49ers vs Giants Prediction, Picks & Odds | 02 Nov 2025

NFL Betting Preview: Niners vs Giants

The San Francisco 49ers face the New York Giants in this NFL Week 9 matchup at MetLife Stadium, with kickoff scheduled for 13:00 on Sunday, November 2. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

The best bet could involve backing the Giants against the spread. There’s an attractive +2.5 available at -110 that the underdogs cover the line against the Niners and that has to be our prediction.

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San Francisco 49ers have now lost back-to-back road games. In their previous game, Houston Texans won 26-15 at NRG Stadium. The 49ers generated 223 total yards, made up of 175 passing and 48 rushing yards. They scored two touchdowns and picked up 12 first downs.

New York Giants have suffered defeat in their last two games. Most recently, a 38-20 scoreline occurred on the road at Lincoln Financial Field against Philadelphia Eagles. The Giants moved the ball for 246 yards, breaking down to 178 passing and 68 rushing yards. They picked up 13 first downs to go along with two touchdowns.

Head-to-Head Statistics

The Niners won the last matchup between the pair. Enjoying a 30-12 triumph when facing the Giants at Levi's Stadium.

Quarterbacks

Mac Jones

245.5 Passing Yards

Over -112

Under -112

Jaxson Dart

209.5 Passing Yards

Over -112

Under -112

49ers vs Giants Prediction & Picks

Get ahead of the game with our 49ers vs Giants betting rundown, featuring our trusted match prediction, likely score outcome, standout player prop plays and a fully loaded bet builder.

Game Prediction

The underdogs look easy to back at -110 considering the Giants have been given a spread of +2.5. This looks a good number when squaring off in this NFL matchup.

Team news plays a key role in our NFL predictions and we’re always tracking players with injury concerns. We also stay on top of the form guide, supported by detailed stats that help paint a clearer picture of what to expect.

Key 49ers vs Giants stats:

• The +2.5 line has been covered by Giants in 3 of their last 5 games.
• The +2.5 line has been covered by Giants in 2 consecutive games at home.
• The -2.5 line hasn’t been covered by 49ers in 6 of their last 10 games.
• The -2.5 line hasn’t been covered by 49ers in 12 of their last 20 games.
• The -2.5 line hasn’t been covered by 49ers in 2 consecutive games on the road.

Giants +2.5 Probability

When you look at the latest betting odds, our pick has a 52.4% chance of winning. However, we think that the probability sits between 55-60% taking all factors into consideration. This is why we can recommend this bet.

Selling points can be a great alternative and allows bettors to enjoy a bigger return on the same selection. For a more conservative spread pick, you can alternatively buy points.

Before you place your bets, explore our updated guide packed with the latest free bets and betting bonuses.

Our Game Prediction

Giants +2.5 @ -110 Bet Now

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Player Prop Picks

Top Pick: Jauan Jennings Anytime TD +180

You can place a bet on Jauan Jennings (Niners) to record a TD at +180. There are appealing odds on offer for this Anytime Touchdown Scorer pick, and we believe it's an attractive wager for him to punch it in.

Latest Jauan Jennings Player Prop Odds

Touchdown

Anytime

+200

First

+1100

Receiving Yards

Over 49.5

-112

Under 49.5

-112

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Jaxson Dart Under 210.5 Passing Yards -114

Jaxson Dart (Giants) is available at -114 to finish with fewer than 210.5 passing yards. He may fall short of the QB Passing Yards line, making this prop bet a strong pick.

Latest Jaxson Dart Player Prop Odds

Touchdown

Anytime

+200

First

+1100

Passing Yards

Over 209.5

-112

Under 209.5

-112

Rushing Yards

Over 34.5

-112

Under 34.5

-112

Correct Score Prediction

49ers 20 - 23 Giants

We’re expecting this to be a close battle and we’ll take the Giants to win 23-20. This is available at huge odds for those that want to have a speculative wager.

49ers vs Giants Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

For this game, the sportsbooks’ Moneyline betting odds mean San Francisco 49ers are -179 favorites to win and that means a 64% chance of landing a victory. New York Giants are regarded as a long shot to win and you can currently back them at +150.

The spread currently stands at 3.5 and the total points line is 44.5. The Totals offers NFL fans an alternative way of getting involved. If you want to bet Under 44.5, there are odds of -110.

The best NFL sportsbooks offer a wide range of team props and game lines for every matchup. Make sure you look through all the available options before deciding which bet to place.

Moneyline

49ers

-179

Giants

+150

Point Spread

49ers -3.5

-110

Giants +3.5

-110

Total Points

Under 44.5

-110

Over 44.5

-110

Christian McCaffrey is the favorite to be First Touchdown Scorer at +350. If you’re interested in backing him to score a TD at anytime, then the price is -222.

