San Francisco 49ers
American Football NFL State Farm Stadium Sun 5 Jan 17:25
Arizona Cardinals
  1. Prediction
  2. SGP Picks
  3. Odds
  4. Player Props
  5. Stats
  6. Team News
  7. Lineups
  8. Injuries
  9. Standings

Cardinals Worthy Favorites

Our betting prediction is that the Cardinals are going to cover the -4.5 on the spread. You can get -110 that there’s a bigger margin of victory against the Niners.

24-23 Win for Cardinals in Pair’s Last Matchup

San Francisco 49ers have been defeated in three straight games. They were recently beaten at home to Detroit Lions by a 40-34 scoreline at Levi's Stadium. The 49ers gained a total of 475 yards, comprising 400 passing and 75 rushing yards. They scored 2 rushing and 3 passing touchdown. 5 TD’s in total.

Arizona Cardinals lost on the road in their last game, making it back-to-back defeats. Los Angeles Rams won 13-9 at SoFi Stadium. The Cardinals had a gain of 113 rushing and 283 passing yards, totalling 396 yards. They scored 1 passing TD and picked up 24 first downs.

Head-to-Head Statistics

It was the Cardinals who came out on top when they last played the Niners. At Levi's Stadium, a 24-23 win was recorded. We’ve seen six Niners wins in the past 10 meetings between the teams.

Quarterbacks

49ers vs Cardinals Prediction & Picks

We are confident that the Cardinals will cover the spread in this NFL matchup. -4.5 seems a generous line and you can get -110 that the favorites will win by a bigger margin.

Our NFL picks are always well-researched and it starts with a combination of team news and form guide. Once we have a clear idea of what might happen, we match up the latest data.

Key 49ers vs Cardinals stats:

  • The -4.5 line has been covered by Cardinals in 3 of their last 5 games at home.
  • The +4.5 line hasn’t been covered by 49ers in 4 of their last 5 games.
  • The +4.5 line hasn’t been covered by 49ers in 6 of their last 10 games.
  • The +4.5 line hasn’t been covered by 49ers in 3 consecutive games.

Cardinals -4.5 Probability

When you look at the latest odds, our pick has a 52.4% chance of landing a return. Our experts think there’s a stronger chance of success and calculate the probability to be closer to 60%. It’s the reason why we are recommending this bet.

Looking for Bigger Odds?

If you want to land a big potential return from a small stake, then a Bet Builder could be the perfect way to go. Back the Cardinals against the spread in a combination with other picks.

Best Bet

Cardinals -4.5 @ -110 Bet Now BetMGM logo
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Published 22:26, 03 January 2025

Same Game Parlay Picks

Spread Cardinals -4.5
Anytime Touchdown Michael Carter
Passing Yards Kyler Murray Over 225.5

We’ve compiled a same game parlay that includes Cardinals -4.5 on the spread, followed by Michael Carter (Cardinals) scoring a touchdown and Kyler Murray (Cardinals) throwing Over 225.5 passing yards.

A same game parlay is a fantastic way of cheering on different picks within the same football game. You can predict a number of outcomes and get bigger odds than a single bet. The odds can combine to great effect.

T&C apply. Gamble responsibly 18+

Correct Score Prediction

49ers 49ers logo 20 - 28 Cardinals logo Cardinals

There are many different ways to back the Cardinals on the correct score betting and something like 28-20 in their favor might be along the right lines at huge odds.

49ers vs Cardinals Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Cardinals Have the Shortest Odds to Win

Sportsbooks’ favorites Arizona Cardinals are regarded as likeliest victors for this game and the -233 about them triumphing means a 70% chance based on their current Moneyline betting odds. San Francisco 49ers are trading at bigger odds than their opponents and they can be backed at +190.

The spread currently stands at 4.5 and the total points line is 42.5. A bet on the Totals allows fans to use the latest NFL data to good effect. There’s the chance to back Under 42.5 at -115.

If you’re wagering on the National Football League, we recommend heading to the betting sites and scanning through the hundreds of game lines and team props. There’s a chance to bet pre-game and in-game.

Kyler Murray Favorite to Be First TD Scorer

There is -100 available that Kyler Murray scores a touchdown anytime. If you’re interested in the favorite to score the first TD, then you are able to secure +500.

