Eagles vs Bills Prediction, Picks & Odds | 28 Dec 2025

NFL Betting Preview: Eagles vs Bills

The Philadelphia Eagles battle the Buffalo Bills at Highmark Stadium, with kickoff scheduled for 16:25 on Sunday, December 28.

We’re keeping things simple by backing the Bills on the Moneyline. They should get the better of the Eagles and our betting prediction is available at -118.

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Philadelphia Eagles have won two on the spin, triumphing 29-18 in their previous game. This was on the road against Washington Commanders at Northwest Stadium. The Eagles moved the ball for 385 yards, split between 178 passing and 207 rushing yards. They produced 26 first downs and found the end zone 4 times, 2 via the pass and 2 on the ground.

Buffalo Bills won last time out by a 23-20 scoreline. On the road against Cleveland Browns at Huntington Bank Field, they made it four wins on the spin. The Bills finished with 259 total yards, breaking down to 95 passing and 164 rushing yards. The offense produced 16 first downs and scored 3 touchdowns, all coming on the ground.

Head-to-Head Statistics

The Eagles won the last matchup between the pair. Enjoying a 37-34 (OT) triumph when facing the Bills at Lincoln Financial Field.

Quarterbacks

Jalen Hurts

185.5 Passing Yards

Over -112

Under -112

Josh Allen

194.5 Passing Yards

Over -112

Under -112

Eagles vs Bills Prediction & Picks

Our Eagles vs Bills tips include the main match prediction, a correct score forecast, bet builder advice and top player prop picks. Each section below offers expert insight into the key betting angles.

Game Prediction

The -118 about the Bills look really attractive when it comes to the Moneyline. We think their opponents can be beaten in this NFL battle, so this is our pick.

We only publish our NFL predictions once we’ve got a clear and confident read on team news and the latest form. We also stay sharp by digging into the most valuable stats to support every pick we make.

Key Eagles vs Bills stats:

• Bills have won 4 consecutive games.
• Bills have won 9 of their last 10 games at home.
• Bills have won 18 of their last 20 games at home.
• Eagles have lost 3 of their last 5 games.

Bills Moneyline Probability

When looking at the latest odds, our pick has a 54.1% chance of delivering a return. In our opinion, there’s actually a probability of success closer to 60%. This is why we regard this as a value bet.

The spread provides you with the opportunity to get more juice on your bets. You can move the line for the Bills and choose the odds to suit you.

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Our Game Prediction

Bills Moneyline @ -118 Bet Now

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Player Prop Picks

Top Pick: Jalen Hurts Under 189.5 Passing Yards -114

Jalen Hurts (Eagles) is available at -114 to have less than 189.5 passing yards. The line looks too high and we’re confident he’ll fall short of the QB Passing Yards total.

Latest Jalen Hurts Player Prop Odds

Touchdown

Anytime

+145

First

+850

Passing Yards

Over 185.5

-112

Under 185.5

-112

Rushing Yards

Over 29.5

-112

Under 29.5

-112

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Josh Allen Under 29.5 Rushing Yards -114

You can place a bet on Josh Allen (Eagles) at -114 to finish with fewer than 29.5 rushing yards. Several factors suggest he will fall short of the Player Rushing Yards line, making this an appealing wager.

Latest Josh Allen Player Prop Odds

Touchdown

Anytime

+110

First

+650

Passing Yards

Over 194.5

-112

Under 194.5

-112

Rushing Yards

Over 31.5

-112

Under 31.5

-112

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Eagles 21 - 31 Bills

We’re going for the Bills to achieve a 31-21 win and the good news is that there are massive odds for this outcome. A small stake can return a potentially large amount.

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Eagles vs Bills Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

There are betting odds of -122 about Buffalo Bills winning, with Philadelphia Eagles currently available at +102. The sportsbooks award a 50% probability that the road team will be settled as a winning bet.

The spread is calculated to be 1.5, while total points comes in at 46.5. A Total bet is always available and can often provide value selections. Those that want to back Under 46.5 can find odds of -110 available.

If you’re betting on the National Football League, we recommend visiting the top betting apps and scanning through the many team props and game lines. There’s the opportunity to wager pre-game and in-game.

Moneyline

Eagles

+102

Bills

-122

Point Spread

Eagles +1.5

-110

Bills -1.5

-110

Total Points

Under 46.5

-110

Over 46.5

-110

James Cook can be backed to score a touchdown at anytime at -120. He is the favorite to score the first TD at odds of +460.

