Eagles vs Bills Prediction, Picks & Odds | 28 Dec 2025

NFL Betting Preview: Eagles vs Bills

The Philadelphia Eagles battle the Buffalo Bills at Highmark Stadium, with kickoff scheduled for 16:25 on Sunday, December 28.

We’re keeping things simple by backing the Bills on the Moneyline. They should get the better of the Eagles and our betting prediction is available at -118.

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Philadelphia Eagles have won two on the spin, triumphing 29-18 in their previous game. This was on the road against Washington Commanders at Northwest Stadium. The Eagles moved the ball for 385 yards, split between 178 passing and 207 rushing yards. They produced 26 first downs and found the end zone 4 times, 2 via the pass and 2 on the ground.

Buffalo Bills won last time out by a 23-20 scoreline. On the road against Cleveland Browns at Huntington Bank Field, they made it four wins on the spin. The Bills finished with 259 total yards, breaking down to 95 passing and 164 rushing yards. The offense produced 16 first downs and scored 3 touchdowns, all coming on the ground.

Head-to-Head Statistics

The Eagles won the last matchup between the pair. Enjoying a 37-34 (OT) triumph when facing the Bills at Lincoln Financial Field.

Quarterbacks

Jalen Hurts

189.5 Passing Yards

Over -114

Under -114

Josh Allen

195.5 Passing Yards

Over -114

Under -114

Eagles vs Bills Prediction & Picks

Our Eagles vs Bills tips include the main match prediction, a correct score forecast, bet builder advice and top player prop picks. Each section below offers expert insight into the key betting angles.

Game Prediction

The -118 about the Bills look really attractive when it comes to the Moneyline. We think their opponents can be beaten in this NFL battle, so this is our pick.

We only publish our NFL predictions once we’ve got a clear and confident read on team news and the latest form. We also stay sharp by digging into the most valuable stats to support every pick we make.

Key Eagles vs Bills stats:

• Bills have won 4 consecutive games.
• Bills have won 9 of their last 10 games at home.
• Bills have won 18 of their last 20 games at home.
• Eagles have lost 3 of their last 5 games.

Bills Moneyline Probability

When looking at the latest odds, our pick has a 54.1% chance of delivering a return. In our opinion, there’s actually a probability of success closer to 60%. This is why we regard this as a value bet.

The spread provides you with the opportunity to get more juice on your bets. You can move the line for the Bills and choose the odds to suit you.

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Our Game Prediction

Bills Moneyline @ -118 Watch Live Bet Now

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Player Prop Picks

Top Pick: Jalen Hurts Under 189.5 Passing Yards -114

Jalen Hurts (Eagles) is available at -114 to have less than 189.5 passing yards. The line looks too high and we’re confident he’ll fall short of the QB Passing Yards total.

Latest Jalen Hurts Player Prop Odds

Touchdown

Anytime

+115

First

+700

Passing Yards

Over 189.5

-114

Under 189.5

-114

Rushing Yards

Over 30.5

-114

Under 30.5

-114

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Josh Allen Under 29.5 Rushing Yards -114

You can place a bet on Josh Allen (Eagles) at -114 to finish with fewer than 29.5 rushing yards. Several factors suggest he will fall short of the Player Rushing Yards line, making this an appealing wager.

Latest Josh Allen Player Prop Odds

Touchdown

Anytime

+120

First

+700

Passing Yards

Over 195.5

-114

Under 195.5

-114

Rushing Yards

Over 29.5

-114

Under 29.5

-114

Correct Score Prediction

Eagles 21 - 31 Bills

We’re going for the Bills to achieve a 31-21 win and the good news is that there are massive odds for this outcome. A small stake can return a potentially large amount.

Eagles vs Bills Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

There are betting odds of -118 about Buffalo Bills winning, with Philadelphia Eagles currently available at -100. The sportsbooks award a 50% probability that the road team will be settled as a winning bet.

The spread is calculated to be 1.5, while total points comes in at 44.5. A Total bet is always available and can often provide value selections. Those that want to back Under 44.5 can find odds of -115 available.

If you’re betting on the National Football League, we recommend visiting the top betting apps and scanning through the many team props and game lines. There’s the opportunity to wager pre-game and in-game.

Moneyline

Eagles

-100

Bills

-118

Point Spread

Eagles +1.5

-110

Bills -1.5

-110

Total Points

Under 44.5

-115

Over 44.5

-105

James Cook can be backed to score a touchdown at anytime at -105. He is the favorite to score the first TD at odds of +500.

