49ers vs Bills Prediction, Picks & Odds | 01 Dec 2024

Roll the Dice on Teams Scoring Over 44.5

There could be plenty of points when the Bills clash with the Niners, with our prediction being Over 44.5 points in total. Odds of -110 look worth taking for this outcome.

Bills Beat Niners in their Last Clash

San Francisco 49ers have now lost back-to-back games. On the road in their previous appearance, Green Bay Packers won 38-10 at Lambeau Field. The 49ers gained 44 rushing and 197 passing yards, making 241 yards in total. They picked up 11 first downs and scored 1 passing TD.

Buffalo Bills were winners for the sixth straight time in their last game. Landing a 30-21 home victory against Kansas City Chiefs at Highmark Stadium. The Bills gained 104 rushing and 262 passing yards, making 366 yards in total. They scored 1 passing TD’s and 3 rushing TD. 4 touchdowns in total.

Head-to-Head Statistics

It was the Bills who came out on top when they last played the Niners. At State Farm Stadium, a 34-24 win was recorded.

49ers vs Bills Prediction & Picks

We’re surprised that the total line is 44.5 and it’s all about going for the Overs option when these NFL teams take to the field. Take the -110 and cheer on points.

Our expert NFL handicappers study the latest form, while injuries and suspensions can also affect the potential outcome. Before coming up with a verdict, we combine this data with the latest stats.

Key 49ers vs Bills stats:

• The 44.5 line has been covered in 13 of the last 20 49ers games.
• The 44.5 line has been covered in 7 of the last 11 49ers games this season.
• The 44.5 line has been covered in 4 of the last 5 Bills games at home this season.
• The 44.5 line has been covered in 7 of the last 10 Bills games at home.
• The 44.5 line has been covered in the last 3 Bills games this season.

Over 44.5 Probability

The sportsbooks imply that our pick has a 52.4% prospect of winning. However, our research has found that the actual probability is closer to 60%. It is the reason why we are recommending this wager.

If you’re confident with your Over pick but want more juice from your wager, then a Bet Builder can offer the chance to add in other selections for a bigger potential return.

Best Bet

Over 44.5 Points @ -110 Bet Now

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Correct Score Prediction

49ers 20 - 34 Bills

Should you wish to go for a speculative wager, try the Bills to win 34-20 on the correct score lines. This should be a fun bet which could potentially yield a big return.

49ers vs Bills Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Books Expecting a Bills Victory

With the sportsbooks giving them a 76% probability of winning this game, Buffalo Bills might be a popular parlay pick. That is reflected in their -313 Moneyline betting odds. At +250, San Francisco 49ers are regarded as having a lower probability of winning.

6.5 is the spread and 44.5 is the total points line. Having a wager on the Totals is one of the most popular NFL bets. If you’re going for Over 44.5, then the odds are -120.

The good news is that you can access a wide range of game lines and team props for every National Football League clash. The betting sites offer a great selection of pre-game and in-game wagering options.

Moneyline

49ers

+250

Bills

-313

Point Spread

49ers +6.5

-110

Bills -6.5

-110

Total Points

Under 44.5

-102

Over 44.5

-120

Player Props & Micro Betting

The best gambling sites offer player and quarterback prop betting to their customers. These can be a great alternative if you want to focus on an individual’s performance within a game and it often involves wagering over or under a line.

Micro betting is an exciting way to wager on the NFL. There are a huge range of live lines and it’s a simple case of predicting what is going to happen next. Field Goal Outcome, Next Play Result and Next Drive Result are often among the options.

Last 5 & H2H

Latest regular season and playoff games stats.

San Francisco 49ers Stats

Buffalo Bills Stats

Moneyline

• 4 wins and 6 defeats in the last 10 games
• 6 wins and 4 defeats in the last 10 games on the road

Moneyline

• 8 wins and 2 defeats in the last 10 games
• 9 wins and 1 defeat in the last 10 home games

Point Spread

• +6 Betting Line: Have covered the spread in 8 of the last 10 games
• +6 Betting Line on the Road: Have covered the spread in 9 of the last 10 games on the road

Point Spread

• -6 Betting Line: Have covered the spread in 6 of the last 10 games
• -6 Betting Line at Home: Have covered the spread in 8 of the last 10 home games

