Seahawks vs Cardinals Prediction, Picks & Odds | 25 Sep 2025

NFL Betting Preview: Seahawks vs Cardinals

The Seattle Seahawks clash with the Arizona Cardinals in this NFL Week 4 Thursday Night Football matchup at State Farm Stadium, with kickoff scheduled for 20:15 on Thursday, September 25. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

We think that the Seahawks should prove too strong for the Cardinals. Therefore, it’s all about going to the Moneyline to back them and there’s juice in the -116 available.

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Seattle Seahawks claimed a home victory in their previous game. A 44-13 triumph against New Orleans Saints at Lumen Field made it back-to-back wins. The Seahawks put up 320 yards, split between 233 passing and 87 rushing yards. The offense moved the chains 22 times and struck for 5 touchdowns.

Arizona Cardinals suffered a defeat in their last game. A 16-15 scoreline occurred on the road at Levi's Stadium against San Francisco 49ers. The Cardinals totaled 260 yards, split between 154 passing and 106 rushing yards. They moved the chains 16 times and found the end zone once through the air.

Head-to-Head Statistics

The Seahawks beat the Cardinals when the teams last met. It was a 30-18 scoreline at State Farm Stadium. The previous 10 games featuring these teams have resulted in eight Seahawks victories.

Quarterbacks

Sam Darnold

226.5 Passing Yards

Over -112

Under -112

Kyler Murray

220.5 Passing Yards

Over -112

Under -112

Seahawks vs Cardinals Prediction & Picks

Take in the full Seahawks vs Cardinals betting outlook — from our expert match prediction and correct score pick to player prop insights and a bet builder tailored for value.

Game Prediction

There are lots of reasons to support the pick that the Seahawks will win this NFL showdown. Therefore, we’re heading to the Moneyline where you can get -116.

To deliver the best possible NFL predictions, we start by locking in the team news and taking time to review the latest form. There’s also no shortage of data to crunch from the most up-to-date stats available.

Key Seahawks vs Cardinals stats:

• Seahawks have won 7 consecutive games on the road.
• Seahawks have won 9 of their last 10 games on the road.
• Seahawks have won 12 of their last 20 games.
• Cardinals have lost 6 of their last 10 games.
• Cardinals have lost 11 of their last 20 games at home.
• Cardinals have lost their last 7 games against Seahawks.

Seahawks Moneyline Probability

If you go by the top betting sites, there’s a 53.8% likelihood of our pick landing a return. Based on our analysts research, we calculate the actual probability to be closer to 60%. The wager can be recommended for this precise reason.

If you’re looking for bigger odds, then the Seahawks on the Double Result lines could be a good way forward. You need them to lead at the halfway stage and then claim a victory.

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Our Game Prediction

Seahawks Moneyline @ -116 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (02:26, 24 September 2025). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Kyler Murray Under 209.5 Passing Yards -114

The odds for Kyler Murray (Cardinals) to record fewer than 209.5 passing yards are -114. He may fall short of the QB Passing Yards line, making this prop bet a strong pick.

Latest Kyler Murray Player Prop Odds

Touchdown

Anytime

+280

First

+1300

Passing Yards

Over 220.5

-112

Under 220.5

-112

Rushing Yards

Over 29.5

-112

Under 29.5

-112

---

Sam Darnold Under 7.5 Rushing Yards -122

You can place a bet on Sam Darnold (Cardinals) at -122 to record fewer than 7.5 rushing yards. There’s no reason to doubt our instinct, so we’ll bet on him falling short of the Player Rushing Yards line.

Latest Sam Darnold Player Prop Odds

Touchdown

Anytime

+700

First

+3000

Passing Yards

Over 226.5

-112

Under 226.5

-112

Rushing Yards

Over 8.5

-112

Under 8.5

-112

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Seahawks 27 - 24 Cardinals

We’re expecting this to be a close battle and we’ll take the Seahawks to win 27-24. This is available at huge odds for those that want to have a speculative wager.

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Seahawks vs Cardinals Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

You can back Arizona Cardinals at +108 to win against Seattle Seahawks, with the latter trading at -127. If you want to know the probability of the road team winning this game, it’s 56% according to the most popular sportsbooks.

The spread is currently 1.5, with the total points line at 43.5. NFL bettors love the chance to get an alternative angle by going for a Total wager. If you’re going for Under 43.5, this outcome can be backed at -110.

Take a well-rounded approach when placing your bets. The top NFL betting sites are packed with team props and game lines, so focus on finding the selection that reflects your read on the matchup.

Moneyline

Seahawks

-127

Cardinals

+108

Point Spread

Seahawks -1.5

-112

Cardinals +1.5

-108

Total Points

Under 43.5

-110

Over 43.5

-110

Kenneth Walker III can be backed to score a TD at any stage at -105. There is the opportunity to back the market leader to grab the first touchdown at +550.

