Chiefs vs Bills Prediction, Picks & Odds | 02 Nov 2025

NFL Betting Preview: Chiefs vs Bills

The Kansas City Chiefs meet the Buffalo Bills in this NFL Week 9 clash at Highmark Stadium, with kickoff scheduled for 16:25 on Sunday, November 2. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

If you agree that the Bills can push the Chiefs to the wire, then back the underdogs against the spread here. The +1.5 makes lots of appeal at -106.

Following our spread pick? Secure the best BetMGM promo code and get the full breakdown in our expert site review ahead of making your move.

Kansas City Chiefs claimed a home victory in their previous game. A 28-7 triumph against Washington Commanders at GEHA Field at Arrowhead Stadium made it three straight wins. The Chiefs totaled 432 yards, split between 284 passing and 148 rushing yards. The offense moved the chains 26 times and produced 4 touchdowns in total, with 3 through the air and one rushing TD.

Buffalo Bills got the win in their last game. A 40-9 triumph occurred on the road at Bank of America Stadium when meeting Carolina Panthers. The Bills recorded 410 total yards, made up of 165 through the air and 245 on the ground. The offense picked up 23 first downs and crossed the goal line 5 times.

Head-to-Head Statistics

The scoreline was 32-29 in favor of the Chiefs when they last played the Bills, with the matchup taking place at GEHA Field at Arrowhead Stadium. The Chiefs have triumphed in five of the previous 9 clashes between these teams.

Quarterbacks

Patrick Mahomes

266.5 Passing Yards

Over -112

Under -112

Josh Allen

225.5 Passing Yards

Over -112

Under -112

Chiefs vs Bills Prediction & Picks

From our main match prediction to correct score advice, must-watch player props and a custom bet builder — this Chiefs vs Bills betting preview covers it all.

Game Prediction

We’re very confident of the Bills staying close in this NFL matchup, with our pick being that they’ll cover the spread. The +1.5 looks more than generous at -106.

Our NFL picks are always well-researched, starting with a combination of the latest team news and current form. Once we’ve got a solid read on the matchup, we layer in the key data to back it up.

Key Chiefs vs Bills stats:

• The +1.5 line has been covered by Bills in 9 of their last 10 games at home.
• The +1.5 line has been covered by Bills in 17 of their last 20 games at home.
• The -1.5 line hasn’t been covered by Chiefs in 4 of their last 5 games on the road.
• The -1.5 line hasn’t been covered by Chiefs in 2 of their last 3 games on the road this season.

Bills +1.5 Probability

According to the top sportsbooks, our pick has a 51.5% chance of delivering a return. Based on our cappers in-depth research, we calculate the actual probability to be 55-60%. It’s why we think it’s worth placing this bet.

Looking for more juice from your spread pick? By moving the betting line, you are able to get bigger odds although you will need to take a riskier wager.

Thinking about placing a wager? Explore our updated guide filled with top betting offers, free bets, and promotions.

Our Game Prediction

Bills +1.5 @ -106 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (22:26, 31 October 2025). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Patrick Mahomes Under 274.5 Passing Yards -114

You can back Patrick Mahomes (Chiefs) at -114 to record fewer than 274.5 passing yards. If you agree with our verdict that the line is too high, this QB Passing Yards wager is worth backing.

Latest Patrick Mahomes Player Prop Odds

Touchdown

Anytime

+360

First

+1900

Passing Yards

Over 266.5

-112

Under 266.5

-112

Rushing Yards

Over 31.5

-112

Under 31.5

-112

---

James Cook Under 75.5 Rushing Yards -114

The odds for James Cook (Bills) to have less than 75.5 rushing yards are -114. Considering all factors, we’re confident he’ll fall short of the Player Rushing Yards line.

Latest James Cook Player Prop Odds

Touchdown

Anytime

-149

First

+500

Receiving Yards

Over 12.5

-112

Under 12.5

-112

Rushing Yards

Over 70.5

-112

Under 70.5

-112

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Chiefs 21 - 24 Bills

There are huge odds available when it comes to the Bills landing a 24-21 win. A close matchup is anticipated between two evenly-matched teams.

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Chiefs vs Bills Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

The betting odds about Buffalo Bills winning is -135, with Kansas City Chiefs priced up at +114 to achieve victory. The hosts have a 57% chance of victory in the eyes of the most popular sportsbooks.

2.5 is the spread and 48.5 is the total points line. The Totals offers NFL fans an alternative way of getting involved. If you fancy Under 48.5, then the odds are -110.

The top NFL sportsbooks offer a huge selection of game lines and team props when it comes to this popular league. Make sure you look through all the available options before deciding which bet to place.

Moneyline

Chiefs

+114

Bills

-135

Point Spread

Chiefs +2.5

-108

Bills -2.5

-112

Total Points

Under 48.5

-110

Over 48.5

-110

James Cook is the market leader at +500 to be the First TD Scorer. Should you think he will score the final touchdown, then a similar price can be found.