Touchdown

James Cook (Bills)

First TD

+460

Anytime TD

-120

Saquon Barkley (Eagles)

First TD

+650

Anytime TD

+105

Josh Allen (Bills)

First TD

+650

Anytime TD

+110

Jalen Hurts (Eagles)

First TD

+850

Anytime TD

+145

AJ Brown (Eagles)

First TD

+950

Anytime TD

+175

Khalil Shakir (Bills)

First TD

+1100

Anytime TD

+220

DeVonta Smith (Eagles)

First TD

+1300

Anytime TD

+250

Dallas Goedert (Eagles)

First TD

+1500

Anytime TD

+270

Dawson Knox (Bills)

First TD

+1500

Anytime TD

+280

Dalton Kincaid (Bills)

First TD

+1500

Anytime TD

+280

Joshua Palmer (Bills)

First TD

+2200

Anytime TD

+500

Gabe Davis (Bills)

First TD

+2500

Anytime TD

+550

Jackson Hawes (Bills)

First TD

+2500

Anytime TD

+550

Keon Coleman (Bills)

First TD

+2500

Anytime TD

+550

Tyrell Shavers (Bills)

First TD

+2500

Anytime TD

+550

Ty Johnson (Bills)

First TD

+3000

Anytime TD

+490

Brandin Cooks (Bills)

First TD

+3000

Anytime TD

+750

Jahan Dotson (Eagles)

First TD

+3000

Anytime TD

+600

Mecole Hardman (Bills)

First TD

+3500

Anytime TD

+800

Tank Bigsby (Eagles)

First TD

+6000

Anytime TD

+1100

Ray Davis (Bills)

First TD

+8000

Anytime TD

+1300

Darius Cooper (Eagles)

First TD

+10000

Anytime TD

+2700

Kylen Granson (Eagles)

First TD

+10000

Anytime TD

+2700

Grant Calcaterra (Eagles)

First TD

+10000

Anytime TD

+1700

Will Shipley (Eagles)

First TD

+10000

Anytime TD

+2500

Reggie Gilliam (Bills)

First TD

+10000

Anytime TD

+3000

Cameron Latu (Eagles)

First TD

+10000

Anytime TD

+3300

Britain Covey (Eagles)

First TD

+10000

Anytime TD

+4000

Keleki Latu (Bills)

First TD

+10000

Anytime TD

+2000

Receiving Yards

AJ Brown (Eagles)

Over 60.5

-112

Under 60.5

-112

DeVonta Smith (Eagles)

Over 46.5

-112

Under 46.5

-112

Khalil Shakir (Bills)

Over 38.5

-112

Under 38.5

-112

Dallas Goedert (Eagles)

Over 33.5

-112

Under 33.5

-112

Dawson Knox (Bills)

Over 18.5

-114

Under 18.5

-114

James Cook (Bills)

Over 13.5

-112

Under 13.5

-112

Saquon Barkley (Eagles)

Over 12.5

-112

Under 12.5

-112

Jahan Dotson (Eagles)

Over 6.5

-112

Under 6.5

-112

Rushing Yards

James Cook (Bills)

Over 86.5

-112

Under 86.5

-112

Saquon Barkley (Eagles)

Over 86.5

-112

Under 86.5

-112

Josh Allen (Bills)

Over 31.5

-112

Under 31.5

-112

Jalen Hurts (Eagles)

Over 29.5

-112

Under 29.5

-112

Tank Bigsby (Eagles)

Over 10.5

-112

Under 10.5

-112

Passing Yards

Josh Allen (Bills)

Over 194.5

-112

Under 194.5

-112

Jalen Hurts (Eagles)

Over 185.5

-112

Under 185.5

-112

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Bills Riding Momentum at Home

The Bills have put together three wins in a row at Highmark Stadium. They have nine wins and one loss in the last 10 home games, averaging 33.20 points on offense and surrendering 23.60 on defense.

The Eagles have gone 6-4 across their last 10 games games on the road, scoring 23.20 points per contest and conceding 22.40.

The Eagles defeated the Bills 31-13 in their last meeting at Highmark Stadium.

Last 10 Games		W-L	P	PF	PA	O44.5	U44.5
Bills Home Stats		9-1	56.80	33.20	23.60	8	2
Eagles Away Stats		6-4	45.60	23.20	22.40	6	4

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O44.5 = Games Over 44.5 Points
• U44.5 = Games Under 44.5 Points

Latest regular season and playoff games stats.

