49ers vs Saints Prediction, Picks & Odds | 14 Sep 2025

NFL Betting Preview: Niners vs Saints

The San Francisco 49ers battle the New Orleans Saints in this NFL Week 2 matchup at Caesars Superdome, with kickoff scheduled for 13:00 on Sunday, September 14. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

There’s some excellent value on the spread and we like the Saints +3. We’re very happy to take them with this advantage against the Niners at -105.

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San Francisco 49ers got the win in their previous game. A 17-13 triumph occurred on the road at Lumen Field when playing Seattle Seahawks. The 49ers totaled 384 yards, with 265 through the air and 119 on the ground. The offense produced 24 first downs and scored two touchdowns.

New Orleans Saints lost when they last took to the field. At Caesars Superdome, they were turned over 20-13 at home to Arizona Cardinals. The Saints generated 315 total yards, made up of 208 passing and 107 rushing yards. They scored one touchdown and moved the chains 21 times.

Head-to-Head Statistics

The Niners triumphed 13-0 when they last played the Saints. This head-to-head was played at Levi's Stadium. The previous 3 games featuring these teams have resulted in two Niners victories.

49ers vs Saints Prediction & Picks

Tackle 49ers vs Saints with all the betting insight you need, including our match prediction, scoreline forecast, key player prop selections and a hand-picked bet builder.

Game Prediction

The Saints should give a good account of themselves in this NFL showdown and the pick is to back them on the spread. The +3 looks very attractive and -105 is available.

Injuries can influence the outcome and our NFL handicappers factor that in alongside the latest form guide. We apply the same approach to the stats to build the clearest picture of how the game might unfold.

Key 49ers vs Saints stats:

• The +3 line has been covered by Saints in 12 of their last 20 games at home.
• The -3 line hasn’t been covered by 49ers in 4 of their last 5 games.
• The -3 line hasn’t been covered by 49ers in 7 of their last 10 games.
• The +3 line has been covered by Saints in 2 of their last 3 games against 49ers.

Saints +3 Probability

The best NFL sportsbooks are suggesting that our pick has a 51.3% chance of landing a return. In the opinion of our analysts, there’s actually a probability of success closer to 60%. It is therefore regarded as a value bet.

It’s good to explore all avenues and you might prefer bigger odds about the selection you want to make. Go ahead and move the line until you’re happy with the price.

Before you place your bets, explore our updated guide packed with the latest free bets and betting bonuses.

Our Game Prediction

Saints +3 @ -105 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (19:26, 12 September 2025). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Spencer Rattler Over 205.5 Passing Yards -114

Spencer Rattler (Saints) can be backed at -114 to reach over 205.5 passing yards. The line for him on the Overs is highly appealing, with QB Passing Yards bettors able to get plenty of juice.

Latest Spencer Rattler Player Prop Odds

Touchdown

Anytime

+490

First

+2000

Passing Yards

Over 203.5

-112

Under 203.5

-112

Rushing Yards

Over 18.5

-112

Under 18.5

-112

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

49ers 21 - 23 Saints

We’re expecting this to be a close battle and we’ll take the Saints to win 23-21. This is available at huge odds for those that want to have a speculative wager.

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49ers vs Saints Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

San Francisco 49ers are regarded as having a 61% chance of winning this game according to the latest betting odds. The sportsbooks have priced them up at -154. If you’re looking for an alternative angle, New Orleans Saints are trading at +130.

The current spread is 3 and total points is 40.5. There is no denying the popularity of betting on the Totals. Those expecting a low total can back Under 40.5 at -110.

Whether you are wagering pre-game or in-game on the National Football League, the best betting apps offer a wide range of game lines and team props. The selections are practically endless and it’s great to have so many different options.

Moneyline

49ers

-154

Saints

+130

Point Spread

49ers -3

-104

Saints +3

-118

Total Points

Under 40.5

-110

Over 40.5

-110

The Anytime Touchdown betting indicates that Christian McCaffrey has odds of %anytime_odds%. He is available at %first_odds% to score the first TD which makes him favorite.