Touchdown

Christian McCaffrey (49ers)

First TD

+350

Anytime TD

-222

Tyrone Tracy Jr. (Giants)

First TD

+650

Anytime TD

+105

George Kittle (49ers)

First TD

+800

Anytime TD

+130

Jauan Jennings (49ers)

First TD

+1100

Anytime TD

+200

Jaxson Dart (Giants)

First TD

+1100

Anytime TD

+200

Theo Johnson (Giants)

First TD

+1200

Anytime TD

+195

Wan'Dale Robinson (Giants)

First TD

+1200

Anytime TD

+210

Darius Slayton (Giants)

First TD

+1400

Anytime TD

+230

Kendrick Bourne (49ers)

First TD

+1900

Anytime TD

+360

Devin Singletary (Giants)

First TD

+2200

Anytime TD

+440

Daniel Bellinger (Giants)

First TD

+2500

Anytime TD

+370

Demarcus Robinson (49ers)

First TD

+3000

Anytime TD

+600

Kyle Juszczyk (49ers)

First TD

+3000

Anytime TD

+600

Chris Manhertz (Giants)

First TD

+3300

Anytime TD

+550

Mac Jones (49ers)

First TD

+3500

Anytime TD

+750

Brian Robinson Jr. (49ers)

First TD

+4000

Anytime TD

+700

Thomas Fidone (Giants)

First TD

+4500

Anytime TD

+900

Ray-Ray McCloud III (Giants)

First TD

+4500

Anytime TD

+850

Jalin Hyatt (Giants)

First TD

+5500

Anytime TD

+1100

Beaux Collins (Giants)

First TD

+6000

Anytime TD

+1100

Jake Tonges (49ers)

First TD

+7000

Anytime TD

+750

Luke Farrell (49ers)

First TD

+8000

Anytime TD

+1200

Gunner Olszewski (Giants)

First TD

+8000

Anytime TD

+1600

Skyy Moore (49ers)

First TD

+10000

Anytime TD

+1900

Jordan Watkins (49ers)

First TD

+10000

Anytime TD

+3300

Isaac Guerendo (49ers)

First TD

+10000

Anytime TD

+1900

Receiving Yards

Wan'Dale Robinson (Giants)

Over 52.5

-112

Under 52.5

-112

George Kittle (49ers)

Over 50.5

-112

Under 50.5

-112

Christian McCaffrey (49ers)

Over 49.5

-112

Under 49.5

-112

Jauan Jennings (49ers)

Over 49.5

-112

Under 49.5

-112

Darius Slayton (Giants)

Over 41.5

-112

Under 41.5

-112

Theo Johnson (Giants)

Over 38.5

-112

Under 38.5

-112

Kendrick Bourne (49ers)

Over 36.5

-112

Under 36.5

-112

Tyrone Tracy Jr. (Giants)

Over 19.5

-112

Under 19.5

-112

Demarcus Robinson (49ers)

Over 18.5

-112

Under 18.5

-112

Kyle Juszczyk (49ers)

Over 7.5

-112

Under 7.5

-112

Rushing Yards

Christian McCaffrey (49ers)

Over 76.5

-112

Under 76.5

-112

Tyrone Tracy Jr. (Giants)

Over 52.5

-112

Under 52.5

-112

Jaxson Dart (Giants)

Over 34.5

-112

Under 34.5

-112

Devin Singletary (Giants)

Over 18.5

-112

Under 18.5

-112

Brian Robinson Jr. (49ers)

Over 15.5

-112

Under 15.5

-112

Mac Jones (49ers)

Over 6.5

-112

Under 6.5

-112

Passing Yards

Mac Jones (49ers)

Over 245.5

-112

Under 245.5

-112

Jaxson Dart (Giants)

Over 209.5

-112

Under 209.5

-112

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Past Ten Giants Home Games Feature Seven Losses

The Giants own a 3-7 mark in their past 10 home games, putting up 17.30 points per contest and giving up 24.10.

The Niners have gone 4-6 across their last 10 games on the road, putting up 18.70 points per contest and giving up 28.20.

The last time these teams met at MetLife Stadium, the Niners came out on top 36-9 against the Giants.

Last 10 Games		W-L	P	PF	PA	O48.5	U48.5
Giants Home Stats		3-7	41.40	17.30	24.10	4	6
49ers Away Stats		4-6	46.90	18.70	28.20	3	7

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O48.5 = Games Over 48.5 Points
• U48.5 = Games Under 48.5 Points

Latest regular season and playoff games stats.