Philadelphia Eagles Stats

Buffalo Bills Stats

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 6 wins and 4 defeats in the last 10 games on the road

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 9 wins and 1 defeat in the last 10 home games

Point Spread

• +1.5 Betting Line: Have covered the spread in 6 of the last 10 games
• +1.5 Betting Line on the Road: Have covered the spread in 6 of the last 10 games on the road

Point Spread

• -1.5 Betting Line: Have covered the spread in 7 of the last 10 games
• -1.5 Betting Line at Home: Have covered the spread in 8 of the last 10 home games

Total Points

• Game Totals: An average of 40.40 pts in the previous 10 games
• Game Totals on the Road: An average of 45.60 pts in the previous 10 games on the road
• Over 44.5: Covered in 5 of the previous 10 games
• Over 44.5 on the Road: Covered in 6 of the previous 10 games on the road
• Team Totals: Have scored an average of 22.40 pts and allowed 18.00 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 23.20 pts and allowed 22.40 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 51.20 pts in the previous 10 games
• Game Totals at Home: An average of 56.80 pts in the previous 10 home games
• Over 44.5: Covered in 5 of the previous 10 games
• Over 44.5 at Home: Covered in 8 of the previous 10 home games
• Team Totals: Have scored an average of 28.10 pts and allowed 23.10 pts in the last 10 games
• Team Totals at Home: Have scored an average of 33.20 pts and allowed 23.60 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 348.60 Yds. Allowed 304.70 Yds
• Rushing Yards: Gained 132.70 Yds. Allowed 122.00 Yds
• Passing Yards: Gained 215.90 Yds. Allowed 182.70 Yds
• Total Touchdowns: Scored 2.70 TD. Allowed 1.90 TD
• Rushing Touchdowns: Scored 0.90 TD. Allowed 1.20 TD
• Passing Touchdowns: Scored 1.70 TD. Allowed 0.70 TD
• Total 1st Downs: Picked up 19.00. Allowed 18.10
• Total Turnovers: Committed 1.30. Committed by opponents 1.30
• Total Penalties: Committed 6.80. Committed by opponents 5.20
• Penalty Yards: Lost 56.80 Yds. Gained 44.90 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 361.70 Yds. Allowed 317.30 Yds
• Rushing Yards: Gained 161.10 Yds. Allowed 143.60 Yds
• Passing Yards: Gained 200.60 Yds. Allowed 173.70 Yds
• Total Touchdowns: Scored 3.70 TD. Allowed 2.80 TD
• Rushing Touchdowns: Scored 1.90 TD. Allowed 1.70 TD
• Passing Touchdowns: Scored 1.60 TD. Allowed 0.90 TD
• Total 1st Downs: Picked up 20.20. Allowed 18.80
• Total Turnovers: Committed 1.40. Committed by opponents 1.50
• Total Penalties: Committed 5.90. Committed by opponents 4.60
• Penalty Yards: Lost 49.30 Yds. Gained 39.10 Yds

Last 10 Games on the Road

• Total Yards: Gained 312.30 Yds. Allowed 339.40 Yds
• Rushing Yards: Gained 122.80 Yds. Allowed 125.60 Yds
• Passing Yards: Gained 189.50 Yds. Allowed 213.80 Yds
• Total Touchdowns: Scored 2.70 TD. Allowed 2.40 TD
• Rushing Touchdowns: Scored 1.40 TD. Allowed 1.00 TD
• Passing Touchdowns: Scored 1.10 TD. Allowed 1.40 TD
• Total 1st Downs: Picked up 17.90. Allowed 20.20
• Total Turnovers: Committed 1.30. Committed by opponents 1.80
• Total Penalties: Committed 7.70. Committed by opponents 5.40
• Penalty Yards: Lost 65.80 Yds. Gained 47.10 Yds

Last 10 Home Games

• Total Yards: Gained 390.20 Yds. Allowed 327.60 Yds
• Rushing Yards: Gained 142.30 Yds. Allowed 133.80 Yds
• Passing Yards: Gained 247.90 Yds. Allowed 193.80 Yds
• Total Touchdowns: Scored 4.10 TD. Allowed 2.90 TD
• Rushing Touchdowns: Scored 1.90 TD. Allowed 1.40 TD
• Passing Touchdowns: Scored 2.10 TD. Allowed 1.50 TD
• Total 1st Downs: Picked up 23.00. Allowed 19.90
• Total Turnovers: Committed 0.80. Committed by opponents 1.50
• Total Penalties: Committed 6.30. Committed by opponents 5.80
• Penalty Yards: Lost 48.60 Yds. Gained 51.70 Yds

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