Los Angeles Rams
American Football NFL Levi's Stadium Sun 9 Nov 16:25
San Francisco 49ers
  1. Prediction
  2. SGP Picks
  3. Odds
  4. Player Props
  5. Stats
  6. Live Stream
  7. Team News
  8. Lineups
  9. Injuries
  10. Standings

NFL Betting Preview: Rams vs Niners

The Los Angeles Rams face the San Francisco 49ers at Levi's Stadium, with kickoff scheduled for 16:25 on Sunday, November 9. Our betting preview features expert NFL predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

Under 49.5 Has to Be the Best Bet on the Totals

We’re not sure that the Niners and the Rams will reach a certain points threshold. Our prediction is to take the -110 that there are Under 49.5 points.

Backing our Totals call? Get up to speed with our in-depth BetMGM review, then grab the promo code to make your bet go further.

Niners Won Last H2H in Overtime

Los Angeles Rams claimed a home victory in their previous game. A 34-10 triumph against New Orleans Saints at SoFi Stadium made it three straight wins. The Rams generated 438 yards, including 267 passing and 171 rushing yards. The offense produced 30 first downs and managed 5 TD's, including 4 passing scores and a rushing touchdown.

San Francisco 49ers won their last game 34-24. This was a road victory at MetLife Stadium against New York Giants. The 49ers put up 380 total yards, made up of 221 through the air and 159 on the ground. They picked up 25 first downs and scored 4 touchdowns, with 2 through the air and 2 on the ground.

Head-to-Head Statistics

The scoreline was 26-23 (OT) in favor of the Niners when they last played the Rams, with the matchup taking place at SoFi Stadium. The Niners have won six of the past 10 games that these teams have played.

Rams vs 49ers Prediction & Picks

Step into Rams vs 49ers with confidence, armed with our expert match prediction, likely scoreline, key player prop plays and a custom-built bet builder for maximum value.

Game Prediction

There’s every chance that the total won’t be as high as 49.5, so we’re prepared to take the -110 that the pair go under the line in this NFL matchup.

Our NFL handicappers study recent form and take injuries into account when assessing each matchup. Before delivering a verdict, we combine that insight with the latest stats to strengthen our analysis.

Key Rams vs 49ers stats:

  • The 49.5 line hasn’t been covered in the last 5 Rams games.
  • The 49.5 line hasn’t been covered in 6 of the last 8 Rams games this season.
  • The 49.5 line hasn’t been covered in 7 of the last 10 Rams games.
  • The 49.5 line hasn’t been covered in 8 of the last 9 49ers games this season.
  • The 49.5 line hasn’t been covered in 8 of the last 10 49ers games.
  • The 49.5 line hasn’t been covered in the last 3 49ers games at home.
  • The 49.5 line hasn’t been covered in the last 2 games between these teams.

Under 49.5 Probability

The top NFL sportsbooks make it a 52.4% chance that our pick is settled as a winner. However, we have this figure between 55-60% based on our in-depth research. It is the reason why we are recommending this wager.

Looking for Bigger Odds?

The bigger odds can be found if you combine your Under bet on the Totals with other picks in a Bet Builder. This is popular way of betting on multiple outcomes in a single game.

Your next bet could start with a welcome bonus. Explore our expert guide to the newest sign-up and betting offers.

Best Bet

Under 49.5 Points @ -110 Watch Live Bet Now BetMGM logo
BetMGM logo
BetMGM Promo Up To $1500 in Bonus Bets Get Bonus T&C apply. Gamble responsibly 18+
Gamble responsibly 18+. All odds are correct at time of publishing and are subject to change. To use the Bookmaker Live Streaming services you will need to be logged in and have a funded account or to have placed a bet in the last 24 hours. Geo-restrictions apply.
Published 22:26, 07 November 2025

Player Prop Picks

Top Pick: Mac Jones Under 250.5 Passing Yards -114 BetMGM logo

You can back Mac Jones (Niners) at -114 to end with fewer than 250.5 passing yards. He is likely to fall short of the line, making this QB Passing Yards bet an appealing option.

