New Orleans Saints
American Football NFL Highmark Stadium Sun 28 Sep 13:00
Buffalo Bills
  1. Prediction
  2. Bet Builder
  3. Odds
  4. Player Props
  5. Stats
  6. Live Stream
  7. Team News
  8. Lineups
  9. Injuries
  10. Standings

NFL Betting Preview: Saints vs Bills

The New Orleans Saints lock horns with the Buffalo Bills in this NFL Week 4 matchup at Highmark Stadium, with kickoff scheduled for 13:00 on Sunday 28 September. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

Expect Saints to Cover the Spread

The Saints look capable of avoiding a heavy defeat against the Bills and we’re happy to bet them against the spread. The underdogs can comfortably cover +15.5 and this can be backed at -110.

Trusting our spread call? Learn more about BetMGM in our expert review, then unlock the best promo code before you make your move.

Bills 31-6 Winners in Previous H2H Matchup

New Orleans Saints have suffered a defeat in their previous three games including a recent 44-13 loss. This occurred on the road at Lumen Field against Seattle Seahawks. The Saints recorded 284 total yards, made up of 205 through the air and 79 on the ground. The offense scored one touchdown and picked up 21 first downs.

Buffalo Bills were winners for the third straight time in their last game. Landing a 31-21 home victory against Miami Dolphins at Highmark Stadium. The Bills finished with 360 yards, including 203 passing and 157 rushing yards. They picked up 23 first downs and produced 4 TD's, including 3 passing scores and a rushing touchdown.

Head-to-Head Statistics

The Bills triumphed 31-6 when they last played the Saints. This head-to-head was played at Caesars Superdome.

Quarterbacks

Saints vs Bills Prediction & Picks

We’ve broken down Saints vs Bills from every angle, offering our expert match prediction, expected final score, best player prop recommendations and a well-constructed bet builder.

Game Prediction

The betting line of +15.5 looks too big. We’re very keen to snap up the -110 that the Saints cover an appealing spread in this NFL battle.

Team news and current form always play a key role in shaping our expert NFL picks. We also dig into the latest stats and trends to help deliver the most accurate predictions possible.

Key Saints vs Bills stats:

  • The +15.5 line has been covered by Saints in 17 of their last 20 games on the road.
  • The +15.5 line has been covered by Saints in 8 of their last 10 games.
  • The -15.5 line hasn’t been covered by Bills in 4 of their last 5 games.
  • The -15.5 line hasn’t been covered by Bills in 7 of their last 10 games.
  • The -15.5 line hasn’t been covered by Bills in 3 consecutive games at home.

Saints +15.5 Probability

The top NFL sportsbooks are estimating that there is a 52.4% chance of this pick winning. However, our analysts in-depth research has found that the actual probability is between 55-60%. It's therefore regarded as a value wager.

Looking for Bigger Odds?

The Winning Margin lines allow you to bet on the Saints to claim a victory by a certain number of points. It’s a different wager and a viable alternative to the spread.

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Best Bet

Saints +15.5 @ -110 Watch Live Bet Now BetMGM logo
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Published 19:26, 26 September 2025

Player Prop Picks

Top Pick: Alvin Kamara Anytime TD +130 BetMGM logo

The odds for Alvin Kamara (Saints) to make it to the end zone are +130. He looks like a value bet to punch it in and we recommend backing this Anytime Touchdown Scorer pick.

Latest Alvin Kamara Player Prop Odds

Spencer Rattler Over 200.5 Passing Yards -114 BetMGM logo

You can back Spencer Rattler (Saints) at -114 to record more than 200.5 passing yards. The line for him on the Overs looks attractive and bettors can get plenty of juice from this QB Passing Yards wager.

Latest Spencer Rattler Player Prop Odds

Same Game Parlay Picks

Spread Saints +15.5
Totals Under 48.5
Anytime Touchdown Alvin Kamara

Get in the game with a same game parlay. Our picks are Saints to cover the +15.5 spread, Under 48.5 on the total and a touchdown to be scored by Alvin Kamara (Saints).

A same game parlay is a single event wager where you make predictions that are going to happen in a particular football game. Should a bettor get these selections correct, then they can achieve a good return from a small stake.

T&C apply. Gamble responsibly 18+

Correct Score Prediction

Saints Saints logo 14 - 27 Bills logo Bills

Should you want to go for a selection at huge odds, head to the correct score lines where the Bills can be backed speculatively to achieve a 27-14 victory.

