San Francisco 49ers
American Football NFL Caesars Superdome Sun 14 Sep 13:00
New Orleans Saints
  1. Prediction
  2. Bet Builder
  3. Odds
  4. Player Props
  5. Stats
  6. Live Stream
  7. Team News
  8. Lineups
  9. Injuries
  10. Standings

NFL Betting Preview: Niners vs Saints

The San Francisco 49ers battle the New Orleans Saints in this NFL Week 2 matchup at Caesars Superdome, with kickoff scheduled for 13:00 on Sunday 14 September. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

Saints to Frustrate Niners

There’s some excellent value on the spread and we like the Saints +3. We’re very happy to take them with this advantage against the Niners at -105.

Thinking we’re on the right side of the line? Learn more about BetMGM in our comprehensive review, then access the latest promo code to add more value.

Niners 13-0 Win in Last H2H Matchup

San Francisco 49ers got the win in their previous game. A 17-13 triumph occurred on the road at Lumen Field when playing Seattle Seahawks. The 49ers totaled 384 yards, with 265 through the air and 119 on the ground. The offense produced 24 first downs and scored two touchdowns.

New Orleans Saints lost when they last took to the field. At Caesars Superdome, they were turned over 20-13 at home to Arizona Cardinals. The Saints generated 315 total yards, made up of 208 passing and 107 rushing yards. They scored one touchdown and moved the chains 21 times.

Head-to-Head Statistics

The Niners triumphed 13-0 when they last played the Saints. This head-to-head was played at Levi's Stadium. The previous 3 games featuring these teams have resulted in two Niners victories.

49ers vs Saints Prediction & Picks

Tackle 49ers vs Saints with all the betting insight you need, including our match prediction, scoreline forecast, key player prop selections and a hand-picked bet builder.

Game Prediction

The Saints should give a good account of themselves in this NFL showdown and the pick is to back them on the spread. The +3 looks very attractive and -105 is available.

Injuries can influence the outcome and our NFL handicappers factor that in alongside the latest form guide. We apply the same approach to the stats to build the clearest picture of how the game might unfold.

Key 49ers vs Saints stats:

  • The +3 line has been covered by Saints in 12 of their last 20 games at home.
  • The -3 line hasn’t been covered by 49ers in 4 of their last 5 games.
  • The -3 line hasn’t been covered by 49ers in 7 of their last 10 games.
  • The +3 line has been covered by Saints in 2 of their last 3 games against 49ers.

Saints +3 Probability

The best NFL sportsbooks are suggesting that our pick has a 51.3% chance of landing a return. In the opinion of our analysts, there’s actually a probability of success closer to 60%. It is therefore regarded as a value bet.

Looking for Bigger Odds?

It’s good to explore all avenues and you might prefer bigger odds about the selection you want to make. Go ahead and move the line until you’re happy with the price.

Before you place your bets, explore our updated guide packed with the latest free bets and betting bonuses.

Best Bet

Saints +3 @ -105 Watch Live Bet Now BetMGM logo
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Published 19:26, 12 September 2025

Player Prop Picks

Top Pick: Spencer Rattler Over 205.5 Passing Yards -114 BetMGM logo

Spencer Rattler (Saints) can be backed at -114 to reach over 205.5 passing yards. The line for him on the Overs is highly appealing, with QB Passing Yards bettors able to get plenty of juice.

Latest Spencer Rattler Player Prop Odds

Same Game Parlay Picks

Spread Saints +3
Totals Over 40.5
Passing Yards Spencer Rattler Over 205.5

Try out our same game parlay pick which starts with Saints +3. We’ve also gone for Over 40.5 points and Spencer Rattler (Saints) to have Over 205.5 passing yards.

The same game parlay option allows you to combine different outcomes within the same football game. You need all your picks to be correct although bettors love to place a tailored wager on the clash which interests them most.

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Correct Score Prediction

49ers 49ers logo 21 - 23 Saints logo Saints

We’re expecting this to be a close battle and we’ll take the Saints to win 23-21. This is available at huge odds for those that want to have a speculative wager.

49ers vs Saints Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Books Expecting a Niners Victory

San Francisco 49ers are regarded as having a 63% chance of winning this game according to the latest betting odds. The sportsbooks have priced them up at -167. If you’re looking for an alternative angle, New Orleans Saints are trading at +140.

The current spread is 3 and total points is 40.5. There is no denying the popularity of betting on the Totals. Those expecting a low total can back Under 40.5 at -110.

Whether you are wagering pre-game or in-game on the National Football League, the best betting apps offer a wide range of game lines and team props. The selections are practically endless and it’s great to have so many different options.