Latest Mac Jones Player Prop Odds

Puka Nacua Anytime TD -149 BetMGM logo

Puka Nacua (Rams) is priced at -149 to record a TD. We believe this is the best of the player props, with attractive odds available when it comes to betting him to score a touchdown at any time.

Latest Puka Nacua Player Prop Odds

Same Game Parlay Picks

Totals Under 49.5
Spread Rams -4.5
Passing Yards Mac Jones Under 250.5

We’ve compiled a same game parlay that includes Under 49.5, along with Rams -4.5 on the spread and Mac Jones (49ers) to go Under 250.5 passing yards.

The same game parlay option is great for bettors wanting a personalised multi-leg wager on the same football game. It’s especially good if you have a strong view on the likely outcomes and the odds for each pick are combined.

T&C apply. Gamble responsibly 18+

Correct Score Prediction

Rams Rams logo 27 - 14 49ers logo 49ers

We’re going for the Rams to achieve a 27-14 win and the good news is that there are massive odds for this outcome. A small stake can return a potentially large amount.

Rams vs 49ers Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Rams Likely to Win According to Latest Odds

Los Angeles Rams have the shortest price to win this game, with the sportsbooks giving them a 70% probability due to their -233 Moneyline betting odds. San Francisco 49ers are regarded as a long shot to win and you can currently back them at +190.

There is a spread of 4.5 and total points has a line of 49.5. The Totals offers NFL fans an alternative way of getting involved. Those who wager Under 49.5 can get -110.

If you're betting on the National Football League, it's a good idea to visit the best sportsbooks and browse the extensive selection of game lines and team props. You'll find great opportunities to place bets both pre-game and in-game.

Puka Nacua Favorite to Be First Touchdown Scorer

There is -149 available that Puka Nacua scores a touchdown anytime. If you’re interested in the favorite to score the first TD, then you are able to secure +430.

Touchdown

Christian McCaffrey (49ers)
First TD
+450
Anytime TD
-179
BetMGM Logo
Davante Adams (Rams)
First TD
+500
Anytime TD
-135
BetMGM Logo
Kyren Williams (Rams)
First TD
+650
Anytime TD
-100
BetMGM Logo

Receiving Yards

Christian McCaffrey (49ers)
Over 51.5
-114
Under 51.5
-114
BetMGM Logo
George Kittle (49ers)
Over 50.5
-114
Under 50.5
-114
BetMGM Logo

Rushing Yards

Kyren Williams (Rams)
Over 63.5
-114
Under 63.5
-114
BetMGM Logo
Christian McCaffrey (49ers)
Over 63.5
-114
Under 63.5
-114
BetMGM Logo
Brian Robinson Jr. (49ers)
Over 13.5
-114
Under 13.5
-114
BetMGM Logo
BetMGM Logo

Passing Yards

Best Betting Offers
Levi's Stadium
Levi's Stadium

Niners On Six Losses From Previous Ten at Home

The Niners own a 4-6 mark in their past 10 home games, putting up 22.30 points per contest and giving up 21.20.

The Rams own a 8-2 mark in their past 10 road games, putting up 23.90 points on average and giving up 16.10.

The last Levi's Stadium meeting saw the Rams beat the Niners 12-6. Looking at the last 6 head-to-head matchups at Levi's Stadium, the Niners have four victories and the Rams two.

Last 10 Games W-L P PF PA O49.5 U49.5
49ers logo 49ers Home Stats 4-6 43.50 22.30 21.20 3 7
Rams logo Rams Away Stats 8-2 40.00 23.90 16.10 4 6
  • W-L = Wins-Losses
  • P = Avg. Points
  • PF = Avg. Points For
  • PA = Avg. Points Against
  • O49.5 = Games Over 49.5 Points
  • U49.5 = Games Under 49.5 Points
Team Stats

Latest regular season and playoff games stats.

