49ers vs Buccaneers Prediction, Picks & Odds | 12 Oct 2025

NFL Betting Preview: Niners vs Buccaneers

The San Francisco 49ers meet the Tampa Bay Buccaneers in this NFL Week 6 matchup at Raymond James Stadium, with kickoff scheduled for 16:25 on Sunday, October 12. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

We’re bullish about the Buccaneers against the spread at -3.5. They should be able to win by a comfortable margin when playing the Niners and you can get -102.

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San Francisco 49ers have won three road games on the spin, triumphing 26-23 (OT) in their previous appearance. This was against Los Angeles Rams at SoFi Stadium. The 49ers recorded 407 yards, split between 333 passing and 74 rushing yards. The offense converted for 27 first downs and crossed the goal line twice.

Tampa Bay Buccaneers won last time out by a 38-35 scoreline. It was on the road against Seattle Seahawks at Lumen Field. The Buccaneers finished with 426 total yards, breaking down to 370 passing and 56 rushing yards. The offense moved the chains 25 times and produced 4 touchdowns, including 2 passing scores and 2 rushing TD's.

Head-to-Head Statistics

It was a 23-20 win for the Niners at Raymond James Stadium when they last played the Bucs. The Niners have won on the past 4 times these teams have gone H2H.

Quarterbacks

Mac Jones

250.5 Passing Yards

Over -112

Under -112

Baker Mayfield

239.5 Passing Yards

Over -112

Under -112

49ers vs Buccaneers Prediction & Picks

We cover the essential 49ers vs Buccaneers betting angles, featuring our main match prediction, correct score pick, top player prop plays and a carefully crafted bet builder.

Game Prediction

We expect the Buccaneers to cover the -3.5 line on the spread. This is a good number and that’s why we’re playing the favorites at -102 for this NFL showdown.

The NFL handicappers at Sportsgambler.com stay on top of the latest injuries, while recent form also shapes our picks. We combine this insight with up-to-date stats for sharper predictions.

Key 49ers vs Buccaneers stats:

• The +3.5 line hasn’t been covered by 49ers in 5 of their last 10 games.

Bucs -3.5 Probability

According to the best NFL betting sites, there’s a 50.5% likelihood of our pick delivering a return. After careful examination, our cappers calculate this probability to be closer to 60%. The bet can be recommended for this precise reason.

A Bet Builder provides you with the chance to combine the Bucs against the spread with other picks. For every additional selection, the odds are boosted.

Get the most from your next wager. Check our expert guide filled with the best free bets and top bonus offers.

Our Game Prediction

Buccaneers -3.5 @ -102 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (22:26, 10 October 2025). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Mac Jones Under 250.5 Passing Yards -114

Mac Jones (Niners) can be backed at -114 to record fewer than 250.5 passing yards. It’s reasonable to expect he may fall short, making the QB Passing Yards line appealing.

Latest Mac Jones Player Prop Odds

Touchdown

Anytime

+1000

First

+6500

Passing Yards

Over 250.5

-112

Under 250.5

-112

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Rachaad White Anytime TD -120

Rachaad White (Bucs) is priced at -120 to hit the end zone. He looks like an attractive wager to take it to the house and we recommend backing this Anytime Touchdown Scorer selection.

Latest Rachaad White Player Prop Odds

Touchdown

Anytime

-115

First

+500

Receiving Yards

Over 25.5

-112

Under 25.5

-112

Rushing Yards

Over 59.5

-112

Under 59.5

-112

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

49ers 23 - 30 Buccaneers

There’s lots of entertainment when it comes to a correct score bet. A play on the Buccaneers to claim a 30-23 victory should give bettors a good run for their money.

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49ers vs Buccaneers Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

Tampa Bay Buccaneers are -122 favorites and that means a 55% chance of winning this game according to the Moneyline betting odds with the sportsbooks. The market suggests that San Francisco 49ers are least likely to win at +102.

1.5 is where the spread lies, with total points being 48.5 right now. A bet on the Totals allows fans to use the latest NFL data to good effect. Those that want to back Under 48.5 can find odds of -105 available.

There are hundreds of team props and game lines when it comes to wagering on the National Football League and we recommend visiting the best sportsbooks to find the bet that matches your view on the game.

Moneyline

49ers

+102

Buccaneers

-122

Point Spread

49ers +1.5

-110

Buccaneers -1.5

-110

Total Points

Under 48.5

-105

Over 48.5

-115

Christian McCaffrey is the market leader to be First TD Scorer at +440. Alternatively, there’s the chance to back him to register a touchdown at any stage at -161.

