San Francisco 49ers
American Football NFL Raymond James Stadium Sun 12 Oct 16:25
Tampa Bay Buccaneers
  1. Prediction
  2. SGP Picks
  3. Odds
  4. Player Props
  5. Stats
  6. Live Stream
  7. Team News
  8. Lineups
  9. Injuries
  10. Standings

NFL Betting Preview: Niners vs Buccaneers

The San Francisco 49ers meet the Tampa Bay Buccaneers in this NFL Week 6 matchup at Raymond James Stadium, with kickoff scheduled for 16:25 on Sunday 12 October. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

Bucs Worthy Favorites

We’re bullish about the Buccaneers against the spread at -3.5. They should be able to win by a comfortable margin when playing the Niners and you can get -102.

Trusting our spread pick? Read our expert BetMGM review, then take advantage of the best promo code before placing your bet.

Teams’ Previous H2H Saw 23-20 Niners Victory

San Francisco 49ers have won three road games on the spin, triumphing 26-23 (OT) in their previous appearance. This was against Los Angeles Rams at SoFi Stadium. The 49ers recorded 407 yards, split between 333 passing and 74 rushing yards. The offense converted for 27 first downs and crossed the goal line twice.

Tampa Bay Buccaneers won last time out by a 38-35 scoreline. It was on the road against Seattle Seahawks at Lumen Field. The Buccaneers finished with 426 total yards, breaking down to 370 passing and 56 rushing yards. The offense moved the chains 25 times and produced 4 touchdowns, including 2 passing scores and 2 rushing TD's.

Head-to-Head Statistics

It was a 23-20 win for the Niners at Raymond James Stadium when they last played the Bucs. The Niners have won on the past 4 times these teams have gone H2H.

Quarterbacks

49ers vs Buccaneers Prediction & Picks

We cover the essential 49ers vs Buccaneers betting angles, featuring our main match prediction, correct score pick, top player prop plays and a carefully crafted bet builder.

Game Prediction

We expect the Buccaneers to cover the -3.5 line on the spread. This is a good number and that’s why we’re playing the favorites at -102 for this NFL showdown.

The NFL handicappers at Sportsgambler.com stay on top of the latest injuries, while recent form also shapes our picks. We combine this insight with up-to-date stats for sharper predictions.

Key 49ers vs Buccaneers stats:

  • The +3.5 line hasn’t been covered by 49ers in 5 of their last 10 games.

Bucs -3.5 Probability

According to the best NFL betting sites, there’s a 50.5% likelihood of our pick delivering a return. After careful examination, our cappers calculate this probability to be closer to 60%. The bet can be recommended for this precise reason.

Looking for Bigger Odds?

A Bet Builder provides you with the chance to combine the Bucs against the spread with other picks. For every additional selection, the odds are boosted.

Get the most from your next wager. Check our expert guide filled with the best free bets and top bonus offers.

Best Bet

Buccaneers -3.5 @ -102 Watch Live Bet Now BetMGM logo
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Published 22:26, 10 October 2025

Player Prop Picks

Top Pick: Mac Jones Under 250.5 Passing Yards -114 BetMGM logo

Mac Jones (Niners) can be backed at -114 to record fewer than 250.5 passing yards. It’s reasonable to expect he may fall short, making the QB Passing Yards line appealing.

Latest Mac Jones Player Prop Odds

Rachaad White Anytime TD -120 BetMGM logo

Rachaad White (Bucs) is priced at -120 to hit the end zone. He looks like an attractive wager to take it to the house and we recommend backing this Anytime Touchdown Scorer selection.

Latest Rachaad White Player Prop Odds

Same Game Parlay Picks

Spread Buccaneers -3.5
Totals Over 47.5
Passing Yards Mac Jones Under 250.5

We’ve loaded up a same game parlay with the combined picks of Bucs -3.5, Over 47.5 and Mac Jones (49ers) to have Under 250.5 passing yards.

A same game parlay allows football bettors to place a multiple wager on the same game. You can go through the available betting lines and select the outcomes that you think will happen. The odds for each pick are then combined together.