Christian McCaffrey Favorite to Be First TD Scorer

The Anytime Touchdown betting indicates that Christian McCaffrey has odds of %anytime_odds%. He is available at %first_odds% to score the first TD which makes him favorite.

Touchdown

Christian McCaffrey (49ers)
First TD
+290
Anytime TD
-200
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Alvin Kamara (Saints)
First TD
+450
Anytime TD
-130
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Ricky Pearsall (49ers)
First TD
+1000
Anytime TD
+210
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Receiving Yards

Ricky Pearsall (49ers)
Over 57.5
-114
Under 57.5
-114
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Rashid Shaheed (Saints)
Over 42.5
-114
Under 42.5
-114
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Juwan Johnson (Saints)
Over 38.5
-114
Under 38.5
-114
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Rushing Yards

Christian McCaffrey (49ers)
Over 78.5
-114
Under 78.5
-114
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Alvin Kamara (Saints)
Over 48.5
-114
Under 48.5
-114
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Spencer Rattler (Saints)
Over 16.5
-114
Under 16.5
-114
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Best Betting Offers
Caesars Superdome
Caesars Superdome

Saints Have Fallen in Four Successive Home Matches

The Saints have suffered four defeats in a row at Caesars Superdome. They have gone 3-7 across their last 10 home games, putting up 20.70 points on average and giving up 22.60.

The Niners have a 3-7 record in their last 10 road games, putting up 20.00 points per contest and giving up 28.10.

When the teams last met at Caesars Superdome, the Saints beat the Niners 27-13.

Last 10 Games W-L P PF PA O40.5 U40.5
Saints logo Saints Home Stats 3-7 43.30 20.70 22.60 4 6
49ers logo 49ers Away Stats 3-7 48.10 20.00 28.10 8 2
  • W-L = Wins-Losses
  • P = Avg. Points
  • PF = Avg. Points For
  • PA = Avg. Points Against
  • O40.5 = Games Over 40.5 Points
  • U40.5 = Games Under 40.5 Points
Team Stats

Latest regular season and playoff games stats.

San Francisco 49ers logo San Francisco 49ers Stats
New Orleans Saints logo New Orleans Saints Stats
Moneyline
  • 3 wins and 7 defeats in the last 10 games
  • 3 wins and 7 defeats in the last 10 games on the road
Moneyline
  • 3 wins and 7 defeats in the last 10 games
  • 3 wins and 7 defeats in the last 10 home games
Point Spread
Point Spread
Total Points
Total Points
Game Stats
Last 10 Games
Game Stats
Last 10 Games
Last 10 Games on the Road
Last 10 Home Games

Live Streaming

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Team News

San Francisco 49ers Injuries

Type
Name
Info
Brandon Aiyuk
Knee - ACL + MCL
Isaac Alarcon
Suspension
Jacob Cowing
Hamstring
Kevin Givens
Pectoral
Tarron Jackson
Undisclosed
Jauan Jennings
Shoulder
George Kittle
Hamstring
Malik Mustapha
Knee - ACL
Brock Purdy
Toe
Demarcus Robinson
Suspension
Jakob Robinson
Forearm
Kurtis Rourke
Knee
Patrick Taylor
Shoulder
Trent Taylor
Undisclosed
Tre Tomlinson
Undisclosed
Trent Williams
Knee

New Orleans Saints Injuries

Type
Name
Info
Julian Blackmon
Shoulder - Labrum
Derek Carr
Shoulder
Will Clapp
Foot
Taliese Fuaga
Knee
Taysom Hill
Knee - ACL
Tyrann Mathieu
Undisclosed
Bub Means
Lower Leg
Foster Moreau
Knee
Trevor Penning
Toe
Mason Pline
Upper Body
Ryan Ramczyk
Undisclosed
John Ridgeway
Pectoral
Nick Saldiveri
Knee
Barry Wesley
Undisclosed
Chase Young
Calf
Landon Young
Ankle

Previous San Francisco 49ers Lineups

07 Sep NFL
49ers 17-13 Seahawks
05 Jan NFL
49ers 24-47 Cardinals
30 Dec NFL
Lions 40-34 49ers
22 Dec NFL
49ers 17-29 Dolphins
12 Dec NFL
Rams 12-6 49ers
08 Dec NFL
Bears 13-38 49ers
01 Dec NFL
49ers 10-35 Bills
24 Nov NFL
49ers 10-38 Packers
17 Nov NFL
Seahawks 20-17 49ers
10 Nov NFL
49ers 23-20 Buccaneers