Los Angeles Rams logo Los Angeles Rams Stats
San Francisco 49ers logo San Francisco 49ers Stats
Moneyline
  • 7 wins and 3 defeats in the last 10 games
  • 8 wins and 2 defeats in the last 10 games on the road
Moneyline
  • 6 wins and 4 defeats in the last 10 games
  • 4 wins and 6 defeats in the last 10 home games
Point Spread
Point Spread
Total Points
Total Points
Game Stats
Last 10 Games
Game Stats
Last 10 Games
Last 10 Games on the Road
Last 10 Home Games

Live Streaming

It’s great to access NFL live streaming on your iPhone, iPad or Android device, with desktop also an option. Place a recent bet or have a funded sportsbook account.

You can log into your betting account on a daily basis and enjoy the chance to access high quality streams.

Team News

Los Angeles Rams Injuries

Type
Name
Info
Tutu Atwell
Hamstring
Keir Thomas
Undisclosed
Jordan Whittington
Back
Ahkello Witherspoon
Collarbone

San Francisco 49ers Injuries

Type
Name
Info
Brandon Aiyuk
Knee - ACL + MCL
Ben Bartch
Ankle
Tatum Bethune
Thigh
Nick Bosa
Knee - ACL
Alfred Collins
Hip
Jacob Cowing
Hamstring
Kalia Davis
Ankle
Yetur Gross-Matos
Knee
Tarron Jackson
Undisclosed
Ricky Pearsall
Knee - PCL
Brock Purdy
Toe
Jakob Robinson
Forearm
Kurtis Rourke
Knee
Patrick Taylor
Shoulder
Trent Taylor
Undisclosed
Tre Tomlinson
Undisclosed
Fred Warner
Ankle
Keion White
Groin
Mykel Williams
Knee - ACL
Dee Winters
Knee

Previous Los Angeles Rams Lineups

02 Nov NFL
Saints 10-34 Rams
19 Oct NFL
Rams 35-7 Jaguars
12 Oct NFL
Rams 17-3 Ravens
02 Oct NFL
49ers 26-23 Rams
28 Sep NFL
Colts 20-27 Rams
21 Sep NFL
Rams 26-33 Eagles
14 Sep NFL
Rams 33-19 Titans
07 Sep NFL
Texans 9-14 Rams
19 Jan NFL Playoffs
Rams 22-28 Eagles
13 Jan NFL Playoffs
Vikings 9-27 Rams

Previous San Francisco 49ers Lineups

02 Nov NFL
49ers 34-24 Giants
26 Oct NFL
49ers 15-26 Texans
19 Oct NFL
Falcons 10-20 49ers
12 Oct NFL
49ers 19-30 Buccaneers
02 Oct NFL
49ers 26-23 Rams
28 Sep NFL
Jaguars 26-21 49ers
21 Sep NFL
Cardinals 15-16 49ers
14 Sep NFL
49ers 26-21 Saints
07 Sep NFL
49ers 17-13 Seahawks
05 Jan NFL
49ers 24-47 Cardinals

