Rams vs 49ers Prediction, Picks & Odds | 09 Nov 2025

NFL Betting Preview: Rams vs Niners

The Los Angeles Rams face the San Francisco 49ers at Levi's Stadium, with kickoff scheduled for 16:25 on Sunday, November 9. Our betting preview features expert NFL predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

We’re not sure that the Niners and the Rams will reach a certain points threshold. Our prediction is to take the -110 that there are Under 49.5 points.

Backing our Totals call? Get up to speed with our in-depth BetMGM review, then grab the promo code to make your bet go further.

Los Angeles Rams claimed a home victory in their previous game. A 34-10 triumph against New Orleans Saints at SoFi Stadium made it three straight wins. The Rams generated 438 yards, including 267 passing and 171 rushing yards. The offense produced 30 first downs and managed 5 TD's, including 4 passing scores and a rushing touchdown.

San Francisco 49ers won their last game 34-24. This was a road victory at MetLife Stadium against New York Giants. The 49ers put up 380 total yards, made up of 221 through the air and 159 on the ground. They picked up 25 first downs and scored 4 touchdowns, with 2 through the air and 2 on the ground.

Head-to-Head Statistics

The scoreline was 26-23 (OT) in favor of the Niners when they last played the Rams, with the matchup taking place at SoFi Stadium. The Niners have won six of the past 10 games that these teams have played.

Rams vs 49ers Prediction & Picks

Step into Rams vs 49ers with confidence, armed with our expert match prediction, likely scoreline, key player prop plays and a custom-built bet builder for maximum value.

Game Prediction

There’s every chance that the total won’t be as high as 49.5, so we’re prepared to take the -110 that the pair go under the line in this NFL matchup.

Our NFL handicappers study recent form and take injuries into account when assessing each matchup. Before delivering a verdict, we combine that insight with the latest stats to strengthen our analysis.

Key Rams vs 49ers stats:

• The 49.5 line hasn’t been covered in the last 5 Rams games.
• The 49.5 line hasn’t been covered in 6 of the last 8 Rams games this season.
• The 49.5 line hasn’t been covered in 7 of the last 10 Rams games.
• The 49.5 line hasn’t been covered in 8 of the last 9 49ers games this season.
• The 49.5 line hasn’t been covered in 8 of the last 10 49ers games.
• The 49.5 line hasn’t been covered in the last 3 49ers games at home.
• The 49.5 line hasn’t been covered in the last 2 games between these teams.

Under 49.5 Probability

The top NFL sportsbooks make it a 52.4% chance that our pick is settled as a winner. However, we have this figure between 55-60% based on our in-depth research. It is the reason why we are recommending this wager.

The bigger odds can be found if you combine your Under bet on the Totals with other picks in a Bet Builder. This is popular way of betting on multiple outcomes in a single game.

Your next bet could start with a welcome bonus. Explore our expert guide to the newest sign-up and betting offers.

Our Game Prediction

Under 49.5 Points @ -110 Bet Now

BetMGM Promo Up To $1500 in Bonus Bets Get Bonus T&C apply. Gamble responsibly 18+

Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (22:26, 07 November 2025). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Mac Jones Under 250.5 Passing Yards -114

You can back Mac Jones (Niners) at -114 to end with fewer than 250.5 passing yards. He is likely to fall short of the line, making this QB Passing Yards bet an appealing option.

Latest Mac Jones Player Prop Odds

Touchdown

Anytime

+1100

First

+6000

Passing Yards

Over 249.5

-112

Under 249.5

-112

Rushing Yards

Over 6.5

-112

Under 6.5

-112

---

Puka Nacua Anytime TD -149

Puka Nacua (Rams) is priced at -149 to record a TD. We believe this is the best of the player props, with attractive odds available when it comes to betting him to score a touchdown at any time.

Latest Puka Nacua Player Prop Odds

Touchdown

Anytime

-141

First

+450

Receiving Yards

Over 91.5

-112

Under 91.5

-112

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Rams 27 - 14 49ers

We’re going for the Rams to achieve a 27-14 win and the good news is that there are massive odds for this outcome. A small stake can return a potentially large amount.

T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Rams vs 49ers Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

Los Angeles Rams have the shortest price to win this game, with the sportsbooks giving them a 50% probability due to their +102 Moneyline betting odds. San Francisco 49ers are regarded as a long shot to win and you can currently back them at -122.

There is a spread of 1.5 and total points has a line of 46.5. The Totals offers NFL fans an alternative way of getting involved. Those who wager Under 46.5 can get -110.

If you're betting on the National Football League, it's a good idea to visit the best sportsbooks and browse the extensive selection of game lines and team props. You'll find great opportunities to place bets both pre-game and in-game.

Moneyline

Rams

+102

49ers

-122

Point Spread

Rams +1.5

-110

49ers -1.5

-110

Total Points

Under 46.5

-110

Over 46.5

-110

There is -141 available that Puka Nacua scores a touchdown anytime. If you’re interested in the favorite to score the first TD, then you are able to secure +450.