Touchdown

Kyler Murray (Cardinals)
First TD
+500
Anytime TD
-100
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Michael Carter (Cardinals)
First TD
+550
Anytime TD
+105
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Trey McBride (Cardinals)
First TD
+750
Anytime TD
+170
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Jauan Jennings (49ers)
First TD
+850
Anytime TD
+165
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Receiving Yards

Trey McBride (Cardinals)
Over 70.5
-110
Under 70.5
-110
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Marvin Harrison Jr. (Cardinals)
Over 54.5
-110
Under 54.5
-110
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Rushing Yards

Michael Carter (Cardinals)
Over 59.5
-110
Under 59.5
-110
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Kyler Murray (Cardinals)
Over 45.5
-110
Under 45.5
-110
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Passing Yards

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Team Stats

Latest regular season and playoff games stats.

San Francisco 49ers logo San Francisco 49ers Stats
Arizona Cardinals logo Arizona Cardinals Stats
Moneyline
  • 3 wins and 7 defeats in the last 10 games
  • 4 wins and 6 defeats in the last 10 games on the road
Moneyline
  • 5 wins and 5 defeats in the last 10 games
  • 5 wins and 5 defeats in the last 10 home games
Point Spread
Point Spread
Total Points
Total Points
Game Stats
Last 10 Games
Game Stats
Last 10 Games
Last 10 Games on the Road
Last 10 Home Games

Team News

San Francisco 49ers @ Arizona Cardinals Lineups

San Francisco 49ers Lineup

  • Head Coach Kyle Shanahan

Arizona Cardinals Lineup

  • Head Coach Jonathan Gannon

San Francisco 49ers Injuries

Type
Name
Info
Brandon Aiyuk
Knee - ACL + MCL
Aaron Banks
Knee - MCL
Ben Bartch
Ankle
Robert Beal
Ankle
Ji'Ayir Brown
Ankle
Spencer Burford
Calf
De'Vondre Campbell
Suspension
Jon Feliciano
Knee
Demetrius Flannigan-Fowles
Calf
Kevin Givens
Pectoral
Dre Greenlaw
Calf
Javon Hargrave
Triceps
Drake Jackson
Knee
George Kittle
Ankle
Deommodore Lenoir
Shoulder
Darrell Luter
Pelvis
Jordan Mason
Ankle
Christian McCaffrey
Knee - PCL
Colton McKivitz
Knee
Elijah Mitchell
Hamstring
Jaylon Moore
Quadriceps
George Odum
Knee
Brock Purdy
Elbow
Curtis Robinson
Knee - ACL
Deebo Samuel
Ribs
Trent Williams
Ankle
Mitch Wishnowsky
Back
Isaac Yiadom
Pelvis

Arizona Cardinals Injuries

Type
Name
Info
Jackson Barton
Ankle
Trey Benson
Ankle
Joey Blount
Ribs
James Conner
Knee
Emari Demercado
Back
Dennis Gardeck
Knee - ACL
Blake Gillikin
Foot
Will Hernandez
Knee
Paris Johnson
Knee
Elijah Jones
Ankle
Justin Jones
Triceps
Jesse Luketa
Thigh
Sean Murphy-Bunting
Toe
Bilal Nichols
Undisclosed
Carter O'Donnell
Undisclosed
BJ Ojulari
Knee - ACL
Matt Prater
Knee - Meniscus
Jonah Williams
Knee
Mack Wilson
Ankle
Michael Wilson
Hamstring

Previous San Francisco 49ers Lineups

30 Dec NFL
Lions 40-34 49ers
22 Dec NFL
49ers 17-29 Dolphins
12 Dec NFL
Rams 12-6 49ers
08 Dec NFL
Bears 13-38 49ers
01 Dec NFL
49ers 10-35 Bills
24 Nov NFL
49ers 10-38 Packers
17 Nov NFL
Seahawks 20-17 49ers
10 Nov NFL
49ers 23-20 Buccaneers
27 Oct NFL
Cowboys 24-30 49ers
20 Oct NFL
Chiefs 28-18 49ers

Previous Arizona Cardinals Lineups

28 Dec NFL
Cardinals 9-13 Rams
22 Dec NFL
Cardinals 30-36 Panthers
15 Dec NFL
Patriots 17-30 Cardinals
08 Dec NFL
Seahawks 30-18 Cardinals
01 Dec NFL
Cardinals 22-23 Vikings
24 Nov NFL
Cardinals 6-16 Seahawks
10 Nov NFL
Jets 6-31 Cardinals
03 Nov NFL
Bears 9-29 Cardinals
27 Oct NFL
Cardinals 28-27 Dolphins
21 Oct NFL
Chargers 15-17 Cardinals

