San Francisco 49ers
American Football NFL SoFi Stadium Thu 2 Oct 20:15
Los Angeles Rams
  1. Prediction
  2. Bet Builder
  3. Odds
  4. Player Props
  5. Stats
  6. Live Stream
  7. Team News
  8. Lineups
  9. Injuries
  10. Standings

NFL Betting Preview: Niners vs Rams

The San Francisco 49ers battle the Los Angeles Rams in this NFL Week 5 Thursday Night Football matchup at SoFi Stadium, with kickoff scheduled for 20:15 on Thursday 2 October. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

Rams ATS Stand Out as a Great Bet

The Rams at -5.5 could be the best bet to have on the spread. Odds of -122 are available and our prediction is a solid win when they go up against the Niners.

Agree with our spread pick? Claim the best BetMGM promo code and see how the sportsbook stacks up in our full site review ahead of making your move.

Rams Beat Niners in Pair’s Last Matchup

San Francisco 49ers have now enjoyed two consecutive road wins, while their previous game was a 26-21 home loss against Jacksonville Jaguars at Levi's Stadium. The 49ers finished with 389 total yards, made up of 306 through the air and 83 on the ground. They managed 22 first downs and produced 2 touchdowns, with both scores coming by pass.

Los Angeles Rams were winners last time out. Their 27-20 victory against Indianapolis Colts at SoFi Stadium made it back-to-back home wins. The Rams moved the ball for 462 yards, with 360 through the air and 102 on the ground. The offense converted for 24 first downs and produced 3 touchdowns, all coming through the air.

Head-to-Head Statistics

It was the Rams who came out on top when they last played the Niners. At Levi's Stadium, a 12-6 win was recorded. The previous 10 H2H meetings have involved the Niners winning six times.

49ers vs Rams Prediction & Picks

Head into 49ers vs Rams with expert betting insights, including our main match prediction, expected scoreline, key player prop picks and a thoughtfully built bet builder.

Game Prediction

Bet on the Rams against the spread, with an attractive line of -5.5 that the favorites get the job done. There are odds of -122 that are currently on offer for this NFL battle.

The NFL handicappers at Sportsgambler.com stay on top of injuries and team form that could impact the outcome. We also leave no stone unturned when analyzing the latest stats to support every prediction.

Key 49ers vs Rams stats:

  • The +5.5 line hasn’t been covered by 49ers in 3 of their last 5 games on the road.

Rams -5.5 Probability

According to the best NFL betting sites, there’s a 54.9% likelihood of our pick delivering a return. Our cappers think there’s a stronger chance of success and calculate the probability to be closer to 60%. This wager can therefore be backed with confidence.

Looking for Bigger Odds?

We recommend moving the line if you are looking for bigger odds about the same selection. Take your pick and get the juice that you want from your spread bet in the process.

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Best Bet

Rams -5.5 @ -122 Watch Live Bet Now BetMGM logo
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Published 02:26, 01 October 2025

Player Prop Picks

Top Pick: Brock Purdy Under 243.5 Passing Yards -114 BetMGM logo

You can place a bet on Brock Purdy (Niners) at -114 to finish with fewer than 243.5 passing yards. We’re confident he’ll fall short of the QB Passing Yards line, as the total looks too high.

Latest Brock Purdy Player Prop Odds

Puka Nacua Anytime TD -105 BetMGM logo

You can place a bet on Puka Nacua (Rams) to record a TD at -105. Attractive odds are available for this Anytime Touchdown Scorer wager, and we believe it's a value proposition for him to take it to the house.

Latest Puka Nacua Player Prop Odds

Same Game Parlay Picks

Spread Rams -5.5
Totals Under 46.5
Passing Yards Brock Purdy Under 243.5

We’ve loaded up a same game parlay with the combined picks of Rams -5.5, Under 46.5 and Brock Purdy (49ers) to have Under 243.5 passing yards.

