Chargers vs Giants Prediction, Picks & Odds | 28 Sep 2025

NFL Betting Preview: Chargers vs Giants

The Los Angeles Chargers face the New York Giants in this NFL Week 4 matchup at MetLife Stadium, with kickoff scheduled for 13:00 on Sunday, September 28. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

Our betting prediction is for the Chargers to cover the appealing -6.5 line against the Giants. They should be able to win by a more comfortable margin and odds of -110 are available on the spread.

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Los Angeles Chargers claimed a home victory in their previous game. A 23-20 triumph against Denver Broncos at SoFi Stadium made it three straight wins. The Chargers moved the ball for 376 yards, with 270 through the air and 106 on the ground. They picked up 29 first downs to go along with two touchdowns.

New York Giants have lost on their last three outings. In a recent home game at MetLife Stadium, they were turned over 22-9 by Kansas City Chiefs. The Giants recorded 281 yards, with 151 through the air and 130 on the ground. They picked up 19 first downs and found the end zone once.

Head-to-Head Statistics

The Chargers won the last matchup between the pair. Enjoying a 37-21 triumph when facing the Giants at SoFi Stadium.

Quarterbacks

Justin Herbert

252.5 Passing Yards

Over -112

Under -112

Jaxson Dart

192.5 Passing Yards

Over -112

Under -112

Chargers vs Giants Prediction & Picks

We dive into the best Chargers vs Giants betting angles, including an expert match prediction, correct score forecast, top player prop bets and a value-focused bet builder.

Game Prediction

Back the Chargers against the spread, with a generous betting line of -6.5 that the favorites get the job done in this NFL matchup. There are odds of -110 that are currently on offer for this value pick.

We track all injuries that could impact each franchise before making our NFL predictions. The form guide and latest stats also help the Sportsgambler.com team crunch the numbers ahead of the action.

Key Chargers vs Giants stats:

• The -6.5 line has been covered by Chargers in 3 of their last 5 games on the road.
• The +6.5 line hasn’t been covered by Giants in 7 of their last 10 games.
• The +6.5 line hasn’t been covered by Giants in 2 of their last 3 games this season.

Chargers -6.5 Probability

The top NFL sportsbooks make it a 52.4% chance that our pick is settled as a winner. However, we have this figure between 55-60% based on our in-depth research. It’s the reason why we are recommending this bet.

There’s the option to move the line for your spread pick and this enables bettors to get bigger odds. If you’re prepared for additional risk, you can get more bang for your buck.

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Our Game Prediction

Chargers -6.5 @ -110 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (19:26, 26 September 2025). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Jaxson Dart Under 189.5 Passing Yards -114

Jaxson Dart (Giants) is priced at -114 to have less than 189.5 passing yards. There’s no reason to doubt our instinct, so we’ll bet on him falling short of the QB Passing Yards line.

Latest Jaxson Dart Player Prop Odds

Touchdown

Anytime

+340

First

+1600

Passing Yards

Over 192.5

-112

Under 192.5

-112

Rushing Yards

Over 32.5

-112

Under 32.5

-112

---

Devin Singletary Under 15.5 Rushing Yards -114

Devin Singletary (Giants) is priced at -114 to record fewer than 15.5 rushing yards. We're confident he’ll fall short of the Player Rushing Yards line, so we're backing the Under.

Latest Devin Singletary Player Prop Odds

Touchdown

Anytime

+700

First

+3300

Rushing Yards

Over 15.5

-112

Under 15.5

-112

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Chargers 31 - 17 Giants

There’s the chance to bet on the Chargers in lots of different ways and this includes predicting the correct winning score. We’ll go for a 31-17 victory in their favor.

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Chargers vs Giants Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

With a 75% chance of securing victory, Los Angeles Chargers are favorites for this game and the sportsbooks have them at betting odds of -294. At +235, New York Giants are regarded as having a lower probability of winning.

The spread is 6.5 and the total points line is currently 43.5. A Total bet is always available and can often provide value selections. There’s the chance to back Under 43.5 at -110.

The good news is that you can access a wide range of game lines and team props for every National Football League matchup. The best betting apps offer a great selection of pre-game and in-game wagering options.

Moneyline

Chargers

-294

Giants

+235

Point Spread

Chargers -6.5

-105

Giants +6.5

-115

Total Points

Under 43.5

-110

Over 43.5

-110

The First Touchdown Scorer favorite is Omarion Hampton at +430. Similar odds can be found if you’re interested in this player to register the final TD.

