49ers vs Cardinals Prediction, Picks & Odds | 16 Nov 2025

NFL Betting Preview: Niners vs Cardinals

The San Francisco 49ers go up against the Arizona Cardinals at State Farm Stadium, with kickoff scheduled for 16:05 on Sunday, November 16.

We’re delighted to see the Cardinals have been given a headstart on the spread. Take the +3 at -110 when they go up against the Niners.

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San Francisco 49ers lost when they last took to the field. At Levi's Stadium, they were turned over 42-26 at home to Los Angeles Rams. The 49ers finished with 393 yards, including 319 passing and 74 rushing yards. They moved the chains 24 times and scored 4 touchdowns, with 3 through the air and one on the ground.

Arizona Cardinals have lost three consecutive games at home. In their last appearance, they suffered a 44-22 road defeat against Seattle Seahawks at Lumen Field. The Cardinals moved the ball for 335 yards, with 206 through the air and 129 on the ground. The offense moved the chains 21 times and managed 3 touchdowns, including 2 passing scores and one rushing TD.

Head-to-Head Statistics

It was the Niners who came out on top when they last played the Cardinals. At Levi's Stadium, a 16-15 win was recorded. We’ve seen six Niners wins in the past 10 meetings between the teams.

Quarterbacks

Brock Purdy

254.5 Passing Yards

Over -112

Under -112

Jacoby Brissett

227.5 Passing Yards

Over -112

Under -112

49ers vs Cardinals Prediction & Picks

Our expert 49ers vs Cardinals betting tips include a main match prediction, a correct score pick, standout player prop selections and bet builder advice. Explore each section below for detailed insights.

Game Prediction

The Cardinals should be able to battle hard and our pick is that they will cover the spread in this NFL matchup. It’s set at an attractive +3 and you can get -110.

We closely track recent form and look for patterns that may impact the outcome. The same goes for injuries to key players. When combined with the most relevant stats, this gives us a strong foundation for accurate NFL predictions.

Key 49ers vs Cardinals stats:

• The +3 line has been covered by Cardinals in 8 of their last 10 games at home.
• The +3 line has been covered by Cardinals in 4 of their last 5 games at home.
• The -3 line hasn’t been covered by 49ers in 6 of their last 10 games on the road.
• The -3 line hasn’t been covered by 49ers in 12 of their last 20 games.
• The +3 line has been covered by Cardinals in 3 consecutive games against 49ers.

Cardinals +3 Probability

When you look at the latest betting odds, our pick has a 52.4% chance of winning. Our experts think there’s a stronger chance of success and calculate the probability to be closer to 60%. The bet can be recommended for this precise reason.

Selling points can be a great alternative and allows bettors to enjoy a bigger return on the same selection. For a more conservative spread pick, you can alternatively buy points.

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Our Game Prediction

Cardinals +3 @ -110 Bet Now

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Player Prop Picks

Top Pick: Brock Purdy Under 259.5 Passing Yards -114

The odds for Brock Purdy (Niners) to have less than 259.5 passing yards are -114. It’s reasonable to expect he may fall short, making the QB Passing Yards line appealing.

Latest Brock Purdy Player Prop Odds

Touchdown

Anytime

+500

First

+2700

Passing Yards

Over 254.5

-112

Under 254.5

-112

Rushing Yards

Over 8.5

-112

Under 8.5

-112

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Bam Knight Anytime TD +125

You can place a bet on Bam Knight (Cardinals) to hit paydirt at +125. We believe there’s merit in backing him for an Anytime Touchdown Scorer prop wager, meaning we need him to punch it in.

Latest Bam Knight Player Prop Odds

Touchdown

Anytime

+220

First

+1200

Rushing Yards

Over 39.5

-112

Under 39.5

-112

Correct Score Prediction

49ers 21 - 24 Cardinals

We’re expecting a close matchup so it might be worth going for the Cardinals to win by a 24-21 scoreline. You can get a huge price and we should hopefully get a run for our money.

49ers vs Cardinals Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

For this game, the sportsbooks’ Moneyline betting odds mean San Francisco 49ers are -189 favorites to win and that means a 65% chance of landing a victory. If you’re looking for an alternative angle, Arizona Cardinals are trading at +160.

3.5 is the spread and 48.5 is the total points line. There are many ways to bet on the NFL including the Totals. If you’re going for Under 48.5, this outcome can be backed at -114.

Every matchup offers a deep selection of team props and game lines and the top NFL betting sites deliver excellent pre-game and in-game wagering opportunities. It’s all about finding the bets that match your game plan.