The same game parlay option allows you to combine different outcomes within the same football game. You need all your picks to be correct although bettors love to place a tailored wager on the clash which interests them most.

T&C apply. Gamble responsibly 18+

Correct Score Prediction

49ers 49ers logo 14 - 27 Rams logo Rams

We’re going for the Rams to win by a 27-14 scoreline, something which is available at huge odds. This speculative wager can provide a big return for a small stake.

49ers vs Rams Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Books Giving Rams Plenty of Respect

Sportsbooks’ favorites Los Angeles Rams are regarded as likeliest victors for this game and the -455 about them triumphing means a 82% chance based on their current Moneyline betting odds. For those wanting to back San Francisco 49ers, you will find +360 about the underdogs.

7.5 is the spread and 45.5 is the total points line. Having a wager on the Totals is one of the most popular NFL bets. If you fancy Under 45.5, then the odds are -115.

You can find hundreds of team props and game lines for every National Football League matchup, with the top sportsbooks creating lots of different options. Check out the pre-game and in-game selections before placing your bets.

Kyren Williams Favorite to Score First Touchdown

The First TD Scorer favorite is Kyren Williams at +340. Similar odds can be found if you’re interested in this player to register the last touchdown.

Touchdown

Kyren Williams (Rams)
First TD
+340
Anytime TD
-208
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Christian McCaffrey (49ers)
First TD
+550
Anytime TD
-130
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Davante Adams (Rams)
First TD
+600
Anytime TD
+105
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Receiving Yards

Christian McCaffrey (49ers)
Over 54.5
-114
Under 54.5
-114
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Kendrick Bourne (49ers)
Over 40.5
-114
Under 40.5
-114
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Rushing Yards

Kyren Williams (Rams)
Over 67.5
-114
Under 67.5
-114
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Christian McCaffrey (49ers)
Over 62.5
-114
Under 62.5
-114
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Brian Robinson Jr. (49ers)
Over 17.5
-114
Under 17.5
-114
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Passing Yards

Best Betting Offers
SoFi Stadium
SoFi Stadium

Rams Have Taken Six Wins From Last Ten Home Outings

The Rams own a 6-4 mark in their past 10 home games, putting up 22.70 points per contest and giving up 22.90.

The Niners have four wins and six losses in the last 10 road games, averaging 20.40 points scored and 27.70 points allowed.

The last time the Rams faced the Niners at SoFi Stadium, they won 27-24. In the last 6 head-to-head games at SoFi Stadium, the Niners have notched four victories, with the Rams posting two.

Last 10 Games W-L P PF PA O46.5 U46.5
Rams logo Rams Home Stats 6-4 45.60 22.70 22.90 5 5
49ers logo 49ers Away Stats 4-6 48.10 20.40 27.70 5 5
  • W-L = Wins-Losses
  • P = Avg. Points
  • PF = Avg. Points For
  • PA = Avg. Points Against
  • O46.5 = Games Over 46.5 Points
  • U46.5 = Games Under 46.5 Points
Team Stats

Latest regular season and playoff games stats.

San Francisco 49ers logo San Francisco 49ers Stats
Los Angeles Rams logo Los Angeles Rams Stats
Moneyline
  • 4 wins and 6 defeats in the last 10 games
  • 4 wins and 6 defeats in the last 10 games on the road
Moneyline
  • 7 wins and 3 defeats in the last 10 games
  • 7 wins and 3 defeats in the last 10 home games
Point Spread
Point Spread
Total Points
Total Points
Game Stats
Last 10 Games
Game Stats
Last 10 Games
Last 10 Games on the Road
Last 10 Home Games

Live Streaming

You can watch and bet on NFL games thanks to the live streaming service that’s available. This is only available to eligible sportsbook customers and is subject to geo-restrictions.

You can log into your betting account on a daily basis and enjoy the chance to access high quality streams.