NFL Standings Select Season

AFC East W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Patriots 5 2 0 0.714 181 133 48 1-2-0 4-0-0 2-0-0 3-2-0 4-1-0 4W
Bills 4 2 0 0.667 167 137 30 3-1-0 1-1-0 2-1-0 3-1-0 3-2-0 2L
Dolphins 1 6 0 0.143 140 205 -65 1-2-0 0-4-0 1-2-0 1-5-0 1-4-0 3L
Jets 0 7 0 0.000 129 183 -54 0-5-0 0-2-0 0-2-0 0-4-0 0-5-0 7L
AFC North W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Steelers 4 2 0 0.667 150 140 10 2-1-0 2-1-0 1-1-0 3-1-0 3-2-0 1L
Bengals 3 4 0 0.429 136 214 -78 2-1-0 1-3-0 2-0-0 3-1-0 1-4-0 1W
Browns 2 5 0 0.286 113 152 -39 2-2-0 0-3-0 0-3-0 1-3-0 2-3-0 1W
Ravens 1 5 0 0.167 144 194 -50 1-3-0 0-2-0 1-0-0 1-3-0 1-4-0 4L
AFC South W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Colts 6 1 0 0.857 232 140 92 4-0-0 2-1-0 1-0-0 5-0-0 4-1-0 3W
Jaguars 4 3 0 0.571 146 155 -9 3-2-0 1-1-0 1-0-0 2-1-0 3-2-0 2L
Texans 2 4 0 0.333 127 88 39 1-1-0 1-3-0 1-1-0 2-1-0 2-3-0 1L
Titans 1 6 0 0.143 96 192 -96 0-3-0 1-3-0 0-2-0 0-5-0 1-4-0 2L
AFC West W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Broncos 5 2 0 0.714 163 127 36 3-0-0 2-2-0 0-1-0 3-2-0 4-1-0 4W
Chargers 5 3 0 0.625 188 173 15 3-2-0 2-1-0 3-0-0 4-1-0 2-3-0 1W
Chiefs 4 3 0 0.571 186 124 62 3-1-0 1-2-0 1-1-0 2-2-0 4-1-0 2W
Raiders 2 5 0 0.286 103 180 -77 1-2-0 1-3-0 0-2-0 2-3-0 1-4-0 1L
NFC East W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Eagles 5 2 0 0.714 170 165 5 2-1-0 3-1-0 1-1-0 4-1-0 3-2-0 1W
Cowboys 3 3 1 0.429 222 206 16 2-0-1 1-3-0 2-1-0 2-3-1 2-2-1 1W
Commanders 3 4 0 0.429 180 170 10 2-1-0 1-3-0 1-1-0 1-4-0 2-3-0 2L
Giants 2 5 0 0.286 153 177 -24 2-1-0 0-4-0 1-2-0 1-3-0 2-3-0 1L
NFC North W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Packers 4 1 1 0.667 158 125 33 3-0-0 1-1-1 1-0-0 3-0-1 3-1-1 2W
Lions 5 2 0 0.714 215 151 64 3-0-0 2-2-0 1-1-0 2-1-0 4-1-0 1W
Bears 4 2 0 0.667 152 155 -3 2-1-0 2-1-0 0-2-0 3-2-0 4-1-0 4W
Vikings 3 4 0 0.429 155 162 -7 1-2-0 2-2-0 1-0-0 1-2-0 2-3-0 2L
NFC South W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Buccaneers 5 2 0 0.714 174 175 -1 2-1-0 3-1-0 1-0-0 3-2-0 3-2-0 1L
Panthers 4 3 0 0.571 145 152 -7 3-0-0 1-3-0 1-0-0 2-1-0 4-1-0 3W
Falcons 3 3 0 0.500 110 120 -10 2-1-0 1-2-0 0-2-0 2-3-0 3-2-0 1L
Saints 1 6 0 0.143 125 186 -61 1-3-0 0-3-0 0-0-0 1-4-0 1-4-0 2L