Touchdown

Puka Nacua (Rams)

First TD

+450

Anytime TD

-141

Christian McCaffrey (49ers)

First TD

+490

Anytime TD

-161

Davante Adams (Rams)

First TD

+500

Anytime TD

-130

Kyren Williams (Rams)

First TD

+550

Anytime TD

-120

George Kittle (49ers)

First TD

+1000

Anytime TD

+150

Jauan Jennings (49ers)

First TD

+1500

Anytime TD

+240

Tyler Higbee (Rams)

First TD

+1600

Anytime TD

+310

Kendrick Bourne (49ers)

First TD

+2200

Anytime TD

+420

Terrance Ferguson (Rams)

First TD

+2700

Anytime TD

+600

Blake Corum (Rams)

First TD

+2700

Anytime TD

+430

Demarcus Robinson (49ers)

First TD

+3500

Anytime TD

+650

Davis Allen (Rams)

First TD

+4000

Anytime TD

+600

Brian Robinson Jr. (49ers)

First TD

+4500

Anytime TD

+1000

Jordan Whittington (Rams)

First TD

+5000

Anytime TD

+800

Colby Parkinson (Rams)

First TD

+5000

Anytime TD

+800

Konata Mumpfield (Rams)

First TD

+5500

Anytime TD

+800

Kyle Juszczyk (49ers)

First TD

+6000

Anytime TD

+1100

Mac Jones (49ers)

First TD

+6000

Anytime TD

+1100

Brock Purdy (49ers)

First TD

+7000

Anytime TD

+1000

Jake Tonges (49ers)

First TD

+7500

Anytime TD

+800

Xavier Smith (Rams)

First TD

+8000

Anytime TD

+1000

Luke Farrell (49ers)

First TD

+10000

Anytime TD

+1300

Skyy Moore (49ers)

First TD

+10000

Anytime TD

+2700

Ronnie Rivers (Rams)

First TD

+10000

Anytime TD

+2200

Jordan Watkins (49ers)

First TD

+10000

Anytime TD

+1500

Matthew Stafford (Rams)

First TD

+10000

Anytime TD

+2200

Isaac Guerendo (49ers)

First TD

+10000

Anytime TD

+3000

Jarquez Hunter (Rams)

First TD

+10000

Anytime TD

+2200

James Jordan (49ers)

First TD

+10000

Anytime TD

+3000

Receiving Yards

Puka Nacua (Rams)

Over 91.5

-112

Under 91.5

-112

Davante Adams (Rams)

Over 61.5

-112

Under 61.5

-112

Christian McCaffrey (49ers)

Over 50.5

-112

Under 50.5

-112

George Kittle (49ers)

Over 50.5

-112

Under 50.5

-112

Jauan Jennings (49ers)

Over 49.5

-112

Under 49.5

-112

Kendrick Bourne (49ers)

Over 32.5

-112

Under 32.5

-112

Tyler Higbee (Rams)

Over 20.5

-112

Under 20.5

-112

Kyren Williams (Rams)

Over 15.5

-112

Under 15.5

-112

Demarcus Robinson (49ers)

Over 13.5

-112

Under 13.5

-112

Terrance Ferguson (Rams)

Over 11.5

-112

Under 11.5

-112

Kyle Juszczyk (49ers)

Over 7.5

-112

Under 7.5

-112

Rushing Yards

Kyren Williams (Rams)

Over 64.5

-112

Under 64.5

-112

Christian McCaffrey (49ers)

Over 63.5

-112

Under 63.5

-112

Blake Corum (Rams)

Over 27.5

-112

Under 27.5

-112

Brian Robinson Jr. (49ers)

Over 13.5

-112

Under 13.5

-112

Mac Jones (49ers)

Over 6.5

-112

Under 6.5

-112

Matthew Stafford (Rams)

Over 0.5

+112

Under 0.5

-143

Passing Yards

Matthew Stafford (Rams)

Over 263.5

-112

Under 263.5

-112

Mac Jones (49ers)

Over 249.5

-112

Under 249.5

-112

Brock Purdy (49ers)

Over 249.5

-114

Under 249.5

-114

An increasing number of bettors are now enjoying micro betting on the NFL and it’s something which is available on an in-game basis. Wait for the action to start and then wager on something specific to happen.

Niners On Six Losses From Previous Ten at Home

The Niners own a 4-6 mark in their past 10 home games, putting up 22.30 points per contest and giving up 21.20.

The Rams own a 8-2 mark in their past 10 road games, putting up 23.90 points on average and giving up 16.10.

The last Levi's Stadium meeting saw the Rams beat the Niners 12-6. Looking at the last 6 head-to-head matchups at Levi's Stadium, the Niners have four victories and the Rams two.