Team News

San Francisco 49ers Injuries

Type
Name
Info
Brandon Aiyuk
Knee - ACL + MCL
Isaac Alarcon
Suspension
Ben Bartch
Ankle
Robert Beal
Ankle
Nick Bosa
Knee - ACL
Spencer Burford
Knee
Jacob Cowing
Hamstring
Kevin Givens
Pectoral
Tarron Jackson
Undisclosed
Jauan Jennings
Ankle
George Kittle
Hamstring
Malik Mustapha
Knee - ACL
Ricky Pearsall
Knee - PCL
Brock Purdy
Toe
Jakob Robinson
Forearm
Kurtis Rourke
Knee
Patrick Taylor
Shoulder
Trent Taylor
Undisclosed
Tre Tomlinson
Undisclosed
Jordan Watkins
Calf
CJ West
Thumb

Los Angeles Rams Injuries

Type
Name
Info
Rob Havenstein
Ankle
Tyler Higbee
Hip
Keir Thomas
Undisclosed
Ahkello Witherspoon
Collarbone

Previous San Francisco 49ers Lineups

28 Sep NFL
Jaguars 26-21 49ers
21 Sep NFL
Cardinals 15-16 49ers
14 Sep NFL
49ers 26-21 Saints
07 Sep NFL
49ers 17-13 Seahawks
05 Jan NFL
49ers 24-47 Cardinals
30 Dec NFL
Lions 40-34 49ers
22 Dec NFL
49ers 17-29 Dolphins
12 Dec NFL
Rams 12-6 49ers
08 Dec NFL
Bears 13-38 49ers
01 Dec NFL
49ers 10-35 Bills

Previous Los Angeles Rams Lineups

28 Sep NFL
Colts 20-27 Rams
21 Sep NFL
Rams 26-33 Eagles
14 Sep NFL
Rams 33-19 Titans
07 Sep NFL
Texans 9-14 Rams
19 Jan NFL Playoffs
Rams 22-28 Eagles
13 Jan NFL Playoffs
Vikings 9-27 Rams
05 Jan NFL
Seahawks 30-25 Rams
28 Dec NFL
Cardinals 9-13 Rams
22 Dec NFL
Rams 19-9 Jets
12 Dec NFL
Rams 12-6 49ers

