unfold.

Key Jaguars vs 49ers stats:

  • The 46.5 line hasn’t been covered in 2 of the last 3 Jaguars games this season.
  • The 46.5 line hasn’t been covered in 6 of the last 10 Jaguars games.
  • The 46.5 line hasn’t been covered in 2 of the last 3 49ers games this season.
  • The 46.5 line hasn’t been covered in 3 of the last 5 49ers games at home.

Under 46.5 Probability

The best betting apps are estimating that there is a 52.4% likelihood of this pick winning. In the opinion of our analysts, there’s actually a probability of success between 55-60%. It’s why we think it’s worth placing this wager.

Looking for Bigger Odds?

For a larger payout, many bettors will include their Under pick on the Totals with other selections. A Bet Builder is perfect for combining all your predictions.

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Best Bet

Under 46.5 Points @ -110 Watch Live Bet Now BetMGM logo
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Published 22:26, 26 September 2025

Player Prop Picks

Top Pick: Trevor Lawrence Under 226.5 Passing Yards -114 BetMGM logo

You can place a bet on Trevor Lawrence (Jaguars) at -114 to finish with fewer than 226.5 passing yards. We’re confident he’ll fall short of the QB Passing Yards line, as the total looks too high.

Latest Trevor Lawrence Player Prop Odds

Bhayshul Tuten Under 23.5 Rushing Yards -114 BetMGM logo

You can place a bet on Bhayshul Tuten (Jaguars) at -114 to have less than 23.5 rushing yards. If you agree with our verdict that the line is too high, this Player Rushing Yards wager is worth backing.

Latest Bhayshul Tuten Player Prop Odds

Same Game Parlay Picks

Totals Under 46.5
Spread Jaguars +3.5
Passing Yards Trevor Lawrence Under 226.5

Take a same game parlay that incorporates Under 46.5 points followed by Jaguars to cover the +3.5 spread. We’ve also gone for Trevor Lawrence (Jaguars) to have Under 226.5 passing yards.

A same game parlay is a single event wager where you make predictions that are going to happen in a particular football game. Should a bettor get these selections correct, then they can achieve a good return from a small stake.

T&C apply. Gamble responsibly 18+

Correct Score Prediction

Jaguars Jaguars logo 21 - 20 49ers logo 49ers

Don’t pass up the opportunity to have a speculative wager on the Jaguars to claim a 21-20 victory. We don’t think that there will be too much between the teams.

Jaguars vs 49ers Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Books Have Niners as Favorites

The sportsbooks have San Francisco 49ers at -164 when it comes to the Moneyline betting, implying the market leaders are 62% likely to win this game according to the latest odds. Jacksonville Jaguars are trading at bigger odds than their opponents and they can be backed at +138.

The spread is currently 3.5, with the total points line at 46.5. The Totals offers NFL fans an alternative way of getting involved. Those expecting a low total can back Under 46.5 at -110.

If you're betting on the matchups, it's worth checking out the best NFL sportsbooks, where you'll find a massive range of game lines and team props. You can place your bets before kickoff or while the action is underway.

Christian McCaffrey Favorite to Score First TD

Favorite Christian McCaffrey is available at +350 to be the First TD Scorer. Similar odds apply if you’re interested in this player to score the final touchdown.

Touchdown

Christian McCaffrey (49ers)
First TD
+350
Anytime TD
-222
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Travis Etienne Jr. (Jaguars)
First TD
+700
Anytime TD
+130
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Brian Thomas Jr (Jaguars)
First TD
+900
Anytime TD
+150
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Jauan Jennings (49ers)
First TD
+1000
Anytime TD
+185
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Receiving Yards

Brian Thomas Jr (Jaguars)
Over 58.5
-114
Under 58.5
-114
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Christian McCaffrey (49ers)
Over 42.5
-114
Under 42.5
-114
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Travis Etienne Jr. (Jaguars)
Over 12.5
-114
Under 12.5
-114
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Rushing Yards

Christian McCaffrey (49ers)
Over 73.5
-114
Under 73.5
-114
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Travis Etienne Jr. (Jaguars)
Over 50.5
-114
Under 50.5
-114
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Bhayshul Tuten (Jaguars)
Over 23.5
-114
Under 23.5
-114
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Trevor Lawrence (Jaguars)
Over 10.5
-114
Under 10.5
-114
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Passing Yards

Best Betting Offers
Levi's Stadium
Levi's Stadium

Last Ten Home Games Have Produced Five Wins for Niners

The Niners own a 5-5 mark in their past 10 home games, averaging 24.40 points scored and 20.80 points allowed.