Touchdown

James Cook (Bills)

First TD

+500

Anytime TD

-149

Rashee Rice (Chiefs)

First TD

+700

Anytime TD

-100

Kareem Hunt (Chiefs)

First TD

+750

Anytime TD

+105

Josh Allen (Bills)

First TD

+750

Anytime TD

+105

Travis Kelce (Chiefs)

First TD

+900

Anytime TD

+125

Xavier Worthy (Chiefs)

First TD

+1300

Anytime TD

+190

Khalil Shakir (Bills)

First TD

+1500

Anytime TD

+240

Dalton Kincaid (Bills)

First TD

+1700

Anytime TD

+270

Brashard Smith (Chiefs)

First TD

+1800

Anytime TD

+300

Keon Coleman (Bills)

First TD

+1800

Anytime TD

+280

Patrick Mahomes (Chiefs)

First TD

+1900

Anytime TD

+360

Marquise Brown (Chiefs)

First TD

+2200

Anytime TD

+400

Elijah Moore (Bills)

First TD

+3000

Anytime TD

+500

Noah Gray (Chiefs)

First TD

+3500

Anytime TD

+600

JuJu Smith-Schuster (Chiefs)

First TD

+3500

Anytime TD

+700

Dawson Knox (Bills)

First TD

+3500

Anytime TD

+650

Joshua Palmer (Bills)

First TD

+4500

Anytime TD

+700

Jackson Hawes (Bills)

First TD

+6000

Anytime TD

+850

Curtis Samuel (Bills)

First TD

+7000

Anytime TD

+1000

Tyrell Shavers (Bills)

First TD

+7500

Anytime TD

+1000

Tyquan Thornton (Chiefs)

First TD

+8000

Anytime TD

+1300

Ty Johnson (Bills)

First TD

+8000

Anytime TD

+1000

Elijah Mitchell (Chiefs)

First TD

+8000

Anytime TD

+1200

Jalen Royals (Chiefs)

First TD

+8000

Anytime TD

+1300

Clyde Edwards-Helaire (Chiefs)

First TD

+8000

Anytime TD

+1200

Ray Davis (Bills)

First TD

+10000

Anytime TD

+1300

Reggie Gilliam (Bills)

First TD

+10000

Anytime TD

+3300

Robert Tonyan (Chiefs)

First TD

+10000

Anytime TD

+2500

Jared Wiley (Chiefs)

First TD

+10000

Anytime TD

+2500

Nikko Remigio (Chiefs)

First TD

+10000

Anytime TD

+3500

Receiving Yards

Rashee Rice (Chiefs)

Over 69.5

-112

Under 69.5

-112

Khalil Shakir (Bills)

Over 50.5

-112

Under 50.5

-112

Travis Kelce (Chiefs)

Over 44.5

-112

Under 44.5

-112

Xavier Worthy (Chiefs)

Over 44.5

-112

Under 44.5

-112

Keon Coleman (Bills)

Over 40.5

-112

Under 40.5

-112

Dalton Kincaid (Bills)

Over 36.5

-112

Under 36.5

-112

Brashard Smith (Chiefs)

Over 18.5

-112

Under 18.5

-112

Marquise Brown (Chiefs)

Over 17.5

-127

Under 17.5

-102

Elijah Moore (Bills)

Over 17.5

-112

Under 17.5

-112

James Cook (Bills)

Over 12.5

-112

Under 12.5

-112

JuJu Smith-Schuster (Chiefs)

Over 12.5

-112

Under 12.5

-112

Noah Gray (Chiefs)

Over 9.5

-112

Under 9.5

-112

Dawson Knox (Bills)

Over 8.5

-112

Under 8.5

-112

Kareem Hunt (Chiefs)

Over 7.5

-106

Under 7.5

-122

Rushing Yards

James Cook (Bills)

Over 70.5

-112

Under 70.5

-112

Kareem Hunt (Chiefs)

Over 46.5

-112

Under 46.5

-112

Josh Allen (Bills)

Over 42.5

-112

Under 42.5

-112

Patrick Mahomes (Chiefs)

Over 31.5

-112

Under 31.5

-112

Brashard Smith (Chiefs)

Over 18.5

-112

Under 18.5

-112

Xavier Worthy (Chiefs)

Over 4.5

-108

Under 4.5

-118

Rashee Rice (Chiefs)

Over 3.5

+108

Under 3.5

-135

Passing Yards

Patrick Mahomes (Chiefs)

Over 266.5

-112

Under 266.5

-112

Josh Allen (Bills)

Over 225.5

-112

Under 225.5

-112

There are always opportunities to enjoy NFL micro betting. It’s generally the case that you will find team and player props in-game and bettors can use their insight to wager on outcomes such as the Next Punt, Turnover or Score Play.

Bills Hold Nine Wins in Previous Ten at Home

The Bills own a 9-1 mark in their past 10 home games, putting up 31.00 points per contest and giving up 20.10.

The Chiefs are 5-5 in their last 10 games on the road, posting 22.10 points per contest while yielding 23.90.

The previous meeting at Highmark Stadium saw the Bills defeat the Chiefs 30-21. The last 3 head-to-heads at Highmark Stadium show the Chiefs with two wins, while the Bills have one to their name.