Total Points

• Game Totals: An average of 46.90 pts in the previous 10 games
• Game Totals on the Road: An average of 50.50 pts in the previous 10 games on the road
• Over 44.5: Covered in 6 of the previous 10 games
• Over 44.5 on the Road: Covered in 6 of the previous 10 games on the road
• Team Totals: Have scored an average of 22.80 pts and allowed 24.10 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 27.70 pts and allowed 22.80 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 47.20 pts in the previous 10 games
• Game Totals at Home: An average of 49.70 pts in the previous 10 home games
• Over 44.5: Covered in 5 of the previous 10 games
• Over 44.5 at Home: Covered in 7 of the previous 10 home games
• Team Totals: Have scored an average of 28.60 pts and allowed 18.60 pts in the last 10 games
• Team Totals at Home: Have scored an average of 32.00 pts and allowed 17.70 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 383.20 Yds. Allowed 308.10 Yds
• Rushing Yards: Gained 134.20 Yds. Allowed 115.10 Yds
• Passing Yards: Gained 249.00 Yds. Allowed 193.00 Yds
• Total Touchdowns: Scored 2.40 TD. Allowed 2.70 TD
• Rushing Touchdowns: Scored 0.80 TD. Allowed 1.50 TD
• Passing Touchdowns: Scored 1.40 TD. Allowed 1.10 TD
• Total 1st Downs: Picked up 20.50. Allowed 18.80
• Total Turnovers: Committed 1.70. Committed by opponents 1.40
• Total Penalties: Committed 6.40. Committed by opponents 5.20
• Penalty Yards: Lost 43.60 Yds. Gained 40.20 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 344.60 Yds. Allowed 334.40 Yds
• Rushing Yards: Gained 118.10 Yds. Allowed 118.00 Yds
• Passing Yards: Gained 226.50 Yds. Allowed 216.40 Yds
• Total Touchdowns: Scored 3.40 TD. Allowed 2.10 TD
• Rushing Touchdowns: Scored 1.60 TD. Allowed 0.50 TD
• Passing Touchdowns: Scored 1.60 TD. Allowed 1.50 TD
• Total 1st Downs: Picked up 20.60. Allowed 19.80
• Total Turnovers: Committed 0.60. Committed by opponents 2.00
• Total Penalties: Committed 5.90. Committed by opponents 7.80
• Penalty Yards: Lost 45.20 Yds. Gained 62.20 Yds

Last 10 Games on the Road

• Total Yards: Gained 399.00 Yds. Allowed 326.60 Yds
• Rushing Yards: Gained 133.90 Yds. Allowed 113.50 Yds
• Passing Yards: Gained 265.10 Yds. Allowed 213.10 Yds
• Total Touchdowns: Scored 3.30 TD. Allowed 2.40 TD
• Rushing Touchdowns: Scored 0.90 TD. Allowed 1.00 TD
• Passing Touchdowns: Scored 2.30 TD. Allowed 1.20 TD
• Total 1st Downs: Picked up 22.70. Allowed 19.30
• Total Turnovers: Committed 1.00. Committed by opponents 1.30
• Total Penalties: Committed 4.90. Committed by opponents 6.10
• Penalty Yards: Lost 33.70 Yds. Gained 48.80 Yds

Last 10 Home Games

• Total Yards: Gained 358.10 Yds. Allowed 275.30 Yds
• Rushing Yards: Gained 140.80 Yds. Allowed 103.30 Yds
• Passing Yards: Gained 217.30 Yds. Allowed 172.00 Yds
• Total Touchdowns: Scored 3.80 TD. Allowed 2.10 TD
• Rushing Touchdowns: Scored 1.70 TD. Allowed 0.60 TD
• Passing Touchdowns: Scored 2.00 TD. Allowed 1.30 TD
• Total 1st Downs: Picked up 23.40. Allowed 18.70
• Total Turnovers: Committed 0.50. Committed by opponents 2.00
• Total Penalties: Committed 4.70. Committed by opponents 5.40
• Penalty Yards: Lost 39.20 Yds. Gained 41.00 Yds

Team News

NFL Standings Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Division Conference League

AFC East	W	L	T	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Patriots	4	2	0	0.667	150	120	30	1-2-0	3-0-0	2-0-0	2-2-0	4-1-0	3W
Bills	4	2	0	0.667	167	137	30	3-1-0	1-1-0	2-1-0	3-1-0	3-2-0	2L
Dolphins	1	5	0	0.167	134	174	-40	1-2-0	0-3-0	1-2-0	1-4-0	1-4-0	2L
Jets	0	6	0	0.000	123	170	-47	0-4-0	0-2-0	0-2-0	0-4-0	0-5-0	6L