Touchdown

Christian McCaffrey (49ers)

First TD

+440

Anytime TD

-161

Rachaad White (Buccaneers)

First TD

+500

Anytime TD

-115

Emeka Egbuka (Buccaneers)

First TD

+600

Anytime TD

+105

Cade Otton (Buccaneers)

First TD

+1100

Anytime TD

+220

Jauan Jennings (49ers)

First TD

+1200

Anytime TD

+210

Sterling Shepard (Buccaneers)

First TD

+1200

Anytime TD

+250

Kendrick Bourne (49ers)

First TD

+1600

Anytime TD

+280

Jake Tonges (49ers)

First TD

+1700

Anytime TD

+290

Tez Johnson (Buccaneers)

First TD

+1700

Anytime TD

+350

Baker Mayfield (Buccaneers)

First TD

+2200

Anytime TD

+500

Sean Tucker (Buccaneers)

First TD

+2500

Anytime TD

+440

Brian Robinson Jr. (49ers)

First TD

+3000

Anytime TD

+600

Demarcus Robinson (49ers)

First TD

+3000

Anytime TD

+550

Ryan Miller (Buccaneers)

First TD

+4000

Anytime TD

+750

Kyle Juszczyk (49ers)

First TD

+4000

Anytime TD

+850

Payne Durham (Buccaneers)

First TD

+5000

Anytime TD

+900

Mac Jones (49ers)

First TD

+6500

Anytime TD

+1000

Jordan Watkins (49ers)

First TD

+6500

Anytime TD

+1100

Luke Farrell (49ers)

First TD

+7500

Anytime TD

+950

Kameron Johnson (Buccaneers)

First TD

+7500

Anytime TD

+1300

Devin Culp (Buccaneers)

First TD

+8000

Anytime TD

+1700

Isaac Guerendo (49ers)

First TD

+10000

Anytime TD

+2000

Brayden Willis (49ers)

First TD

+10000

Anytime TD

+3500

Skyy Moore (49ers)

First TD

+10000

Anytime TD

+1800

Marquez Valdes-Scantling (49ers)

First TD

+10000

Anytime TD

+1600

Josh Williams (Buccaneers)

First TD

+10000

Anytime TD

+2000

James Jordan (49ers)

First TD

+10000

Anytime TD

+2000

Receiving Yards

Emeka Egbuka (Buccaneers)

Over 74.5

-112

Under 74.5

-112

Jauan Jennings (49ers)

Over 52.5

-112

Under 52.5

-112

Christian McCaffrey (49ers)

Over 52.5

-112

Under 52.5

-112

Kendrick Bourne (49ers)

Over 46.5

-112

Under 46.5

-112

Tez Johnson (Buccaneers)

Over 32.5

-112

Under 32.5

-112

Jake Tonges (49ers)

Over 32.5

-112

Under 32.5

-112

Sterling Shepard (Buccaneers)

Over 31.5

-112

Under 31.5

-112

Cade Otton (Buccaneers)

Over 31.5

-112

Under 31.5

-112

Rachaad White (Buccaneers)

Over 25.5

-112

Under 25.5

-112

Demarcus Robinson (49ers)

Over 19.5

-112

Under 19.5

-112

Kyle Juszczyk (49ers)

Over 9.5

-112

Under 9.5

-112

Rushing Yards

Rachaad White (Buccaneers)

Over 59.5

-112

Under 59.5

-112

Christian McCaffrey (49ers)

Over 55.5

-112

Under 55.5

-112

Baker Mayfield (Buccaneers)

Over 17.5

-112

Under 17.5

-112

Brian Robinson Jr. (49ers)

Over 15.5

-112

Under 15.5

-112

Passing Yards

Mac Jones (49ers)

Over 250.5

-112

Under 250.5

-112

Baker Mayfield (Buccaneers)

Over 239.5

-112

Under 239.5

-112

Instead of focusing on the overall outcome, some bettors prefer to look at the NFL micro betting lines. As the name suggests, it means placing short-term wagers and this might include the Next Play or Next Drive Result.

Bucs Have Five Wins From Past Ten Home Game

The Bucs have gone 5-5 across their last 10 home games, putting up 28.70 points per contest and giving up 23.80.

The Niners have chalked up three consecutive victories on their travels. They are 5-5 in their last 10 road games, averaging 21.30 points on offense and surrendering 27.70 on defense.

The last time these teams met at Raymond James Stadium, the Niners came out on top 23-20 against the Bucs.

Last 10 Games		W-L	P	PF	PA	O47.5	U47.5
Buccaneers Home Stats		5-5	52.50	28.70	23.80	6	4
49ers Away Stats		5-5	49.00	21.30	27.70	5	5

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O47.5 = Games Over 47.5 Points
• U47.5 = Games Under 47.5 Points

Latest regular season and playoff games stats.

