Chargers vs Cowboys Prediction, Picks & Odds | 21 Dec 2025

NFL Betting Preview: Chargers vs Cowboys

The Los Angeles Chargers battle the Dallas Cowboys at AT&T Stadium, with kickoff scheduled for 13:00 on Sunday, December 21.

There’s a strong case that the Chargers will end up winning and that means wagering them on the Moneyline. You can get a value +112 that they overcome the Cowboys.

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Los Angeles Chargers won their previous game 16-13. This road victory at GEHA Field at Arrowhead Stadium against Kansas City Chiefs was their third on the spin. The Chargers recorded 295 yards, with 201 through the air and 94 on the ground. The offense found the end zone once through the air and picked up 18 first downs.

Dallas Cowboys have lost in back-to-back outings. In a recent home game at AT&T Stadium, they were turned over 34-26 by Minnesota Vikings. The Cowboys finished with 423 total yards, breaking down to 285 passing and 138 rushing yards. They scored two touchdowns and picked up 25 first downs.

Head-to-Head Statistics

The Cowboys beat the Chargers in their last head-to-head matchup. It was a 20-17 scoreline at SoFi Stadium.

Quarterbacks

Justin Herbert

245.5 Passing Yards

Over -112

Under -112

Dak Prescott

249.5 Passing Yards

Over -112

Under -112

Chargers vs Cowboys Prediction & Picks

This Chargers vs Cowboys betting breakdown features a main match prediction, a correct score insight, expert player prop picks and a sharply constructed bet builder to guide your wagers.

Game Prediction

It is time to side with the Chargers to record a victory in this NFL battle. They should have the upper hand and the +112 for our pick on the Moneyline looks a good price.

Sportsgambler.com brings strong NFL expertise, built on knowing the team news as soon as it’s confirmed. Recent form plays a big part in our predictions and we always back it up with the most relevant stats.

Key Chargers vs Cowboys stats:

• Chargers have won 4 of their last 5 games.
• Chargers have won 10 of their last 14 games this season.
• Chargers have won 3 consecutive games.
• Cowboys have lost their last 2 games.

Chargers Moneyline Probability

When you look at the latest betting odds, our pick has a 47.2% chance of winning. After careful examination, our experts calculate this probability to be somewhere between 50-55%. That means we’re regarding it as a value bet.

The spread provides you with the chance to get more juice on your wagers. You can move the line for the Chargers and choose the odds to suit you.

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Our Game Prediction

Chargers Moneyline @ +112 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (19:25, 19 December 2025). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Omarion Hampton Anytime TD +105

Omarion Hampton (Chargers) can be backed at +105 to record a TD. We think this is the pick of the player props, with generous odds available when it comes to backing him to score a touchdown at any time.

Latest Omarion Hampton Player Prop Odds

Touchdown

Anytime

-100

First

+650

Receiving Yards

Over 10.5

-112

Under 10.5

-112

Rushing Yards

Over 48.5

-112

Under 48.5

-112

---

Dak Prescott Over 8.5 Rushing Yards -110

You can place a bet on Dak Prescott (Chargers) at -110 to reach over 8.5 rushing yards. We feel confident that he’ll cover the Player Rushing Yards line, which looks generous.

Latest Dak Prescott Player Prop Odds

Touchdown

Anytime

+550

First

+2700

Passing Yards

Over 249.5

-112

Under 249.5

-112

Rushing Yards

Over 8.5

-108

Under 8.5

-118

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Chargers 24 - 20 Cowboys

Don’t pass up the opportunity to have a speculative wager on the Chargers to claim a 24-20 victory. We don’t think that there will be too much between the teams.

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Chargers vs Cowboys Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

The Moneyline odds about Dallas Cowboys triumphing is priced at +102 and you can get Los Angeles Chargers at -122. The sportsbook traders give the road team a 55% probability of success.

There is a spread of 1.5 and total points has a line of 46.5. A Total bet is always available and can often provide value selections. If you want to bet Under 46.5, there are odds of -110.

If you're betting on the matchups, it's worth checking out the best NFL sportsbooks, where you'll find a massive range of game lines and team props. You can place your bets before kickoff or while the action is underway.

Moneyline

Chargers

-122

Cowboys

+102

Point Spread

Chargers -1.5

-110

Cowboys +1.5

-110

Total Points

Under 46.5

-110

Over 46.5

-110

Javonte Williams can be backed to score a TD at any stage at -130. There is the opportunity to back the market leader to grab the first touchdown at +500.