T&C apply. Gamble responsibly 18+

Correct Score Prediction

49ers 49ers logo 23 - 30 Buccaneers logo Buccaneers

There’s lots of entertainment when it comes to a correct score bet. A play on the Buccaneers to claim a 30-23 victory should give bettors a good run for their money.

49ers vs Buccaneers Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Books Expecting a Bucs Victory

Tampa Bay Buccaneers are -175 favorites and that means a 64% chance of winning this game according to the Moneyline betting odds with the sportsbooks. The market suggests that San Francisco 49ers are least likely to win at +148.

3.5 is where the spread lies, with total points being 47.5 right now. A bet on the Totals allows fans to use the latest NFL data to good effect. Those that want to back Under 47.5 can find odds of -112 available.

There are hundreds of team props and game lines when it comes to wagering on the National Football League and we recommend visiting the best sportsbooks to find the bet that matches your view on the game.

Christian McCaffrey Favorite to Be First Touchdown Scorer

Christian McCaffrey is the market leader to be First TD Scorer at +400. Alternatively, there’s the chance to back him to register a touchdown at any stage at -179.

Touchdown

Christian McCaffrey (49ers)
First TD
+400
Anytime TD
-179
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Rachaad White (Buccaneers)
First TD
+500
Anytime TD
-120
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Emeka Egbuka (Buccaneers)
First TD
+650
Anytime TD
-100
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Jauan Jennings (49ers)
First TD
+1100
Anytime TD
+180
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Receiving Yards

Emeka Egbuka (Buccaneers)
Over 72.5
-114
Under 72.5
-114
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Christian McCaffrey (49ers)
Over 53.5
-114
Under 53.5
-114
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Sterling Shepard (Buccaneers)
Over 31.5
-114
Under 31.5
-114
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Cade Otton (Buccaneers)
Over 29.5
-114
Under 29.5
-114
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Rushing Yards

Rachaad White (Buccaneers)
Over 59.5
-114
Under 59.5
-114
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Christian McCaffrey (49ers)
Over 53.5
-114
Under 53.5
-114
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Baker Mayfield (Buccaneers)
Over 17.5
-114
Under 17.5
-114
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Brian Robinson Jr. (49ers)
Over 15.5
-114
Under 15.5
-114
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Passing Yards

Best Betting Offers
Raymond James Stadium
Raymond James Stadium

Bucs Have Five Wins From Past Ten Home Game

The Bucs have gone 5-5 across their last 10 home games, putting up 28.70 points per contest and giving up 23.80.

The Niners have chalked up three consecutive victories on their travels. They are 5-5 in their last 10 road games, averaging 21.30 points on offense and surrendering 27.70 on defense.

The last time these teams met at Raymond James Stadium, the Niners came out on top 23-20 against the Bucs.

Last 10 Games W-L P PF PA O47.5 U47.5
Buccaneers logo Buccaneers Home Stats 5-5 52.50 28.70 23.80 6 4
49ers logo 49ers Away Stats 5-5 49.00 21.30 27.70 5 5
  • W-L = Wins-Losses
  • P = Avg. Points
  • PF = Avg. Points For
  • PA = Avg. Points Against
  • O47.5 = Games Over 47.5 Points
  • U47.5 = Games Under 47.5 Points
Team Stats

Latest regular season and playoff games stats.

San Francisco 49ers logo San Francisco 49ers Stats
Tampa Bay Buccaneers logo Tampa Bay Buccaneers Stats
Moneyline
  • 5 wins and 5 defeats in the last 10 games
  • 5 wins and 5 defeats in the last 10 games on the road
Moneyline
  • 7 wins and 3 defeats in the last 10 games
  • 5 wins and 5 defeats in the last 10 home games
Point Spread
Point Spread
Total Points
Total Points
Game Stats
Last 10 Games
Game Stats
Last 10 Games
Last 10 Games on the Road
Last 10 Home Games