NFC West W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
49ers 5 2 0 0.714 145 138 7 2-1-0 3-1-0 3-0-0 5-1-0 3-2-0 1W
Seahawks 5 2 0 0.714 193 136 57 2-2-0 3-0-0 1-1-0 2-2-0 4-1-0 2W
Rams 5 2 0 0.714 175 117 58 2-1-0 3-1-0 0-1-0 0-2-0 3-2-0 2W
Cardinals 2 5 0 0.286 153 154 -1 1-3-0 1-2-0 0-2-0 2-3-0 0-5-0 5L
AFC Conference W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Colts 6 1 0 0.857 232 140 92 4-0-0 2-1-0 1-0-0 5-0-0 4-1-0 3W
Patriots 5 2 0 0.714 181 133 48 1-2-0 4-0-0 2-0-0 3-2-0 4-1-0 4W
Broncos 5 2 0 0.714 163 127 36 3-0-0 2-2-0 0-1-0 3-2-0 4-1-0 4W
Steelers 4 2 0 0.667 150 140 10 2-1-0 2-1-0 1-1-0 3-1-0 3-2-0 1L
Bills 4 2 0 0.667 167 137 30 3-1-0 1-1-0 2-1-0 3-1-0 3-2-0 2L
Chargers 5 3 0 0.625 188 173 15 3-2-0 2-1-0 3-0-0 4-1-0 2-3-0 1W
Jaguars 4 3 0 0.571 146 155 -9 3-2-0 1-1-0 1-0-0 2-1-0 3-2-0 2L
Chiefs 4 3 0 0.571 186 124 62 3-1-0 1-2-0 1-1-0 2-2-0 4-1-0 2W
Bengals 3 4 0 0.429 136 214 -78 2-1-0 1-3-0 2-0-0 3-1-0 1-4-0 1W
Texans 2 4 0 0.333 127 88 39 1-1-0 1-3-0 1-1-0 2-1-0 2-3-0 1L
Raiders 2 5 0 0.286 103 180 -77 1-2-0 1-3-0 0-2-0 2-3-0 1-4-0 1L
Browns 2 5 0 0.286 113 152 -39 2-2-0 0-3-0 0-3-0 1-3-0 2-3-0 1W
Ravens 1 5 0 0.167 144 194 -50 1-3-0 0-2-0 1-0-0 1-3-0 1-4-0 4L
Dolphins 1 6 0 0.143 140 205 -65 1-2-0 0-4-0 1-2-0 1-5-0 1-4-0 3L
Titans 1 6 0 0.143 96 192 -96 0-3-0 1-3-0 0-2-0 0-5-0 1-4-0 2L
Jets 0 7 0 0.000 129 183 -54 0-5-0 0-2-0 0-2-0 0-4-0 0-5-0 7L
NFC Conference W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Packers 4 1 1 0.667 158 125 33 3-0-0 1-1-1 1-0-0 3-0-1 3-1-1 2W
49ers 5 2 0 0.714 145 138 7 2-1-0 3-1-0 3-0-0 5-1-0 3-2-0 1W
Eagles 5 2 0 0.714 170 165 5 2-1-0 3-1-0 1-1-0 4-1-0 3-2-0 1W
Buccaneers 5 2 0 0.714 174 175 -1 2-1-0 3-1-0 1-0-0 3-2-0 3-2-0 1L
Lions 5 2 0 0.714 215 151 64 3-0-0 2-2-0 1-1-0 2-1-0 4-1-0 1W
Seahawks 5 2 0 0.714 193 136 57 2-2-0 3-0-0 1-1-0 2-2-0 4-1-0 2W
Rams 5 2 0 0.714 175 117 58 2-1-0 3-1-0 0-1-0 0-2-0 3-2-0 2W
Bears 4 2 0 0.667 152 155 -3 2-1-0 2-1-0 0-2-0 3-2-0 4-1-0 4W
Panthers 4 3 0 0.571 145 152 -7 3-0-0 1-3-0 1-0-0 2-1-0 4-1-0 3W
Cowboys 3 3 1 0.429 222 206 16 2-0-1 1-3-0 2-1-0 2-3-1 2-2-1 1W
Falcons 3 3 0 0.500 110 120 -10 2-1-0 1-2-0 0-2-0 2-3-0 3-2-0 1L
Vikings 3 4 0 0.429 155 162 -7 1-2-0 2-2-0 1-0-0 1-2-0 2-3-0 2L
Commanders 3 4 0 0.429 180 170 10 2-1-0 1-3-0 1-1-0 1-4-0 2-3-0 2L
