49ers vs Browns Prediction, Picks & Odds | 30 Nov 2025

NFL Betting Preview: Niners vs Browns

The San Francisco 49ers go up against the Cleveland Browns at Huntington Bank Field, with kickoff scheduled for 13:00 on Sunday, November 30.

We’re predicting that the Browns and the Niners will produce a significant combined points total. Therefore, our pick is to take the -106 that there are Over 36.5 points.

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San Francisco 49ers beat Carolina Panthers in their previous game, making it back-to-back victories. It was a 20-9 home win at Levi's Stadium. The 49ers moved the ball for 340 yards, breaking down to 193 passing and 147 rushing yards. They produced 23 first downs and scored 2 touchdowns, one on the ground and one through the air.

Cleveland Browns won their last game 24-10. This was a road victory at Allegiant Stadium against Las Vegas Raiders. The Browns recorded 270 yards, split between 206 passing and 64 rushing yards. They produced 11 first downs and scored 3 touchdowns, one coming through the air and 2 on the ground.

Head-to-Head Statistics

The Browns triumphed 19-17 when they last played the Niners. This head-to-head was played at Huntington Bank Field.

Quarterbacks

Brock Purdy

191.5 Passing Yards

Over -112

Under -112

Shedeur Sanders

147.5 Passing Yards

Over -112

Under -112

49ers vs Browns Prediction & Picks

This 49ers vs Browns betting breakdown features a main match prediction, a correct score insight, expert player prop picks and a sharply constructed bet builder to guide your wagers.

Game Prediction

The teams are certainly capable of exceeding the set points total line which leads us to predict Over 36.5 as a value bet at -106 for this NFL battle.

We keep a close eye on team news and our expert NFL handicappers stay sharp by tracking the latest form and lineups. You’ll also find a full set of stats that offer valuable insight and help shape smarter predictions ahead of the action.

Key 49ers vs Browns stats:

• The 36.5 line has been covered in the last 6 49ers games on the road.
• The 36.5 line has been covered in 19 of the last 20 49ers games on the road.
• The 36.5 line has been covered in 9 of the last 10 49ers games on the road.
• The 36.5 line has been covered in 4 of the last 5 Browns games.
• The 36.5 line has been covered in 7 of the last 10 Browns games.
• The 36.5 line has been covered in the last 3 Browns games at home.

Over 36.5 Probability

When you look at the latest betting odds, our pick has a 51.5% chance of winning. However, our research has found that the actual probability is closer to 60%. This is why we can recommend this bet.

The leading sportbooks allow you to shoot for a bigger price by moving the line on the Totals. Choose a number where you’re happy and get more juice.

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Our Game Prediction

Over 36.5 Points @ -106 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (19:25, 28 November 2025). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Brock Purdy Over 204.5 Passing Yards -114

The odds for Brock Purdy (Niners) to go beyond 204.5 passing yards stand at -114. We believe it makes sense to stick with him on the Over and bettors can be confident in this QB Passing Yards pick.

Latest Brock Purdy Player Prop Odds

Touchdown

Anytime

+1000

First

+3300

Passing Yards

Over 191.5

-112

Under 191.5

-112

Rushing Yards

Over 10.5

-112

Under 10.5

-112

---

Shedeur Sanders Over 10.5 Rushing Yards -114

Shedeur Sanders (Browns) is available at -114 to rack up over 10.5 rushing yards. We feel confident that he’ll cover the Player Rushing Yards line, which looks generous.

Latest Shedeur Sanders Player Prop Odds

Touchdown

Anytime

+650

First

+2200

Passing Yards

Over 147.5

-112

Under 147.5

-112

Rushing Yards

Over 10.5

-112

Under 10.5

-112

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

49ers 23 - 21 Browns

A close matchup could be on the cards. We’ll wager the 49ers to secure a 23-21 win at massive odds and this correct score prediction should hopefully be a fun one.

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49ers vs Browns Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

The sportsbooks have San Francisco 49ers at -244 when it comes to the Moneyline betting, implying the market leaders are 71% likely to win this game according to the latest odds. For those wanting to back Cleveland Browns, you will find +200 about the underdogs.

The spread is currently 6, with the total points line at 42.5. NFL fans regularly enjoy the opportunity to bet on the Totals. The Over 42.5 selection is available to back at -110.

Whether you are wagering pre-game or in-game on the National Football League, the best betting apps offer a wide range of game lines and team props. The selections are practically endless and it’s great to have so many different options.

Moneyline

49ers

-244

Browns

+200

Point Spread

49ers -6

-110

Browns +6

-110

Total Points

Under 42.5

-110

Over 42.5

-110

There’s the chance to back Christian McCaffrey at +330 to be the First Touchdown Scorer. He’s the favorite and available at similar odds to record the last TD instead.