Touchdown

Christian McCaffrey (49ers)

First TD

+320

Anytime TD

-175

Alvin Kamara (Saints)

First TD

+420

Anytime TD

-135

Ricky Pearsall (49ers)

First TD

+1100

Anytime TD

+240

Chris Olave (Saints)

First TD

+1200

Anytime TD

+230

Jauan Jennings (49ers)

First TD

+1500

Anytime TD

+340

Rashid Shaheed (Saints)

First TD

+1600

Anytime TD

+360

Juwan Johnson (Saints)

First TD

+1800

Anytime TD

+400

Spencer Rattler (Saints)

First TD

+2000

Anytime TD

+490

Brian Robinson Jr. (49ers)

First TD

+2200

Anytime TD

+500

Kyle Juszczyk (49ers)

First TD

+2200

Anytime TD

+500

Kendre Miller (Saints)

First TD

+2500

Anytime TD

+550

Jake Tonges (49ers)

First TD

+2700

Anytime TD

+600

Brandin Cooks (Saints)

First TD

+3000

Anytime TD

+700

Luke Farrell (49ers)

First TD

+4000

Anytime TD

+1100

Isaac Guerendo (49ers)

First TD

+6500

Anytime TD

+1500

Trey Palmer (Saints)

First TD

+6500

Anytime TD

+1600

Devaughn Vele (Saints)

First TD

+6500

Anytime TD

+1600

Devin Neal (Saints)

First TD

+8000

Anytime TD

+1900

Jordan Watkins (49ers)

First TD

+10000

Anytime TD

+2700

Skyy Moore (49ers)

First TD

+10000

Anytime TD

+3500

Jack Stoll (Saints)

First TD

+10000

Anytime TD

+3000

Moliki Matavao (Saints)

First TD

+10000

Anytime TD

+3500

Mason Tipton (Saints)

First TD

+10000

Anytime TD

+4000

Brayden Willis (49ers)

First TD

+10000

Anytime TD

+3000

Velus Jones Jr. (Saints)

First TD

+10000

Anytime TD

+3300

Receiving Yards

Ricky Pearsall (49ers)

Over 58.5

-112

Under 58.5

-112

Chris Olave (Saints)

Over 56.5

-112

Under 56.5

-112

Rashid Shaheed (Saints)

Over 41.5

-112

Under 41.5

-112

Jauan Jennings (49ers)

Over 38.5

-112

Under 38.5

-112

Juwan Johnson (Saints)

Over 34.5

-112

Under 34.5

-112

Christian McCaffrey (49ers)

Over 34.5

-112

Under 34.5

-112

Alvin Kamara (Saints)

Over 23.5

-112

Under 23.5

-112

Jake Tonges (49ers)

Over 16.5

-112

Under 16.5

-112

Brandin Cooks (Saints)

Over 15.5

-112

Under 15.5

-112

Kyle Juszczyk (49ers)

Over 11.5

-112

Under 11.5

-112

Rushing Yards

Christian McCaffrey (49ers)

Over 78.5

-112

Under 78.5

-112

Alvin Kamara (Saints)

Over 48.5

-112

Under 48.5

-112

Brian Robinson Jr. (49ers)

Over 27.5

-112

Under 27.5

-112

Spencer Rattler (Saints)

Over 18.5

-112

Under 18.5

-112

Kendre Miller (Saints)

Over 16.5

-112

Under 16.5

-112

Among the various options for wagering on the NFL, you will find that micro betting is provided. It focuses on short-term in-game outcomes such as whether a touchdown will be scored within the next 10 minutes.

Saints Have Fallen in Four Successive Home Matches

The Saints have suffered four defeats in a row at Caesars Superdome. They have gone 3-7 across their last 10 home games, putting up 20.70 points on average and giving up 22.60.

The Niners have a 3-7 record in their last 10 road games, putting up 20.00 points per contest and giving up 28.10.

When the teams last met at Caesars Superdome, the Saints beat the Niners 27-13.

Last 10 Games		W-L	P	PF	PA	O40.5	U40.5
Saints Home Stats		3-7	43.30	20.70	22.60	4	6
49ers Away Stats		3-7	48.10	20.00	28.10	8	2

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O40.5 = Games Over 40.5 Points
• U40.5 = Games Under 40.5 Points

Latest regular season and playoff games stats.