The Jaguars have dropped three road games in a row. They are 1-9 in their last 10 road games, averaging 16.60 points on offense and surrendering 28.80 on defense.

Last 10 Games W-L P PF PA O46.5 U46.5
49ers logo 49ers Home Stats 5-5 45.20 24.40 20.80 5 5
Jaguars logo Jaguars Away Stats 1-9 45.40 16.60 28.80 6 4
  • W-L = Wins-Losses
  • P = Avg. Points
  • PF = Avg. Points For
  • PA = Avg. Points Against
  • O46.5 = Games Over 46.5 Points
  • U46.5 = Games Under 46.5 Points
Team Stats

Latest regular season and playoff games stats.

Jacksonville Jaguars logo Jacksonville Jaguars Stats
San Francisco 49ers logo San Francisco 49ers Stats
Moneyline
  • 4 wins and 6 defeats in the last 10 games
  • 1 win and 9 defeats in the last 10 games on the road
Moneyline
  • 4 wins and 6 defeats in the last 10 games
  • 5 wins and 5 defeats in the last 10 home games
Point Spread
Point Spread
Total Points
Total Points
Game Stats
Last 10 Games
Game Stats
Last 10 Games
Last 10 Games on the Road
Last 10 Home Games

Live Streaming

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The leading betting apps stream many of the latest events across a wide range of sports and leagues.

Team News

Jacksonville Jaguars Injuries

Type
Name
Info
Yasir Abdullah
Hamstring
Dyami Brown
Shoulder
Joshua Cephus
Undisclosed
Dennis Daley
Undisclosed
Cooper Hodges
Knee
Jalen McLeod
Lower Body
Wyatt Milum
Knee
Caleb Ransaw
Lower Body

San Francisco 49ers Injuries

Type
Name
Info
Brandon Aiyuk
Knee - ACL + MCL
Isaac Alarcon
Suspension
Ben Bartch
Ankle
Nick Bosa
Knee - ACL
Spencer Burford
Knee
Connor Colby
Groin
Jacob Cowing
Hamstring
Kevin Givens
Pectoral
Renardo Green
Neck
Tarron Jackson
Undisclosed
Jauan Jennings
Ankle
Mac Jones
Knee - PCL
George Kittle
Hamstring
Malik Mustapha
Knee - ACL
Ricky Pearsall
Knee
Jakob Robinson
Forearm
Kurtis Rourke
Knee
Patrick Taylor
Shoulder
Trent Taylor
Undisclosed
Tre Tomlinson
Undisclosed
Jordan Watkins
Calf
CJ West
Thumb

Previous Jacksonville Jaguars Lineups

21 Sep NFL
Texans 10-17 Jaguars
14 Sep NFL
Jaguars 27-31 Bengals
07 Sep NFL
Panthers 10-26 Jaguars
05 Jan NFL
Jaguars 23-26 Colts
29 Dec NFL
Titans 13-20 Jaguars
22 Dec NFL
Jaguars 14-19 Raiders
15 Dec NFL
Jets 32-25 Jaguars
08 Dec NFL
Jaguars 10-6 Titans
01 Dec NFL
Texans 23-20 Jaguars
17 Nov NFL
Jaguars 6-52 Lions

Previous San Francisco 49ers Lineups

21 Sep NFL
Cardinals 15-16 49ers
14 Sep NFL
49ers 26-21 Saints
07 Sep NFL
49ers 17-13 Seahawks
05 Jan NFL
49ers 24-47 Cardinals
30 Dec NFL
Lions 40-34 49ers
22 Dec NFL
49ers 17-29 Dolphins
12 Dec NFL
Rams 12-6 49ers
08 Dec NFL
Bears 13-38 49ers
01 Dec NFL
49ers 10-35 Bills
24 Nov NFL
49ers 10-38 Packers

