Kansas City Chiefs
American Football NFL Highmark Stadium Sun 2 Nov 17:25
Buffalo Bills
  1. Prediction
  2. SGP Picks
  3. Odds
  4. Player Props
  5. Stats
  6. Live Stream
  7. Team News
  8. Lineups
  9. Injuries
  10. Standings

NFL Betting Preview: Chiefs vs Bills

The Kansas City Chiefs meet the Buffalo Bills in this NFL matchup at Highmark Stadium, with kickoff scheduled for 17:25 on Sunday, November 2. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

Will Bills Stay in Reach of the Favorites?

If you agree that the Bills can push the Chiefs to the wire, then back the underdogs against the spread here. The +1.5 makes lots of appeal at -106.

Following our spread pick? Secure the best BetMGM promo code and get the full breakdown in our expert site review ahead of making your move.

Chiefs Beat Bills in Pair’s Previous Matchup

Kansas City Chiefs claimed a home victory in their previous game. A 28-7 triumph against Washington Commanders at GEHA Field at Arrowhead Stadium made it three straight wins. The Chiefs totaled 432 yards, split between 284 passing and 148 rushing yards. The offense moved the chains 26 times and produced 4 touchdowns in total, with 3 through the air and one rushing TD.

Buffalo Bills got the win in their last game. A 40-9 triumph occurred on the road at Bank of America Stadium when meeting Carolina Panthers. The Bills recorded 410 total yards, made up of 165 through the air and 245 on the ground. The offense picked up 23 first downs and crossed the goal line 5 times.

Head-to-Head Statistics

The scoreline was 32-29 in favor of the Chiefs when they last played the Bills, with the matchup taking place at GEHA Field at Arrowhead Stadium. The Chiefs have triumphed in five of the previous 9 clashes between these teams.

Quarterbacks

Chiefs vs Bills Prediction & Picks

From our main match prediction to correct score advice, must-watch player props and a custom bet builder — this Chiefs vs Bills betting preview covers it all.

Game Prediction

We’re very confident of the Bills staying close in this NFL matchup, with our pick being that they’ll cover the spread. The +1.5 looks more than generous at -106.

Our NFL picks are always well-researched, starting with a combination of the latest team news and current form. Once we’ve got a solid read on the matchup, we layer in the key data to back it up.

Key Chiefs vs Bills stats:

  • The +1.5 line has been covered by Bills in 9 of their last 10 games at home.
  • The +1.5 line has been covered by Bills in 17 of their last 20 games at home.
  • The -1.5 line hasn’t been covered by Chiefs in 4 of their last 5 games on the road.
  • The -1.5 line hasn’t been covered by Chiefs in 2 of their last 3 games on the road this season.

Bills +1.5 Probability

According to the top sportsbooks, our pick has a 51.5% chance of delivering a return. Based on our cappers in-depth research, we calculate the actual probability to be 55-60%. It’s why we think it’s worth placing this bet.

Looking for Bigger Odds?

Looking for more juice from your spread pick? By moving the betting line, you are able to get bigger odds although you will need to take a riskier wager.

Thinking about placing a wager? Explore our updated guide filled with top betting offers, free bets, and promotions.

Best Bet

Bills +1.5 @ -106 Watch Live Bet Now BetMGM logo
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Gamble responsibly 18+. All odds are correct at time of publishing and are subject to change. To use the Bookmaker Live Streaming services you will need to be logged in and have a funded account or to have placed a bet in the last 24 hours. Geo-restrictions apply.
Published 23:26, 31 October 2025

Player Prop Picks

Top Pick: Patrick Mahomes Under 274.5 Passing Yards -114 BetMGM logo

You can back Patrick Mahomes (Chiefs) at -114 to record fewer than 274.5 passing yards. If you agree with our verdict that the line is too high, this QB Passing Yards wager is worth backing.