NFL Standings Select Season

AFC East W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Bills 4 0 0 1.000 133 90 43 3-0-0 1-0-0 2-0-0 3-0-0 4-0-0 4W
Patriots 2 2 0 0.500 102 81 21 1-2-0 1-0-0 1-0-0 1-2-0 2-2-0 1W
Dolphins 1 3 0 0.250 83 118 -35 1-1-0 0-2-0 1-2-0 1-3-0 1-3-0 1W
Jets 0 4 0 0.000 90 120 -30 0-2-0 0-2-0 0-2-0 0-3-0 0-4-0 4L
AFC North W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Steelers 3 1 0 0.750 96 98 -2 1-1-0 2-0-0 0-0-0 2-0-0 3-1-0 2W
Bengals 2 2 0 0.500 61 119 -58 1-0-0 1-2-0 1-0-0 2-1-0 2-2-0 2L
Ravens 1 3 0 0.250 131 133 -2 1-1-0 0-2-0 1-0-0 1-2-0 1-3-0 2L
Browns 1 3 0 0.250 56 102 -46 1-1-0 0-2-0 0-2-0 0-2-0 1-3-0 1L
AFC South W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Colts 3 1 0 0.750 123 83 40 2-0-0 1-1-0 1-0-0 3-0-0 3-1-0 1L
Jaguars 3 1 0 0.750 96 72 24 2-0-0 1-1-0 1-0-0 1-1-0 3-1-0 2W
Texans 1 3 0 0.250 64 51 13 1-1-0 0-2-0 1-1-0 1-1-0 1-3-0 1W
Titans 0 4 0 0.000 51 120 -69 0-2-0 0-2-0 0-2-0 0-3-0 0-4-0 4L
AFC West W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Chargers 3 1 0 0.750 88 71 17 2-0-0 1-1-0 3-0-0 3-0-0 3-1-0 1L
Broncos 2 2 0 0.500 96 67 29 2-0-0 0-2-0 0-1-0 2-2-0 2-2-0 1W
Chiefs 2 2 0 0.500 97 76 21 1-1-0 1-1-0 0-1-0 1-1-0 2-2-0 2W
Raiders 1 3 0 0.250 77 99 -22 0-2-0 1-1-0 0-1-0 1-1-0 1-3-0 3L
NFC East W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Eagles 4 0 0 1.000 108 88 20 2-0-0 2-0-0 1-0-0 3-0-0 4-0-0 4W
Commanders 2 2 0 0.500 107 91 16 2-0-0 0-2-0 1-0-0 1-2-0 2-2-0 1L
Cowboys 1 2 1 0.250 114 132 -18 1-0-1 0-2-0 1-1-0 1-2-1 1-2-1 1D
Giants 1 3 0 0.250 73 101 -28 1-1-0 0-2-0 0-2-0 0-2-0 1-3-0 1W
NFC North W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Lions 3 1 0 0.750 137 88 49 2-0-0 1-1-0 1-1-0 1-1-0 3-1-0 3W
Packers 2 1 1 0.500 104 84 20 2-0-0 0-1-1 1-0-0 2-0-1 2-1-1 1D
Vikings 2 2 0 0.500 102 80 22 1-1-0 1-1-0 1-0-0 1-1-0 2-2-0 1L
Bears 2 2 0 0.500 101 117 -16 1-1-0 1-1-0 0-2-0 1-2-0 2-2-0 2W
NFC South W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Buccaneers 3 1 0 0.750 97 97 0 1-1-0 2-0-0 1-0-0 1-1-0 3-1-0 1L
Falcons 2 2 0 0.500 76 86 -10 1-1-0 1-1-0 0-2-0 2-2-0 2-2-0 1W
Panthers 1 3 0 0.250 75 95 -20 1-0-0 0-3-0 1-0-0 1-1-0 1-3-0 1L
Saints 0 4 0 0.000 66 121 -55 0-2-0 0-2-0 0-0-0 0-3-0 0-4-0 4L