NFL Standings Select Season

AFC East W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Bills 3 0 0 1.000 102 71 31 2-0-0 1-0-0 2-0-0 3-0-0 3-0-0 3W
Patriots 1 2 0 0.333 60 68 -8 0-2-0 1-0-0 1-0-0 1-2-0 1-2-0 1L
Jets 0 3 0 0.000 69 93 -24 0-2-0 0-1-0 0-1-0 0-2-0 0-3-0 3L
Dolphins 0 3 0 0.000 56 97 -41 0-1-0 0-2-0 0-2-0 0-3-0 0-3-0 3L
AFC North W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Bengals 2 1 0 0.667 58 91 -33 1-0-0 1-1-0 1-0-0 2-0-0 2-1-0 1L
Steelers 2 1 0 0.667 72 77 -5 0-1-0 2-0-0 0-0-0 2-0-0 2-1-0 1W
Ravens 1 2 0 0.333 111 96 15 1-1-0 0-1-0 1-0-0 1-1-0 1-2-0 1L
Browns 1 2 0 0.333 46 68 -22 1-1-0 0-1-0 0-2-0 0-2-0 1-2-0 1W
AFC South W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Colts 3 0 0 1.000 103 56 47 2-0-0 1-0-0 1-0-0 3-0-0 3-0-0 3W
Jaguars 2 1 0 0.667 70 51 19 2-0-0 0-1-0 1-0-0 1-1-0 2-1-0 1W
Texans 0 3 0 0.000 38 51 -13 0-1-0 0-2-0 0-1-0 0-1-0 0-3-0 3L
Titans 0 3 0 0.000 51 94 -43 0-2-0 0-1-0 0-1-0 0-2-0 0-3-0 3L
AFC West W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Chargers 3 0 0 1.000 70 50 20 2-0-0 1-0-0 3-0-0 3-0-0 3-0-0 3W
Raiders 1 2 0 0.333 53 74 -21 0-1-0 1-1-0 0-1-0 1-1-0 1-2-0 2L
Broncos 1 2 0 0.333 68 64 4 1-0-0 0-2-0 0-1-0 1-2-0 1-2-0 2L
Chiefs 1 2 0 0.333 60 56 4 0-1-0 1-1-0 0-1-0 0-1-0 1-2-0 1W
NFC East W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Eagles 3 0 0 1.000 77 63 14 2-0-0 1-0-0 1-0-0 2-0-0 3-0-0 3W
Commanders 2 1 0 0.667 80 57 23 2-0-0 0-1-0 1-0-0 1-1-0 2-1-0 1W
Cowboys 1 2 0 0.333 74 92 -18 1-0-0 0-2-0 1-1-0 1-2-0 1-2-0 1L
Giants 0 3 0 0.000 52 83 -31 0-1-0 0-2-0 0-2-0 0-2-0 0-3-0 3L
NFC North W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Packers 2 1 0 0.667 64 44 20 2-0-0 0-1-0 1-0-0 2-0-0 2-1-0 1L
Vikings 2 1 0 0.667 81 56 25 1-1-0 1-0-0 1-0-0 1-1-0 2-1-0 1W
Lions 2 1 0 0.667 103 78 25 1-0-0 1-1-0 1-1-0 1-1-0 2-1-0 2W
Bears 1 2 0 0.333 76 93 -17 1-1-0 0-1-0 0-2-0 1-2-0 1-2-0 1W
NFC South W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Buccaneers 3 0 0 1.000 72 66 6 1-0-0 2-0-0 1-0-0 1-0-0 3-0-0 3W
Panthers 1 2 0 0.333 62 53 9 1-0-0 0-2-0 1-0-0 1-1-0 1-2-0 1W
Falcons 1 2 0 0.333 42 59 -17 0-1-0 1-1-0 0-2-0 1-2-0 1-2-0 1L
Saints 0 3 0 0.000 47 90 -43 0-2-0 0-1-0 0-0-0 0-3-0 0-3-0 3L