Touchdown

Christian McCaffrey (49ers)

First TD

+330

Anytime TD

-135

Quinshon Judkins (Browns)

First TD

+430

Anytime TD

-105

George Kittle (49ers)

First TD

+650

Anytime TD

+200

Jauan Jennings (49ers)

First TD

+1000

Anytime TD

+300

Ricky Pearsall (49ers)

First TD

+1300

Anytime TD

+410

Harold Fannin Jr. (Browns)

First TD

+1800

Anytime TD

+500

Jerry Jeudy (Browns)

First TD

+2000

Anytime TD

+600

Cedric Tillman (Browns)

First TD

+2200

Anytime TD

+600

Shedeur Sanders (Browns)

First TD

+2200

Anytime TD

+650

David Njoku (Browns)

First TD

+2500

Anytime TD

+700

Brian Robinson Jr. (49ers)

First TD

+2700

Anytime TD

+700

Dylan Sampson (Browns)

First TD

+3000

Anytime TD

+750

Jerome Ford (Browns)

First TD

+3000

Anytime TD

+750

Kyle Juszczyk (49ers)

First TD

+3000

Anytime TD

+1100

Brock Purdy (49ers)

First TD

+3300

Anytime TD

+1000

Demarcus Robinson (49ers)

First TD

+4500

Anytime TD

+1000

Luke Farrell (49ers)

First TD

+5500

Anytime TD

+1200

Isaiah Bond (Browns)

First TD

+7000

Anytime TD

+1500

Kendrick Bourne (49ers)

First TD

+7500

Anytime TD

+2000

Brenden Bates (Browns)

First TD

+7500

Anytime TD

+1900

Jamari Thrash (Browns)

First TD

+8000

Anytime TD

+2000

Malachi Corley (Browns)

First TD

+8000

Anytime TD

+2000

Jake Tonges (49ers)

First TD

+10000

Anytime TD

+2700

Blake Whiteheart (Browns)

First TD

+10000

Anytime TD

+2200

Isaac Guerendo (49ers)

First TD

+10000

Anytime TD

+3500

Gage Larvadain (Browns)

First TD

+10000

Anytime TD

+4500

Skyy Moore (49ers)

First TD

+10000

Anytime TD

+3000

Jordan Watkins (49ers)

First TD

+10000

Anytime TD

+3000

James Jordan (49ers)

First TD

+10000

Anytime TD

+3500

Receiving Yards

George Kittle (49ers)

Over 45.5

-112

Under 45.5

-112

Christian McCaffrey (49ers)

Over 37.5

-112

Under 37.5

-112

Jauan Jennings (49ers)

Over 35.5

-112

Under 35.5

-112

Harold Fannin Jr. (Browns)

Over 32.5

-112

Under 32.5

-112

Ricky Pearsall (49ers)

Over 27.5

-112

Under 27.5

-112

Jerry Jeudy (Browns)

Over 26.5

-112

Under 26.5

-112

Cedric Tillman (Browns)

Over 17.5

-112

Under 17.5

-112

David Njoku (Browns)

Over 13.5

-112

Under 13.5

-112

Quinshon Judkins (Browns)

Over 5.5

-112

Under 5.5

-112

Kyle Juszczyk (49ers)

Over 5.5

-112

Under 5.5

-112

Rushing Yards

Quinshon Judkins (Browns)

Over 69.5

-112

Under 69.5

-112

Christian McCaffrey (49ers)

Over 68.5

-112

Under 68.5

-112

Brian Robinson Jr. (49ers)

Over 22.5

-112

Under 22.5

-112

Shedeur Sanders (Browns)

Over 10.5

-112

Under 10.5

-112

Brock Purdy (49ers)

Over 10.5

-112

Under 10.5

-112

Passing Yards

Brock Purdy (49ers)

Over 191.5

-112

Under 191.5

-112

Shedeur Sanders (Browns)

Over 147.5

-112

Under 147.5

-112

Among the various options for wagering on the NFL, you will find that micro betting is provided. It focuses on short-term in-game outcomes such as whether a touchdown will be scored within the next 10 minutes.

Browns Home Record Reads Six Losses in Previous Ten Matches

The Browns have a 4-6 record in their last 10 home games, scoring 16.30 points per contest and conceding 18.80.

The Niners have gone 5-5 across their last 10 road games, posting 22.90 points per contest while yielding 27.00.

The Browns beat the Niners 19-17 when the teams last met at Huntington Bank Field.

Last 10 Games		W-L	P	PF	PA	O36.5	U36.5
Browns Home Stats		4-6	35.10	16.30	18.80	5	5
49ers Away Stats		5-5	49.90	22.90	27.00	9	1

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O36.5 = Games Over 36.5 Points
• U36.5 = Games Under 36.5 Points

Latest regular season and playoff games stats.