NFC West W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Seahawks 3 1 0 0.750 111 67 44 1-1-0 2-0-0 1-1-0 2-1-0 3-1-0 3W
49ers 3 1 0 0.750 80 75 5 1-1-0 2-0-0 2-0-0 3-0-0 3-1-0 1L
Rams 3 1 0 0.750 100 81 19 2-0-0 1-1-0 0-0-0 0-1-0 3-1-0 1W
Cardinals 2 2 0 0.500 82 74 8 1-1-0 1-1-0 0-2-0 2-2-0 2-2-0 2L
AFC Conference W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Bills 4 0 0 1.000 133 90 43 3-0-0 1-0-0 2-0-0 3-0-0 4-0-0 4W
Steelers 3 1 0 0.750 96 98 -2 1-1-0 2-0-0 0-0-0 2-0-0 3-1-0 2W
Chargers 3 1 0 0.750 88 71 17 2-0-0 1-1-0 3-0-0 3-0-0 3-1-0 1L
Colts 3 1 0 0.750 123 83 40 2-0-0 1-1-0 1-0-0 3-0-0 3-1-0 1L
Jaguars 3 1 0 0.750 96 72 24 2-0-0 1-1-0 1-0-0 1-1-0 3-1-0 2W
Bengals 2 2 0 0.500 61 119 -58 1-0-0 1-2-0 1-0-0 2-1-0 2-2-0 2L
Broncos 2 2 0 0.500 96 67 29 2-0-0 0-2-0 0-1-0 2-2-0 2-2-0 1W
Chiefs 2 2 0 0.500 97 76 21 1-1-0 1-1-0 0-1-0 1-1-0 2-2-0 2W
Patriots 2 2 0 0.500 102 81 21 1-2-0 1-0-0 1-0-0 1-2-0 2-2-0 1W
Raiders 1 3 0 0.250 77 99 -22 0-2-0 1-1-0 0-1-0 1-1-0 1-3-0 3L
Texans 1 3 0 0.250 64 51 13 1-1-0 0-2-0 1-1-0 1-1-0 1-3-0 1W
Ravens 1 3 0 0.250 131 133 -2 1-1-0 0-2-0 1-0-0 1-2-0 1-3-0 2L
Browns 1 3 0 0.250 56 102 -46 1-1-0 0-2-0 0-2-0 0-2-0 1-3-0 1L
Dolphins 1 3 0 0.250 83 118 -35 1-1-0 0-2-0 1-2-0 1-3-0 1-3-0 1W
Jets 0 4 0 0.000 90 120 -30 0-2-0 0-2-0 0-2-0 0-3-0 0-4-0 4L
Titans 0 4 0 0.000 51 120 -69 0-2-0 0-2-0 0-2-0 0-3-0 0-4-0 4L
NFC Conference W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Eagles 4 0 0 1.000 108 88 20 2-0-0 2-0-0 1-0-0 3-0-0 4-0-0 4W
49ers 3 1 0 0.750 80 75 5 1-1-0 2-0-0 2-0-0 3-0-0 3-1-0 1L
Lions 3 1 0 0.750 137 88 49 2-0-0 1-1-0 1-1-0 1-1-0 3-1-0 3W
Buccaneers 3 1 0 0.750 97 97 0 1-1-0 2-0-0 1-0-0 1-1-0 3-1-0 1L
Seahawks 3 1 0 0.750 111 67 44 1-1-0 2-0-0 1-1-0 2-1-0 3-1-0 3W
Rams 3 1 0 0.750 100 81 19 2-0-0 1-1-0 0-0-0 0-1-0 3-1-0 1W
Packers 2 1 1 0.500 104 84 20 2-0-0 0-1-1 1-0-0 2-0-1 2-1-1 1D
Vikings 2 2 0 0.500 102 80 22 1-1-0 1-1-0 1-0-0 1-1-0 2-2-0 1L
Falcons 2 2 0 0.500 76 86 -10 1-1-0 1-1-0 0-2-0 2-2-0 2-2-0 1W
Cardinals 2 2 0 0.500 82 74 8 1-1-0 1-1-0 0-2-0 2-2-0 2-2-0 2L
Bears 2 2 0 0.500 101 117 -16 1-1-0 1-1-0 0-2-0 1-2-0 2-2-0 2W
Commanders 2 2 0 0.500 107 91 16 2-0-0 0-2-0 1-0-0 1-2-0 2-2-0 1L
Cowboys 1 2 1 0.250 114 132 -18 1-0-1 0-2-0 1-1-0 1-2-1 1-2-1 1D