Last 10 Games		W-L	P	PF	PA	O49.5	U49.5
49ers Home Stats		4-6	43.50	22.30	21.20	3	7
Rams Away Stats		8-2	40.00	23.90	16.10	4	6

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O49.5 = Games Over 49.5 Points
• U49.5 = Games Under 49.5 Points

Latest regular season and playoff games stats.

Los Angeles Rams Stats

San Francisco 49ers Stats

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 8 wins and 2 defeats in the last 10 games on the road

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 home games

Point Spread

• -4.5 Betting Line: Have covered the spread in 7 of the last 10 games
• -4.5 Betting Line on the Road: Have covered the spread in 8 of the last 10 games on the road

Point Spread

• +4.5 Betting Line: Have covered the spread in 6 of the last 10 games
• +4.5 Betting Line at Home: Have covered the spread in 6 of the last 10 home games

Total Points

• Game Totals: An average of 42.20 pts in the previous 10 games
• Game Totals on the Road: An average of 40.00 pts in the previous 10 games on the road
• Over 49.5: Covered in 3 of the previous 10 games
• Over 49.5 on the Road: Covered in 4 of the previous 10 games on the road
• Team Totals: Have scored an average of 25.80 pts and allowed 16.40 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 23.90 pts and allowed 16.10 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 45.30 pts in the previous 10 games
• Game Totals at Home: An average of 43.50 pts in the previous 10 home games
• Over 49.5: Covered in 2 of the previous 10 games
• Over 49.5 at Home: Covered in 3 of the previous 10 home games
• Team Totals: Have scored an average of 21.80 pts and allowed 23.50 pts in the last 10 games
• Team Totals at Home: Have scored an average of 22.30 pts and allowed 21.20 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 365.30 Yds. Allowed 304.20 Yds
• Rushing Yards: Gained 109.60 Yds. Allowed 118.90 Yds
• Passing Yards: Gained 255.70 Yds. Allowed 185.30 Yds
• Total Touchdowns: Scored 3.10 TD. Allowed 1.60 TD
• Rushing Touchdowns: Scored 0.50 TD. Allowed 0.50 TD
• Passing Touchdowns: Scored 2.50 TD. Allowed 1.00 TD
• Total 1st Downs: Picked up 21.80. Allowed 18.50
• Total Turnovers: Committed 0.90. Committed by opponents 1.40
• Total Penalties: Committed 5.40. Committed by opponents 7.50
• Penalty Yards: Lost 47.10 Yds. Gained 59.00 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 360.50 Yds. Allowed 337.70 Yds
• Rushing Yards: Gained 101.20 Yds. Allowed 113.20 Yds
• Passing Yards: Gained 259.30 Yds. Allowed 224.50 Yds
• Total Touchdowns: Scored 2.20 TD. Allowed 2.70 TD
• Rushing Touchdowns: Scored 0.60 TD. Allowed 0.70 TD
• Passing Touchdowns: Scored 1.60 TD. Allowed 1.90 TD
• Total 1st Downs: Picked up 21.80. Allowed 20.20
• Total Turnovers: Committed 1.60. Committed by opponents 0.70
• Total Penalties: Committed 6.70. Committed by opponents 5.90
• Penalty Yards: Lost 50.70 Yds. Gained 38.80 Yds

Last 10 Games on the Road

• Total Yards: Gained 334.30 Yds. Allowed 318.90 Yds
• Rushing Yards: Gained 118.80 Yds. Allowed 126.60 Yds
• Passing Yards: Gained 215.50 Yds. Allowed 192.30 Yds
• Total Touchdowns: Scored 2.70 TD. Allowed 1.70 TD
• Rushing Touchdowns: Scored 0.50 TD. Allowed 0.40 TD
• Passing Touchdowns: Scored 2.10 TD. Allowed 1.20 TD
• Total 1st Downs: Picked up 19.70. Allowed 18.60
• Total Turnovers: Committed 0.70. Committed by opponents 1.30
• Total Penalties: Committed 4.90. Committed by opponents 7.30
• Penalty Yards: Lost 44.90 Yds. Gained 59.00 Yds

Last 10 Home Games

• Total Yards: Gained 362.60 Yds. Allowed 304.80 Yds
• Rushing Yards: Gained 120.70 Yds. Allowed 118.40 Yds
• Passing Yards: Gained 241.90 Yds. Allowed 186.40 Yds
• Total Touchdowns: Scored 2.40 TD. Allowed 2.30 TD
• Rushing Touchdowns: Scored 1.20 TD. Allowed 1.10 TD
• Passing Touchdowns: Scored 1.10 TD. Allowed 1.10 TD
• Total 1st Downs: Picked up 20.70. Allowed 18.20
• Total Turnovers: Committed 1.80. Committed by opponents 0.80
• Total Penalties: Committed 5.60. Committed by opponents 5.10
• Penalty Yards: Lost 42.20 Yds. Gained 39.30 Yds

Top American Football Pages