NFC West W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
49ers 3 0 0 1.000 59 49 10 1-0-0 2-0-0 2-0-0 3-0-0 3-0-0 3W
Cardinals 2 2 0 0.500 82 74 8 1-1-0 1-1-0 0-2-0 2-2-0 2-2-0 2L
Seahawks 3 1 0 0.750 111 67 44 1-1-0 2-0-0 1-1-0 2-1-0 3-1-0 3W
Rams 2 1 0 0.667 73 61 12 1-0-0 1-1-0 0-0-0 0-1-0 2-1-0 1L
AFC Conference W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Chargers 3 0 0 1.000 70 50 20 2-0-0 1-0-0 3-0-0 3-0-0 3-0-0 3W
Colts 3 0 0 1.000 103 56 47 2-0-0 1-0-0 1-0-0 3-0-0 3-0-0 3W
Bills 3 0 0 1.000 102 71 31 2-0-0 1-0-0 2-0-0 3-0-0 3-0-0 3W
Bengals 2 1 0 0.667 58 91 -33 1-0-0 1-1-0 1-0-0 2-0-0 2-1-0 1L
Steelers 2 1 0 0.667 72 77 -5 0-1-0 2-0-0 0-0-0 2-0-0 2-1-0 1W
Jaguars 2 1 0 0.667 70 51 19 2-0-0 0-1-0 1-0-0 1-1-0 2-1-0 1W
Raiders 1 2 0 0.333 53 74 -21 0-1-0 1-1-0 0-1-0 1-1-0 1-2-0 2L
Ravens 1 2 0 0.333 111 96 15 1-1-0 0-1-0 1-0-0 1-1-0 1-2-0 1L
Broncos 1 2 0 0.333 68 64 4 1-0-0 0-2-0 0-1-0 1-2-0 1-2-0 2L
Patriots 1 2 0 0.333 60 68 -8 0-2-0 1-0-0 1-0-0 1-2-0 1-2-0 1L
Browns 1 2 0 0.333 46 68 -22 1-1-0 0-1-0 0-2-0 0-2-0 1-2-0 1W
Chiefs 1 2 0 0.333 60 56 4 0-1-0 1-1-0 0-1-0 0-1-0 1-2-0 1W
Titans 0 3 0 0.000 51 94 -43 0-2-0 0-1-0 0-1-0 0-2-0 0-3-0 3L
Dolphins 0 3 0 0.000 56 97 -41 0-1-0 0-2-0 0-2-0 0-3-0 0-3-0 3L
Jets 0 3 0 0.000 69 93 -24 0-2-0 0-1-0 0-1-0 0-2-0 0-3-0 3L
Texans 0 3 0 0.000 38 51 -13 0-1-0 0-2-0 0-1-0 0-1-0 0-3-0 3L
NFC Conference W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Eagles 3 0 0 1.000 77 63 14 2-0-0 1-0-0 1-0-0 2-0-0 3-0-0 3W
49ers 3 0 0 1.000 59 49 10 1-0-0 2-0-0 2-0-0 3-0-0 3-0-0 3W
Buccaneers 3 0 0 1.000 72 66 6 1-0-0 2-0-0 1-0-0 1-0-0 3-0-0 3W
Seahawks 3 1 0 0.750 111 67 44 1-1-0 2-0-0 1-1-0 2-1-0 3-1-0 3W
Packers 2 1 0 0.667 64 44 20 2-0-0 0-1-0 1-0-0 2-0-0 2-1-0 1L
Cardinals 2 2 0 0.500 82 74 8 1-1-0 1-1-0 0-2-0 2-2-0 2-2-0 2L
Vikings 2 1 0 0.667 81 56 25 1-1-0 1-0-0 1-0-0 1-1-0 2-1-0 1W
Commanders 2 1 0 0.667 80 57 23 2-0-0 0-1-0 1-0-0 1-1-0 2-1-0 1W
Lions 2 1 0 0.667 103 78 25 1-0-0 1-1-0 1-1-0 1-1-0 2-1-0 2W
Rams 2 1 0 0.667 73 61 12 1-0-0 1-1-0 0-0-0 0-1-0 2-1-0 1L
Panthers 1 2 0 0.333 62 53 9 1-0-0 0-2-0 1-0-0 1-1-0 1-2-0 1W
Falcons 1 2 0 0.333 42 59 -17 0-1-0 1-1-0 0-2-0 1-2-0 1-2-0 1L
Bears 1 2 0 0.333 76 93 -17 1-1-0 0-1-0 0-2-0 1-2-0 1-2-0 1W