Live Streaming

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Team News

San Francisco 49ers @ Tampa Bay Buccaneers Lineups

Tampa Bay Buccaneers

Manager:
Todd Bowles

San Francisco 49ers

Manager:
Kyle Shanahan

Tampa Bay Buccaneers Substitutes

San Francisco 49ers Substitutes

San Francisco 49ers Injuries

Type
Name
Info
Brandon Aiyuk
Knee - ACL + MCL
Isaac Alarcon
Suspension
Ben Bartch
Ankle
Nick Bosa
Knee - ACL
Spencer Burford
Knee
Alfred Collins
Knee
Jacob Cowing
Hamstring
Kalia Davis
Hand
Kevin Givens
Pectoral
Yetur Gross-Matos
Hamstring
Tarron Jackson
Undisclosed
Jauan Jennings
Ankle
Mac Jones
Knee
George Kittle
Hamstring
Malik Mustapha
Knee - ACL
Ricky Pearsall
Knee - PCL
Brock Purdy
Toe
Jakob Robinson
Forearm
Kurtis Rourke
Knee
Upton Stout
Ankle
Patrick Taylor
Shoulder
Trent Taylor
Undisclosed
Tre Tomlinson
Undisclosed
Jordan Watkins
Calf

Tampa Bay Buccaneers Injuries

Type
Name
Info
Mike Evans
Hamstring
Chris Godwin
Lower Leg
Luke Goedeke
Foot
Garret Greenfield
Undisclosed
Bucky Irving
Shoulder
Christian Izien
Quadriceps
Calijah Kancey
Pectoral
Ko Kieft
Leg
Cody Mauch
Knee
Zyon McCollum
Thumb
Jalen McMillan
Neck
Benjamin Morrison
Hamstring
J.J. Roberts
Knee
Jaden Smith
Undisclosed
David Walker
Knee
Josh Williams
Concussion
Rashad Wisdom
Quadriceps

Previous San Francisco 49ers Lineups

02 Oct NFL
49ers 26-23 Rams
28 Sep NFL
Jaguars 26-21 49ers
21 Sep NFL
Cardinals 15-16 49ers
14 Sep NFL
49ers 26-21 Saints
07 Sep NFL
49ers 17-13 Seahawks
05 Jan NFL
49ers 24-47 Cardinals
30 Dec NFL
Lions 40-34 49ers
22 Dec NFL
49ers 17-29 Dolphins
12 Dec NFL
Rams 12-6 49ers
08 Dec NFL
Bears 13-38 49ers

Previous Tampa Bay Buccaneers Lineups

05 Oct NFL
Buccaneers 38-35 Seahawks
28 Sep NFL
Eagles 31-25 Buccaneers
21 Sep NFL
Jets 27-29 Buccaneers
15 Sep NFL
Buccaneers 20-19 Texans
07 Sep NFL
Buccaneers 23-20 Falcons
12 Jan NFL Playoffs
Commanders 23-20 Buccaneers
05 Jan NFL
Saints 19-27 Buccaneers
29 Dec NFL
Panthers 14-48 Buccaneers
22 Dec NFL
Buccaneers 24-26 Cowboys
15 Dec NFL
Buccaneers 40-17 Chargers

