Kansas City Chiefs
American Football NFL SoFi Stadium Fri 5 Sep 20:00
Los Angeles Chargers
  1. Prediction
  2. Bet Builder
  3. Odds
  4. Player Props
  5. Stats
  6. Live Stream
  7. Team News
  8. Lineups
  9. Injuries
  10. Standings

NFL Betting Preview: Chiefs vs Chargers

The AFC champions and Super Bowl runners-up Kansas City Chiefs lock horns with the Los Angeles Chargers in this NFL Week 1 matchup at SoFi Stadium, with kickoff scheduled for 20:00 on Friday 5 September. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

Don’t Write Off Chargers

The market might have underrated the Chargers and -105 makes lots of appeal considering the underdogs are +3 on the spread. Back them to cover the line against the Chiefs.

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Chiefs Are 8 From 10 on the H2H

Kansas City Chiefs lost their last game, a 40–22 defeat to the Philadelphia Eagles in Super Bowl LIX at Caesars Superdome. It marked the franchise’s third consecutive Super Bowl appearance.

The Chiefs generated 275 total yards of offense, with 226 coming through the air and 49 on the ground. They picked up 12 first downs and scored three touchdowns, all via the passing game.

Los Angeles Chargers suffered a defeat in their last game. A 32-12 scoreline occurred on the road at NRG Stadium against Houston Texans. The Chargers recorded 261 yards, split between 211 passing and 50 rushing yards. The offense produced 15 first downs and scored one touchdown.

Head-to-Head Statistics

The Chiefs won the most recent matchup between these teams. A 19-17 victory was registered against the Chargers at GEHA Field at Arrowhead Stadium. In the past 10 H2H meetings, the Chiefs have won eight.

Quarterbacks

Chiefs vs Chargers Prediction & Picks

Get the edge with our best Chiefs vs Chargers tips: a key match prediction, correct score recommendation, top player prop bets and a ready-made bet builder.

Game Prediction

We’re confident that the Chargers can push for a victory in this NFL matchup and the +3 about the underdogs on the spread makes appeal. Take -105 that they cover the line.

The NFL handicappers at Sportsgambler.com stay on top of injuries and team form that could impact the outcome. We also leave no stone unturned when analyzing the latest stats to support every prediction.

Key Chiefs vs Chargers stats:

  • The +3 line has been covered by Chargers in 15 of their last 20 games at home.
  • The +3 line has been covered by Chargers in 7 of their last 10 games.
  • The -3 line hasn’t been covered by Chiefs in 2 consecutive games on the road.
  • The +3 line has been covered by Chargers in 7 of their last 10 games against Chiefs.

Chargers +3 Probability

The top NFL sportsbooks make it a 51.3% chance that our pick is settled as a winner. However, our research has found that the actual probability is closer to 60%. This is why we regard this as a value bet.

Looking for Bigger Odds?

If the initial odds don’t grab your fancy, there’s the option to shoot for more juice by moving the line when it comes to your point spread pick. It all comes down to how confident you feel.

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Best Bet

Chargers +3 @ -105 Watch Live Bet Now BetMGM logo
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Published 02:26, 04 September 2025

Player Prop Picks

Top Pick: Justin Herbert Over 231.5 Passing Yards -114 BetMGM logo

Justin Herbert (Chargers) can be backed at -114 to go beyond 231.5 passing yards. We’re confident in taking him to cover the QB Passing Yards line and bettors can place this bet with confidence.

Latest Justin Herbert Player Prop Odds

Travis Kelce Anytime TD +155 BetMGM logo

You can back Travis Kelce (Chiefs) at odds of +155 to score a TD. Based on all the evidence, we're happy to back him to punch it in on the Anytime Touchdown Scorer market.

Latest Travis Kelce Player Prop Odds

Same Game Parlay Picks

Spread Chargers +3
Totals Over 46.5
Passing Yards Justin Herbert Over 231.5

We’ve got a same game parlay with three options: Chargers +3, Over 46.5 points and Justin Herbert (Chargers) to have Over 231.5 passing yards.

A same game parlay allows football bettors to place a multiple wager on the same game. You can go through the available betting lines and select the outcomes that you think will happen. The odds for each pick are then combined together.