San Francisco 49ers Stats

Tampa Bay Buccaneers Stats

Moneyline

• 5 wins and 5 defeats in the last 10 games
• 5 wins and 5 defeats in the last 10 games on the road

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 5 wins and 5 defeats in the last 10 home games

Point Spread

• +3.5 Betting Line: Have covered the spread in 5 of the last 10 games
• +3.5 Betting Line on the Road: Have covered the spread in 6 of the last 10 games on the road

Point Spread

• -3.5 Betting Line: Have covered the spread in 3 of the last 10 games
• -3.5 Betting Line at Home: Have covered the spread in 4 of the last 10 home games

Total Points

• Game Totals: An average of 46.40 pts in the previous 10 games
• Game Totals on the Road: An average of 49.00 pts in the previous 10 games on the road
• Over 47.5: Covered in 4 of the previous 10 games
• Over 47.5 on the Road: Covered in 5 of the previous 10 games on the road
• Team Totals: Have scored an average of 22.50 pts and allowed 23.90 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 21.30 pts and allowed 27.70 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 52.50 pts in the previous 10 games
• Game Totals at Home: An average of 52.50 pts in the previous 10 home games
• Over 47.5: Covered in 6 of the previous 10 games
• Over 47.5 at Home: Covered in 6 of the previous 10 home games
• Team Totals: Have scored an average of 29.40 pts and allowed 23.10 pts in the last 10 games
• Team Totals at Home: Have scored an average of 28.70 pts and allowed 23.80 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 380.70 Yds. Allowed 324.70 Yds
• Rushing Yards: Gained 91.40 Yds. Allowed 122.10 Yds
• Passing Yards: Gained 289.30 Yds. Allowed 202.60 Yds
• Total Touchdowns: Scored 2.50 TD. Allowed 2.60 TD
• Rushing Touchdowns: Scored 0.60 TD. Allowed 0.70 TD
• Passing Touchdowns: Scored 1.90 TD. Allowed 1.80 TD
• Total 1st Downs: Picked up 22.30. Allowed 19.50
• Total Turnovers: Committed 1.60. Committed by opponents 0.60
• Total Penalties: Committed 7.20. Committed by opponents 5.30
• Penalty Yards: Lost 52.90 Yds. Gained 40.80 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 391.60 Yds. Allowed 295.70 Yds
• Rushing Yards: Gained 139.10 Yds. Allowed 74.40 Yds
• Passing Yards: Gained 252.50 Yds. Allowed 221.30 Yds
• Total Touchdowns: Scored 3.20 TD. Allowed 2.50 TD
• Rushing Touchdowns: Scored 0.50 TD. Allowed 0.60 TD
• Passing Touchdowns: Scored 2.50 TD. Allowed 1.70 TD
• Total 1st Downs: Picked up 22.40. Allowed 18.20
• Total Turnovers: Committed 0.80. Committed by opponents 0.60
• Total Penalties: Committed 7.30. Committed by opponents 6.60
• Penalty Yards: Lost 63.10 Yds. Gained 55.60 Yds

Last 10 Games on the Road

• Total Yards: Gained 374.60 Yds. Allowed 332.50 Yds
• Rushing Yards: Gained 112.60 Yds. Allowed 125.10 Yds
• Passing Yards: Gained 262.00 Yds. Allowed 207.40 Yds
• Total Touchdowns: Scored 2.30 TD. Allowed 3.30 TD
• Rushing Touchdowns: Scored 0.30 TD. Allowed 1.40 TD
• Passing Touchdowns: Scored 2.00 TD. Allowed 1.80 TD
• Total 1st Downs: Picked up 21.60. Allowed 21.10
• Total Turnovers: Committed 1.50. Committed by opponents 0.80
• Total Penalties: Committed 7.50. Committed by opponents 5.50
• Penalty Yards: Lost 50.50 Yds. Gained 42.20 Yds

Last 10 Home Games

• Total Yards: Gained 394.60 Yds. Allowed 317.50 Yds
• Rushing Yards: Gained 130.80 Yds. Allowed 105.80 Yds
• Passing Yards: Gained 263.80 Yds. Allowed 211.70 Yds
• Total Touchdowns: Scored 3.20 TD. Allowed 2.60 TD
• Rushing Touchdowns: Scored 0.60 TD. Allowed 0.40 TD
• Passing Touchdowns: Scored 2.40 TD. Allowed 2.00 TD
• Total 1st Downs: Picked up 22.90. Allowed 18.90
• Total Turnovers: Committed 1.20. Committed by opponents 0.80
• Total Penalties: Committed 7.00. Committed by opponents 6.00
• Penalty Yards: Lost 57.20 Yds. Gained 55.90 Yds

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