NFL Standings Select Season

AFC East W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Bills 4 1 0 0.800 153 113 40 3-1-0 1-0-0 2-1-0 3-1-0 4-1-0 1L
Patriots 3 2 0 0.600 125 101 24 1-2-0 2-0-0 2-0-0 2-2-0 3-2-0 2W
Dolphins 1 4 0 0.200 107 145 -38 1-1-0 0-3-0 1-2-0 1-3-0 1-4-0 1L
Jets 0 5 0 0.000 112 157 -45 0-3-0 0-2-0 0-2-0 0-3-0 0-5-0 5L
AFC North W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Steelers 3 1 0 0.750 96 98 -2 1-1-0 2-0-0 0-0-0 2-0-0 3-1-0 2W
Bengals 2 3 0 0.400 85 156 -71 1-1-0 1-2-0 1-0-0 2-1-0 2-3-0 3L
Ravens 1 4 0 0.200 141 177 -36 1-2-0 0-2-0 1-0-0 1-3-0 1-4-0 3L
Browns 1 4 0 0.200 73 123 -50 1-2-0 0-2-0 0-2-0 0-2-0 1-4-0 2L
AFC South W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Colts 4 1 0 0.800 163 89 74 3-0-0 1-1-0 1-0-0 4-0-0 4-1-0 1W
Jaguars 4 1 0 0.800 127 100 27 3-0-0 1-1-0 1-0-0 2-1-0 4-1-0 3W
Texans 2 3 0 0.400 108 61 47 1-1-0 1-2-0 1-1-0 2-1-0 2-3-0 2W
Titans 1 4 0 0.200 73 141 -68 0-2-0 1-2-0 0-2-0 0-3-0 1-4-0 1W
AFC West W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Chargers 3 2 0 0.600 98 98 0 2-1-0 1-1-0 3-0-0 3-0-0 3-2-0 2L
Broncos 3 2 0 0.600 117 84 33 2-0-0 1-2-0 0-1-0 2-2-0 3-2-0 2W
Chiefs 2 3 0 0.400 125 107 18 1-1-0 1-2-0 0-1-0 1-2-0 2-3-0 1L
Raiders 1 4 0 0.200 83 139 -56 0-2-0 1-2-0 0-1-0 1-2-0 1-4-0 4L
NFC East W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Eagles 4 2 0 0.667 142 143 -1 2-1-0 2-1-0 1-1-0 3-1-0 3-2-0 2L
Commanders 3 2 0 0.600 134 101 33 2-0-0 1-2-0 1-0-0 1-2-0 3-2-0 1W
Cowboys 2 2 1 0.400 151 154 -3 1-0-1 1-2-0 1-1-0 1-2-1 2-2-1 1W
Giants 2 4 0 0.333 121 144 -23 2-1-0 0-3-0 1-2-0 1-3-0 2-3-0 1W
NFC North W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Lions 4 1 0 0.800 174 112 62 2-0-0 2-1-0 1-1-0 1-1-0 4-1-0 4W
Packers 2 1 1 0.500 104 84 20 2-0-0 0-1-1 1-0-0 2-0-1 2-1-1 1D
Vikings 3 2 0 0.600 123 97 26 1-1-0 2-1-0 1-0-0 1-1-0 3-2-0 1W
Bears 2 2 0 0.500 101 117 -16 1-1-0 1-1-0 0-2-0 1-2-0 2-2-0 2W
NFC South W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Buccaneers 4 1 0 0.800 135 132 3 1-1-0 3-0-0 1-0-0 2-1-0 4-1-0 1W
Falcons 2 2 0 0.500 76 86 -10 1-1-0 1-1-0 0-2-0 2-2-0 2-2-0 1W
Panthers 2 3 0 0.400 102 119 -17 2-0-0 0-3-0 1-0-0 1-1-0 2-3-0 1W
Saints 1 4 0 0.200 92 135 -43 1-2-0 0-2-0 0-0-0 1-3-0 1-4-0 1W