AFC North	W	L	T	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Steelers	4	1	0	0.800	119	107	12	2-1-0	2-0-0	1-0-0	3-0-0	4-1-0	3W
Bengals	2	4	0	0.333	103	183	-80	1-1-0	1-3-0	1-0-0	2-1-0	1-4-0	4L
Ravens	1	5	0	0.167	144	194	-50	1-3-0	0-2-0	1-0-0	1-3-0	1-4-0	4L
Browns	1	5	0	0.167	82	146	-64	1-2-0	0-3-0	0-3-0	0-3-0	1-4-0	3L

AFC South	W	L	T	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Colts	5	1	0	0.833	194	116	78	4-0-0	1-1-0	1-0-0	4-0-0	4-1-0	2W
Jaguars	4	2	0	0.667	139	120	19	3-1-0	1-1-0	1-0-0	2-1-0	3-2-0	1L
Texans	2	3	0	0.400	108	61	47	1-1-0	1-2-0	1-1-0	2-1-0	2-3-0	2W
Titans	1	5	0	0.167	83	161	-78	0-2-0	1-3-0	0-2-0	0-4-0	1-4-0	1L

AFC West	W	L	T	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Chargers	4	2	0	0.667	127	125	2	2-1-0	2-1-0	3-0-0	4-0-0	3-2-0	1W
Broncos	4	2	0	0.667	130	95	35	2-0-0	2-2-0	0-1-0	3-2-0	3-2-0	3W
Chiefs	3	3	0	0.500	155	124	31	2-1-0	1-2-0	0-1-0	1-2-0	3-2-0	1W
Raiders	2	4	0	0.333	103	149	-46	1-2-0	1-2-0	0-1-0	2-2-0	1-4-0	1W

NFC East	W	L	T	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Eagles	4	2	0	0.667	142	143	-1	2-1-0	2-1-0	1-1-0	3-1-0	3-2-0	2L
Commanders	3	3	0	0.500	158	126	32	2-1-0	1-2-0	1-0-0	1-3-0	2-3-0	1L
Cowboys	2	3	1	0.333	178	184	-6	1-0-1	1-3-0	1-1-0	1-3-1	2-2-1	1L
Giants	2	4	0	0.333	121	144	-23	2-1-0	0-3-0	1-2-0	1-3-0	2-3-0	1W

NFC North	W	L	T	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Packers	3	1	1	0.600	131	102	29	3-0-0	0-1-1	1-0-0	2-0-1	3-1-1	1W
Lions	4	2	0	0.667	191	142	49	2-0-0	2-2-0	1-1-0	1-1-0	4-1-0	1L
Vikings	3	2	0	0.600	123	97	26	1-1-0	2-1-0	1-0-0	1-1-0	3-2-0	1W
Bears	3	2	0	0.600	126	141	-15	1-1-0	2-1-0	0-2-0	2-2-0	3-2-0	3W

NFC South	W	L	T	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Buccaneers	5	1	0	0.833	165	151	14	2-1-0	3-0-0	1-0-0	3-1-0	4-1-0	2W
Falcons	3	2	0	0.600	100	100	0	2-1-0	1-1-0	0-2-0	2-2-0	3-2-0	2W
Panthers	3	3	0	0.500	132	146	-14	3-0-0	0-3-0	1-0-0	2-1-0	3-2-0	2W
Saints	1	5	0	0.167	111	160	-49	1-3-0	0-2-0	0-0-0	1-3-0	1-4-0	1L

NFC West	W	L	T	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
49ers	4	2	0	0.667	125	128	-3	1-1-0	3-1-0	3-0-0	4-1-0	3-2-0	1L
Seahawks	4	2	0	0.667	166	117	49	1-2-0	3-0-0	1-1-0	2-2-0	4-1-0	1W
Rams	4	2	0	0.667	140	110	30	2-1-0	2-1-0	0-1-0	0-2-0	3-2-0	1W
Cardinals	2	4	0	0.333	130	127	3	1-2-0	1-2-0	0-2-0	2-2-0	1-4-0	4L