Saints vs Bills Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Bills Heavy Favorites to Win

Buffalo Bills have short betting odds and they’re overwhelming -1429 favorites for this game. This means the sportsbooks give them a 93% chance of winning. At +870, New Orleans Saints are regarded as having a lower probability of winning.

The current spread is 15.5 and the total points line is 48.5. There is no denying the popularity of betting on the Totals. Those who wager Under 48.5 can get -118.

There are a wide range of game lines and team props when it comes to the National Football League and we recommend heading to the top betting apps to find the bet that matches your view on the matchup.

James Cook Favorite to Score First Touchdown

Favorite James Cook is now available at +360 to be the First Touchdown Scorer. You will find similar odds apply when it comes to him scoring the last TD.

Touchdown

Receiving Yards

Rushing Yards

Passing Yards

Best Betting Offers
Highmark Stadium
Highmark Stadium

Can Bills Make It Another Home Victory?

The Bills own a 10-0 mark in their past 10 home games, scoring 32.30 points per contest and conceding 19.60.

The Saints are on a skid of three straight road defeats. They have three wins and seven losses in the last 10 games on the road, scoring 18.00 points per contest and conceding 24.90.

Last 10 Games W-L P PF PA O48.5 U48.5
Bills logo Bills Home Stats 10-0 51.90 32.30 19.60 6 4
Saints logo Saints Away Stats 3-7 42.90 18.00 24.90 3 7
  • W-L = Wins-Losses
  • P = Avg. Points
  • PF = Avg. Points For
  • PA = Avg. Points Against
  • O48.5 = Games Over 48.5 Points
  • U48.5 = Games Under 48.5 Points
Team Stats

Latest regular season and playoff games stats.

New Orleans Saints logo New Orleans Saints Stats
Buffalo Bills logo Buffalo Bills Stats
Moneyline
  • 2 wins and 8 defeats in the last 10 games
  • 3 wins and 7 defeats in the last 10 games on the road
Moneyline
  • 8 wins and 2 defeats in the last 10 games
  • 10 wins and 0 defeats in the last 10 home games
Point Spread
Point Spread
Total Points
Total Points
Game Stats
Last 10 Games
Game Stats
Last 10 Games
Last 10 Games on the Road
Last 10 Home Games

Live Streaming

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Team News

New Orleans Saints Injuries

Type
Name
Info
Julian Blackmon
Shoulder - Labrum
Vernon Broughton
Hip
Derek Carr
Shoulder
Will Clapp
Foot
Taysom Hill
Knee - ACL
Tyrann Mathieu
Undisclosed
Bub Means
Lower Leg
Foster Moreau
Knee
Mason Pline
Upper Body
Ja'Lynn Polk
Shoulder
Dillon Radunz
Toe
Ryan Ramczyk
Undisclosed
John Ridgeway
Pectoral
Nick Saldiveri
Knee
Devaughn Vele
Hip
Barry Wesley
Undisclosed
Chase Young
Calf
Landon Young
Ankle

Buffalo Bills Injuries

Type
Name
Info
Tyler Bass
Hip
Spencer Brown
Calf
DeWayne Carter
Achilles
A.J. Epenesa
Pectoral
Tylan Grable
Concussion
Maxwell Hairston
Knee
Michael Hoecht
Suspension
Matt Milano
Pectoral
Larry Ogunjobi
Suspension
Ed Oliver
Ankle
Wande Owens
Undisclosed

Previous New Orleans Saints Lineups

21 Sep NFL
Saints 13-44 Seahawks
14 Sep NFL
49ers 26-21 Saints
07 Sep NFL
Cardinals 20-13 Saints
05 Jan NFL
Saints 19-27 Buccaneers
29 Dec NFL
Raiders 25-10 Saints
23 Dec NFL
Saints 0-34 Packers
15 Dec NFL
Commanders 20-19 Saints
08 Dec NFL
Saints 14-11 Giants
01 Dec NFL
Rams 21-14 Saints
17 Nov NFL
Browns 14-35 Saints

Previous Buffalo Bills Lineups

18 Sep NFL
Dolphins 21-31 Bills
14 Sep NFL
Bills 30-10 Jets
07 Sep NFL
Ravens 40-41 Bills
26 Jan NFL Playoffs
Bills 29-32 Chiefs
19 Jan NFL Playoffs
Ravens 25-27 Bills
12 Jan NFL Playoffs
Broncos 7-31 Bills
05 Jan NFL
Bills 16-23 Patriots
29 Dec NFL
Jets 14-40 Bills
22 Dec NFL
Patriots 21-24 Bills
15 Dec NFL
Bills 48-42 Lions