Latest Patrick Mahomes Player Prop Odds

James Cook Under 75.5 Rushing Yards -114 BetMGM logo

The odds for James Cook (Bills) to have less than 75.5 rushing yards are -114. Considering all factors, we’re confident he’ll fall short of the Player Rushing Yards line.

Latest James Cook Player Prop Odds

Same Game Parlay Picks

Spread Bills +1.5
Totals Under 52.5
Passing Yards Patrick Mahomes Under 274.5

Take a same game parlay that incorporates Bills to cover the +1.5 spread along with Under 52.5 points. We’ve also gone for Patrick Mahomes (Chiefs) to go Under 274.5 passing yards.

A same game parlay is a great alternative for football bettors who want to focus their wagering on a single event. You can predict different outcomes and see their odds combined before going ahead and placing this tailored bet.

T&C apply. Gamble responsibly 18+

Correct Score Prediction

Chiefs Chiefs logo 21 - 24 Bills logo Bills

There are huge odds available when it comes to the Bills landing a 24-21 win. A close matchup is anticipated between two evenly-matched teams.

Chiefs vs Bills Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Books Anticipating a Tight Affair

The betting odds about Buffalo Bills winning is +116, with Kansas City Chiefs priced up at -135 to achieve victory. The hosts have a 46% chance of victory in the eyes of the most popular sportsbooks.

1.5 is the spread and 52.5 is the total points line. The Totals offers NFL fans an alternative way of getting involved. If you fancy Under 52.5, then the odds are -112.

The top NFL sportsbooks offer a huge selection of game lines and team props when it comes to this popular league. Make sure you look through all the available options before deciding which bet to place.

James Cook Favorite to Be First TD Scorer

James Cook is the market leader at +550 to be the First TD Scorer. Should you think he will score the final touchdown, then a similar price can be found.

Touchdown

Receiving Yards

Rushing Yards

Passing Yards

Best Betting Offers
Highmark Stadium
Highmark Stadium

Bills Hold Nine Wins in Previous Ten at Home

The Bills own a 9-1 mark in their past 10 home games, putting up 31.00 points per contest and giving up 20.10.

The Chiefs are 5-5 in their last 10 games on the road, posting 22.10 points per contest while yielding 23.90.

The previous meeting at Highmark Stadium saw the Bills defeat the Chiefs 30-21. The last 3 head-to-heads at Highmark Stadium show the Chiefs with two wins, while the Bills have one to their name.

Last 10 Games W-L P PF PA O52.5 U52.5
Bills logo Bills Home Stats 9-1 51.10 31.00 20.10 2 8
Chiefs logo Chiefs Away Stats 5-5 46.00 22.10 23.90 3 7
  • W-L = Wins-Losses
  • P = Avg. Points
  • PF = Avg. Points For
  • PA = Avg. Points Against
  • O52.5 = Games Over 52.5 Points
  • U52.5 = Games Under 52.5 Points
Team Stats

Latest regular season and playoff games stats.

Kansas City Chiefs logo Kansas City Chiefs Stats
Buffalo Bills logo Buffalo Bills Stats
Moneyline
  • 6 wins and 4 defeats in the last 10 games
  • 5 wins and 5 defeats in the last 10 games on the road
Moneyline
  • 7 wins and 3 defeats in the last 10 games
  • 9 wins and 1 defeat in the last 10 home games
Point Spread
Point Spread
Total Points
Total Points
Game Stats
Last 10 Games
Game Stats
Last 10 Games
Last 10 Games on the Road
Last 10 Home Games

Live Streaming

You can watch and bet on NFL games thanks to the live streaming service that’s available. This is only available to eligible sportsbook customers and is subject to geo-restrictions.

You’re never short of viewing opportunities. Check out the daily list of sporting events that are being covered through this service.