AFC Conference	W	L	T	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Colts	5	1	0	0.833	194	116	78	4-0-0	1-1-0	1-0-0	4-0-0	4-1-0	2W
Steelers	4	1	0	0.800	119	107	12	2-1-0	2-0-0	1-0-0	3-0-0	4-1-0	3W
Chargers	4	2	0	0.667	127	125	2	2-1-0	2-1-0	3-0-0	4-0-0	3-2-0	1W
Patriots	4	2	0	0.667	150	120	30	1-2-0	3-0-0	2-0-0	2-2-0	4-1-0	3W
Bills	4	2	0	0.667	167	137	30	3-1-0	1-1-0	2-1-0	3-1-0	3-2-0	2L
Jaguars	4	2	0	0.667	139	120	19	3-1-0	1-1-0	1-0-0	2-1-0	3-2-0	1L
Broncos	4	2	0	0.667	130	95	35	2-0-0	2-2-0	0-1-0	3-2-0	3-2-0	3W
Chiefs	3	3	0	0.500	155	124	31	2-1-0	1-2-0	0-1-0	1-2-0	3-2-0	1W
Texans	2	3	0	0.400	108	61	47	1-1-0	1-2-0	1-1-0	2-1-0	2-3-0	2W
Bengals	2	4	0	0.333	103	183	-80	1-1-0	1-3-0	1-0-0	2-1-0	1-4-0	4L
Raiders	2	4	0	0.333	103	149	-46	1-2-0	1-2-0	0-1-0	2-2-0	1-4-0	1W
Ravens	1	5	0	0.167	144	194	-50	1-3-0	0-2-0	1-0-0	1-3-0	1-4-0	4L
Dolphins	1	5	0	0.167	134	174	-40	1-2-0	0-3-0	1-2-0	1-4-0	1-4-0	2L
Browns	1	5	0	0.167	82	146	-64	1-2-0	0-3-0	0-3-0	0-3-0	1-4-0	3L
Titans	1	5	0	0.167	83	161	-78	0-2-0	1-3-0	0-2-0	0-4-0	1-4-0	1L
Jets	0	6	0	0.000	123	170	-47	0-4-0	0-2-0	0-2-0	0-4-0	0-5-0	6L

NFC Conference	W	L	T	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Buccaneers	5	1	0	0.833	165	151	14	2-1-0	3-0-0	1-0-0	3-1-0	4-1-0	2W
Packers	3	1	1	0.600	131	102	29	3-0-0	0-1-1	1-0-0	2-0-1	3-1-1	1W
49ers	4	2	0	0.667	125	128	-3	1-1-0	3-1-0	3-0-0	4-1-0	3-2-0	1L
Eagles	4	2	0	0.667	142	143	-1	2-1-0	2-1-0	1-1-0	3-1-0	3-2-0	2L
Seahawks	4	2	0	0.667	166	117	49	1-2-0	3-0-0	1-1-0	2-2-0	4-1-0	1W
Lions	4	2	0	0.667	191	142	49	2-0-0	2-2-0	1-1-0	1-1-0	4-1-0	1L
Rams	4	2	0	0.667	140	110	30	2-1-0	2-1-0	0-1-0	0-2-0	3-2-0	1W
Falcons	3	2	0	0.600	100	100	0	2-1-0	1-1-0	0-2-0	2-2-0	3-2-0	2W
Vikings	3	2	0	0.600	123	97	26	1-1-0	2-1-0	1-0-0	1-1-0	3-2-0	1W
Commanders	3	3	0	0.500	158	126	32	2-1-0	1-2-0	1-0-0	1-3-0	2-3-0	1L
Panthers	3	3	0	0.500	132	146	-14	3-0-0	0-3-0	1-0-0	2-1-0	3-2-0	2W
Bears	3	2	0	0.600	126	141	-15	1-1-0	2-1-0	0-2-0	2-2-0	3-2-0	3W
Cowboys	2	3	1	0.333	178	184	-6	1-0-1	1-3-0	1-1-0	1-3-1	2-2-1	1L
Cardinals	2	4	0	0.333	130	127	3	1-2-0	1-2-0	0-2-0	2-2-0	1-4-0	4L
Giants	2	4	0	0.333	121	144	-23	2-1-0	0-3-0	1-2-0	1-3-0	2-3-0	1W
Saints	1	5	0	0.167	111	160	-49	1-3-0	0-2-0	0-0-0	1-3-0	1-4-0	1L