Previous New Orleans Saints Lineups

07 Sep NFL
Cardinals 20-13 Saints
05 Jan NFL
Saints 19-27 Buccaneers
29 Dec NFL
Raiders 25-10 Saints
23 Dec NFL
Saints 0-34 Packers
15 Dec NFL
Commanders 20-19 Saints
08 Dec NFL
Saints 14-11 Giants
01 Dec NFL
Rams 21-14 Saints
17 Nov NFL
Browns 14-35 Saints
10 Nov NFL
Falcons 17-20 Saints
03 Nov NFL
Saints 22-23 Panthers

NFL Standings Select Season

AFC East W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Bills 1 0 0 1.000 41 40 1 1-0-0 0-0-0 0-0-0 1-0-0 1-0-0 1W
Jets 0 1 0 0.000 32 34 -2 0-1-0 0-0-0 0-0-0 0-1-0 0-1-0 1L
Patriots 0 1 0 0.000 13 20 -7 0-1-0 0-0-0 0-0-0 0-1-0 0-1-0 1L
Dolphins 0 1 0 0.000 8 33 -25 0-0-0 0-1-0 0-0-0 0-1-0 0-1-0 1L
AFC North W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Bengals 1 0 0 1.000 17 16 1 0-0-0 1-0-0 1-0-0 1-0-0 1-0-0 1W
Steelers 1 0 0 1.000 34 32 2 0-0-0 1-0-0 0-0-0 1-0-0 1-0-0 1W
Ravens 0 1 0 0.000 40 41 -1 0-0-0 0-1-0 0-0-0 0-1-0 0-1-0 1L
Browns 0 1 0 0.000 16 17 -1 0-1-0 0-0-0 0-1-0 0-1-0 0-1-0 1L
AFC South W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Colts 1 0 0 1.000 33 8 25 1-0-0 0-0-0 0-0-0 1-0-0 1-0-0 1W
Jaguars 1 0 0 1.000 26 10 16 1-0-0 0-0-0 0-0-0 0-0-0 1-0-0 1W
Texans 0 1 0 0.000 9 14 -5 0-0-0 0-1-0 0-0-0 0-0-0 0-1-0 1L
Titans 0 1 0 0.000 12 20 -8 0-0-0 0-1-0 0-0-0 0-1-0 0-1-0 1L
AFC West W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Chargers 1 0 0 1.000 27 21 6 1-0-0 0-0-0 1-0-0 1-0-0 1-0-0 1W
Broncos 1 0 0 1.000 20 12 8 1-0-0 0-0-0 0-0-0 1-0-0 1-0-0 1W
Raiders 1 0 0 1.000 20 13 7 0-0-0 1-0-0 0-0-0 1-0-0 1-0-0 1W
Chiefs 0 1 0 0.000 21 27 -6 0-0-0 0-1-0 0-1-0 0-1-0 0-1-0 1L
NFC East W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Eagles 1 0 0 1.000 24 20 4 1-0-0 0-0-0 1-0-0 1-0-0 1-0-0 1W
Commanders 1 1 0 0.500 39 33 6 1-0-0 0-1-0 1-0-0 1-1-0 1-1-0 1L
Cowboys 0 1 0 0.000 20 24 -4 0-0-0 0-1-0 0-1-0 0-1-0 0-1-0 1L
Giants 0 1 0 0.000 6 21 -15 0-0-0 0-1-0 0-1-0 0-1-0 0-1-0 1L
NFC North W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Packers 2 0 0 1.000 54 31 23 2-0-0 0-0-0 1-0-0 2-0-0 2-0-0 2W
Vikings 1 0 0 1.000 27 24 3 0-0-0 1-0-0 1-0-0 1-0-0 1-0-0 1W
Bears 0 1 0 0.000 24 27 -3 0-1-0 0-0-0 0-1-0 0-1-0 0-1-0 1L
Lions 0 1 0 0.000 13 27 -14 0-0-0 0-1-0 0-1-0 0-1-0 0-1-0 1L
NFC South W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Buccaneers 1 0 0 1.000 23 20 3 0-0-0 1-0-0 1-0-0 1-0-0 1-0-0 1W