Touchdown

Kenneth Walker III (Seahawks)

First TD

+550

Anytime TD

-105

Trey Benson (Cardinals)

First TD

+650

Anytime TD

+120

Trey McBride (Cardinals)

First TD

+850

Anytime TD

+170

Jaxon Smith-Njigba (Seahawks)

First TD

+850

Anytime TD

+165

Zach Charbonnet (Seahawks)

First TD

+950

Anytime TD

+175

Marvin Harrison Jr. (Cardinals)

First TD

+1000

Anytime TD

+195

Kyler Murray (Cardinals)

First TD

+1300

Anytime TD

+280

Cooper Kupp (Seahawks)

First TD

+1600

Anytime TD

+320

Michael Wilson (Cardinals)

First TD

+1800

Anytime TD

+380

Tory Horton (Seahawks)

First TD

+1800

Anytime TD

+390

Emari Demercado (Cardinals)

First TD

+2200

Anytime TD

+460

AJ Barner (Seahawks)

First TD

+2200

Anytime TD

+500

Greg Dortch (Cardinals)

First TD

+2700

Anytime TD

+600

Sam Darnold (Seahawks)

First TD

+3000

Anytime TD

+700

Zay Jones (Cardinals)

First TD

+4500

Anytime TD

+850

Tip Reiman (Cardinals)

First TD

+5000

Anytime TD

+1000

Elijah Arroyo (Seahawks)

First TD

+5500

Anytime TD

+1000

Elijah Higgins (Cardinals)

First TD

+6500

Anytime TD

+1600

Michael Carter (Cardinals)

First TD

+8000

Anytime TD

+2000

Bam Knight (Cardinals)

First TD

+8000

Anytime TD

+2200

Travis Vokolek (Cardinals)

First TD

+8000

Anytime TD

+1500

Xavier Weaver (Cardinals)

First TD

+10000

Anytime TD

+4000

Simi Fehoko (Cardinals)

First TD

+10000

Anytime TD

+2200

Eric Saubert (Seahawks)

First TD

+10000

Anytime TD

+2000

Nick Kallerup (Seahawks)

First TD

+10000

Anytime TD

+1700

Jake Bobo (Seahawks)

First TD

+10000

Anytime TD

+2000

Brady Russell (Seahawks)

First TD

+10000

Anytime TD

+3500

Dareke Young (Seahawks)

First TD

+10000

Anytime TD

+3500

George Holani (Seahawks)

First TD

+10000

Anytime TD

+2500

Cody White (Seahawks)

First TD

+10000

Anytime TD

+3000

Robbie Ouzts (Seahawks)

First TD

+10000

Anytime TD

+3300

Receiving Yards

Jaxon Smith-Njigba (Seahawks)

Over 84.5

-112

Under 84.5

-112

Trey McBride (Cardinals)

Over 64.5

-112

Under 64.5

-112

Marvin Harrison Jr. (Cardinals)

Over 50.5

-112

Under 50.5

-112

Cooper Kupp (Seahawks)

Over 42.5

-112

Under 42.5

-112

Tory Horton (Seahawks)

Over 25.5

-112

Under 25.5

-112

Michael Wilson (Cardinals)

Over 23.5

-112

Under 23.5

-112

Trey Benson (Cardinals)

Over 20.5

-112

Under 20.5

-112

Greg Dortch (Cardinals)

Over 15.5

-112

Under 15.5

-112

AJ Barner (Seahawks)

Over 14.5

-112

Under 14.5

-112

Kenneth Walker III (Seahawks)

Over 10.5

-112

Under 10.5

-112

Rushing Yards

Trey Benson (Cardinals)

Over 54.5

-112

Under 54.5

-112

Kenneth Walker III (Seahawks)

Over 52.5

-112

Under 52.5

-112

Zach Charbonnet (Seahawks)

Over 41.5

-112

Under 41.5

-112

Kyler Murray (Cardinals)

Over 29.5

-112

Under 29.5

-112

Emari Demercado (Cardinals)

Over 14.5

-112

Under 14.5

-112

Sam Darnold (Seahawks)

Over 8.5

-112

Under 8.5

-112

Passing Yards

Sam Darnold (Seahawks)

Over 226.5

-112

Under 226.5

-112

Kyler Murray (Cardinals)

Over 220.5

-112

Under 220.5

-112

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Seahawks Have Bossed Recent Head-to-Heads at State Farm Stadium

The Cardinals have run off three straight victories at State Farm Stadium. They have seven wins and three losses in the last 10 home games, putting up 26.70 points per contest and giving up 19.50.

The Seahawks have reeled off seven straight road wins. They have nine wins and one loss in the last 10 road games, averaging 25.00 points on offense and surrendering 19.70 on defense.

The last time the Seahawks faced the Cardinals at State Farm Stadium, they won 30-18. Over the previous 6 head-to-head clashes at State Farm Stadium, the Seahawks have collected five victories, while the Cardinals have one.