Panthers 1 3 0 0.250 75 95 -20 1-0-0 0-3-0 1-0-0 1-1-0 1-3-0 1L
Giants 1 3 0 0.250 73 101 -28 1-1-0 0-2-0 0-2-0 0-2-0 1-3-0 1W
Saints 0 4 0 0.000 66 121 -55 0-2-0 0-2-0 0-0-0 0-3-0 0-4-0 4L
NFL Team W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Bills 4 0 0 1.000 133 90 43 3-0-0 1-0-0 2-0-0 3-0-0 4-0-0 4W
Eagles 4 0 0 1.000 108 88 20 2-0-0 2-0-0 1-0-0 3-0-0 4-0-0 4W
Lions 3 1 0 0.750 137 88 49 2-0-0 1-1-0 1-1-0 1-1-0 3-1-0 3W
Colts 3 1 0 0.750 123 83 40 2-0-0 1-1-0 1-0-0 3-0-0 3-1-0 1L
Jaguars 3 1 0 0.750 96 72 24 2-0-0 1-1-0 1-0-0 1-1-0 3-1-0 2W
Chargers 3 1 0 0.750 88 71 17 2-0-0 1-1-0 3-0-0 3-0-0 3-1-0 1L
Rams 3 1 0 0.750 100 81 19 2-0-0 1-1-0 0-0-0 0-1-0 3-1-0 1W
Steelers 3 1 0 0.750 96 98 -2 1-1-0 2-0-0 0-0-0 2-0-0 3-1-0 2W
49ers 3 1 0 0.750 80 75 5 1-1-0 2-0-0 2-0-0 3-0-0 3-1-0 1L
Seahawks 3 1 0 0.750 111 67 44 1-1-0 2-0-0 1-1-0 2-1-0 3-1-0 3W
Buccaneers 3 1 0 0.750 97 97 0 1-1-0 2-0-0 1-0-0 1-1-0 3-1-0 1L
Packers 2 1 1 0.500 104 84 20 2-0-0 0-1-1 1-0-0 2-0-1 2-1-1 1D
Cardinals 2 2 0 0.500 82 74 8 1-1-0 1-1-0 0-2-0 2-2-0 2-2-0 2L
Falcons 2 2 0 0.500 76 86 -10 1-1-0 1-1-0 0-2-0 2-2-0 2-2-0 1W
Bears 2 2 0 0.500 101 117 -16 1-1-0 1-1-0 0-2-0 1-2-0 2-2-0 2W
Bengals 2 2 0 0.500 61 119 -58 1-0-0 1-2-0 1-0-0 2-1-0 2-2-0 2L
Broncos 2 2 0 0.500 96 67 29 2-0-0 0-2-0 0-1-0 2-2-0 2-2-0 1W
Chiefs 2 2 0 0.500 97 76 21 1-1-0 1-1-0 0-1-0 1-1-0 2-2-0 2W
Vikings 2 2 0 0.500 102 80 22 1-1-0 1-1-0 1-0-0 1-1-0 2-2-0 1L
Patriots 2 2 0 0.500 102 81 21 1-2-0 1-0-0 1-0-0 1-2-0 2-2-0 1W
Commanders 2 2 0 0.500 107 91 16 2-0-0 0-2-0 1-0-0 1-2-0 2-2-0 1L
Cowboys 1 2 1 0.250 114 132 -18 1-0-1 0-2-0 1-1-0 1-2-1 1-2-1 1D
Ravens 1 3 0 0.250 131 133 -2 1-1-0 0-2-0 1-0-0 1-2-0 1-3-0 2L
Panthers 1 3 0 0.250 75 95 -20 1-0-0 0-3-0 1-0-0 1-1-0 1-3-0 1L
Browns 1 3 0 0.250 56 102 -46 1-1-0 0-2-0 0-2-0 0-2-0 1-3-0 1L
Texans 1 3 0 0.250 64 51 13 1-1-0 0-2-0 1-1-0 1-1-0 1-3-0 1W
Raiders 1 3 0 0.250 77 99 -22 0-2-0 1-1-0 0-1-0 1-1-0 1-3-0 3L
Dolphins 1 3 0 0.250 83 118 -35 1-1-0 0-2-0 1-2-0 1-3-0 1-3-0 1W
Giants 1 3 0 0.250 73 101 -28 1-1-0 0-2-0 0-2-0 0-2-0 1-3-0 1W
Saints 0 4 0 0.000 66 121 -55 0-2-0 0-2-0 0-0-0 0-3-0 0-4-0 4L
Jets 0 4 0 0.000 90 120 -30 0-2-0 0-2-0 0-2-0 0-3-0 0-4-0 4L
Titans 0 4 0 0.000 51 120 -69 0-2-0 0-2-0 0-2-0 0-3-0 0-4-0 4L