Touchdown

Javonte Williams (Cowboys)

First TD

+500

Anytime TD

-130

Omarion Hampton (Chargers)

First TD

+650

Anytime TD

-100

CeeDee Lamb (Cowboys)

First TD

+800

Anytime TD

+135

Ladd McConkey (Chargers)

First TD

+850

Anytime TD

+145

George Pickens (Cowboys)

First TD

+1000

Anytime TD

+175

Jake Ferguson (Cowboys)

First TD

+1000

Anytime TD

+175

Oronde Gadsden II (Chargers)

First TD

+1100

Anytime TD

+185

Keenan Allen (Chargers)

First TD

+1100

Anytime TD

+190

Kimani Vidal (Chargers)

First TD

+1600

Anytime TD

+250

Ryan Flournoy (Cowboys)

First TD

+2000

Anytime TD

+390

Quentin Johnston (Chargers)

First TD

+2200

Anytime TD

+270

Tre Harris (Chargers)

First TD

+2200

Anytime TD

+270

Dak Prescott (Cowboys)

First TD

+2700

Anytime TD

+550

Justin Herbert (Chargers)

First TD

+2700

Anytime TD

+500

Jaydon Blue (Cowboys)

First TD

+3300

Anytime TD

+600

Malik Davis (Cowboys)

First TD

+3300

Anytime TD

+600

Derius Davis (Chargers)

First TD

+4500

Anytime TD

+700

KeAndre Lambert-Smith (Chargers)

First TD

+5000

Anytime TD

+850

Tyler Conklin (Chargers)

First TD

+5500

Anytime TD

+850

Will Dissly (Chargers)

First TD

+5500

Anytime TD

+850

KaVontae Turpin (Cowboys)

First TD

+5500

Anytime TD

+550

Luke Schoonmaker (Cowboys)

First TD

+8000

Anytime TD

+1000

Brevyn Spann-Ford (Cowboys)

First TD

+8000

Anytime TD

+1200

Scott Matlock (Chargers)

First TD

+10000

Anytime TD

+2200

Jonathan Mingo (Cowboys)

First TD

+10000

Anytime TD

+2700

Jalen Tolbert (Cowboys)

First TD

+10000

Anytime TD

+2700

Hassan Haskins (Chargers)

First TD

+10000

Anytime TD

+2200

Hunter Luepke (Cowboys)

First TD

+10000

Anytime TD

+1800

Receiving Yards

CeeDee Lamb (Cowboys)

Over 75.5

-112

Under 75.5

-112

George Pickens (Cowboys)

Over 64.5

-112

Under 64.5

-112

Ladd McConkey (Chargers)

Over 47.5

-112

Under 47.5

-112

Oronde Gadsden II (Chargers)

Over 41.5

-112

Under 41.5

-112

Keenan Allen (Chargers)

Over 39.5

-112

Under 39.5

-112

Jake Ferguson (Cowboys)

Over 33.5

-112

Under 33.5

-112

Ryan Flournoy (Cowboys)

Over 27.5

-112

Under 27.5

-112

Omarion Hampton (Chargers)

Over 10.5

-112

Under 10.5

-112

Javonte Williams (Cowboys)

Over 8.5

-112

Under 8.5

-112

Rushing Yards

Javonte Williams (Cowboys)

Over 68.5

-112

Under 68.5

-112

Omarion Hampton (Chargers)

Over 48.5

-112

Under 48.5

-112

Kimani Vidal (Chargers)

Over 34.5

-112

Under 34.5

-112

Justin Herbert (Chargers)

Over 20.5

-112

Under 20.5

-112

Malik Davis (Cowboys)

Over 11.5

-112

Under 11.5

-112

Dak Prescott (Cowboys)

Over 8.5

-108

Under 8.5

-118

Passing Yards

Dak Prescott (Cowboys)

Over 249.5

-112

Under 249.5

-112

Justin Herbert (Chargers)

Over 245.5

-112

Under 245.5

-112

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Cowboys Sitting on Five Wins in Past Ten at Home

The Chargers have six wins and four losses in the last 10 road games, putting up 21.90 points per matchup and giving up 20.30.

The Chargers defeated the Cowboys 26-19 in their last meeting at AT&T Stadium.

Last 10 Games		W-L	P	PF	PA	O49.5	U49.5
Cowboys Home Stats		5-4	57.00	28.70	28.30	6	4
Chargers Away Stats		6-4	42.20	21.90	20.30	2	8

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O49.5 = Games Over 49.5 Points
• U49.5 = Games Under 49.5 Points

Latest regular season and playoff games stats.