T&C apply. Gamble responsibly 18+

Correct Score Prediction

Chiefs Chiefs logo 23 - 27 Chargers logo Chargers

We’ll throw a dart when it comes to the Chargers claiming a 27-23 victory. This correct score prediction is available at monster odds and could be an entertaining wager to place.

Chiefs vs Chargers Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Latest Odds Suggest Chiefs Win

With a 63% chance of securing victory, Kansas City Chiefs are favorites for this game and the sportsbooks have them at betting odds of -167. For those wanting to oppose the market leader, you can get +142 about Los Angeles Chargers.

The spread currently stands at 3 and the total points line is 47.5. NFL fans regularly enjoy the opportunity to bet on the Totals. There’s the chance to back Under 47.5 at -115.

National Football League fans are spoilt for choice thanks to the wide range of game lines and team props which are available for every game on the coupon. Visit the top betting apps and find the best value wagers.

Xavier Worthy Favorite to Be First TD Scorer

There is +124 available that Xavier Worthy scores a TD at any stage. He is available at +700 to record the first touchdown which makes him favorite.

Touchdown

Xavier Worthy (Chiefs)
First TD
+700
Anytime TD
+124
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Omarion Hampton (Chargers)
First TD
+750
Anytime TD
+154
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Isiah Pacheco (Chiefs)
First TD
+800
Anytime TD
+176
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Rashee Rice (Chiefs)
First TD
+850
Anytime TD
+160
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Receiving Yards

Ladd McConkey (Chargers)
Over 73.5
-114
Under 73.5
-114
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Xavier Worthy (Chiefs)
Over 60.5
-114
Under 60.5
-114
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Travis Kelce (Chiefs)
Over 47.5
-114
Under 47.5
-114
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Rushing Yards

Isiah Pacheco (Chiefs)
Over 48.5
-114
Under 48.5
-114
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Omarion Hampton (Chargers)
Over 47.5
-114
Under 47.5
-114
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Najee Harris (Chargers)
Over 21.5
-114
Under 21.5
-114
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Passing Yards

Patrick Mahomes (Chiefs)
Over 249.5
-114
Under 249.5
-114
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Justin Herbert (Chargers)
Over 233.5
-114
Under 233.5
-114
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Micro Betting

An increasing number of bettors are now enjoying micro betting on the NFL and it’s something which is available on an in-game basis. Wait for the action to start and then wager on something specific to happen.

Best Betting Offers
SoFi Stadium
SoFi Stadium

Chiefs Have Won Last Five Head-to-Head Meetings at SoFi Stadium

The Chargers have a 5-5 record in their last 10 home games, averaging 22.70 points on offense and surrendering 21.30 on defense.

The Chiefs have a 7-3 record in their last 10 games on the road, averaging 21.70 points scored and 21.70 points allowed.

The Chiefs earned a 17-10 win over the Chargers the last time they played at SoFi Stadium. From 5 head-to-head games at SoFi Stadium, the Chiefs have been victorious in all.

Last 10 Games W-L P PF PA O46.5 U46.5
Chargers logo Chargers Home Stats 5-5 44.00 22.70 21.30 4 6
Chiefs logo Chiefs Away Stats 7-3 43.40 21.70 21.70 4 6
  • W-L = Wins-Losses
  • P = Avg. Points
  • PF = Avg. Points For
  • PA = Avg. Points Against
  • O46.5 = Games Over 46.5 Points
  • U46.5 = Games Under 46.5 Points

Last 5 & H2H

Team Stats

Latest regular season and playoff games stats.

Kansas City Chiefs logo Kansas City Chiefs Stats
Los Angeles Chargers logo Los Angeles Chargers Stats
Moneyline
  • 8 wins and 2 defeats in the last 10 games
  • 7 wins and 3 defeats in the last 10 games on the road
Moneyline
  • 6 wins and 4 defeats in the last 10 games
  • 5 wins and 5 defeats in the last 10 home games
Point Spread
Point Spread
Total Points
Total Points
Game Stats
Last 10 Games
Game Stats
Last 10 Games
Last 10 Games on the Road
Last 10 Home Games

Live Streaming

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Team News

Kansas City Chiefs Injuries

Type
Name
Info
Felix Anudike-Uzomah
Hamstring
Jake Briningstool
Hamstring
Deon Bush
Achilles
Ethan Driskell
Appendix
Brandon George
Undisclosed
Keaontay Ingram
Undisclosed
Nazeeh Johnson
Shoulder
Omarr Norman-Lott
Ankle
Rashee Rice
Suspension
Janarius Robinson
Foot
Jalen Royals
Knee
Eric Scott
Undisclosed
BJ Thompson
Chest