NFL Standings Select Season

AFC East W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Patriots 7 2 0 0.778 237 169 68 3-2-0 4-0-0 2-0-0 4-2-0 5-0-0 6W
Bills 6 2 0 0.750 235 167 68 4-1-0 2-1-0 2-1-0 4-1-0 3-2-0 2W
Dolphins 2 7 0 0.222 180 243 -63 1-3-0 1-4-0 1-2-0 1-6-0 1-4-0 1L
Jets 1 7 0 0.125 168 221 -53 0-5-0 1-2-0 0-2-0 1-4-0 1-4-0 1W
AFC North W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Steelers 5 3 0 0.625 202 195 7 3-2-0 2-1-0 1-1-0 4-1-0 3-2-0 1W
Ravens 3 5 0 0.375 202 216 -14 2-3-0 1-2-0 1-0-0 2-3-0 2-3-0 2W
Bengals 3 6 0 0.333 216 300 -84 2-3-0 1-3-0 2-0-0 3-2-0 1-4-0 2L
Browns 2 6 0 0.250 126 184 -58 2-2-0 0-4-0 0-3-0 1-4-0 1-4-0 1L
AFC South W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Colts 7 2 0 0.778 290 181 109 5-0-0 2-2-0 2-0-0 6-1-0 4-1-0 1L
Jaguars 5 3 0 0.625 176 184 -8 3-2-0 2-1-0 1-0-0 3-1-0 3-2-0 1W
Texans 3 5 0 0.375 168 121 47 2-2-0 1-3-0 1-1-0 2-2-0 3-2-0 1L
Titans 1 8 0 0.111 130 257 -127 0-4-0 1-4-0 0-3-0 0-7-0 1-4-0 4L
AFC West W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Broncos 7 2 0 0.778 225 166 59 4-0-0 3-2-0 0-1-0 4-2-0 5-0-0 6W
Chargers 6 3 0 0.667 215 193 22 3-2-0 3-1-0 3-0-0 5-1-0 3-2-0 2W
Chiefs 5 4 0 0.556 235 159 76 4-1-0 1-3-0 1-1-0 2-3-0 3-2-0 1L
Raiders 2 6 0 0.250 132 210 -78 1-3-0 1-3-0 0-2-0 2-4-0 1-4-0 2L
NFC East W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Eagles 6 2 0 0.750 208 185 23 3-1-0 3-1-0 2-1-0 5-1-0 3-2-0 2W
Cowboys 3 5 1 0.333 263 277 -14 2-1-1 1-4-0 2-1-0 2-4-1 2-3-0 2L
Commanders 3 6 0 0.333 201 236 -35 2-2-0 1-4-0 1-1-0 1-5-0 1-4-0 4L
Giants 2 7 0 0.222 197 249 -52 2-2-0 0-5-0 1-3-0 1-5-0 1-4-0 3L
NFC North W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Packers 5 2 1 0.625 206 166 40 3-1-0 2-1-1 1-0-0 3-1-1 3-1-1 1L
Lions 5 3 0 0.625 239 178 61 3-1-0 2-2-0 1-2-0 2-2-0 3-2-0 1L
Bears 5 3 0 0.625 215 227 -12 2-1-0 3-2-0 0-2-0 3-2-0 4-1-0 1W
Vikings 4 4 0 0.500 182 186 -4 1-2-0 3-2-0 2-0-0 2-2-0 2-3-0 1W
NFC South W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Buccaneers 6 2 0 0.750 197 178 19 2-1-0 4-1-0 2-0-0 4-2-0 3-2-0 1W
Panthers 5 4 0 0.556 170 205 -35 3-1-0 2-3-0 1-0-0 3-1-0 4-1-0 1W
Falcons 3 5 0 0.375 143 178 -35 2-2-0 1-3-0 0-2-0 2-3-0 2-3-0 3L
Saints 1 8 0 0.111 138 243 -105 1-4-0 0-4-0 0-1-0 1-6-0 1-4-0 4L