Touchdown

Omarion Hampton (Chargers)

First TD

+430

Anytime TD

-125

Cam Skattebo (Giants)

First TD

+600

Anytime TD

-100

Keenan Allen (Chargers)

First TD

+800

Anytime TD

+170

Quentin Johnston (Chargers)

First TD

+900

Anytime TD

+185

Ladd McConkey (Chargers)

First TD

+950

Anytime TD

+200

Malik Nabers (Giants)

First TD

+1000

Anytime TD

+180

Jaxson Dart (Giants)

First TD

+1600

Anytime TD

+340

Justin Herbert (Chargers)

First TD

+1600

Anytime TD

+360

Oronde Gadsden II (Chargers)

First TD

+1700

Anytime TD

+380

Wan'Dale Robinson (Giants)

First TD

+2200

Anytime TD

+430

Will Dissly (Chargers)

First TD

+2200

Anytime TD

+410

Darius Slayton (Giants)

First TD

+2500

Anytime TD

+500

Theo Johnson (Giants)

First TD

+3000

Anytime TD

+700

Devin Singletary (Giants)

First TD

+3300

Anytime TD

+700

Tre Harris (Chargers)

First TD

+3500

Anytime TD

+950

Hassan Haskins (Chargers)

First TD

+4000

Anytime TD

+650

Tyler Conklin (Chargers)

First TD

+4500

Anytime TD

+750

Derius Davis (Chargers)

First TD

+6000

Anytime TD

+1300

Kimani Vidal (Chargers)

First TD

+7000

Anytime TD

+1200

Daniel Bellinger (Giants)

First TD

+7500

Anytime TD

+1100

KeAndre Lambert-Smith (Chargers)

First TD

+8000

Anytime TD

+1800

Jalin Hyatt (Giants)

First TD

+10000

Anytime TD

+1700

Beaux Collins (Giants)

First TD

+10000

Anytime TD

+1700

Chris Manhertz (Giants)

First TD

+10000

Anytime TD

+2200

Tucker Fisk (Chargers)

First TD

+10000

Anytime TD

+2000

Scott Matlock (Chargers)

First TD

+10000

Anytime TD

+3300

Gunner Olszewski (Giants)

First TD

+10000

Anytime TD

+3500

Thomas Fidone (Giants)

First TD

+10000

Anytime TD

+2200

Receiving Yards

Malik Nabers (Giants)

Over 65.5

-112

Under 65.5

-112

Ladd McConkey (Chargers)

Over 61.5

-112

Under 61.5

-112

Quentin Johnston (Chargers)

Over 51.5

-112

Under 51.5

-112

Keenan Allen (Chargers)

Over 51.5

-112

Under 51.5

-112

Wan'Dale Robinson (Giants)

Over 39.5

-112

Under 39.5

-112

Oronde Gadsden II (Chargers)

Over 21.5

-112

Under 21.5

-112

Cam Skattebo (Giants)

Over 20.5

-112

Under 20.5

-112

Darius Slayton (Giants)

Over 19.5

-112

Under 19.5

-112

Theo Johnson (Giants)

Over 18.5

-112

Under 18.5

-112

Omarion Hampton (Chargers)

Over 17.5

-112

Under 17.5

-112

Tre Harris (Chargers)

Over 8.5

-112

Under 8.5

-112

Rushing Yards

Omarion Hampton (Chargers)

Over 70.5

-112

Under 70.5

-112

Cam Skattebo (Giants)

Over 54.5

-112

Under 54.5

-112

Jaxson Dart (Giants)

Over 32.5

-112

Under 32.5

-112

Justin Herbert (Chargers)

Over 18.5

-112

Under 18.5

-112

Devin Singletary (Giants)

Over 15.5

-112

Under 15.5

-112

Passing Yards

Justin Herbert (Chargers)

Over 252.5

-112

Under 252.5

-112

Jaxson Dart (Giants)

Over 192.5

-112

Under 192.5

-112

Micro betting provides a rollercoaster ride for NFL bettors. It can be great to enjoy the live lines, with the opportunity to wager on the Next Scoring Play. Watch the live action before deciding which way to go.

Giants Record Shows Nine Home Defeats in Last Ten Matches

The Giants are 1-9 in their last 10 home games, posting 13.90 points per contest while yielding 25.40.

The Chargers have gone 6-4 across their last 10 games away from home, averaging 21.50 points on offense and surrendering 16.30 on defense.

Last 10 Games		W-L	P	PF	PA	O43.5	U43.5
Giants Home Stats		1-9	39.30	13.90	25.40	3	7
Chargers Away Stats		6-4	37.80	21.50	16.30	3	7

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O43.5 = Games Over 43.5 Points
• U43.5 = Games Under 43.5 Points

Latest regular season and playoff games stats.

