49ers vs Rams Prediction, Picks & Odds | 02 Oct 2025

NFL Betting Preview: Niners vs Rams

The San Francisco 49ers battle the Los Angeles Rams in this NFL Week 5 Thursday Night Football matchup at SoFi Stadium, with kickoff scheduled for 20:15 on Thursday, October 2. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

The Rams at -5.5 could be the best bet to have on the spread. Odds of -122 are available and our prediction is a solid win when they go up against the Niners.

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San Francisco 49ers have now enjoyed two consecutive road wins, while their previous game was a 26-21 home loss against Jacksonville Jaguars at Levi's Stadium. The 49ers finished with 389 total yards, made up of 306 through the air and 83 on the ground. They managed 22 first downs and produced 2 touchdowns, with both scores coming by pass.

Los Angeles Rams were winners last time out. Their 27-20 victory against Indianapolis Colts at SoFi Stadium made it back-to-back home wins. The Rams moved the ball for 462 yards, with 360 through the air and 102 on the ground. The offense converted for 24 first downs and produced 3 touchdowns, all coming through the air.

Head-to-Head Statistics

It was the Rams who came out on top when they last played the Niners. At Levi's Stadium, a 12-6 win was recorded. The previous 10 H2H meetings have involved the Niners winning six times.

49ers vs Rams Prediction & Picks

Head into 49ers vs Rams with expert betting insights, including our main match prediction, expected scoreline, key player prop picks and a thoughtfully built bet builder.

Game Prediction

Bet on the Rams against the spread, with an attractive line of -5.5 that the favorites get the job done. There are odds of -122 that are currently on offer for this NFL battle.

The NFL handicappers at Sportsgambler.com stay on top of injuries and team form that could impact the outcome. We also leave no stone unturned when analyzing the latest stats to support every prediction.

Key 49ers vs Rams stats:

• The +5.5 line hasn’t been covered by 49ers in 3 of their last 5 games on the road.

Rams -5.5 Probability

According to the best NFL betting sites, there’s a 54.9% likelihood of our pick delivering a return. Our cappers think there’s a stronger chance of success and calculate the probability to be closer to 60%. This wager can therefore be backed with confidence.

We recommend moving the line if you are looking for bigger odds about the same selection. Take your pick and get the juice that you want from your spread bet in the process.

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Our Game Prediction

Rams -5.5 @ -122 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (02:26, 01 October 2025). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Brock Purdy Under 243.5 Passing Yards -114

You can place a bet on Brock Purdy (Niners) at -114 to finish with fewer than 243.5 passing yards. We’re confident he’ll fall short of the QB Passing Yards line, as the total looks too high.

Latest Brock Purdy Player Prop Odds

Touchdown

Anytime

+1000

First

+5500

Passing Yards

Over 243.5

-114

Under 243.5

-114

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Puka Nacua Anytime TD -105

You can place a bet on Puka Nacua (Rams) to record a TD at -105. Attractive odds are available for this Anytime Touchdown Scorer wager, and we believe it's a value proposition for him to take it to the house.

Latest Puka Nacua Player Prop Odds

Touchdown

Anytime

-105

First

+480

Receiving Yards

Over 95.5

-112

Under 95.5

-112

Rushing Yards

Over 3.5

-108

Under 3.5

-118

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

49ers 14 - 27 Rams

We’re going for the Rams to win by a 27-14 scoreline, something which is available at huge odds. This speculative wager can provide a big return for a small stake.

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49ers vs Rams Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

Sportsbooks’ favorites Los Angeles Rams are regarded as likeliest victors for this game and the -125 about them triumphing means a 56% chance based on their current Moneyline betting odds. For those wanting to back San Francisco 49ers, you will find +105 about the underdogs.

1.5 is the spread and 47.5 is the total points line. Having a wager on the Totals is one of the most popular NFL bets. If you fancy Under 47.5, then the odds are -110.

You can find hundreds of team props and game lines for every National Football League matchup, with the top sportsbooks creating lots of different options. Check out the pre-game and in-game selections before placing your bets.

Moneyline

49ers

+105

Rams

-125

Point Spread

49ers +1.5

-110

Rams -1.5

-110

Total Points

Under 47.5

-110

Over 47.5

-110

The First TD Scorer favorite is Kyren Williams at +400. Similar odds can be found if you’re interested in this player to register the last touchdown.