Last 10 Games		W-L	P	PF	PA	O43.5	U43.5
Cardinals Home Stats		7-3	46.20	26.70	19.50	6	4
Seahawks Away Stats		9-1	44.70	25.00	19.70	6	4

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O43.5 = Games Over 43.5 Points
• U43.5 = Games Under 43.5 Points

Latest regular season and playoff games stats.

Seattle Seahawks Stats

Arizona Cardinals Stats

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 9 wins and 1 defeat in the last 10 games on the road

Moneyline

• 4 wins and 6 defeats in the last 10 games
• 7 wins and 3 defeats in the last 10 home games

Point Spread

• -1.5 Betting Line: Have covered the spread in 7 of the last 10 games
• -1.5 Betting Line on the Road: Have covered the spread in 8 of the last 10 games on the road

Point Spread

• +1.5 Betting Line: Have covered the spread in 6 of the last 10 games
• +1.5 Betting Line at Home: Have covered the spread in 7 of the last 10 home games

Total Points

• Game Totals: An average of 41.00 pts in the previous 10 games
• Game Totals on the Road: An average of 44.70 pts in the previous 10 games on the road
• Over 43.5: Covered in 6 of the previous 10 games
• Over 43.5 on the Road: Covered in 6 of the previous 10 games on the road
• Team Totals: Have scored an average of 23.30 pts and allowed 17.70 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 25.00 pts and allowed 19.70 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 43.40 pts in the previous 10 games
• Game Totals at Home: An average of 46.20 pts in the previous 10 home games
• Over 43.5: Covered in 6 of the previous 10 games
• Over 43.5 at Home: Covered in 6 of the previous 10 home games
• Team Totals: Have scored an average of 22.40 pts and allowed 21.00 pts in the last 10 games
• Team Totals at Home: Have scored an average of 26.70 pts and allowed 19.50 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 306.50 Yds. Allowed 309.60 Yds
• Rushing Yards: Gained 100.00 Yds. Allowed 93.70 Yds
• Passing Yards: Gained 206.50 Yds. Allowed 215.90 Yds
• Total Touchdowns: Scored 2.60 TD. Allowed 1.70 TD
• Rushing Touchdowns: Scored 0.80 TD. Allowed 0.10 TD
• Passing Touchdowns: Scored 1.50 TD. Allowed 1.50 TD
• Total 1st Downs: Picked up 17.50. Allowed 18.20
• Total Turnovers: Committed 1.30. Committed by opponents 1.30
• Total Penalties: Committed 5.50. Committed by opponents 6.30
• Penalty Yards: Lost 50.60 Yds. Gained 47.50 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 345.20 Yds. Allowed 333.30 Yds
• Rushing Yards: Gained 127.40 Yds. Allowed 104.70 Yds
• Passing Yards: Gained 217.80 Yds. Allowed 228.60 Yds
• Total Touchdowns: Scored 2.20 TD. Allowed 2.30 TD
• Rushing Touchdowns: Scored 0.70 TD. Allowed 0.90 TD
• Passing Touchdowns: Scored 1.30 TD. Allowed 1.40 TD
• Total 1st Downs: Picked up 20.50. Allowed 19.50
• Total Turnovers: Committed 1.00. Committed by opponents 0.90
• Total Penalties: Committed 7.00. Committed by opponents 7.50
• Penalty Yards: Lost 56.00 Yds. Gained 65.00 Yds

Last 10 Games on the Road

• Total Yards: Gained 349.30 Yds. Allowed 329.00 Yds
• Rushing Yards: Gained 113.90 Yds. Allowed 126.20 Yds
• Passing Yards: Gained 235.40 Yds. Allowed 202.80 Yds
• Total Touchdowns: Scored 2.80 TD. Allowed 2.20 TD
• Rushing Touchdowns: Scored 1.10 TD. Allowed 0.70 TD
• Passing Touchdowns: Scored 1.40 TD. Allowed 1.40 TD
• Total 1st Downs: Picked up 19.80. Allowed 18.90
• Total Turnovers: Committed 0.80. Committed by opponents 1.30
• Total Penalties: Committed 4.60. Committed by opponents 6.30
• Penalty Yards: Lost 35.20 Yds. Gained 47.60 Yds

Last 10 Home Games

• Total Yards: Gained 357.90 Yds. Allowed 341.80 Yds
• Rushing Yards: Gained 154.70 Yds. Allowed 114.30 Yds
• Passing Yards: Gained 203.20 Yds. Allowed 227.50 Yds
• Total Touchdowns: Scored 3.20 TD. Allowed 2.00 TD
• Rushing Touchdowns: Scored 1.40 TD. Allowed 1.00 TD
• Passing Touchdowns: Scored 1.40 TD. Allowed 1.00 TD
• Total 1st Downs: Picked up 21.00. Allowed 20.60
• Total Turnovers: Committed 0.90. Committed by opponents 1.20
• Total Penalties: Committed 4.60. Committed by opponents 6.30
• Penalty Yards: Lost 43.70 Yds. Gained 52.80 Yds

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