NFL Standings Select Season

AFC East W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Bills 3 0 0 1.000 102 71 31 2-0-0 1-0-0 2-0-0 3-0-0 3-0-0 3W
Patriots 1 2 0 0.333 60 68 -8 0-2-0 1-0-0 1-0-0 1-2-0 1-2-0 1L
Jets 0 3 0 0.000 69 93 -24 0-2-0 0-1-0 0-1-0 0-2-0 0-3-0 3L
Dolphins 0 3 0 0.000 56 97 -41 0-1-0 0-2-0 0-2-0 0-3-0 0-3-0 3L
AFC North W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Bengals 2 1 0 0.667 58 91 -33 1-0-0 1-1-0 1-0-0 2-0-0 2-1-0 1L
Steelers 2 1 0 0.667 72 77 -5 0-1-0 2-0-0 0-0-0 2-0-0 2-1-0 1W
Ravens 1 2 0 0.333 111 96 15 1-1-0 0-1-0 1-0-0 1-1-0 1-2-0 1L
Browns 1 2 0 0.333 46 68 -22 1-1-0 0-1-0 0-2-0 0-2-0 1-2-0 1W
AFC South W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Colts 3 0 0 1.000 103 56 47 2-0-0 1-0-0 1-0-0 3-0-0 3-0-0 3W
Jaguars 2 1 0 0.667 70 51 19 2-0-0 0-1-0 1-0-0 1-1-0 2-1-0 1W
Texans 0 3 0 0.000 38 51 -13 0-1-0 0-2-0 0-1-0 0-1-0 0-3-0 3L
Titans 0 3 0 0.000 51 94 -43 0-2-0 0-1-0 0-1-0 0-2-0 0-3-0 3L
AFC West W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Chargers 3 0 0 1.000 70 50 20 2-0-0 1-0-0 3-0-0 3-0-0 3-0-0 3W
Raiders 1 2 0 0.333 53 74 -21 0-1-0 1-1-0 0-1-0 1-1-0 1-2-0 2L
Broncos 1 2 0 0.333 68 64 4 1-0-0 0-2-0 0-1-0 1-2-0 1-2-0 2L
Chiefs 1 2 0 0.333 60 56 4 0-1-0 1-1-0 0-1-0 0-1-0 1-2-0 1W
NFC East W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Eagles 3 0 0 1.000 77 63 14 2-0-0 1-0-0 1-0-0 2-0-0 3-0-0 3W
Commanders 2 1 0 0.667 80 57 23 2-0-0 0-1-0 1-0-0 1-1-0 2-1-0 1W
Cowboys 1 2 0 0.333 74 92 -18 1-0-0 0-2-0 1-1-0 1-2-0 1-2-0 1L
Giants 0 3 0 0.000 52 83 -31 0-1-0 0-2-0 0-2-0 0-2-0 0-3-0 3L
NFC North W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Packers 2 1 0 0.667 64 44 20 2-0-0 0-1-0 1-0-0 2-0-0 2-1-0 1L
Vikings 2 1 0 0.667 81 56 25 1-1-0 1-0-0 1-0-0 1-1-0 2-1-0 1W
Lions 2 1 0 0.667 103 78 25 1-0-0 1-1-0 1-1-0 1-1-0 2-1-0 2W
Bears 1 2 0 0.333 76 93 -17 1-1-0 0-1-0 0-2-0 1-2-0 1-2-0 1W
NFC South W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Buccaneers 3 0 0 1.000 72 66 6 1-0-0 2-0-0 1-0-0 1-0-0 3-0-0 3W
Panthers 1 2 0 0.333 62 53 9 1-0-0 0-2-0 1-0-0 1-1-0 1-2-0 1W
Falcons 1 2 0 0.333 42 59 -17 0-1-0 1-1-0 0-2-0 1-2-0 1-2-0 1L
Saints 0 3 0 0.000 47 90 -43 0-2-0 0-1-0 0-0-0 0-3-0 0-3-0 3L