Team News

Kansas City Chiefs Injuries

Type
Name
Info
Felix Anudike-Uzomah
Hamstring
Jake Briningstool
Hamstring
Deon Bush
Achilles
Ethan Driskell
Appendix
Brandon George
Undisclosed
Keaontay Ingram
Undisclosed
Nazeeh Johnson
Shoulder
Jaylon Moore
Illness
Omarr Norman-Lott
Knee - ACL
Isiah Pacheco
Knee - MCL
Janarius Robinson
Foot
Eric Scott
Undisclosed
Josh Simmons
Personal
Trey Smith
Back

Buffalo Bills Injuries

Type
Name
Info
Tyler Bass
Hip
DeWayne Carter
Achilles
Tylan Grable
Concussion
Damar Hamlin
Pectoral
Taron Johnson
Groin
Cameron Johnston
Foot
DaQuan Jones
Calf
Ed Oliver
Biceps
Wande Owens
Undisclosed
Joshua Palmer
Knee
Taylor Rapp
Knee
T.J. Sanders
Knee
Dorian Strong
Neck
Shaq Thompson
Hamstring

Previous Kansas City Chiefs Lineups

27 Oct NFL
Commanders 7-28 Chiefs
19 Oct NFL
Raiders 0-31 Chiefs
12 Oct NFL
Lions 17-30 Chiefs
06 Oct NFL
Chiefs 28-31 Jaguars
28 Sep NFL
Ravens 20-37 Chiefs
21 Sep NFL
Chiefs 22-9 Giants
14 Sep NFL
Eagles 20-17 Chiefs
05 Sep NFL
Chiefs 21-27 Chargers
09 Feb NFL Playoffs
Chiefs 22-40 Eagles
26 Jan NFL Playoffs
Bills 29-32 Chiefs

Previous Buffalo Bills Lineups

26 Oct NFL
Bills 40-9 Panthers
13 Oct NFL
Bills 14-24 Falcons
05 Oct NFL
Patriots 23-20 Bills
28 Sep NFL
Saints 19-31 Bills
18 Sep NFL
Dolphins 21-31 Bills
14 Sep NFL
Bills 30-10 Jets
07 Sep NFL
Ravens 40-41 Bills
26 Jan NFL Playoffs
Bills 29-32 Chiefs
19 Jan NFL Playoffs
Ravens 25-27 Bills
12 Jan NFL Playoffs
Broncos 7-31 Bills