Touchdown

Kyren Williams (Rams)

First TD

+400

Anytime TD

-161

Puka Nacua (Rams)

First TD

+480

Anytime TD

-105

Christian McCaffrey (49ers)

First TD

+550

Anytime TD

-110

Davante Adams (Rams)

First TD

+600

Anytime TD

+110

Ricky Pearsall (49ers)

First TD

+1100

Anytime TD

+190

Jauan Jennings (49ers)

First TD

+1100

Anytime TD

+190

Blake Corum (Rams)

First TD

+1600

Anytime TD

+290

Kendrick Bourne (49ers)

First TD

+1800

Anytime TD

+350

Demarcus Robinson (49ers)

First TD

+1900

Anytime TD

+360

Tyler Higbee (Rams)

First TD

+2000

Anytime TD

+420

Jordan Whittington (Rams)

First TD

+2000

Anytime TD

+500

Jake Tonges (49ers)

First TD

+2200

Anytime TD

+430

Tutu Atwell (Rams)

First TD

+2700

Anytime TD

+650

Brian Robinson Jr. (49ers)

First TD

+3000

Anytime TD

+650

Davis Allen (Rams)

First TD

+3000

Anytime TD

+550

Kyle Juszczyk (49ers)

First TD

+3500

Anytime TD

+750

Colby Parkinson (Rams)

First TD

+4000

Anytime TD

+800

Brock Purdy (49ers)

First TD

+5500

Anytime TD

+1000

Mac Jones (49ers)

First TD

+6000

Anytime TD

+1200

Luke Farrell (49ers)

First TD

+7000

Anytime TD

+1200

Konata Mumpfield (Rams)

First TD

+8000

Anytime TD

+1800

Matthew Stafford (Rams)

First TD

+8000

Anytime TD

+2000

Xavier Smith (Rams)

First TD

+8000

Anytime TD

+1800

Skyy Moore (49ers)

First TD

+8000

Anytime TD

+1400

Marquez Valdes-Scantling (49ers)

First TD

+8000

Anytime TD

+1400

Terrance Ferguson (Rams)

First TD

+8000

Anytime TD

+1700

Jarquez Hunter (Rams)

First TD

+10000

Anytime TD

+2700

Brayden Willis (49ers)

First TD

+10000

Anytime TD

+2500

James Jordan (49ers)

First TD

+10000

Anytime TD

+4500

Isaac Guerendo (49ers)

First TD

+10000

Anytime TD

+3000

Malik Turner (49ers)

First TD

+10000

Anytime TD

+2700

Receiving Yards

Puka Nacua (Rams)

Over 95.5

-112

Under 95.5

-112

Davante Adams (Rams)

Over 57.5

-112

Under 57.5

-112

Christian McCaffrey (49ers)

Over 53.5

-112

Under 53.5

-112

Kendrick Bourne (49ers)

Over 41.5

-112

Under 41.5

-112

Demarcus Robinson (49ers)

Over 34.5

-112

Under 34.5

-112

Jake Tonges (49ers)

Over 30.5

-112

Under 30.5

-112

Jordan Whittington (Rams)

Over 13.5

-112

Under 13.5

-112

Kyren Williams (Rams)

Over 9.5

-112

Under 9.5

-112

Kyle Juszczyk (49ers)

Over 9.5

-112

Under 9.5

-112

Tutu Atwell (Rams)

Over 8.5

-112

Under 8.5

-112

Rushing Yards

Kyren Williams (Rams)

Over 67.5

-112

Under 67.5

-112

Christian McCaffrey (49ers)

Over 59.5

-112

Under 59.5

-112

Blake Corum (Rams)

Over 31.5

-112

Under 31.5

-112

Brian Robinson Jr. (49ers)

Over 19.5

-112

Under 19.5

-112

Mac Jones (49ers)

Over 4.5

-102

Under 4.5

-123

Puka Nacua (Rams)

Over 3.5

-108

Under 3.5

-118

Matthew Stafford (Rams)

Over 0.5

+120

Under 0.5

-154

Passing Yards

Brock Purdy (49ers)

Over 243.5

-114

Under 243.5

-114

Matthew Stafford (Rams)

Over 234.5

-112

Under 234.5

-112

Mac Jones (49ers)

Over 218.5

-112

Under 218.5

-112

There are always opportunities to enjoy NFL micro betting. It’s generally the case that you will find team and player props in-game and bettors can use their insight to wager on outcomes such as the Next Punt, Turnover or Score Play.

Rams Have Taken Six Wins From Last Ten Home Outings

The Rams own a 6-4 mark in their past 10 home games, putting up 22.70 points per contest and giving up 22.90.

The Niners have four wins and six losses in the last 10 road games, averaging 20.40 points scored and 27.70 points allowed.

The last time the Rams faced the Niners at SoFi Stadium, they won 27-24. In the last 6 head-to-head games at SoFi Stadium, the Niners have notched four victories, with the Rams posting two.

Last 10 Games		W-L	P	PF	PA	O46.5	U46.5
Rams Home Stats		6-4	45.60	22.70	22.90	5	5
49ers Away Stats		4-6	48.10	20.40	27.70	5	5

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O46.5 = Games Over 46.5 Points
• U46.5 = Games Under 46.5 Points

Latest regular season and playoff games stats.