Falcons 0 1 0 0.000 20 23 -3 0-1-0 0-0-0 0-1-0 0-1-0 0-1-0 1L
Saints 0 1 0 0.000 13 20 -7 0-1-0 0-0-0 0-0-0 0-1-0 0-1-0 1L
Panthers 0 1 0 0.000 10 26 -16 0-0-0 0-1-0 0-0-0 0-0-0 0-1-0 1L
NFC West W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
49ers 1 0 0 1.000 17 13 4 0-0-0 1-0-0 1-0-0 1-0-0 1-0-0 1W
Cardinals 1 0 0 1.000 20 13 7 0-0-0 1-0-0 0-0-0 1-0-0 1-0-0 1W
Rams 1 0 0 1.000 14 9 5 1-0-0 0-0-0 0-0-0 0-0-0 1-0-0 1W
Seahawks 0 1 0 0.000 13 17 -4 0-1-0 0-0-0 0-1-0 0-1-0 0-1-0 1L
AFC Conference W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Colts 1 0 0 1.000 33 8 25 1-0-0 0-0-0 0-0-0 1-0-0 1-0-0 1W
Bills 1 0 0 1.000 41 40 1 1-0-0 0-0-0 0-0-0 1-0-0 1-0-0 1W
Chargers 1 0 0 1.000 27 21 6 1-0-0 0-0-0 1-0-0 1-0-0 1-0-0 1W
Bengals 1 0 0 1.000 17 16 1 0-0-0 1-0-0 1-0-0 1-0-0 1-0-0 1W
Broncos 1 0 0 1.000 20 12 8 1-0-0 0-0-0 0-0-0 1-0-0 1-0-0 1W
Steelers 1 0 0 1.000 34 32 2 0-0-0 1-0-0 0-0-0 1-0-0 1-0-0 1W
Raiders 1 0 0 1.000 20 13 7 0-0-0 1-0-0 0-0-0 1-0-0 1-0-0 1W
Jaguars 1 0 0 1.000 26 10 16 1-0-0 0-0-0 0-0-0 0-0-0 1-0-0 1W
Dolphins 0 1 0 0.000 8 33 -25 0-0-0 0-1-0 0-0-0 0-1-0 0-1-0 1L
Browns 0 1 0 0.000 16 17 -1 0-1-0 0-0-0 0-1-0 0-1-0 0-1-0 1L
Patriots 0 1 0 0.000 13 20 -7 0-1-0 0-0-0 0-0-0 0-1-0 0-1-0 1L
Titans 0 1 0 0.000 12 20 -8 0-0-0 0-1-0 0-0-0 0-1-0 0-1-0 1L
Ravens 0 1 0 0.000 40 41 -1 0-0-0 0-1-0 0-0-0 0-1-0 0-1-0 1L
Chiefs 0 1 0 0.000 21 27 -6 0-0-0 0-1-0 0-1-0 0-1-0 0-1-0 1L
Jets 0 1 0 0.000 32 34 -2 0-1-0 0-0-0 0-0-0 0-1-0 0-1-0 1L
Texans 0 1 0 0.000 9 14 -5 0-0-0 0-1-0 0-0-0 0-0-0 0-1-0 1L
NFC Conference W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Packers 2 0 0 1.000 54 31 23 2-0-0 0-0-0 1-0-0 2-0-0 2-0-0 2W
Eagles 1 0 0 1.000 24 20 4 1-0-0 0-0-0 1-0-0 1-0-0 1-0-0 1W
Buccaneers 1 0 0 1.000 23 20 3 0-0-0 1-0-0 1-0-0 1-0-0 1-0-0 1W
49ers 1 0 0 1.000 17 13 4 0-0-0 1-0-0 1-0-0 1-0-0 1-0-0 1W
Cardinals 1 0 0 1.000 20 13 7 0-0-0 1-0-0 0-0-0 1-0-0 1-0-0 1W
Vikings 1 0 0 1.000 27 24 3 0-0-0 1-0-0 1-0-0 1-0-0 1-0-0 1W
Rams 1 0 0 1.000 14 9 5 1-0-0 0-0-0 0-0-0 0-0-0 1-0-0 1W
Commanders 1 1 0 0.500 39 33 6 1-0-0 0-1-0 1-0-0 1-1-0 1-1-0 1L
Panthers 0 1 0 0.000 10 26 -16 0-0-0 0-1-0 0-0-0 0-0-0 0-1-0 1L
Saints 0 1 0 0.000 13 20 -7 0-1-0 0-0-0 0-0-0 0-1-0 0-1-0 1L
Giants 0 1 0 0.000 6 21 -15 0-0-0 0-1-0 0-1-0 0-1-0 0-1-0 1L