Touchdown

James Cook (Bills)

First TD

+500

Anytime TD

-105

Saquon Barkley (Eagles)

First TD

+600

Anytime TD

-105

Josh Allen (Bills)

First TD

+700

Anytime TD

+120

Jalen Hurts (Eagles)

First TD

+700

Anytime TD

+115

AJ Brown (Eagles)

First TD

+850

Anytime TD

+170

Khalil Shakir (Bills)

First TD

+1100

Anytime TD

+230

DeVonta Smith (Eagles)

First TD

+1200

Anytime TD

+220

Dallas Goedert (Eagles)

First TD

+1400

Anytime TD

+250

Dawson Knox (Bills)

First TD

+1400

Anytime TD

+270

Dalton Kincaid (Bills)

First TD

+1400

Anytime TD

+270

Joshua Palmer (Bills)

First TD

+2200

Anytime TD

+470

Jackson Hawes (Bills)

First TD

+2500

Anytime TD

+500

Keon Coleman (Bills)

First TD

+2700

Anytime TD

+550

Gabe Davis (Bills)

First TD

+2700

Anytime TD

+550

Tyrell Shavers (Bills)

First TD

+2700

Anytime TD

+550

Mecole Hardman (Bills)

First TD

+3300

Anytime TD

+750

Brandin Cooks (Bills)

First TD

+3300

Anytime TD

+750

Ty Johnson (Bills)

First TD

+3500

Anytime TD

+500

Tank Bigsby (Eagles)

First TD

+8000

Anytime TD

+1000

Jahan Dotson (Eagles)

First TD

+10000

Anytime TD

+1100

Ray Davis (Bills)

First TD

+10000

Anytime TD

+1400

Darius Cooper (Eagles)

First TD

+10000

Anytime TD

+1700

Kylen Granson (Eagles)

First TD

+10000

Anytime TD

+1700

Grant Calcaterra (Eagles)

First TD

+10000

Anytime TD

+1800

Will Shipley (Eagles)

First TD

+10000

Anytime TD

+2200

Reggie Gilliam (Bills)

First TD

+10000

Anytime TD

+3000

Cameron Latu (Eagles)

First TD

+10000

Anytime TD

+3500

Britain Covey (Eagles)

First TD

+10000

Anytime TD

+4000

Receiving Yards

AJ Brown (Eagles)

Over 61.5

-114

Under 61.5

-114

DeVonta Smith (Eagles)

Over 46.5

-114

Under 46.5

-114

Khalil Shakir (Bills)

Over 42.5

-114

Under 42.5

-114

Dallas Goedert (Eagles)

Over 33.5

-114

Under 33.5

-114

Dawson Knox (Bills)

Over 18.5

-114

Under 18.5

-114

Saquon Barkley (Eagles)

Over 12.5

-114

Under 12.5

-114

James Cook (Bills)

Over 12.5

-114

Under 12.5

-114

Rushing Yards

James Cook (Bills)

Over 87.5

-114

Under 87.5

-114

Saquon Barkley (Eagles)

Over 83.5

-114

Under 83.5

-114

Jalen Hurts (Eagles)

Over 30.5

-114

Under 30.5

-114

Josh Allen (Bills)

Over 29.5

-114

Under 29.5

-114

Passing Yards

Josh Allen (Bills)

Over 195.5

-114

Under 195.5

-114

Jalen Hurts (Eagles)

Over 189.5

-114

Under 189.5

-114

Bills Riding Momentum at Home

The Bills have put together three wins in a row at Highmark Stadium. They have nine wins and one loss in the last 10 home games, averaging 33.20 points on offense and surrendering 23.60 on defense.

The Eagles have gone 6-4 across their last 10 games games on the road, scoring 23.20 points per contest and conceding 22.40.

The Eagles defeated the Bills 31-13 in their last meeting at Highmark Stadium.

Last 10 Games		W-L	P	PF	PA	O44.5	U44.5
Bills Home Stats		9-1	56.80	33.20	23.60	8	2
Eagles Away Stats		6-4	45.60	23.20	22.40	6	4

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O44.5 = Games Over 44.5 Points
• U44.5 = Games Under 44.5 Points

Latest regular season and playoff games stats.