NFC West W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Seahawks 6 2 0 0.750 231 150 81 2-2-0 4-0-0 1-1-0 3-2-0 4-1-0 3W
Rams 6 2 0 0.750 209 127 82 3-1-0 3-1-0 0-1-0 1-2-0 4-1-0 3W
49ers 6 3 0 0.667 194 188 6 2-1-0 4-2-0 3-0-0 6-1-0 3-2-0 1W
Cardinals 3 5 0 0.375 180 171 9 1-3-0 2-2-0 0-2-0 3-3-0 1-4-0 1W
AFC Conference W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Colts 7 2 0 0.778 290 181 109 5-0-0 2-2-0 2-0-0 6-1-0 4-1-0 1L
Patriots 7 2 0 0.778 237 169 68 3-2-0 4-0-0 2-0-0 4-2-0 5-0-0 6W
Broncos 7 2 0 0.778 225 166 59 4-0-0 3-2-0 0-1-0 4-2-0 5-0-0 6W
Steelers 5 3 0 0.625 202 195 7 3-2-0 2-1-0 1-1-0 4-1-0 3-2-0 1W
Bills 6 2 0 0.750 235 167 68 4-1-0 2-1-0 2-1-0 4-1-0 3-2-0 2W
Chargers 6 3 0 0.667 215 193 22 3-2-0 3-1-0 3-0-0 5-1-0 3-2-0 2W
Jaguars 5 3 0 0.625 176 184 -8 3-2-0 2-1-0 1-0-0 3-1-0 3-2-0 1W
Chiefs 5 4 0 0.556 235 159 76 4-1-0 1-3-0 1-1-0 2-3-0 3-2-0 1L
Texans 3 5 0 0.375 168 121 47 2-2-0 1-3-0 1-1-0 2-2-0 3-2-0 1L
Ravens 3 5 0 0.375 202 216 -14 2-3-0 1-2-0 1-0-0 2-3-0 2-3-0 2W
Bengals 3 6 0 0.333 216 300 -84 2-3-0 1-3-0 2-0-0 3-2-0 1-4-0 2L
Raiders 2 6 0 0.250 132 210 -78 1-3-0 1-3-0 0-2-0 2-4-0 1-4-0 2L
Browns 2 6 0 0.250 126 184 -58 2-2-0 0-4-0 0-3-0 1-4-0 1-4-0 1L
Dolphins 2 7 0 0.222 180 243 -63 1-3-0 1-4-0 1-2-0 1-6-0 1-4-0 1L
Jets 1 7 0 0.125 168 221 -53 0-5-0 1-2-0 0-2-0 1-4-0 1-4-0 1W
Titans 1 8 0 0.111 130 257 -127 0-4-0 1-4-0 0-3-0 0-7-0 1-4-0 4L
NFC Conference W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Eagles 6 2 0 0.750 208 185 23 3-1-0 3-1-0 2-1-0 5-1-0 3-2-0 2W
Buccaneers 6 2 0 0.750 197 178 19 2-1-0 4-1-0 2-0-0 4-2-0 3-2-0 1W
Seahawks 6 2 0 0.750 231 150 81 2-2-0 4-0-0 1-1-0 3-2-0 4-1-0 3W
Packers 5 2 1 0.625 206 166 40 3-1-0 2-1-1 1-0-0 3-1-1 3-1-1 1L
Rams 6 2 0 0.750 209 127 82 3-1-0 3-1-0 0-1-0 1-2-0 4-1-0 3W
49ers 6 3 0 0.667 194 188 6 2-1-0 4-2-0 3-0-0 6-1-0 3-2-0 1W
Lions 5 3 0 0.625 239 178 61 3-1-0 2-2-0 1-2-0 2-2-0 3-2-0 1L
Bears 5 3 0 0.625 215 227 -12 2-1-0 3-2-0 0-2-0 3-2-0 4-1-0 1W
Panthers 5 4 0 0.556 170 205 -35 3-1-0 2-3-0 1-0-0 3-1-0 4-1-0 1W
Vikings 4 4 0 0.500 182 186 -4 1-2-0 3-2-0 2-0-0 2-2-0 2-3-0 1W
Cowboys 3 5 1 0.333 263 277 -14 2-1-1 1-4-0 2-1-0 2-4-1 2-3-0 2L
Falcons 3 5 0 0.375 143 178 -35 2-2-0 1-3-0 0-2-0 2-3-0 2-3-0 3L
Commanders 3 6 0 0.333 201 236 -35 2-2-0 1-4-0 1-1-0 1-5-0 1-4-0 4L