Lions 0 1 0 0.000 13 27 -14 0-0-0 0-1-0 0-1-0 0-1-0 0-1-0 1L
Falcons 0 1 0 0.000 20 23 -3 0-1-0 0-0-0 0-1-0 0-1-0 0-1-0 1L
Seahawks 0 1 0 0.000 13 17 -4 0-1-0 0-0-0 0-1-0 0-1-0 0-1-0 1L
Bears 0 1 0 0.000 24 27 -3 0-1-0 0-0-0 0-1-0 0-1-0 0-1-0 1L
Cowboys 0 1 0 0.000 20 24 -4 0-0-0 0-1-0 0-1-0 0-1-0 0-1-0 1L
NFL Team W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Cardinals 1 0 0 1.000 20 13 7 0-0-0 1-0-0 0-0-0 1-0-0 1-0-0 1W
Bills 1 0 0 1.000 41 40 1 1-0-0 0-0-0 0-0-0 1-0-0 1-0-0 1W
Bengals 1 0 0 1.000 17 16 1 0-0-0 1-0-0 1-0-0 1-0-0 1-0-0 1W
Broncos 1 0 0 1.000 20 12 8 1-0-0 0-0-0 0-0-0 1-0-0 1-0-0 1W
Colts 1 0 0 1.000 33 8 25 1-0-0 0-0-0 0-0-0 1-0-0 1-0-0 1W
Jaguars 1 0 0 1.000 26 10 16 1-0-0 0-0-0 0-0-0 0-0-0 1-0-0 1W
Raiders 1 0 0 1.000 20 13 7 0-0-0 1-0-0 0-0-0 1-0-0 1-0-0 1W
Chargers 1 0 0 1.000 27 21 6 1-0-0 0-0-0 1-0-0 1-0-0 1-0-0 1W
Rams 1 0 0 1.000 14 9 5 1-0-0 0-0-0 0-0-0 0-0-0 1-0-0 1W
Vikings 1 0 0 1.000 27 24 3 0-0-0 1-0-0 1-0-0 1-0-0 1-0-0 1W
Eagles 1 0 0 1.000 24 20 4 1-0-0 0-0-0 1-0-0 1-0-0 1-0-0 1W
Steelers 1 0 0 1.000 34 32 2 0-0-0 1-0-0 0-0-0 1-0-0 1-0-0 1W
49ers 1 0 0 1.000 17 13 4 0-0-0 1-0-0 1-0-0 1-0-0 1-0-0 1W
Buccaneers 1 0 0 1.000 23 20 3 0-0-0 1-0-0 1-0-0 1-0-0 1-0-0 1W
Packers 2 0 0 1.000 54 31 23 2-0-0 0-0-0 1-0-0 2-0-0 2-0-0 2W
Commanders 1 1 0 0.500 39 33 6 1-0-0 0-1-0 1-0-0 1-1-0 1-1-0 1L
Falcons 0 1 0 0.000 20 23 -3 0-1-0 0-0-0 0-1-0 0-1-0 0-1-0 1L
Ravens 0 1 0 0.000 40 41 -1 0-0-0 0-1-0 0-0-0 0-1-0 0-1-0 1L
Panthers 0 1 0 0.000 10 26 -16 0-0-0 0-1-0 0-0-0 0-0-0 0-1-0 1L
Bears 0 1 0 0.000 24 27 -3 0-1-0 0-0-0 0-1-0 0-1-0 0-1-0 1L
Browns 0 1 0 0.000 16 17 -1 0-1-0 0-0-0 0-1-0 0-1-0 0-1-0 1L
Cowboys 0 1 0 0.000 20 24 -4 0-0-0 0-1-0 0-1-0 0-1-0 0-1-0 1L
Lions 0 1 0 0.000 13 27 -14 0-0-0 0-1-0 0-1-0 0-1-0 0-1-0 1L
Texans 0 1 0 0.000 9 14 -5 0-0-0 0-1-0 0-0-0 0-0-0 0-1-0 1L
Chiefs 0 1 0 0.000 21 27 -6 0-0-0 0-1-0 0-1-0 0-1-0 0-1-0 1L
Dolphins 0 1 0 0.000 8 33 -25 0-0-0 0-1-0 0-0-0 0-1-0 0-1-0 1L
Patriots 0 1 0 0.000 13 20 -7 0-1-0 0-0-0 0-0-0 0-1-0 0-1-0 1L
Saints 0 1 0 0.000 13 20 -7 0-1-0 0-0-0 0-0-0 0-1-0 0-1-0 1L
Giants 0 1 0 0.000 6 21 -15 0-0-0 0-1-0 0-1-0 0-1-0 0-1-0 1L
Jets 0 1 0 0.000 32 34 -2 0-1-0 0-0-0 0-0-0 0-1-0 0-1-0 1L
Seahawks 0 1 0 0.000 13 17 -4 0-1-0 0-0-0 0-1-0 0-1-0 0-1-0 1L
Titans 0 1 0 0.000 12 20 -8 0-0-0 0-1-0 0-0-0 0-1-0 0-1-0 1L