San Francisco 49ers Stats

New Orleans Saints Stats

Moneyline

• 3 wins and 7 defeats in the last 10 games
• 3 wins and 7 defeats in the last 10 games on the road

Moneyline

• 3 wins and 7 defeats in the last 10 games
• 3 wins and 7 defeats in the last 10 home games

Point Spread

• -3 Betting Line: Have covered the spread in 3 of the last 10 games
• -3 Betting Line on the Road: Have covered the spread in 3 of the last 10 games on the road

Point Spread

• +3 Betting Line: Have covered the spread in 5 of the last 10 games
• +3 Betting Line at Home: Have covered the spread in 5 of the last 10 home games

Total Points

• Game Totals: An average of 46.30 pts in the previous 10 games
• Game Totals on the Road: An average of 48.10 pts in the previous 10 games on the road
• Over 40.5: Covered in 7 of the previous 10 games
• Over 40.5 on the Road: Covered in 8 of the previous 10 games on the road
• Team Totals: Have scored an average of 19.60 pts and allowed 26.70 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 20.00 pts and allowed 28.10 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 37.80 pts in the previous 10 games
• Game Totals at Home: An average of 43.30 pts in the previous 10 home games
• Over 40.5: Covered in 3 of the previous 10 games
• Over 40.5 at Home: Covered in 4 of the previous 10 home games
• Team Totals: Have scored an average of 16.60 pts and allowed 21.20 pts in the last 10 games
• Team Totals at Home: Have scored an average of 20.70 pts and allowed 22.60 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 348.20 Yds. Allowed 310.60 Yds
• Rushing Yards: Gained 101.00 Yds. Allowed 135.70 Yds
• Passing Yards: Gained 247.20 Yds. Allowed 174.90 Yds
• Total Touchdowns: Scored 2.30 TD. Allowed 3.00 TD
• Rushing Touchdowns: Scored 0.80 TD. Allowed 1.50 TD
• Passing Touchdowns: Scored 1.50 TD. Allowed 1.50 TD
• Total 1st Downs: Picked up 20.30. Allowed 19.20
• Total Turnovers: Committed 1.90. Committed by opponents 0.40
• Total Penalties: Committed 7.40. Committed by opponents 4.20
• Penalty Yards: Lost 51.20 Yds. Gained 34.40 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 320.10 Yds. Allowed 359.80 Yds
• Rushing Yards: Gained 113.00 Yds. Allowed 140.10 Yds
• Passing Yards: Gained 207.10 Yds. Allowed 219.20 Yds
• Total Touchdowns: Scored 1.80 TD. Allowed 2.40 TD
• Rushing Touchdowns: Scored 0.60 TD. Allowed 1.00 TD
• Passing Touchdowns: Scored 1.10 TD. Allowed 1.40 TD
• Total 1st Downs: Picked up 17.90. Allowed 20.80
• Total Turnovers: Committed 0.80. Committed by opponents 0.40
• Total Penalties: Committed 7.50. Committed by opponents 6.90
• Penalty Yards: Lost 63.10 Yds. Gained 56.40 Yds

Last 10 Games on the Road

• Total Yards: Gained 377.60 Yds. Allowed 342.60 Yds
• Rushing Yards: Gained 118.70 Yds. Allowed 132.70 Yds
• Passing Yards: Gained 258.90 Yds. Allowed 209.90 Yds
• Total Touchdowns: Scored 2.20 TD. Allowed 3.10 TD
• Rushing Touchdowns: Scored 0.40 TD. Allowed 1.40 TD
• Passing Touchdowns: Scored 1.80 TD. Allowed 1.60 TD
• Total 1st Downs: Picked up 21.30. Allowed 20.40
• Total Turnovers: Committed 1.80. Committed by opponents 0.90
• Total Penalties: Committed 7.20. Committed by opponents 5.60
• Penalty Yards: Lost 49.10 Yds. Gained 44.90 Yds

Last 10 Home Games

• Total Yards: Gained 316.60 Yds. Allowed 386.40 Yds
• Rushing Yards: Gained 115.70 Yds. Allowed 157.40 Yds
• Passing Yards: Gained 200.90 Yds. Allowed 228.50 Yds
• Total Touchdowns: Scored 2.20 TD. Allowed 2.60 TD
• Rushing Touchdowns: Scored 0.70 TD. Allowed 1.10 TD
• Passing Touchdowns: Scored 1.40 TD. Allowed 1.40 TD
• Total 1st Downs: Picked up 17.10. Allowed 21.70
• Total Turnovers: Committed 1.20. Committed by opponents 1.00
• Total Penalties: Committed 6.90. Committed by opponents 6.50
• Penalty Yards: Lost 59.00 Yds. Gained 50.50 Yds

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