NFL Team	W	L	T	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Colts	5	1	0	0.833	194	116	78	4-0-0	1-1-0	1-0-0	4-0-0	4-1-0	2W
Buccaneers	5	1	0	0.833	165	151	14	2-1-0	3-0-0	1-0-0	3-1-0	4-1-0	2W
Steelers	4	1	0	0.800	119	107	12	2-1-0	2-0-0	1-0-0	3-0-0	4-1-0	3W
Packers	3	1	1	0.600	131	102	29	3-0-0	0-1-1	1-0-0	2-0-1	3-1-1	1W
Bills	4	2	0	0.667	167	137	30	3-1-0	1-1-0	2-1-0	3-1-0	3-2-0	2L
Broncos	4	2	0	0.667	130	95	35	2-0-0	2-2-0	0-1-0	3-2-0	3-2-0	3W
Lions	4	2	0	0.667	191	142	49	2-0-0	2-2-0	1-1-0	1-1-0	4-1-0	1L
Jaguars	4	2	0	0.667	139	120	19	3-1-0	1-1-0	1-0-0	2-1-0	3-2-0	1L
Chargers	4	2	0	0.667	127	125	2	2-1-0	2-1-0	3-0-0	4-0-0	3-2-0	1W
Rams	4	2	0	0.667	140	110	30	2-1-0	2-1-0	0-1-0	0-2-0	3-2-0	1W
Patriots	4	2	0	0.667	150	120	30	1-2-0	3-0-0	2-0-0	2-2-0	4-1-0	3W
Eagles	4	2	0	0.667	142	143	-1	2-1-0	2-1-0	1-1-0	3-1-0	3-2-0	2L
49ers	4	2	0	0.667	125	128	-3	1-1-0	3-1-0	3-0-0	4-1-0	3-2-0	1L
Seahawks	4	2	0	0.667	166	117	49	1-2-0	3-0-0	1-1-0	2-2-0	4-1-0	1W
Falcons	3	2	0	0.600	100	100	0	2-1-0	1-1-0	0-2-0	2-2-0	3-2-0	2W
Bears	3	2	0	0.600	126	141	-15	1-1-0	2-1-0	0-2-0	2-2-0	3-2-0	3W
Vikings	3	2	0	0.600	123	97	26	1-1-0	2-1-0	1-0-0	1-1-0	3-2-0	1W
Panthers	3	3	0	0.500	132	146	-14	3-0-0	0-3-0	1-0-0	2-1-0	3-2-0	2W
Chiefs	3	3	0	0.500	155	124	31	2-1-0	1-2-0	0-1-0	1-2-0	3-2-0	1W
Commanders	3	3	0	0.500	158	126	32	2-1-0	1-2-0	1-0-0	1-3-0	2-3-0	1L
Cowboys	2	3	1	0.333	178	184	-6	1-0-1	1-3-0	1-1-0	1-3-1	2-2-1	1L
Texans	2	3	0	0.400	108	61	47	1-1-0	1-2-0	1-1-0	2-1-0	2-3-0	2W
Cardinals	2	4	0	0.333	130	127	3	1-2-0	1-2-0	0-2-0	2-2-0	1-4-0	4L
Bengals	2	4	0	0.333	103	183	-80	1-1-0	1-3-0	1-0-0	2-1-0	1-4-0	4L
Raiders	2	4	0	0.333	103	149	-46	1-2-0	1-2-0	0-1-0	2-2-0	1-4-0	1W
Giants	2	4	0	0.333	121	144	-23	2-1-0	0-3-0	1-2-0	1-3-0	2-3-0	1W
Ravens	1	5	0	0.167	144	194	-50	1-3-0	0-2-0	1-0-0	1-3-0	1-4-0	4L
Browns	1	5	0	0.167	82	146	-64	1-2-0	0-3-0	0-3-0	0-3-0	1-4-0	3L
Dolphins	1	5	0	0.167	134	174	-40	1-2-0	0-3-0	1-2-0	1-4-0	1-4-0	2L
Saints	1	5	0	0.167	111	160	-49	1-3-0	0-2-0	0-0-0	1-3-0	1-4-0	1L
Titans	1	5	0	0.167	83	161	-78	0-2-0	1-3-0	0-2-0	0-4-0	1-4-0	1L
Jets	0	6	0	0.000	123	170	-47	0-4-0	0-2-0	0-2-0	0-4-0	0-5-0	6L