San Francisco 49ers Stats

Los Angeles Rams Stats

Moneyline

• 4 wins and 6 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 games on the road

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 7 wins and 3 defeats in the last 10 home games

Point Spread

• +5.5 Betting Line: Have covered the spread in 5 of the last 10 games
• +5.5 Betting Line on the Road: Have covered the spread in 5 of the last 10 games on the road

Point Spread

• -5.5 Betting Line: Have covered the spread in 5 of the last 10 games
• -5.5 Betting Line at Home: Have covered the spread in 3 of the last 10 home games

Total Points

• Game Totals: An average of 46.00 pts in the previous 10 games
• Game Totals on the Road: An average of 48.10 pts in the previous 10 games on the road
• Over 46.5: Covered in 5 of the previous 10 games
• Over 46.5 on the Road: Covered in 5 of the previous 10 games on the road
• Team Totals: Have scored an average of 20.90 pts and allowed 25.10 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 20.40 pts and allowed 27.70 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 39.00 pts in the previous 10 games
• Game Totals at Home: An average of 44.90 pts in the previous 10 home games
• Over 46.5: Covered in 5 of the previous 10 games
• Over 46.5 at Home: Covered in 5 of the previous 10 home games
• Team Totals: Have scored an average of 21.80 pts and allowed 17.20 pts in the last 10 games
• Team Totals at Home: Have scored an average of 23.50 pts and allowed 21.40 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 363.90 Yds. Allowed 316.30 Yds
• Rushing Yards: Gained 99.30 Yds. Allowed 136.30 Yds
• Passing Yards: Gained 264.60 Yds. Allowed 180.00 Yds
• Total Touchdowns: Scored 2.40 TD. Allowed 2.80 TD
• Rushing Touchdowns: Scored 0.70 TD. Allowed 1.00 TD
• Passing Touchdowns: Scored 1.70 TD. Allowed 1.70 TD
• Total 1st Downs: Picked up 21.10. Allowed 18.80
• Total Turnovers: Committed 1.90. Committed by opponents 0.40
• Total Penalties: Committed 6.60. Committed by opponents 5.30
• Penalty Yards: Lost 49.50 Yds. Gained 40.70 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 345.10 Yds. Allowed 300.10 Yds
• Rushing Yards: Gained 111.00 Yds. Allowed 116.20 Yds
• Passing Yards: Gained 234.10 Yds. Allowed 183.90 Yds
• Total Touchdowns: Scored 2.10 TD. Allowed 1.80 TD
• Rushing Touchdowns: Scored 0.50 TD. Allowed 0.50 TD
• Passing Touchdowns: Scored 1.50 TD. Allowed 1.20 TD
• Total 1st Downs: Picked up 18.30. Allowed 17.80
• Total Turnovers: Committed 0.80. Committed by opponents 1.40
• Total Penalties: Committed 5.30. Committed by opponents 6.60
• Penalty Yards: Lost 45.90 Yds. Gained 48.60 Yds

Last 10 Games on the Road

• Total Yards: Gained 373.80 Yds. Allowed 327.20 Yds
• Rushing Yards: Gained 115.40 Yds. Allowed 131.90 Yds
• Passing Yards: Gained 258.40 Yds. Allowed 195.30 Yds
• Total Touchdowns: Scored 2.30 TD. Allowed 3.20 TD
• Rushing Touchdowns: Scored 0.40 TD. Allowed 1.40 TD
• Passing Touchdowns: Scored 1.90 TD. Allowed 1.70 TD
• Total 1st Downs: Picked up 21.30. Allowed 20.10
• Total Turnovers: Committed 1.70. Committed by opponents 0.80
• Total Penalties: Committed 7.10. Committed by opponents 5.70
• Penalty Yards: Lost 49.10 Yds. Gained 43.90 Yds

Last 10 Home Games

• Total Yards: Gained 342.90 Yds. Allowed 335.60 Yds
• Rushing Yards: Gained 93.70 Yds. Allowed 121.40 Yds
• Passing Yards: Gained 249.20 Yds. Allowed 214.20 Yds
• Total Touchdowns: Scored 2.70 TD. Allowed 2.20 TD
• Rushing Touchdowns: Scored 0.80 TD. Allowed 0.80 TD
• Passing Touchdowns: Scored 1.60 TD. Allowed 1.40 TD
• Total 1st Downs: Picked up 20.20. Allowed 19.80
• Total Turnovers: Committed 0.80. Committed by opponents 1.50
• Total Penalties: Committed 6.10. Committed by opponents 6.70
• Penalty Yards: Lost 54.30 Yds. Gained 52.90 Yds

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