NFC West W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
49ers 3 0 0 1.000 59 49 10 1-0-0 2-0-0 2-0-0 3-0-0 3-0-0 3W
Cardinals 2 2 0 0.500 82 74 8 1-1-0 1-1-0 0-2-0 2-2-0 2-2-0 2L
Seahawks 3 1 0 0.750 111 67 44 1-1-0 2-0-0 1-1-0 2-1-0 3-1-0 3W
Rams 2 1 0 0.667 73 61 12 1-0-0 1-1-0 0-0-0 0-1-0 2-1-0 1L
AFC Conference W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Chargers 3 0 0 1.000 70 50 20 2-0-0 1-0-0 3-0-0 3-0-0 3-0-0 3W
Colts 3 0 0 1.000 103 56 47 2-0-0 1-0-0 1-0-0 3-0-0 3-0-0 3W
Bills 3 0 0 1.000 102 71 31 2-0-0 1-0-0 2-0-0 3-0-0 3-0-0 3W
Bengals 2 1 0 0.667 58 91 -33 1-0-0 1-1-0 1-0-0 2-0-0 2-1-0 1L
Steelers 2 1 0 0.667 72 77 -5 0-1-0 2-0-0 0-0-0 2-0-0 2-1-0 1W
Jaguars 2 1 0 0.667 70 51 19 2-0-0 0-1-0 1-0-0 1-1-0 2-1-0 1W
Raiders 1 2 0 0.333 53 74 -21 0-1-0 1-1-0 0-1-0 1-1-0 1-2-0 2L
Ravens 1 2 0 0.333 111 96 15 1-1-0 0-1-0 1-0-0 1-1-0 1-2-0 1L
Broncos 1 2 0 0.333 68 64 4 1-0-0 0-2-0 0-1-0 1-2-0 1-2-0 2L
Patriots 1 2 0 0.333 60 68 -8 0-2-0 1-0-0 1-0-0 1-2-0 1-2-0 1L
Browns 1 2 0 0.333 46 68 -22 1-1-0 0-1-0 0-2-0 0-2-0 1-2-0 1W
Chiefs 1 2 0 0.333 60 56 4 0-1-0 1-1-0 0-1-0 0-1-0 1-2-0 1W
Titans 0 3 0 0.000 51 94 -43 0-2-0 0-1-0 0-1-0 0-2-0 0-3-0 3L
Dolphins 0 3 0 0.000 56 97 -41 0-1-0 0-2-0 0-2-0 0-3-0 0-3-0 3L
Jets 0 3 0 0.000 69 93 -24 0-2-0 0-1-0 0-1-0 0-2-0 0-3-0 3L
Texans 0 3 0 0.000 38 51 -13 0-1-0 0-2-0 0-1-0 0-1-0 0-3-0 3L
NFC Conference W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Eagles 3 0 0 1.000 77 63 14 2-0-0 1-0-0 1-0-0 2-0-0 3-0-0 3W
49ers 3 0 0 1.000 59 49 10 1-0-0 2-0-0 2-0-0 3-0-0 3-0-0 3W
Buccaneers 3 0 0 1.000 72 66 6 1-0-0 2-0-0 1-0-0 1-0-0 3-0-0 3W
Seahawks 3 1 0 0.750 111 67 44 1-1-0 2-0-0 1-1-0 2-1-0 3-1-0 3W
Packers 2 1 0 0.667 64 44 20 2-0-0 0-1-0 1-0-0 2-0-0 2-1-0 1L
Cardinals 2 2 0 0.500 82 74 8 1-1-0 1-1-0 0-2-0 2-2-0 2-2-0 2L
Vikings 2 1 0 0.667 81 56 25 1-1-0 1-0-0 1-0-0 1-1-0 2-1-0 1W
Commanders 2 1 0 0.667 80 57 23 2-0-0 0-1-0 1-0-0 1-1-0 2-1-0 1W
Lions 2 1 0 0.667 103 78 25 1-0-0 1-1-0 1-1-0 1-1-0 2-1-0 2W
Rams 2 1 0 0.667 73 61 12 1-0-0 1-1-0 0-0-0 0-1-0 2-1-0 1L
Panthers 1 2 0 0.333 62 53 9 1-0-0 0-2-0 1-0-0 1-1-0 1-2-0 1W
Falcons 1 2 0 0.333 42 59 -17 0-1-0 1-1-0 0-2-0 1-2-0 1-2-0 1L
Bears 1 2 0 0.333 76 93 -17 1-1-0 0-1-0 0-2-0 1-2-0 1-2-0 1W