San Francisco 49ers Stats

Cleveland Browns Stats

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 5 wins and 5 defeats in the last 10 games on the road

Moneyline

• 3 wins and 7 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 home games

Point Spread

• -4.5 Betting Line: Have covered the spread in 4 of the last 10 games
• -4.5 Betting Line on the Road: Have covered the spread in 3 of the last 10 games on the road

Point Spread

• +4.5 Betting Line: Have covered the spread in 4 of the last 10 games
• +4.5 Betting Line at Home: Have covered the spread in 6 of the last 10 home games

Total Points

• Game Totals: An average of 46.50 pts in the previous 10 games
• Game Totals on the Road: An average of 49.90 pts in the previous 10 games on the road
• Over 36.5: Covered in 7 of the previous 10 games
• Over 36.5 on the Road: Covered in 9 of the previous 10 games on the road
• Team Totals: Have scored an average of 23.80 pts and allowed 22.70 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 22.90 pts and allowed 27.00 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 39.70 pts in the previous 10 games
• Game Totals at Home: An average of 35.40 pts in the previous 10 home games
• Over 36.5: Covered in 7 of the previous 10 games
• Over 36.5 at Home: Covered in 6 of the previous 10 home games
• Team Totals: Have scored an average of 17.00 pts and allowed 22.70 pts in the last 10 games
• Team Totals at Home: Have scored an average of 16.60 pts and allowed 18.80 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 345.50 Yds. Allowed 357.50 Yds
• Rushing Yards: Gained 99.40 Yds. Allowed 100.60 Yds
• Passing Yards: Gained 246.10 Yds. Allowed 256.90 Yds
• Total Touchdowns: Scored 2.50 TD. Allowed 2.70 TD
• Rushing Touchdowns: Scored 0.90 TD. Allowed 0.70 TD
• Passing Touchdowns: Scored 1.60 TD. Allowed 1.90 TD
• Total 1st Downs: Picked up 21.60. Allowed 20.80
• Total Turnovers: Committed 1.50. Committed by opponents 0.90
• Total Penalties: Committed 5.00. Committed by opponents 6.80
• Penalty Yards: Lost 38.70 Yds. Gained 46.80 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 251.60 Yds. Allowed 259.80 Yds
• Rushing Yards: Gained 99.50 Yds. Allowed 93.70 Yds
• Passing Yards: Gained 152.10 Yds. Allowed 166.10 Yds
• Total Touchdowns: Scored 1.80 TD. Allowed 2.40 TD
• Rushing Touchdowns: Scored 0.70 TD. Allowed 0.40 TD
• Passing Touchdowns: Scored 0.90 TD. Allowed 1.60 TD
• Total 1st Downs: Picked up 15.60. Allowed 15.60
• Total Turnovers: Committed 1.10. Committed by opponents 1.50
• Total Penalties: Committed 6.90. Committed by opponents 8.50
• Penalty Yards: Lost 56.10 Yds. Gained 60.00 Yds

Last 10 Games on the Road

• Total Yards: Gained 343.10 Yds. Allowed 374.20 Yds
• Rushing Yards: Gained 101.10 Yds. Allowed 123.60 Yds
• Passing Yards: Gained 242.00 Yds. Allowed 250.60 Yds
• Total Touchdowns: Scored 2.50 TD. Allowed 3.20 TD
• Rushing Touchdowns: Scored 0.70 TD. Allowed 1.10 TD
• Passing Touchdowns: Scored 1.80 TD. Allowed 2.10 TD
• Total 1st Downs: Picked up 21.30. Allowed 21.50
• Total Turnovers: Committed 1.40. Committed by opponents 0.90
• Total Penalties: Committed 6.80. Committed by opponents 6.30
• Penalty Yards: Lost 47.40 Yds. Gained 43.50 Yds

Last 10 Home Games

• Total Yards: Gained 280.20 Yds. Allowed 271.40 Yds
• Rushing Yards: Gained 99.20 Yds. Allowed 91.10 Yds
• Passing Yards: Gained 181.00 Yds. Allowed 180.30 Yds
• Total Touchdowns: Scored 1.80 TD. Allowed 2.20 TD
• Rushing Touchdowns: Scored 0.90 TD. Allowed 1.00 TD
• Passing Touchdowns: Scored 0.70 TD. Allowed 1.20 TD
• Total 1st Downs: Picked up 17.30. Allowed 15.20
• Total Turnovers: Committed 1.90. Committed by opponents 1.10
• Total Penalties: Committed 6.90. Committed by opponents 7.60
• Penalty Yards: Lost 57.50 Yds. Gained 53.80 Yds

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