Los Angeles Chargers Stats

Dallas Cowboys Stats

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 6 wins and 4 defeats in the last 10 games on the road

Moneyline

• 5 wins and 5 defeats in the last 10 games
• 5 wins, 4 defeats and 1 draw in the last 10 home games

Point Spread

• +2.5 Betting Line: Have covered the spread in 7 of the last 10 games
• +2.5 Betting Line on the Road: Have covered the spread in 7 of the last 10 games on the road

Point Spread

• -2.5 Betting Line: Have covered the spread in 5 of the last 10 games
• -2.5 Betting Line at Home: Have covered the spread in 4 of the last 10 home games

Total Points

• Game Totals: An average of 44.00 pts in the previous 10 games
• Game Totals on the Road: An average of 42.20 pts in the previous 10 games on the road
• Over 49.5: Covered in 2 of the previous 10 games
• Over 49.5 on the Road: Covered in 2 of the previous 10 games on the road
• Team Totals: Have scored an average of 22.70 pts and allowed 21.30 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 21.90 pts and allowed 20.30 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 58.10 pts in the previous 10 games
• Game Totals at Home: An average of 57.00 pts in the previous 10 home games
• Over 49.5: Covered in 7 of the previous 10 games
• Over 49.5 at Home: Covered in 6 of the previous 10 home games
• Team Totals: Have scored an average of 29.30 pts and allowed 28.80 pts in the last 10 games
• Team Totals at Home: Have scored an average of 28.70 pts and allowed 28.30 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 330.60 Yds. Allowed 282.70 Yds
• Rushing Yards: Gained 129.90 Yds. Allowed 102.10 Yds
• Passing Yards: Gained 200.70 Yds. Allowed 180.60 Yds
• Total Touchdowns: Scored 2.10 TD. Allowed 2.40 TD
• Rushing Touchdowns: Scored 0.50 TD. Allowed 1.30 TD
• Passing Touchdowns: Scored 1.60 TD. Allowed 0.90 TD
• Total 1st Downs: Picked up 19.50. Allowed 17.60
• Total Turnovers: Committed 1.30. Committed by opponents 1.70
• Total Penalties: Committed 6.30. Committed by opponents 5.30
• Penalty Yards: Lost 48.90 Yds. Gained 46.20 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 394.00 Yds. Allowed 356.70 Yds
• Rushing Yards: Gained 119.90 Yds. Allowed 118.90 Yds
• Passing Yards: Gained 274.10 Yds. Allowed 237.80 Yds
• Total Touchdowns: Scored 3.20 TD. Allowed 3.40 TD
• Rushing Touchdowns: Scored 0.90 TD. Allowed 1.30 TD
• Passing Touchdowns: Scored 2.10 TD. Allowed 2.00 TD
• Total 1st Downs: Picked up 22.60. Allowed 21.40
• Total Turnovers: Committed 1.20. Committed by opponents 0.90
• Total Penalties: Committed 7.70. Committed by opponents 7.70
• Penalty Yards: Lost 64.50 Yds. Gained 61.00 Yds

Last 10 Games on the Road

• Total Yards: Gained 328.10 Yds. Allowed 277.10 Yds
• Rushing Yards: Gained 106.80 Yds. Allowed 109.40 Yds
• Passing Yards: Gained 221.30 Yds. Allowed 167.70 Yds
• Total Touchdowns: Scored 2.00 TD. Allowed 2.00 TD
• Rushing Touchdowns: Scored 0.50 TD. Allowed 0.90 TD
• Passing Touchdowns: Scored 1.50 TD. Allowed 0.80 TD
• Total 1st Downs: Picked up 18.90. Allowed 17.80
• Total Turnovers: Committed 1.10. Committed by opponents 1.40
• Total Penalties: Committed 6.20. Committed by opponents 6.00
• Penalty Yards: Lost 48.00 Yds. Gained 53.60 Yds

Last 10 Home Games

• Total Yards: Gained 402.60 Yds. Allowed 381.70 Yds
• Rushing Yards: Gained 126.40 Yds. Allowed 108.30 Yds
• Passing Yards: Gained 276.20 Yds. Allowed 273.40 Yds
• Total Touchdowns: Scored 2.90 TD. Allowed 3.50 TD
• Rushing Touchdowns: Scored 1.10 TD. Allowed 1.20 TD
• Passing Touchdowns: Scored 1.60 TD. Allowed 2.20 TD
• Total 1st Downs: Picked up 22.90. Allowed 22.00
• Total Turnovers: Committed 0.90. Committed by opponents 1.10
• Total Penalties: Committed 8.10. Committed by opponents 8.20
• Penalty Yards: Lost 64.60 Yds. Gained 75.20 Yds

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