Moneyline

49ers

-189

Cardinals

+160

Point Spread

49ers -3.5

-106

Cardinals +3.5

-114

Total Points

Under 48.5

-114

Over 48.5

-106

The First TD Scorer favorite is Christian McCaffrey at +300. Similar odds can be found if you’re interested in this player to register the last touchdown.

Touchdown

Christian McCaffrey (49ers)

First TD

+300

Anytime TD

-250

Trey McBride (Cardinals)

First TD

+600

Anytime TD

-105

George Kittle (49ers)

First TD

+800

Anytime TD

+145

Bam Knight (Cardinals)

First TD

+1200

Anytime TD

+220

Jauan Jennings (49ers)

First TD

+1200

Anytime TD

+240

Michael Wilson (Cardinals)

First TD

+1300

Anytime TD

+250

Ricky Pearsall (49ers)

First TD

+1300

Anytime TD

+260

Emari Demercado (Cardinals)

First TD

+1500

Anytime TD

+270

Greg Dortch (Cardinals)

First TD

+1600

Anytime TD

+280

Elijah Higgins (Cardinals)

First TD

+2700

Anytime TD

+320

Brock Purdy (49ers)

First TD

+2700

Anytime TD

+500

Brian Robinson Jr. (49ers)

First TD

+2700

Anytime TD

+460

Jacoby Brissett (Cardinals)

First TD

+3000

Anytime TD

+600

Xavier Weaver (Cardinals)

First TD

+5500

Anytime TD

+750

Michael Carter (Cardinals)

First TD

+5500

Anytime TD

+950

Demarcus Robinson (49ers)

First TD

+6000

Anytime TD

+850

Kendrick Bourne (49ers)

First TD

+6500

Anytime TD

+900

Jake Tonges (49ers)

First TD

+6500

Anytime TD

+900

Pharaoh Brown (Cardinals)

First TD

+7500

Anytime TD

+1100

Andre Baccellia (Cardinals)

First TD

+8000

Anytime TD

+1500

Kyle Juszczyk (49ers)

First TD

+8000

Anytime TD

+1200

Jordan Watkins (49ers)

First TD

+10000

Anytime TD

+1300

Skyy Moore (49ers)

First TD

+10000

Anytime TD

+1300

Luke Farrell (49ers)

First TD

+10000

Anytime TD

+1600

James Jordan (49ers)

First TD

+10000

Anytime TD

+2500

Isaac Guerendo (49ers)

First TD

+10000

Anytime TD

+2500

Josiah Deguara (Cardinals)

First TD

+10000

Anytime TD

+1800

Receiving Yards

Trey McBride (Cardinals)

Over 76.5

-112

Under 76.5

-112

George Kittle (49ers)

Over 53.5

-112

Under 53.5

-112

Christian McCaffrey (49ers)

Over 52.5

-112

Under 52.5

-112

Jauan Jennings (49ers)

Over 48.5

-112

Under 48.5

-112

Michael Wilson (Cardinals)

Over 46.5

-112

Under 46.5

-112

Ricky Pearsall (49ers)

Over 38.5

-112

Under 38.5

-112

Greg Dortch (Cardinals)

Over 28.5

-112

Under 28.5

-112

Rushing Yards

Christian McCaffrey (49ers)

Over 69.5

-112

Under 69.5

-112

Bam Knight (Cardinals)

Over 39.5

-112

Under 39.5

-112

Brian Robinson Jr. (49ers)

Over 21.5

-118

Under 21.5

-108

Jacoby Brissett (Cardinals)

Over 17.5

-112

Under 17.5

-112

Brock Purdy (49ers)

Over 8.5

-112

Under 8.5

-112

Passing Yards

Brock Purdy (49ers)

Over 254.5

-112

Under 254.5

-112

Jacoby Brissett (Cardinals)

Over 227.5

-112

Under 227.5

-112

There are lots of exciting NFL micro betting lines that are created and they are available in-game. Among them are whether a field goal will be scored and you simply bet whether the player will make it or miss.

Can Cardinals Stop the Home Slide?

The Cardinals have hit a skid with three losses in succession at State Farm Stadium. They own a 6-4 mark in their past 10 home games, putting up 26.30 points per contest and giving up 19.50.

The Niners have gone 4-6 across their last 10 games on the road, putting up 19.80 points per contest and giving up 28.60.

The Cardinals beat the Niners 47-24 when the teams last met at State Farm Stadium. In the past 5 head-to-head meetings at State Farm Stadium, the Niners have won three while the Cardinals have two victories.

Last 10 Games		W-L	P	PF	PA	O47.5	U47.5
Cardinals Home Stats		6-4	45.80	26.30	19.50	4	6
49ers Away Stats		4-6	48.40	19.80	28.60	5	5

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O47.5 = Games Over 47.5 Points
• U47.5 = Games Under 47.5 Points

Latest regular season and playoff games stats.