Cardinals 3 5 0 0.375 180 171 9 1-3-0 2-2-0 0-2-0 3-3-0 1-4-0 1W
Giants 2 7 0 0.222 197 249 -52 2-2-0 0-5-0 1-3-0 1-5-0 1-4-0 3L
Saints 1 8 0 0.111 138 243 -105 1-4-0 0-4-0 0-1-0 1-6-0 1-4-0 4L
NFL Team W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Broncos 7 2 0 0.778 225 166 59 4-0-0 3-2-0 0-1-0 4-2-0 5-0-0 6W
Colts 7 2 0 0.778 290 181 109 5-0-0 2-2-0 2-0-0 6-1-0 4-1-0 1L
Patriots 7 2 0 0.778 237 169 68 3-2-0 4-0-0 2-0-0 4-2-0 5-0-0 6W
Bills 6 2 0 0.750 235 167 68 4-1-0 2-1-0 2-1-0 4-1-0 3-2-0 2W
Rams 6 2 0 0.750 209 127 82 3-1-0 3-1-0 0-1-0 1-2-0 4-1-0 3W
Eagles 6 2 0 0.750 208 185 23 3-1-0 3-1-0 2-1-0 5-1-0 3-2-0 2W
Seahawks 6 2 0 0.750 231 150 81 2-2-0 4-0-0 1-1-0 3-2-0 4-1-0 3W
Buccaneers 6 2 0 0.750 197 178 19 2-1-0 4-1-0 2-0-0 4-2-0 3-2-0 1W
Packers 5 2 1 0.625 206 166 40 3-1-0 2-1-1 1-0-0 3-1-1 3-1-1 1L
Chargers 6 3 0 0.667 215 193 22 3-2-0 3-1-0 3-0-0 5-1-0 3-2-0 2W
49ers 6 3 0 0.667 194 188 6 2-1-0 4-2-0 3-0-0 6-1-0 3-2-0 1W
Bears 5 3 0 0.625 215 227 -12 2-1-0 3-2-0 0-2-0 3-2-0 4-1-0 1W
Lions 5 3 0 0.625 239 178 61 3-1-0 2-2-0 1-2-0 2-2-0 3-2-0 1L
Jaguars 5 3 0 0.625 176 184 -8 3-2-0 2-1-0 1-0-0 3-1-0 3-2-0 1W
Steelers 5 3 0 0.625 202 195 7 3-2-0 2-1-0 1-1-0 4-1-0 3-2-0 1W
Panthers 5 4 0 0.556 170 205 -35 3-1-0 2-3-0 1-0-0 3-1-0 4-1-0 1W
Chiefs 5 4 0 0.556 235 159 76 4-1-0 1-3-0 1-1-0 2-3-0 3-2-0 1L
Vikings 4 4 0 0.500 182 186 -4 1-2-0 3-2-0 2-0-0 2-2-0 2-3-0 1W
Cowboys 3 5 1 0.333 263 277 -14 2-1-1 1-4-0 2-1-0 2-4-1 2-3-0 2L
Cardinals 3 5 0 0.375 180 171 9 1-3-0 2-2-0 0-2-0 3-3-0 1-4-0 1W
Falcons 3 5 0 0.375 143 178 -35 2-2-0 1-3-0 0-2-0 2-3-0 2-3-0 3L
Ravens 3 5 0 0.375 202 216 -14 2-3-0 1-2-0 1-0-0 2-3-0 2-3-0 2W
Texans 3 5 0 0.375 168 121 47 2-2-0 1-3-0 1-1-0 2-2-0 3-2-0 1L
Bengals 3 6 0 0.333 216 300 -84 2-3-0 1-3-0 2-0-0 3-2-0 1-4-0 2L
Commanders 3 6 0 0.333 201 236 -35 2-2-0 1-4-0 1-1-0 1-5-0 1-4-0 4L
Browns 2 6 0 0.250 126 184 -58 2-2-0 0-4-0 0-3-0 1-4-0 1-4-0 1L
Raiders 2 6 0 0.250 132 210 -78 1-3-0 1-3-0 0-2-0 2-4-0 1-4-0 2L
Dolphins 2 7 0 0.222 180 243 -63 1-3-0 1-4-0 1-2-0 1-6-0 1-4-0 1L
Giants 2 7 0 0.222 197 249 -52 2-2-0 0-5-0 1-3-0 1-5-0 1-4-0 3L
Jets 1 7 0 0.125 168 221 -53 0-5-0 1-2-0 0-2-0 1-4-0 1-4-0 1W
Saints 1 8 0 0.111 138 243 -105 1-4-0 0-4-0 0-1-0 1-6-0 1-4-0 4L
Titans 1 8 0 0.111 130 257 -127 0-4-0 1-4-0 0-3-0 0-7-0 1-4-0 4L