Cardinals 2 5 0 0.286 153 154 -1 1-3-0 1-2-0 0-2-0 2-3-0 0-5-0 5L
Giants 2 5 0 0.286 153 177 -24 2-1-0 0-4-0 1-2-0 1-3-0 2-3-0 1L
Saints 1 6 0 0.143 125 186 -61 1-3-0 0-3-0 0-0-0 1-4-0 1-4-0 2L
NFL Team W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Colts 6 1 0 0.857 232 140 92 4-0-0 2-1-0 1-0-0 5-0-0 4-1-0 3W
Packers 4 1 1 0.667 158 125 33 3-0-0 1-1-1 1-0-0 3-0-1 3-1-1 2W
Broncos 5 2 0 0.714 163 127 36 3-0-0 2-2-0 0-1-0 3-2-0 4-1-0 4W
Lions 5 2 0 0.714 215 151 64 3-0-0 2-2-0 1-1-0 2-1-0 4-1-0 1W
Rams 5 2 0 0.714 175 117 58 2-1-0 3-1-0 0-1-0 0-2-0 3-2-0 2W
Patriots 5 2 0 0.714 181 133 48 1-2-0 4-0-0 2-0-0 3-2-0 4-1-0 4W
Eagles 5 2 0 0.714 170 165 5 2-1-0 3-1-0 1-1-0 4-1-0 3-2-0 1W
49ers 5 2 0 0.714 145 138 7 2-1-0 3-1-0 3-0-0 5-1-0 3-2-0 1W
Seahawks 5 2 0 0.714 193 136 57 2-2-0 3-0-0 1-1-0 2-2-0 4-1-0 2W
Buccaneers 5 2 0 0.714 174 175 -1 2-1-0 3-1-0 1-0-0 3-2-0 3-2-0 1L
Bills 4 2 0 0.667 167 137 30 3-1-0 1-1-0 2-1-0 3-1-0 3-2-0 2L
Bears 4 2 0 0.667 152 155 -3 2-1-0 2-1-0 0-2-0 3-2-0 4-1-0 4W
Steelers 4 2 0 0.667 150 140 10 2-1-0 2-1-0 1-1-0 3-1-0 3-2-0 1L
Chargers 5 3 0 0.625 188 173 15 3-2-0 2-1-0 3-0-0 4-1-0 2-3-0 1W
Panthers 4 3 0 0.571 145 152 -7 3-0-0 1-3-0 1-0-0 2-1-0 4-1-0 3W
Jaguars 4 3 0 0.571 146 155 -9 3-2-0 1-1-0 1-0-0 2-1-0 3-2-0 2L
Chiefs 4 3 0 0.571 186 124 62 3-1-0 1-2-0 1-1-0 2-2-0 4-1-0 2W
Falcons 3 3 0 0.500 110 120 -10 2-1-0 1-2-0 0-2-0 2-3-0 3-2-0 1L
Cowboys 3 3 1 0.429 222 206 16 2-0-1 1-3-0 2-1-0 2-3-1 2-2-1 1W
Bengals 3 4 0 0.429 136 214 -78 2-1-0 1-3-0 2-0-0 3-1-0 1-4-0 1W
Vikings 3 4 0 0.429 155 162 -7 1-2-0 2-2-0 1-0-0 1-2-0 2-3-0 2L
Commanders 3 4 0 0.429 180 170 10 2-1-0 1-3-0 1-1-0 1-4-0 2-3-0 2L
Texans 2 4 0 0.333 127 88 39 1-1-0 1-3-0 1-1-0 2-1-0 2-3-0 1L
Cardinals 2 5 0 0.286 153 154 -1 1-3-0 1-2-0 0-2-0 2-3-0 0-5-0 5L
Browns 2 5 0 0.286 113 152 -39 2-2-0 0-3-0 0-3-0 1-3-0 2-3-0 1W
Raiders 2 5 0 0.286 103 180 -77 1-2-0 1-3-0 0-2-0 2-3-0 1-4-0 1L
Giants 2 5 0 0.286 153 177 -24 2-1-0 0-4-0 1-2-0 1-3-0 2-3-0 1L
Ravens 1 5 0 0.167 144 194 -50 1-3-0 0-2-0 1-0-0 1-3-0 1-4-0 4L
Dolphins 1 6 0 0.143 140 205 -65 1-2-0 0-4-0 1-2-0 1-5-0 1-4-0 3L
Saints 1 6 0 0.143 125 186 -61 1-3-0 0-3-0 0-0-0 1-4-0 1-4-0 2L
Titans 1 6 0 0.143 96 192 -96 0-3-0 1-3-0 0-2-0 0-5-0 1-4-0 2L
Jets 0 7 0 0.000 129 183 -54 0-5-0 0-2-0 0-2-0 0-4-0 0-5-0 7L