49ers vs Cardinals Prediction, Picks & Odds | 05 Jan 2025

Our betting prediction is that the Cardinals are going to cover the -4.5 on the spread. You can get -110 that there’s a bigger margin of victory against the Niners.

San Francisco 49ers have been defeated in three straight games. They were recently beaten at home to Detroit Lions by a 40-34 scoreline at Levi's Stadium. The 49ers gained a total of 475 yards, comprising 400 passing and 75 rushing yards. They scored 2 rushing and 3 passing touchdown. 5 TD’s in total.

Arizona Cardinals lost on the road in their last game, making it back-to-back defeats. Los Angeles Rams won 13-9 at SoFi Stadium. The Cardinals had a gain of 113 rushing and 283 passing yards, totalling 396 yards. They scored 1 passing TD and picked up 24 first downs.

Head-to-Head Statistics

It was the Cardinals who came out on top when they last played the Niners. At Levi's Stadium, a 24-23 win was recorded. We’ve seen six Niners wins in the past 10 meetings between the teams.

Quarterbacks

Joshua Dobbs

196.5 Passing Yards

Over -110

Under -110

Kyler Murray

225.5 Passing Yards

Over -110

Under -110

49ers vs Cardinals Prediction & Picks

We are confident that the Cardinals will cover the spread in this NFL matchup. -4.5 seems a generous line and you can get -110 that the favorites will win by a bigger margin.

Our NFL picks are always well-researched and it starts with a combination of team news and form guide. Once we have a clear idea of what might happen, we match up the latest data.

Key 49ers vs Cardinals stats:

• The -4.5 line has been covered by Cardinals in 3 of their last 5 games at home.
• The +4.5 line hasn’t been covered by 49ers in 4 of their last 5 games.
• The +4.5 line hasn’t been covered by 49ers in 6 of their last 10 games.
• The +4.5 line hasn’t been covered by 49ers in 3 consecutive games.

Cardinals -4.5 Probability

When you look at the latest odds, our pick has a 52.4% chance of landing a return. Our experts think there’s a stronger chance of success and calculate the probability to be closer to 60%. It’s the reason why we are recommending this bet.

If you want to land a big potential return from a small stake, then a Bet Builder could be the perfect way to go. Back the Cardinals against the spread in a combination with other picks.

Our Game Prediction

Cardinals -4.5 @ -110 Bet Now

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Correct Score Prediction

49ers 20 - 28 Cardinals

There are many different ways to back the Cardinals on the correct score betting and something like 28-20 in their favor might be along the right lines at huge odds.

49ers vs Cardinals Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Sportsbooks’ favorites Arizona Cardinals are regarded as likeliest victors for this game and the -233 about them triumphing means a 70% chance based on their current Moneyline betting odds. San Francisco 49ers are trading at bigger odds than their opponents and they can be backed at +190.

The spread currently stands at 4.5 and the total points line is 42.5. A bet on the Totals allows fans to use the latest NFL data to good effect. There’s the chance to back Under 42.5 at -115.

If you’re wagering on the National Football League, we recommend heading to the betting sites and scanning through the hundreds of game lines and team props. There’s a chance to bet pre-game and in-game.

Moneyline

49ers

+190

Cardinals

-233

Point Spread

49ers +4.5

-106

Cardinals -4.5

-114

Total Points

Under 42.5

-115

Over 42.5

-105

There is -100 available that Kyler Murray scores a touchdown anytime. If you’re interested in the favorite to score the first TD, then you are able to secure +500.

Touchdown

Kyler Murray (Cardinals)

First TD

+500

Anytime TD

-100

Michael Carter (Cardinals)

First TD

+550

Anytime TD

+105

Trey McBride (Cardinals)

First TD

+750

Anytime TD

+170

Jauan Jennings (49ers)

First TD

+850

Anytime TD

+165

Isaac Guerendo (49ers)

First TD

+900

Anytime TD

+160

Marvin Harrison Jr. (Cardinals)

First TD

+900

Anytime TD

+210

Eric Saubert (49ers)

First TD

+1400

Anytime TD

+220

George Kittle (49ers)

First TD

+1400

Anytime TD

+220

Michael Wilson (Cardinals)

First TD

+1600

Anytime TD

+320

Greg Dortch (Cardinals)

First TD

+1600

Anytime TD

+320

Joshua Dobbs (49ers)

First TD

+1700

Anytime TD

+390

Ricky Pearsall (49ers)

First TD

+1800

Anytime TD

+320

DeeJay Dallas (Cardinals)

First TD

+2200

Anytime TD

+420

Israel Abanikanda (49ers)

First TD

+2400

Anytime TD

+500

Patrick Taylor (49ers)

First TD

+2400

Anytime TD

+500

Arizona Cardinals Defense (Cardinals)

First TD

+3100

Anytime TD

+650

Elijah Higgins (Cardinals)

First TD

+3400

Anytime TD

+750

Tip Reiman (Cardinals)

First TD

+3400

Anytime TD

+750

Zay Jones (Cardinals)

First TD

+4000

Anytime TD

+950

San Francisco 49ers Defense (49ers)

First TD

+4000

Anytime TD

+1000

Zach Pascal (Cardinals)

First TD

+4400

Anytime TD

+1100

Kyle Juszczyk (49ers)

First TD

+5000

Anytime TD

+1200

Jacob Cowing (49ers)

First TD

+5000

Anytime TD

+1300

Chris Conley (49ers)