Cowboys 1 2 0 0.333 74 92 -18 1-0-0 0-2-0 1-1-0 1-2-0 1-2-0 1L
Saints 0 3 0 0.000 47 90 -43 0-2-0 0-1-0 0-0-0 0-3-0 0-3-0 3L
Giants 0 3 0 0.000 52 83 -31 0-1-0 0-2-0 0-2-0 0-2-0 0-3-0 3L
NFL Team W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Bills 3 0 0 1.000 102 71 31 2-0-0 1-0-0 2-0-0 3-0-0 3-0-0 3W
Colts 3 0 0 1.000 103 56 47 2-0-0 1-0-0 1-0-0 3-0-0 3-0-0 3W
Chargers 3 0 0 1.000 70 50 20 2-0-0 1-0-0 3-0-0 3-0-0 3-0-0 3W
Eagles 3 0 0 1.000 77 63 14 2-0-0 1-0-0 1-0-0 2-0-0 3-0-0 3W
49ers 3 0 0 1.000 59 49 10 1-0-0 2-0-0 2-0-0 3-0-0 3-0-0 3W
Buccaneers 3 0 0 1.000 72 66 6 1-0-0 2-0-0 1-0-0 1-0-0 3-0-0 3W
Seahawks 3 1 0 0.750 111 67 44 1-1-0 2-0-0 1-1-0 2-1-0 3-1-0 3W
Bengals 2 1 0 0.667 58 91 -33 1-0-0 1-1-0 1-0-0 2-0-0 2-1-0 1L
Lions 2 1 0 0.667 103 78 25 1-0-0 1-1-0 1-1-0 1-1-0 2-1-0 2W
Packers 2 1 0 0.667 64 44 20 2-0-0 0-1-0 1-0-0 2-0-0 2-1-0 1L
Jaguars 2 1 0 0.667 70 51 19 2-0-0 0-1-0 1-0-0 1-1-0 2-1-0 1W
Rams 2 1 0 0.667 73 61 12 1-0-0 1-1-0 0-0-0 0-1-0 2-1-0 1L
Vikings 2 1 0 0.667 81 56 25 1-1-0 1-0-0 1-0-0 1-1-0 2-1-0 1W
Steelers 2 1 0 0.667 72 77 -5 0-1-0 2-0-0 0-0-0 2-0-0 2-1-0 1W
Commanders 2 1 0 0.667 80 57 23 2-0-0 0-1-0 1-0-0 1-1-0 2-1-0 1W
Cardinals 2 2 0 0.500 82 74 8 1-1-0 1-1-0 0-2-0 2-2-0 2-2-0 2L
Falcons 1 2 0 0.333 42 59 -17 0-1-0 1-1-0 0-2-0 1-2-0 1-2-0 1L
Ravens 1 2 0 0.333 111 96 15 1-1-0 0-1-0 1-0-0 1-1-0 1-2-0 1L
Panthers 1 2 0 0.333 62 53 9 1-0-0 0-2-0 1-0-0 1-1-0 1-2-0 1W
Bears 1 2 0 0.333 76 93 -17 1-1-0 0-1-0 0-2-0 1-2-0 1-2-0 1W
Browns 1 2 0 0.333 46 68 -22 1-1-0 0-1-0 0-2-0 0-2-0 1-2-0 1W
Cowboys 1 2 0 0.333 74 92 -18 1-0-0 0-2-0 1-1-0 1-2-0 1-2-0 1L
Broncos 1 2 0 0.333 68 64 4 1-0-0 0-2-0 0-1-0 1-2-0 1-2-0 2L
Chiefs 1 2 0 0.333 60 56 4 0-1-0 1-1-0 0-1-0 0-1-0 1-2-0 1W
Raiders 1 2 0 0.333 53 74 -21 0-1-0 1-1-0 0-1-0 1-1-0 1-2-0 2L
Patriots 1 2 0 0.333 60 68 -8 0-2-0 1-0-0 1-0-0 1-2-0 1-2-0 1L
Texans 0 3 0 0.000 38 51 -13 0-1-0 0-2-0 0-1-0 0-1-0 0-3-0 3L
Dolphins 0 3 0 0.000 56 97 -41 0-1-0 0-2-0 0-2-0 0-3-0 0-3-0 3L
Saints 0 3 0 0.000 47 90 -43 0-2-0 0-1-0 0-0-0 0-3-0 0-3-0 3L
Giants 0 3 0 0.000 52 83 -31 0-1-0 0-2-0 0-2-0 0-2-0 0-3-0 3L
Jets 0 3 0 0.000 69 93 -24 0-2-0 0-1-0 0-1-0 0-2-0 0-3-0 3L
Titans 0 3 0 0.000 51 94 -43 0-2-0 0-1-0 0-1-0 0-2-0 0-3-0 3L