NFL Standings Select Season

AFC East W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Patriots 6 2 0 0.750 213 146 67 2-2-0 4-0-0 2-0-0 4-2-0 5-0-0 5W
Bills 5 2 0 0.714 207 146 61 3-1-0 2-1-0 2-1-0 3-1-0 3-2-0 1W
Dolphins 2 7 0 0.222 180 243 -63 1-3-0 1-4-0 1-2-0 1-6-0 1-4-0 1L
Jets 1 7 0 0.125 168 221 -53 0-5-0 1-2-0 0-2-0 1-4-0 1-4-0 1W
AFC North W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Steelers 4 3 0 0.571 175 175 0 2-2-0 2-1-0 1-1-0 3-1-0 3-2-0 2L
Bengals 3 5 0 0.375 174 253 -79 2-2-0 1-3-0 2-0-0 3-2-0 1-4-0 1L
Ravens 3 5 0 0.375 202 216 -14 2-3-0 1-2-0 1-0-0 2-3-0 2-3-0 2W
Browns 2 6 0 0.250 126 184 -58 2-2-0 0-4-0 0-3-0 1-4-0 1-4-0 1L
AFC South W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Colts 7 1 0 0.875 270 154 116 5-0-0 2-1-0 2-0-0 6-0-0 4-1-0 4W
Jaguars 4 3 0 0.571 146 155 -9 3-2-0 1-1-0 1-0-0 2-1-0 3-2-0 2L
Texans 3 4 0 0.429 153 103 50 2-1-0 1-3-0 1-1-0 2-1-0 3-2-0 1W
Titans 1 7 0 0.125 110 230 -120 0-3-0 1-4-0 0-3-0 0-6-0 1-4-0 3L
AFC West W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Broncos 6 2 0 0.750 207 151 56 4-0-0 2-2-0 0-1-0 3-2-0 5-0-0 5W
Chargers 5 3 0 0.625 188 173 15 3-2-0 2-1-0 3-0-0 4-1-0 2-3-0 1W
Chiefs 5 3 0 0.625 214 131 83 4-1-0 1-2-0 1-1-0 2-2-0 4-1-0 3W
Raiders 2 5 0 0.286 103 180 -77 1-2-0 1-3-0 0-2-0 2-3-0 1-4-0 1L
NFC East W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Eagles 6 2 0 0.750 208 185 23 3-1-0 3-1-0 2-1-0 5-1-0 3-2-0 2W
Cowboys 3 4 1 0.375 246 250 -4 2-0-1 1-4-0 2-1-0 2-3-1 2-2-1 1L
Commanders 3 5 0 0.375 187 198 -11 2-1-0 1-4-0 1-1-0 1-4-0 1-4-0 3L
Giants 2 6 0 0.250 173 215 -42 2-1-0 0-5-0 1-3-0 1-4-0 2-3-0 2L
NFC North W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Packers 5 1 1 0.714 193 150 43 3-0-0 2-1-1 1-0-0 3-0-1 3-1-1 3W
Lions 5 2 0 0.714 215 151 64 3-0-0 2-2-0 1-1-0 2-1-0 4-1-0 1W
Bears 4 3 0 0.571 168 185 -17 2-1-0 2-2-0 0-2-0 3-2-0 4-1-0 1L
Vikings 3 4 0 0.429 155 162 -7 1-2-0 2-2-0 1-0-0 1-2-0 2-3-0 2L
NFC South W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Buccaneers 6 2 0 0.750 197 178 19 2-1-0 4-1-0 2-0-0 4-2-0 3-2-0 1W
Panthers 4 4 0 0.500 154 192 -38 3-1-0 1-3-0 1-0-0 2-1-0 3-2-0 1L
Falcons 3 4 0 0.429 120 154 -34 2-2-0 1-2-0 0-2-0 2-3-0 2-3-0 2L
Saints 1 7 0 0.125 128 209 -81 1-4-0 0-3-0 0-1-0 1-5-0 1-4-0 3L