First TD

+5000

Anytime TD

+1300

Jake Tonges (49ers)

First TD

+6500

Anytime TD

+1400

Brayden Willis (49ers)

First TD

+6500

Anytime TD

+1400

Receiving Yards

Trey McBride (Cardinals)

Over 70.5

-110

Under 70.5

-110

Marvin Harrison Jr. (Cardinals)

Over 54.5

-110

Under 54.5

-110

Rushing Yards

Michael Carter (Cardinals)

Over 59.5

-110

Under 59.5

-110

Kyler Murray (Cardinals)

Over 45.5

-110

Under 45.5

-110

Passing Yards

Kyler Murray (Cardinals)

Over 225.5

-110

Under 225.5

-110

Joshua Dobbs (49ers)

Over 196.5

-110

Under 196.5

-110

Latest regular season and playoff games stats.

San Francisco 49ers Stats

Arizona Cardinals Stats

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 games on the road

Moneyline

• 4 wins and 6 defeats in the last 10 games
• 6 wins and 4 defeats in the last 10 home games

Point Spread

• -3 Betting Line: Have covered the spread in 5 of the last 10 games
• -3 Betting Line on the Road: Have covered the spread in 4 of the last 10 games on the road

Point Spread

• +3 Betting Line: Have covered the spread in 7 of the last 10 games
• +3 Betting Line at Home: Have covered the spread in 8 of the last 10 home games

Total Points

• Game Totals: An average of 45.00 pts in the previous 10 games
• Game Totals on the Road: An average of 48.40 pts in the previous 10 games on the road
• Over 47.5: Covered in 4 of the previous 10 games
• Over 47.5 on the Road: Covered in 5 of the previous 10 games on the road
• Team Totals: Have scored an average of 22.00 pts and allowed 23.00 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 19.80 pts and allowed 28.60 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 48.80 pts in the previous 10 games
• Game Totals at Home: An average of 45.80 pts in the previous 10 home games
• Over 47.5: Covered in 5 of the previous 10 games
• Over 47.5 at Home: Covered in 4 of the previous 10 home games
• Team Totals: Have scored an average of 24.90 pts and allowed 23.90 pts in the last 10 games
• Team Totals at Home: Have scored an average of 26.30 pts and allowed 19.50 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 356.20 Yds. Allowed 338.50 Yds
• Rushing Yards: Gained 94.80 Yds. Allowed 110.70 Yds
• Passing Yards: Gained 261.40 Yds. Allowed 227.80 Yds
• Total Touchdowns: Scored 2.30 TD. Allowed 2.70 TD
• Rushing Touchdowns: Scored 0.60 TD. Allowed 0.70 TD
• Passing Touchdowns: Scored 1.70 TD. Allowed 1.90 TD
• Total 1st Downs: Picked up 21.60. Allowed 20.70
• Total Turnovers: Committed 1.50. Committed by opponents 0.70
• Total Penalties: Committed 6.10. Committed by opponents 5.80
• Penalty Yards: Lost 46.70 Yds. Gained 38.30 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 324.00 Yds. Allowed 349.10 Yds
• Rushing Yards: Gained 117.20 Yds. Allowed 116.50 Yds
• Passing Yards: Gained 206.80 Yds. Allowed 232.60 Yds
• Total Touchdowns: Scored 2.80 TD. Allowed 2.60 TD
• Rushing Touchdowns: Scored 0.90 TD. Allowed 1.00 TD
• Passing Touchdowns: Scored 1.80 TD. Allowed 1.20 TD
• Total 1st Downs: Picked up 20.30. Allowed 22.00
• Total Turnovers: Committed 1.00. Committed by opponents 1.60
• Total Penalties: Committed 6.20. Committed by opponents 7.40
• Penalty Yards: Lost 44.50 Yds. Gained 64.40 Yds

Last 10 Games on the Road

• Total Yards: Gained 339.10 Yds. Allowed 357.90 Yds
• Rushing Yards: Gained 96.00 Yds. Allowed 136.90 Yds
• Passing Yards: Gained 243.10 Yds. Allowed 221.00 Yds
• Total Touchdowns: Scored 2.10 TD. Allowed 3.40 TD
• Rushing Touchdowns: Scored 0.50 TD. Allowed 1.30 TD
• Passing Touchdowns: Scored 1.60 TD. Allowed 2.10 TD
• Total 1st Downs: Picked up 20.00. Allowed 21.30
• Total Turnovers: Committed 1.70. Committed by opponents 0.60
• Total Penalties: Committed 7.60. Committed by opponents 5.10
• Penalty Yards: Lost 53.60 Yds. Gained 34.50 Yds

Last 10 Home Games

• Total Yards: Gained 346.20 Yds. Allowed 332.40 Yds
• Rushing Yards: Gained 140.90 Yds. Allowed 101.30 Yds
• Passing Yards: Gained 205.30 Yds. Allowed 231.10 Yds
• Total Touchdowns: Scored 3.10 TD. Allowed 1.80 TD
• Rushing Touchdowns: Scored 1.50 TD. Allowed 0.80 TD
• Passing Touchdowns: Scored 1.30 TD. Allowed 0.90 TD
• Total 1st Downs: Picked up 20.90. Allowed 19.90
• Total Turnovers: Committed 1.20. Committed by opponents 1.20
• Total Penalties: Committed 5.40. Committed by opponents 6.90
• Penalty Yards: Lost 42.10 Yds. Gained 59.30 Yds

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