San Francisco 49ers Stats

Arizona Cardinals Stats

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 games on the road

Moneyline

• 4 wins and 6 defeats in the last 10 games
• 6 wins and 4 defeats in the last 10 home games

Point Spread

• -3 Betting Line: Have covered the spread in 5 of the last 10 games
• -3 Betting Line on the Road: Have covered the spread in 4 of the last 10 games on the road

Point Spread

• +3 Betting Line: Have covered the spread in 7 of the last 10 games
• +3 Betting Line at Home: Have covered the spread in 8 of the last 10 home games

Total Points

• Game Totals: An average of 45.00 pts in the previous 10 games
• Game Totals on the Road: An average of 48.40 pts in the previous 10 games on the road
• Over 47.5: Covered in 4 of the previous 10 games
• Over 47.5 on the Road: Covered in 5 of the previous 10 games on the road
• Team Totals: Have scored an average of 22.00 pts and allowed 23.00 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 19.80 pts and allowed 28.60 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 48.80 pts in the previous 10 games
• Game Totals at Home: An average of 45.80 pts in the previous 10 home games
• Over 47.5: Covered in 5 of the previous 10 games
• Over 47.5 at Home: Covered in 4 of the previous 10 home games
• Team Totals: Have scored an average of 24.90 pts and allowed 23.90 pts in the last 10 games
• Team Totals at Home: Have scored an average of 26.30 pts and allowed 19.50 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 356.20 Yds. Allowed 338.50 Yds
• Rushing Yards: Gained 94.80 Yds. Allowed 110.70 Yds
• Passing Yards: Gained 261.40 Yds. Allowed 227.80 Yds
• Total Touchdowns: Scored 2.30 TD. Allowed 2.70 TD
• Rushing Touchdowns: Scored 0.60 TD. Allowed 0.70 TD
• Passing Touchdowns: Scored 1.70 TD. Allowed 1.90 TD
• Total 1st Downs: Picked up 21.60. Allowed 20.70
• Total Turnovers: Committed 1.50. Committed by opponents 0.70
• Total Penalties: Committed 6.10. Committed by opponents 5.80
• Penalty Yards: Lost 46.70 Yds. Gained 38.30 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 324.00 Yds. Allowed 349.10 Yds
• Rushing Yards: Gained 117.20 Yds. Allowed 116.50 Yds
• Passing Yards: Gained 206.80 Yds. Allowed 232.60 Yds
• Total Touchdowns: Scored 2.80 TD. Allowed 2.60 TD
• Rushing Touchdowns: Scored 0.90 TD. Allowed 1.00 TD
• Passing Touchdowns: Scored 1.80 TD. Allowed 1.20 TD
• Total 1st Downs: Picked up 20.30. Allowed 22.00
• Total Turnovers: Committed 1.00. Committed by opponents 1.60
• Total Penalties: Committed 6.20. Committed by opponents 7.40
• Penalty Yards: Lost 44.50 Yds. Gained 64.40 Yds

Last 10 Games on the Road

• Total Yards: Gained 339.10 Yds. Allowed 357.90 Yds
• Rushing Yards: Gained 96.00 Yds. Allowed 136.90 Yds
• Passing Yards: Gained 243.10 Yds. Allowed 221.00 Yds
• Total Touchdowns: Scored 2.10 TD. Allowed 3.40 TD
• Rushing Touchdowns: Scored 0.50 TD. Allowed 1.30 TD
• Passing Touchdowns: Scored 1.60 TD. Allowed 2.10 TD
• Total 1st Downs: Picked up 20.00. Allowed 21.30
• Total Turnovers: Committed 1.70. Committed by opponents 0.60
• Total Penalties: Committed 7.60. Committed by opponents 5.10
• Penalty Yards: Lost 53.60 Yds. Gained 34.50 Yds

Last 10 Home Games

• Total Yards: Gained 346.20 Yds. Allowed 332.40 Yds
• Rushing Yards: Gained 140.90 Yds. Allowed 101.30 Yds
• Passing Yards: Gained 205.30 Yds. Allowed 231.10 Yds
• Total Touchdowns: Scored 3.10 TD. Allowed 1.80 TD
• Rushing Touchdowns: Scored 1.50 TD. Allowed 0.80 TD
• Passing Touchdowns: Scored 1.30 TD. Allowed 0.90 TD
• Total 1st Downs: Picked up 20.90. Allowed 19.90
• Total Turnovers: Committed 1.20. Committed by opponents 1.20
• Total Penalties: Committed 5.40. Committed by opponents 6.90
• Penalty Yards: Lost 42.10 Yds. Gained 59.30 Yds

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