NFC West W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
49ers 4 1 0 0.800 106 98 8 1-1-0 3-0-0 3-0-0 4-0-0 4-1-0 1W
Seahawks 3 2 0 0.600 146 105 41 1-2-0 2-0-0 1-1-0 2-2-0 3-2-0 1L
Rams 3 2 0 0.600 123 107 16 2-1-0 1-1-0 0-1-0 0-2-0 3-2-0 1L
Cardinals 2 3 0 0.400 103 96 7 1-2-0 1-1-0 0-2-0 2-2-0 2-3-0 3L
AFC Conference W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Colts 4 1 0 0.800 163 89 74 3-0-0 1-1-0 1-0-0 4-0-0 4-1-0 1W
Bills 4 1 0 0.800 153 113 40 3-1-0 1-0-0 2-1-0 3-1-0 4-1-0 1L
Steelers 3 1 0 0.750 96 98 -2 1-1-0 2-0-0 0-0-0 2-0-0 3-1-0 2W
Chargers 3 2 0 0.600 98 98 0 2-1-0 1-1-0 3-0-0 3-0-0 3-2-0 2L
Jaguars 4 1 0 0.800 127 100 27 3-0-0 1-1-0 1-0-0 2-1-0 4-1-0 3W
Broncos 3 2 0 0.600 117 84 33 2-0-0 1-2-0 0-1-0 2-2-0 3-2-0 2W
Patriots 3 2 0 0.600 125 101 24 1-2-0 2-0-0 2-0-0 2-2-0 3-2-0 2W
Bengals 2 3 0 0.400 85 156 -71 1-1-0 1-2-0 1-0-0 2-1-0 2-3-0 3L
Texans 2 3 0 0.400 108 61 47 1-1-0 1-2-0 1-1-0 2-1-0 2-3-0 2W
Chiefs 2 3 0 0.400 125 107 18 1-1-0 1-2-0 0-1-0 1-2-0 2-3-0 1L
Raiders 1 4 0 0.200 83 139 -56 0-2-0 1-2-0 0-1-0 1-2-0 1-4-0 4L
Ravens 1 4 0 0.200 141 177 -36 1-2-0 0-2-0 1-0-0 1-3-0 1-4-0 3L
Dolphins 1 4 0 0.200 107 145 -38 1-1-0 0-3-0 1-2-0 1-3-0 1-4-0 1L
Browns 1 4 0 0.200 73 123 -50 1-2-0 0-2-0 0-2-0 0-2-0 1-4-0 2L
Titans 1 4 0 0.200 73 141 -68 0-2-0 1-2-0 0-2-0 0-3-0 1-4-0 1W
Jets 0 5 0 0.000 112 157 -45 0-3-0 0-2-0 0-2-0 0-3-0 0-5-0 5L
NFC Conference W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Eagles 4 2 0 0.667 142 143 -1 2-1-0 2-1-0 1-1-0 3-1-0 3-2-0 2L
49ers 4 1 0 0.800 106 98 8 1-1-0 3-0-0 3-0-0 4-0-0 4-1-0 1W
Buccaneers 4 1 0 0.800 135 132 3 1-1-0 3-0-0 1-0-0 2-1-0 4-1-0 1W
Lions 4 1 0 0.800 174 112 62 2-0-0 2-1-0 1-1-0 1-1-0 4-1-0 4W
Packers 2 1 1 0.500 104 84 20 2-0-0 0-1-1 1-0-0 2-0-1 2-1-1 1D
Seahawks 3 2 0 0.600 146 105 41 1-2-0 2-0-0 1-1-0 2-2-0 3-2-0 1L
Vikings 3 2 0 0.600 123 97 26 1-1-0 2-1-0 1-0-0 1-1-0 3-2-0 1W
Commanders 3 2 0 0.600 134 101 33 2-0-0 1-2-0 1-0-0 1-2-0 3-2-0 1W
Rams 3 2 0 0.600 123 107 16 2-1-0 1-1-0 0-1-0 0-2-0 3-2-0 1L
Falcons 2 2 0 0.500 76 86 -10 1-1-0 1-1-0 0-2-0 2-2-0 2-2-0 1W
Bears 2 2 0 0.500 101 117 -16 1-1-0 1-1-0 0-2-0 1-2-0 2-2-0 2W
Cowboys 2 2 1 0.400 151 154 -3 1-0-1 1-2-0 1-1-0 1-2-1 2-2-1 1W
Cardinals 2 3 0 0.400 103 96 7 1-2-0 1-1-0 0-2-0 2-2-0 2-3-0 3L