Los Angeles Chargers Stats

New York Giants Stats

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 6 wins and 4 defeats in the last 10 games on the road

Moneyline

• 1 win and 9 defeats in the last 10 games
• 1 win and 9 defeats in the last 10 home games

Point Spread

• -6.5 Betting Line: Have covered the spread in 4 of the last 10 games
• -6.5 Betting Line on the Road: Have covered the spread in 5 of the last 10 games on the road

Point Spread

• +6.5 Betting Line: Have covered the spread in 3 of the last 10 games
• +6.5 Betting Line at Home: Have covered the spread in 4 of the last 10 home games

Total Points

• Game Totals: An average of 44.90 pts in the previous 10 games
• Game Totals on the Road: An average of 37.80 pts in the previous 10 games on the road
• Over 43.5: Covered in 6 of the previous 10 games
• Over 43.5 on the Road: Covered in 3 of the previous 10 games on the road
• Team Totals: Have scored an average of 24.10 pts and allowed 20.80 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 21.50 pts and allowed 16.30 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 44.50 pts in the previous 10 games
• Game Totals at Home: An average of 39.30 pts in the previous 10 home games
• Over 43.5: Covered in 4 of the previous 10 games
• Over 43.5 at Home: Covered in 3 of the previous 10 home games
• Team Totals: Have scored an average of 16.90 pts and allowed 27.60 pts in the last 10 games
• Team Totals at Home: Have scored an average of 13.90 pts and allowed 25.40 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 331.00 Yds. Allowed 321.30 Yds
• Rushing Yards: Gained 91.00 Yds. Allowed 113.20 Yds
• Passing Yards: Gained 240.00 Yds. Allowed 208.10 Yds
• Total Touchdowns: Scored 2.40 TD. Allowed 1.90 TD
• Rushing Touchdowns: Scored 0.50 TD. Allowed 0.50 TD
• Passing Touchdowns: Scored 1.70 TD. Allowed 1.30 TD
• Total 1st Downs: Picked up 20.30. Allowed 17.90
• Total Turnovers: Committed 1.10. Committed by opponents 1.40
• Total Penalties: Committed 5.30. Committed by opponents 6.80
• Penalty Yards: Lost 36.20 Yds. Gained 63.40 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 293.20 Yds. Allowed 379.80 Yds
• Rushing Yards: Gained 87.20 Yds. Allowed 130.40 Yds
• Passing Yards: Gained 206.00 Yds. Allowed 249.40 Yds
• Total Touchdowns: Scored 1.90 TD. Allowed 3.30 TD
• Rushing Touchdowns: Scored 0.80 TD. Allowed 1.50 TD
• Passing Touchdowns: Scored 1.00 TD. Allowed 1.50 TD
• Total 1st Downs: Picked up 16.60. Allowed 23.50
• Total Turnovers: Committed 1.20. Committed by opponents 0.80
• Total Penalties: Committed 8.50. Committed by opponents 6.70
• Penalty Yards: Lost 72.00 Yds. Gained 56.00 Yds

Last 10 Games on the Road

• Total Yards: Gained 320.90 Yds. Allowed 302.00 Yds
• Rushing Yards: Gained 90.90 Yds. Allowed 106.70 Yds
• Passing Yards: Gained 230.00 Yds. Allowed 195.30 Yds
• Total Touchdowns: Scored 2.10 TD. Allowed 1.60 TD
• Rushing Touchdowns: Scored 0.60 TD. Allowed 0.40 TD
• Passing Touchdowns: Scored 1.30 TD. Allowed 1.00 TD
• Total 1st Downs: Picked up 18.00. Allowed 18.60
• Total Turnovers: Committed 0.80. Committed by opponents 1.90
• Total Penalties: Committed 5.50. Committed by opponents 5.00
• Penalty Yards: Lost 40.10 Yds. Gained 42.10 Yds

Last 10 Home Games

• Total Yards: Gained 277.30 Yds. Allowed 354.50 Yds
• Rushing Yards: Gained 91.20 Yds. Allowed 138.00 Yds
• Passing Yards: Gained 186.10 Yds. Allowed 216.50 Yds
• Total Touchdowns: Scored 1.60 TD. Allowed 3.20 TD
• Rushing Touchdowns: Scored 0.70 TD. Allowed 1.50 TD
• Passing Touchdowns: Scored 0.70 TD. Allowed 1.60 TD
• Total 1st Downs: Picked up 17.50. Allowed 19.90
• Total Turnovers: Committed 1.00. Committed by opponents 0.90
• Total Penalties: Committed 6.00. Committed by opponents 6.80
• Penalty Yards: Lost 52.70 Yds. Gained 59.30 Yds

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