Philadelphia Eagles Stats

Buffalo Bills Stats

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 6 wins and 4 defeats in the last 10 games on the road

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 9 wins and 1 defeat in the last 10 home games

Point Spread

• +1.5 Betting Line: Have covered the spread in 6 of the last 10 games
• +1.5 Betting Line on the Road: Have covered the spread in 6 of the last 10 games on the road

Point Spread

• -1.5 Betting Line: Have covered the spread in 7 of the last 10 games
• -1.5 Betting Line at Home: Have covered the spread in 8 of the last 10 home games

Total Points

• Game Totals: An average of 40.40 pts in the previous 10 games
• Game Totals on the Road: An average of 45.60 pts in the previous 10 games on the road
• Over 44.5: Covered in 5 of the previous 10 games
• Over 44.5 on the Road: Covered in 6 of the previous 10 games on the road
• Team Totals: Have scored an average of 22.40 pts and allowed 18.00 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 23.20 pts and allowed 22.40 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 51.20 pts in the previous 10 games
• Game Totals at Home: An average of 56.80 pts in the previous 10 home games
• Over 44.5: Covered in 5 of the previous 10 games
• Over 44.5 at Home: Covered in 8 of the previous 10 home games
• Team Totals: Have scored an average of 28.10 pts and allowed 23.10 pts in the last 10 games
• Team Totals at Home: Have scored an average of 33.20 pts and allowed 23.60 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 348.60 Yds. Allowed 304.70 Yds
• Rushing Yards: Gained 132.70 Yds. Allowed 122.00 Yds
• Passing Yards: Gained 215.90 Yds. Allowed 182.70 Yds
• Total Touchdowns: Scored 2.70 TD. Allowed 1.90 TD
• Rushing Touchdowns: Scored 0.90 TD. Allowed 1.20 TD
• Passing Touchdowns: Scored 1.70 TD. Allowed 0.70 TD
• Total 1st Downs: Picked up 19.00. Allowed 18.10
• Total Turnovers: Committed 1.30. Committed by opponents 1.30
• Total Penalties: Committed 6.80. Committed by opponents 5.20
• Penalty Yards: Lost 56.80 Yds. Gained 44.90 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 361.70 Yds. Allowed 317.30 Yds
• Rushing Yards: Gained 161.10 Yds. Allowed 143.60 Yds
• Passing Yards: Gained 200.60 Yds. Allowed 173.70 Yds
• Total Touchdowns: Scored 3.70 TD. Allowed 2.80 TD
• Rushing Touchdowns: Scored 1.90 TD. Allowed 1.70 TD
• Passing Touchdowns: Scored 1.60 TD. Allowed 0.90 TD
• Total 1st Downs: Picked up 20.20. Allowed 18.80
• Total Turnovers: Committed 1.40. Committed by opponents 1.50
• Total Penalties: Committed 5.90. Committed by opponents 4.60
• Penalty Yards: Lost 49.30 Yds. Gained 39.10 Yds

Last 10 Games on the Road

• Total Yards: Gained 312.30 Yds. Allowed 339.40 Yds
• Rushing Yards: Gained 122.80 Yds. Allowed 125.60 Yds
• Passing Yards: Gained 189.50 Yds. Allowed 213.80 Yds
• Total Touchdowns: Scored 2.70 TD. Allowed 2.40 TD
• Rushing Touchdowns: Scored 1.40 TD. Allowed 1.00 TD
• Passing Touchdowns: Scored 1.10 TD. Allowed 1.40 TD
• Total 1st Downs: Picked up 17.90. Allowed 20.20
• Total Turnovers: Committed 1.30. Committed by opponents 1.80
• Total Penalties: Committed 7.70. Committed by opponents 5.40
• Penalty Yards: Lost 65.80 Yds. Gained 47.10 Yds

Last 10 Home Games

• Total Yards: Gained 390.20 Yds. Allowed 327.60 Yds
• Rushing Yards: Gained 142.30 Yds. Allowed 133.80 Yds
• Passing Yards: Gained 247.90 Yds. Allowed 193.80 Yds
• Total Touchdowns: Scored 4.10 TD. Allowed 2.90 TD
• Rushing Touchdowns: Scored 1.90 TD. Allowed 1.40 TD
• Passing Touchdowns: Scored 2.10 TD. Allowed 1.50 TD
• Total 1st Downs: Picked up 23.00. Allowed 19.90
• Total Turnovers: Committed 0.80. Committed by opponents 1.50
• Total Penalties: Committed 6.30. Committed by opponents 5.80
• Penalty Yards: Lost 48.60 Yds. Gained 51.70 Yds

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