NFC West W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Seahawks 5 2 0 0.714 193 136 57 2-2-0 3-0-0 1-1-0 2-2-0 4-1-0 2W
Rams 5 2 0 0.714 175 117 58 2-1-0 3-1-0 0-1-0 0-2-0 3-2-0 2W
49ers 5 3 0 0.625 160 164 -4 2-1-0 3-2-0 3-0-0 5-1-0 2-3-0 1L
Cardinals 2 5 0 0.286 153 154 -1 1-3-0 1-2-0 0-2-0 2-3-0 0-5-0 5L
AFC Conference W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Colts 7 1 0 0.875 270 154 116 5-0-0 2-1-0 2-0-0 6-0-0 4-1-0 4W
Patriots 6 2 0 0.750 213 146 67 2-2-0 4-0-0 2-0-0 4-2-0 5-0-0 5W
Broncos 6 2 0 0.750 207 151 56 4-0-0 2-2-0 0-1-0 3-2-0 5-0-0 5W
Steelers 4 3 0 0.571 175 175 0 2-2-0 2-1-0 1-1-0 3-1-0 3-2-0 2L
Bills 5 2 0 0.714 207 146 61 3-1-0 2-1-0 2-1-0 3-1-0 3-2-0 1W
Chargers 5 3 0 0.625 188 173 15 3-2-0 2-1-0 3-0-0 4-1-0 2-3-0 1W
Chiefs 5 3 0 0.625 214 131 83 4-1-0 1-2-0 1-1-0 2-2-0 4-1-0 3W
Jaguars 4 3 0 0.571 146 155 -9 3-2-0 1-1-0 1-0-0 2-1-0 3-2-0 2L
Texans 3 4 0 0.429 153 103 50 2-1-0 1-3-0 1-1-0 2-1-0 3-2-0 1W
Bengals 3 5 0 0.375 174 253 -79 2-2-0 1-3-0 2-0-0 3-2-0 1-4-0 1L
Raiders 2 5 0 0.286 103 180 -77 1-2-0 1-3-0 0-2-0 2-3-0 1-4-0 1L
Ravens 3 5 0 0.375 202 216 -14 2-3-0 1-2-0 1-0-0 2-3-0 2-3-0 2W
Browns 2 6 0 0.250 126 184 -58 2-2-0 0-4-0 0-3-0 1-4-0 1-4-0 1L
Dolphins 2 7 0 0.222 180 243 -63 1-3-0 1-4-0 1-2-0 1-6-0 1-4-0 1L
Jets 1 7 0 0.125 168 221 -53 0-5-0 1-2-0 0-2-0 1-4-0 1-4-0 1W
Titans 1 7 0 0.125 110 230 -120 0-3-0 1-4-0 0-3-0 0-6-0 1-4-0 3L
NFC Conference W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Packers 5 1 1 0.714 193 150 43 3-0-0 2-1-1 1-0-0 3-0-1 3-1-1 3W
Eagles 6 2 0 0.750 208 185 23 3-1-0 3-1-0 2-1-0 5-1-0 3-2-0 2W
Buccaneers 6 2 0 0.750 197 178 19 2-1-0 4-1-0 2-0-0 4-2-0 3-2-0 1W
Seahawks 5 2 0 0.714 193 136 57 2-2-0 3-0-0 1-1-0 2-2-0 4-1-0 2W
Lions 5 2 0 0.714 215 151 64 3-0-0 2-2-0 1-1-0 2-1-0 4-1-0 1W
Rams 5 2 0 0.714 175 117 58 2-1-0 3-1-0 0-1-0 0-2-0 3-2-0 2W
49ers 5 3 0 0.625 160 164 -4 2-1-0 3-2-0 3-0-0 5-1-0 2-3-0 1L
Bears 4 3 0 0.571 168 185 -17 2-1-0 2-2-0 0-2-0 3-2-0 4-1-0 1L
Panthers 4 4 0 0.500 154 192 -38 3-1-0 1-3-0 1-0-0 2-1-0 3-2-0 1L
Cowboys 3 4 1 0.375 246 250 -4 2-0-1 1-4-0 2-1-0 2-3-1 2-2-1 1L
Falcons 3 4 0 0.429 120 154 -34 2-2-0 1-2-0 0-2-0 2-3-0 2-3-0 2L
Vikings 3 4 0 0.429 155 162 -7 1-2-0 2-2-0 1-0-0 1-2-0 2-3-0 2L
Commanders 3 5 0 0.375 187 198 -11 2-1-0 1-4-0 1-1-0 1-4-0 1-4-0 3L