Los Angeles Chargers Injuries

Type
Name
Info
Mekhi Becton
Illness
Junior Colson
Shoulder
Josh Fuga
Undisclosed
Josh Harris
Undisclosed
Deane Leonard
Leg
Jordan Oladokun
Undisclosed
Eric Rogers
Undisclosed
Rashawn Slater
Kneecap
Savion Washington
Undisclosed
Mike Williams
Undisclosed

Previous Kansas City Chiefs Lineups

09 Feb NFL Playoffs
Chiefs 22-40 Eagles
26 Jan NFL Playoffs
Bills 29-32 Chiefs
18 Jan NFL Playoffs
Texans 14-23 Chiefs
05 Jan NFL
Chiefs 0-38 Broncos
25 Dec NFL
Chiefs 29-10 Steelers
21 Dec NFL
Texans 19-27 Chiefs
15 Dec NFL
Chiefs 21-7 Browns
08 Dec NFL
Chargers 17-19 Chiefs
29 Nov NFL
Raiders 17-19 Chiefs
24 Nov NFL
Chiefs 30-27 Panthers

Previous Los Angeles Chargers Lineups

11 Jan NFL Playoffs
Chargers 12-32 Texans
05 Jan NFL
Chargers 34-20 Raiders
28 Dec NFL
Chargers 40-7 Patriots
19 Dec NFL
Broncos 27-34 Chargers
15 Dec NFL
Buccaneers 40-17 Chargers
08 Dec NFL
Chargers 17-19 Chiefs
01 Dec NFL
Chargers 17-13 Falcons
25 Nov NFL
Ravens 30-23 Chargers
17 Nov NFL
Bengals 27-34 Chargers
10 Nov NFL
Titans 17-27 Chargers

NFL Standings Select Season

AFC East W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Bills 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Dolphins 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Patriots 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Jets 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
AFC North W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Ravens 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Bengals 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Browns 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Steelers 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
AFC South W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Texans 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Colts 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Jaguars 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Titans 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
AFC West W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Broncos 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Chiefs 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Raiders 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Chargers 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
NFC East W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Eagles 1 0 0 1.000 24 20 4 1-0-0 0-0-0 1-0-0 1-0-0 1-0-0 1W
Giants 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Commanders 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Cowboys 0 1 0 0.000 20 24 -4 0-0-0 0-1-0 0-1-0 0-1-0 0-1-0 1L
NFC North W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Bears 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Lions 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Packers 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Vikings 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
NFC South W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Falcons 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Panthers 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Saints 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Buccaneers 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
NFC West W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Cardinals 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Rams 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
49ers 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Seahawks 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
AFC Conference W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Bills 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Dolphins 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Patriots 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Jets 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Ravens 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Bengals 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Browns 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Steelers 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Texans 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Colts 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Jaguars 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Titans 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Broncos 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Chiefs 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Raiders 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Chargers 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
NFC Conference W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Eagles 1 0 0 1.000 24 20 4 1-0-0 0-0-0 1-0-0 1-0-0 1-0-0 1W
Giants 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Commanders 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Bears 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Lions 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Packers 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Vikings 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Falcons 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Panthers 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Saints 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Buccaneers 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Cardinals 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Rams 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
49ers 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Seahawks 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Cowboys 0 1 0 0.000 20 24 -4 0-0-0 0-1-0 0-1-0 0-1-0 0-1-0 1L
NFL Team W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Eagles 1 0 0 1.000 24 20 4 1-0-0 0-0-0 1-0-0 1-0-0 1-0-0 1W
Cardinals 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Falcons 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Ravens 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Bills 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Panthers 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Bears 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Bengals 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Browns 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Broncos 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Lions 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Packers 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Texans 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Colts 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Jaguars 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Chiefs 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Raiders 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Chargers 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Rams 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Dolphins 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Vikings 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Patriots 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Saints 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Giants 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Jets 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Steelers 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
49ers 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Seahawks 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Buccaneers 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Titans 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Commanders 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Cowboys 0 1 0 0.000 20 24 -4 0-0-0 0-1-0 0-1-0 0-1-0 0-1-0 1L