Cowboys 1 2 0 0.333 74 92 -18 1-0-0 0-2-0 1-1-0 1-2-0 1-2-0 1L
Saints 0 3 0 0.000 47 90 -43 0-2-0 0-1-0 0-0-0 0-3-0 0-3-0 3L
Giants 0 3 0 0.000 52 83 -31 0-1-0 0-2-0 0-2-0 0-2-0 0-3-0 3L
NFL Team W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Bills 3 0 0 1.000 102 71 31 2-0-0 1-0-0 2-0-0 3-0-0 3-0-0 3W
Colts 3 0 0 1.000 103 56 47 2-0-0 1-0-0 1-0-0 3-0-0 3-0-0 3W
Chargers 3 0 0 1.000 70 50 20 2-0-0 1-0-0 3-0-0 3-0-0 3-0-0 3W
Eagles 3 0 0 1.000 77 63 14 2-0-0 1-0-0 1-0-0 2-0-0 3-0-0 3W
49ers 3 0 0 1.000 59 49 10 1-0-0 2-0-0 2-0-0 3-0-0 3-0-0 3W
Buccaneers 3 0 0 1.000 72 66 6 1-0-0 2-0-0 1-0-0 1-0-0 3-0-0 3W
Seahawks 3 1 0 0.750 111 67 44 1-1-0 2-0-0 1-1-0 2-1-0 3-1-0 3W
Bengals 2 1 0 0.667 58 91 -33 1-0-0 1-1-0 1-0-0 2-0-0 2-1-0 1L
Lions 2 1 0 0.667 103 78 25 1-0-0 1-1-0 1-1-0 1-1-0 2-1-0 2W
Packers 2 1 0 0.667 64 44 20 2-0-0 0-1-0 1-0-0 2-0-0 2-1-0 1L
Jaguars 2 1 0 0.667 70 51 19 2-0-0 0-1-0 1-0-0 1-1-0 2-1-0 1W
Rams 2 1 0 0.667 73 61 12 1-0-0 1-1-0 0-0-0 0-1-0 2-1-0 1L
Vikings 2 1 0 0.667 81 56 25 1-1-0 1-0-0 1-0-0 1-1-0 2-1-0 1W
Steelers 2 1 0 0.667 72 77 -5 0-1-0 2-0-0 0-0-0 2-0-0 2-1-0 1W
Commanders 2 1 0 0.667 80 57 23 2-0-0 0-1-0 1-0-0 1-1-0 2-1-0 1W
Cardinals 2 2 0 0.500 82 74 8 1-1-0 1-1-0 0-2-0 2-2-0 2-2-0 2L
Falcons 1 2 0 0.333 42 59 -17 0-1-0 1-1-0 0-2-0 1-2-0 1-2-0 1L
Ravens 1 2 0 0.333 111 96 15 1-1-0 0-1-0 1-0-0 1-1-0 1-2-0 1L
Panthers 1 2 0 0.333 62 53 9 1-0-0 0-2-0 1-0-0 1-1-0 1-2-0 1W
Bears 1 2 0 0.333 76 93 -17 1-1-0 0-1-0 0-2-0 1-2-0 1-2-0 1W
Browns 1 2 0 0.333 46 68 -22 1-1-0 0-1-0 0-2-0 0-2-0 1-2-0 1W
Cowboys 1 2 0 0.333 74 92 -18 1-0-0 0-2-0 1-1-0 1-2-0 1-2-0 1L
Broncos 1 2 0 0.333 68 64 4 1-0-0 0-2-0 0-1-0 1-2-0 1-2-0 2L
Chiefs 1 2 0 0.333 60 56 4 0-1-0 1-1-0 0-1-0 0-1-0 1-2-0 1W
Raiders 1 2 0 0.333 53 74 -21 0-1-0 1-1-0 0-1-0 1-1-0 1-2-0 2L
Patriots 1 2 0 0.333 60 68 -8 0-2-0 1-0-0 1-0-0 1-2-0 1-2-0 1L
Texans 0 3 0 0.000 38 51 -13 0-1-0 0-2-0 0-1-0 0-1-0 0-3-0 3L
Dolphins 0 3 0 0.000 56 97 -41 0-1-0 0-2-0 0-2-0 0-3-0 0-3-0 3L
Saints 0 3 0 0.000 47 90 -43 0-2-0 0-1-0 0-0-0 0-3-0 0-3-0 3L
Giants 0 3 0 0.000 52 83 -31 0-1-0 0-2-0 0-2-0 0-2-0 0-3-0 3L
Jets 0 3 0 0.000 69 93 -24 0-2-0 0-1-0 0-1-0 0-2-0 0-3-0 3L
Titans 0 3 0 0.000 51 94 -43 0-2-0 0-1-0 0-1-0 0-2-0 0-3-0 3L