San Francisco 49ers Stats

New York Giants Stats

Moneyline

• 5 wins and 5 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 games on the road

Moneyline

• 3 wins and 7 defeats in the last 10 games
• 3 wins and 7 defeats in the last 10 home games

Point Spread

• -2.5 Betting Line: Have covered the spread in 4 of the last 10 games
• -2.5 Betting Line on the Road: Have covered the spread in 4 of the last 10 games on the road

Point Spread

• +2.5 Betting Line: Have covered the spread in 4 of the last 10 games
• +2.5 Betting Line at Home: Have covered the spread in 3 of the last 10 home games

Total Points

• Game Totals: An average of 46.90 pts in the previous 10 games
• Game Totals on the Road: An average of 46.90 pts in the previous 10 games on the road
• Over 48.5: Covered in 4 of the previous 10 games
• Over 48.5 on the Road: Covered in 3 of the previous 10 games on the road
• Team Totals: Have scored an average of 21.80 pts and allowed 25.10 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 18.70 pts and allowed 28.20 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 49.90 pts in the previous 10 games
• Game Totals at Home: An average of 41.40 pts in the previous 10 home games
• Over 48.5: Covered in 5 of the previous 10 games
• Over 48.5 at Home: Covered in 4 of the previous 10 home games
• Team Totals: Have scored an average of 23.10 pts and allowed 26.80 pts in the last 10 games
• Team Totals at Home: Have scored an average of 17.30 pts and allowed 24.10 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 370.00 Yds. Allowed 352.00 Yds
• Rushing Yards: Gained 92.80 Yds. Allowed 116.70 Yds
• Passing Yards: Gained 277.20 Yds. Allowed 235.30 Yds
• Total Touchdowns: Scored 2.30 TD. Allowed 2.90 TD
• Rushing Touchdowns: Scored 0.60 TD. Allowed 0.80 TD
• Passing Touchdowns: Scored 1.70 TD. Allowed 2.00 TD
• Total 1st Downs: Picked up 22.20. Allowed 20.60
• Total Turnovers: Committed 1.70. Committed by opponents 0.70
• Total Penalties: Committed 6.60. Committed by opponents 6.00
• Penalty Yards: Lost 50.30 Yds. Gained 42.20 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 323.10 Yds. Allowed 380.80 Yds
• Rushing Yards: Gained 112.60 Yds. Allowed 136.80 Yds
• Passing Yards: Gained 210.50 Yds. Allowed 244.00 Yds
• Total Touchdowns: Scored 2.80 TD. Allowed 3.00 TD
• Rushing Touchdowns: Scored 1.10 TD. Allowed 1.20 TD
• Passing Touchdowns: Scored 1.60 TD. Allowed 1.70 TD
• Total 1st Downs: Picked up 19.00. Allowed 22.80
• Total Turnovers: Committed 1.00. Committed by opponents 0.80
• Total Penalties: Committed 7.70. Committed by opponents 7.80
• Penalty Yards: Lost 62.20 Yds. Gained 65.40 Yds

Last 10 Games on the Road

• Total Yards: Gained 342.40 Yds. Allowed 349.80 Yds
• Rushing Yards: Gained 87.60 Yds. Allowed 136.20 Yds
• Passing Yards: Gained 254.80 Yds. Allowed 213.60 Yds
• Total Touchdowns: Scored 1.90 TD. Allowed 3.30 TD
• Rushing Touchdowns: Scored 0.30 TD. Allowed 1.30 TD
• Passing Touchdowns: Scored 1.60 TD. Allowed 2.00 TD
• Total 1st Downs: Picked up 19.90. Allowed 21.20
• Total Turnovers: Committed 1.70. Committed by opponents 0.60
• Total Penalties: Committed 7.60. Committed by opponents 5.10
• Penalty Yards: Lost 55.10 Yds. Gained 36.40 Yds

Last 10 Home Games

• Total Yards: Gained 284.80 Yds. Allowed 361.70 Yds
• Rushing Yards: Gained 114.70 Yds. Allowed 141.40 Yds
• Passing Yards: Gained 170.10 Yds. Allowed 220.30 Yds
• Total Touchdowns: Scored 2.30 TD. Allowed 3.00 TD
• Rushing Touchdowns: Scored 1.20 TD. Allowed 1.60 TD
• Passing Touchdowns: Scored 0.90 TD. Allowed 1.40 TD
• Total 1st Downs: Picked up 19.00. Allowed 20.50
• Total Turnovers: Committed 0.70. Committed by opponents 1.10
• Total Penalties: Committed 6.10. Committed by opponents 6.80
• Penalty Yards: Lost 49.50 Yds. Gained 59.40 Yds

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