Last 10 Games		W-L	P	PF	PA	O52.5	U52.5
Bills Home Stats		9-1	51.10	31.00	20.10	2	8
Chiefs Away Stats		5-5	46.00	22.10	23.90	3	7

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O52.5 = Games Over 52.5 Points
• U52.5 = Games Under 52.5 Points

Latest regular season and playoff games stats.

Kansas City Chiefs Stats

Buffalo Bills Stats

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 5 wins and 5 defeats in the last 10 games on the road

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 9 wins and 1 defeat in the last 10 home games

Point Spread

• -1.5 Betting Line: Have covered the spread in 6 of the last 10 games
• -1.5 Betting Line on the Road: Have covered the spread in 5 of the last 10 games on the road

Point Spread

• +1.5 Betting Line: Have covered the spread in 7 of the last 10 games
• +1.5 Betting Line at Home: Have covered the spread in 9 of the last 10 home games

Total Points

• Game Totals: An average of 46.80 pts in the previous 10 games
• Game Totals on the Road: An average of 46.00 pts in the previous 10 games on the road
• Over 52.5: Covered in 4 of the previous 10 games
• Over 52.5 on the Road: Covered in 3 of the previous 10 games on the road
• Team Totals: Have scored an average of 26.80 pts and allowed 20.00 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 22.10 pts and allowed 23.90 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 50.40 pts in the previous 10 games
• Game Totals at Home: An average of 51.10 pts in the previous 10 home games
• Over 52.5: Covered in 2 of the previous 10 games
• Over 52.5 at Home: Covered in 2 of the previous 10 home games
• Team Totals: Have scored an average of 29.40 pts and allowed 21.00 pts in the last 10 games
• Team Totals at Home: Have scored an average of 31.00 pts and allowed 20.10 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 366.90 Yds. Allowed 294.10 Yds
• Rushing Yards: Gained 119.60 Yds. Allowed 108.20 Yds
• Passing Yards: Gained 247.30 Yds. Allowed 185.90 Yds
• Total Touchdowns: Scored 3.30 TD. Allowed 2.30 TD
• Rushing Touchdowns: Scored 1.20 TD. Allowed 0.90 TD
• Passing Touchdowns: Scored 2.10 TD. Allowed 1.20 TD
• Total 1st Downs: Picked up 22.90. Allowed 17.40
• Total Turnovers: Committed 0.80. Committed by opponents 1.00
• Total Penalties: Committed 6.80. Committed by opponents 5.80
• Penalty Yards: Lost 57.90 Yds. Gained 42.60 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 379.80 Yds. Allowed 319.40 Yds
• Rushing Yards: Gained 165.50 Yds. Allowed 144.20 Yds
• Passing Yards: Gained 214.30 Yds. Allowed 175.20 Yds
• Total Touchdowns: Scored 3.50 TD. Allowed 2.50 TD
• Rushing Touchdowns: Scored 1.90 TD. Allowed 1.40 TD
• Passing Touchdowns: Scored 1.60 TD. Allowed 1.10 TD
• Total 1st Downs: Picked up 23.00. Allowed 19.70
• Total Turnovers: Committed 0.60. Committed by opponents 1.20
• Total Penalties: Committed 6.50. Committed by opponents 5.30
• Penalty Yards: Lost 51.40 Yds. Gained 42.30 Yds

Last 10 Games on the Road

• Total Yards: Gained 318.60 Yds. Allowed 337.60 Yds
• Rushing Yards: Gained 96.30 Yds. Allowed 118.50 Yds
• Passing Yards: Gained 222.30 Yds. Allowed 219.10 Yds
• Total Touchdowns: Scored 2.70 TD. Allowed 2.70 TD
• Rushing Touchdowns: Scored 0.80 TD. Allowed 1.10 TD
• Passing Touchdowns: Scored 1.90 TD. Allowed 1.40 TD
• Total 1st Downs: Picked up 19.00. Allowed 21.10
• Total Turnovers: Committed 0.70. Committed by opponents 1.50
• Total Penalties: Committed 7.80. Committed by opponents 5.70
• Penalty Yards: Lost 67.80 Yds. Gained 36.30 Yds

Last 10 Home Games

• Total Yards: Gained 373.00 Yds. Allowed 314.30 Yds
• Rushing Yards: Gained 149.80 Yds. Allowed 135.20 Yds
• Passing Yards: Gained 223.20 Yds. Allowed 179.10 Yds
• Total Touchdowns: Scored 3.80 TD. Allowed 2.50 TD
• Rushing Touchdowns: Scored 1.90 TD. Allowed 1.00 TD
• Passing Touchdowns: Scored 1.80 TD. Allowed 1.50 TD
• Total 1st Downs: Picked up 22.90. Allowed 19.90
• Total Turnovers: Committed 0.60. Committed by opponents 1.80
• Total Penalties: Committed 6.60. Committed by opponents 6.20
• Penalty Yards: Lost 47.00 Yds. Gained 53.30 Yds

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