Panthers 2 3 0 0.400 102 119 -17 2-0-0 0-3-0 1-0-0 1-1-0 2-3-0 1W
Saints 1 4 0 0.200 92 135 -43 1-2-0 0-2-0 0-0-0 1-3-0 1-4-0 1W
Giants 2 4 0 0.333 121 144 -23 2-1-0 0-3-0 1-2-0 1-3-0 2-3-0 1W
NFL Team W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Bills 4 1 0 0.800 153 113 40 3-1-0 1-0-0 2-1-0 3-1-0 4-1-0 1L
Lions 4 1 0 0.800 174 112 62 2-0-0 2-1-0 1-1-0 1-1-0 4-1-0 4W
Colts 4 1 0 0.800 163 89 74 3-0-0 1-1-0 1-0-0 4-0-0 4-1-0 1W
Jaguars 4 1 0 0.800 127 100 27 3-0-0 1-1-0 1-0-0 2-1-0 4-1-0 3W
49ers 4 1 0 0.800 106 98 8 1-1-0 3-0-0 3-0-0 4-0-0 4-1-0 1W
Buccaneers 4 1 0 0.800 135 132 3 1-1-0 3-0-0 1-0-0 2-1-0 4-1-0 1W
Steelers 3 1 0 0.750 96 98 -2 1-1-0 2-0-0 0-0-0 2-0-0 3-1-0 2W
Eagles 4 2 0 0.667 142 143 -1 2-1-0 2-1-0 1-1-0 3-1-0 3-2-0 2L
Packers 2 1 1 0.500 104 84 20 2-0-0 0-1-1 1-0-0 2-0-1 2-1-1 1D
Broncos 3 2 0 0.600 117 84 33 2-0-0 1-2-0 0-1-0 2-2-0 3-2-0 2W
Chargers 3 2 0 0.600 98 98 0 2-1-0 1-1-0 3-0-0 3-0-0 3-2-0 2L
Rams 3 2 0 0.600 123 107 16 2-1-0 1-1-0 0-1-0 0-2-0 3-2-0 1L
Vikings 3 2 0 0.600 123 97 26 1-1-0 2-1-0 1-0-0 1-1-0 3-2-0 1W
Patriots 3 2 0 0.600 125 101 24 1-2-0 2-0-0 2-0-0 2-2-0 3-2-0 2W
Seahawks 3 2 0 0.600 146 105 41 1-2-0 2-0-0 1-1-0 2-2-0 3-2-0 1L
Commanders 3 2 0 0.600 134 101 33 2-0-0 1-2-0 1-0-0 1-2-0 3-2-0 1W
Falcons 2 2 0 0.500 76 86 -10 1-1-0 1-1-0 0-2-0 2-2-0 2-2-0 1W
Bears 2 2 0 0.500 101 117 -16 1-1-0 1-1-0 0-2-0 1-2-0 2-2-0 2W
Cowboys 2 2 1 0.400 151 154 -3 1-0-1 1-2-0 1-1-0 1-2-1 2-2-1 1W
Cardinals 2 3 0 0.400 103 96 7 1-2-0 1-1-0 0-2-0 2-2-0 2-3-0 3L
Panthers 2 3 0 0.400 102 119 -17 2-0-0 0-3-0 1-0-0 1-1-0 2-3-0 1W
Bengals 2 3 0 0.400 85 156 -71 1-1-0 1-2-0 1-0-0 2-1-0 2-3-0 3L
Texans 2 3 0 0.400 108 61 47 1-1-0 1-2-0 1-1-0 2-1-0 2-3-0 2W
Chiefs 2 3 0 0.400 125 107 18 1-1-0 1-2-0 0-1-0 1-2-0 2-3-0 1L
Giants 2 4 0 0.333 121 144 -23 2-1-0 0-3-0 1-2-0 1-3-0 2-3-0 1W
Ravens 1 4 0 0.200 141 177 -36 1-2-0 0-2-0 1-0-0 1-3-0 1-4-0 3L
Browns 1 4 0 0.200 73 123 -50 1-2-0 0-2-0 0-2-0 0-2-0 1-4-0 2L
Raiders 1 4 0 0.200 83 139 -56 0-2-0 1-2-0 0-1-0 1-2-0 1-4-0 4L
Dolphins 1 4 0 0.200 107 145 -38 1-1-0 0-3-0 1-2-0 1-3-0 1-4-0 1L
Saints 1 4 0 0.200 92 135 -43 1-2-0 0-2-0 0-0-0 1-3-0 1-4-0 1W
Titans 1 4 0 0.200 73 141 -68 0-2-0 1-2-0 0-2-0 0-3-0 1-4-0 1W
Jets 0 5 0 0.000 112 157 -45 0-3-0 0-2-0 0-2-0 0-3-0 0-5-0 5L