Cardinals 2 5 0 0.286 153 154 -1 1-3-0 1-2-0 0-2-0 2-3-0 0-5-0 5L
Giants 2 6 0 0.250 173 215 -42 2-1-0 0-5-0 1-3-0 1-4-0 2-3-0 2L
Saints 1 7 0 0.125 128 209 -81 1-4-0 0-3-0 0-1-0 1-5-0 1-4-0 3L
NFL Team W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Colts 7 1 0 0.875 270 154 116 5-0-0 2-1-0 2-0-0 6-0-0 4-1-0 4W
Packers 5 1 1 0.714 193 150 43 3-0-0 2-1-1 1-0-0 3-0-1 3-1-1 3W
Broncos 6 2 0 0.750 207 151 56 4-0-0 2-2-0 0-1-0 3-2-0 5-0-0 5W
Patriots 6 2 0 0.750 213 146 67 2-2-0 4-0-0 2-0-0 4-2-0 5-0-0 5W
Eagles 6 2 0 0.750 208 185 23 3-1-0 3-1-0 2-1-0 5-1-0 3-2-0 2W
Buccaneers 6 2 0 0.750 197 178 19 2-1-0 4-1-0 2-0-0 4-2-0 3-2-0 1W
Bills 5 2 0 0.714 207 146 61 3-1-0 2-1-0 2-1-0 3-1-0 3-2-0 1W
Lions 5 2 0 0.714 215 151 64 3-0-0 2-2-0 1-1-0 2-1-0 4-1-0 1W
Rams 5 2 0 0.714 175 117 58 2-1-0 3-1-0 0-1-0 0-2-0 3-2-0 2W
Seahawks 5 2 0 0.714 193 136 57 2-2-0 3-0-0 1-1-0 2-2-0 4-1-0 2W
Chiefs 5 3 0 0.625 214 131 83 4-1-0 1-2-0 1-1-0 2-2-0 4-1-0 3W
Chargers 5 3 0 0.625 188 173 15 3-2-0 2-1-0 3-0-0 4-1-0 2-3-0 1W
49ers 5 3 0 0.625 160 164 -4 2-1-0 3-2-0 3-0-0 5-1-0 2-3-0 1L
Bears 4 3 0 0.571 168 185 -17 2-1-0 2-2-0 0-2-0 3-2-0 4-1-0 1L
Jaguars 4 3 0 0.571 146 155 -9 3-2-0 1-1-0 1-0-0 2-1-0 3-2-0 2L
Steelers 4 3 0 0.571 175 175 0 2-2-0 2-1-0 1-1-0 3-1-0 3-2-0 2L
Panthers 4 4 0 0.500 154 192 -38 3-1-0 1-3-0 1-0-0 2-1-0 3-2-0 1L
Cowboys 3 4 1 0.375 246 250 -4 2-0-1 1-4-0 2-1-0 2-3-1 2-2-1 1L
Falcons 3 4 0 0.429 120 154 -34 2-2-0 1-2-0 0-2-0 2-3-0 2-3-0 2L
Texans 3 4 0 0.429 153 103 50 2-1-0 1-3-0 1-1-0 2-1-0 3-2-0 1W
Vikings 3 4 0 0.429 155 162 -7 1-2-0 2-2-0 1-0-0 1-2-0 2-3-0 2L
Ravens 3 5 0 0.375 202 216 -14 2-3-0 1-2-0 1-0-0 2-3-0 2-3-0 2W
Bengals 3 5 0 0.375 174 253 -79 2-2-0 1-3-0 2-0-0 3-2-0 1-4-0 1L
Commanders 3 5 0 0.375 187 198 -11 2-1-0 1-4-0 1-1-0 1-4-0 1-4-0 3L
Cardinals 2 5 0 0.286 153 154 -1 1-3-0 1-2-0 0-2-0 2-3-0 0-5-0 5L
Raiders 2 5 0 0.286 103 180 -77 1-2-0 1-3-0 0-2-0 2-3-0 1-4-0 1L
Browns 2 6 0 0.250 126 184 -58 2-2-0 0-4-0 0-3-0 1-4-0 1-4-0 1L
Giants 2 6 0 0.250 173 215 -42 2-1-0 0-5-0 1-3-0 1-4-0 2-3-0 2L
Dolphins 2 7 0 0.222 180 243 -63 1-3-0 1-4-0 1-2-0 1-6-0 1-4-0 1L
Saints 1 7 0 0.125 128 209 -81 1-4-0 0-3-0 0-1-0 1-5-0 1-4-0 3L
Jets 1 7 0 0.125 168 221 -53 0-5-0 1-2-0 0-2-0 1-4-0 1-4-0 1W
Titans 1 7 0 0.125 110 230 -120 0-3-0 1-4-0 0-3-0 0-6-0 1-4-0 3L