Buccaneers vs Bills Prediction, Picks & Odds | 16 Nov 2025

NFL Betting Preview: Buccaneers vs Bills

The Tampa Bay Buccaneers go up against the Buffalo Bills at Highmark Stadium, with kickoff scheduled for 13:00 on Sunday, November 16.

Let’s take a chance on the Buccaneers who have been given a very generous +5.5 on the spread. We think -110 can be taken with confidence that they cover the line against the Bills.

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Tampa Bay Buccaneers were beaten 28-23 at Raymond James Stadium in their previous game, being turned over at home to New England Patriots. The Buccaneers finished with 371 total yards, breaking down to 258 passing and 113 rushing yards. The offense moved the chains 24 times and scored 3 touchdowns, every one through the air.

Buffalo Bills were beaten last game and this was on the road at Hard Rock Stadium. Miami Dolphins claimed a 30-13 win. The Bills finished with 376 yards, including 289 passing and 87 rushing yards. They moved the chains 20 times and crossed the goal line twice.

Head-to-Head Statistics

The Bills beat the Bucs in their last head-to-head matchup. It was a 24-18 scoreline at Highmark Stadium.

Quarterbacks

Baker Mayfield

203.5 Passing Yards

Over -112

Under -112

Josh Allen

216.5 Passing Yards

Over -112

Under -112

Buccaneers vs Bills Prediction & Picks

This Buccaneers vs Bills betting guide features sharp analysis across major markets, including a match prediction, correct score bet, valuable player prop picks and a strategic bet builder.

Game Prediction

Our best wager is for the Buccaneers to cover the spread. +5.5 at odds of -110 look very generous and we’re happy to back this NFL betting pick.

Tracking injury updates is a big part of our analysis and team news plays a major role in shaping our NFL predictions. We combine this with recent form and the most important stats to get a complete picture.

Key Buccaneers vs Bills stats:

• The +5.5 line has been covered by Buccaneers in 17 of their last 20 games.
• The +5.5 line has been covered by Buccaneers in 8 of their last 10 games.
• The +5.5 line has been covered by Buccaneers in 2 consecutive games.
• The -5.5 line hasn’t been covered by Bills in 3 of their last 5 games.

Bucs +5.5 Probability

Based on the betting odds from the top sportsbooks, our pick has a 52.4% chance of winning. In the opinion of our cappers, there’s actually a probability of success closer to 60%. This is why we regard this as a value wager.

Bettors can choose between buying or selling points depending on their attitude to risk. When you move the line in either direction, the odds change accordingly.

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Our Game Prediction

Buccaneers +5.5 @ -110 Bet Now

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Player Prop Picks

Top Pick: Baker Mayfield Over 218.5 Passing Yards -114

You can back Baker Mayfield (Bucs) at -114 to exceed 218.5 passing yards. The line for QB Passing Yards looks attractive and we’re confident of securing a return.

Latest Baker Mayfield Player Prop Odds

Touchdown

Anytime

+650

First

+3500

Passing Yards

Over 203.5

-112

Under 203.5

-112

Rushing Yards

Over 11.5

-112

Under 11.5

-112

---

Sean Tucker Anytime TD +185

Sean Tucker (Bucs) can be backed at +185 to reach the end zone. The Anytime Touchdown Scorer odds are appealing from all angles and we’re willing to take a chance on him.

Latest Sean Tucker Player Prop Odds

Touchdown

Anytime

+220

First

+1400

Rushing Yards

Over 41.5

-112

Under 41.5

-112

Correct Score Prediction

Buccaneers 20 - 23 Bills

There’s every chance that this is going to be a close battle and we’ll have a play on the Bills enjoying a 23-20 winning scoreline. Hopefully this can go close.

Buccaneers vs Bills Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

The Buffalo Bills odds have been priced up by the sportsbooks and they are -227 betting favorites to land victory in this game which means a 69% chance of winning. Tampa Bay Buccaneers are regarded as a long shot to win and you can currently back them at +185.

There is a spread of 5.5 and total points has a line of 49.5. There is no denying the popularity of betting on the Totals. Those who wager Under 49.5 can get -110.

Whether you are wagering pre-game or in-game on the National Football League, the best betting apps offer a wide range of game lines and team props. The selections are practically endless and it’s great to have so many different options.

Moneyline

Buccaneers

+185

Bills

-227

Point Spread

Buccaneers +5.5

-110

Bills -5.5

-110

Total Points

Under 49.5

-110

Over 49.5

-110

James Cook is the market leader at +380 to be the First TD Scorer. Should you think he will score the final touchdown, then a similar price can be found.

Touchdown

James Cook (Bills)

First TD

+380

Anytime TD

-164

Josh Allen (Bills)

First TD

+550

Anytime TD

-115

Emeka Egbuka (Buccaneers)

First TD

+900

Anytime TD

+155

Rachaad White (Buccaneers)

First TD

+1000

Anytime TD

+165

Khalil Shakir (Bills)

First TD

+1000

Anytime TD

+230

Keon Coleman (Bills)

First TD

+1300

Anytime TD

+250

Sean Tucker (Buccaneers)

First TD

+1400

Anytime TD

+220

Cade Otton (Buccaneers)

First TD

+1400

Anytime TD

+250

Tez Johnson (Buccaneers)

First TD

+1700

Anytime TD

+300

Dawson Knox (Bills)

First TD

+1700

Anytime TD

+390

Joshua Palmer (Bills)

First TD

+2000

Anytime TD

+430

Gabe Davis (Bills)

First TD

+2000

Anytime TD

+420

Sterling Shepard (Buccaneers)

First TD

+2500

Anytime TD

+490

Jackson Hawes (Bills)

First TD

+2500

Anytime TD

+500

Tyrell Shavers (Bills)

First TD

+2700

Anytime TD

+550

Mecole Hardman (Bills)

First TD

+3500

Anytime TD

+800

Elijah Moore (Bills)

First TD

+3500

Anytime TD

+800

Curtis Samuel (Bills)

First TD

+3500

Anytime TD

+800

Baker Mayfield (Buccaneers)

First TD

+3500

Anytime TD

+650

Ty Johnson (Bills)

First TD

+4500

Anytime TD

+800

Ray Davis (Bills)

First TD

+8000

Anytime TD

+1100

Payne Durham (Buccaneers)

First TD

+10000

Anytime TD

+1400

Kameron Johnson (Buccaneers)

First TD

+10000

Anytime TD

+1700

Ryan Miller (Buccaneers)

First TD

+10000

Anytime TD

+1700

Reggie Gilliam (Bills)

First TD

+10000

Anytime TD

+2500

Devin Culp (Buccaneers)

First TD

+10000

Anytime TD

+3300

Owen Wright (Buccaneers)

First TD

+10000

Anytime TD

+1700

Keleki Latu (Bills)

First TD

+10000

Anytime TD

+2500

Receiving Yards

Emeka Egbuka (Buccaneers)

Over 57.5

-112

Under 57.5

-112

Khalil Shakir (Bills)

Over 47.5

-112

Under 47.5

-112

Cade Otton (Buccaneers)

Over 37.5

-112

Under 37.5

-112

Tez Johnson (Buccaneers)

Over 31.5

-112

Under 31.5

-112

Keon Coleman (Bills)

Over 30.5

-114

Under 30.5

-114

Joshua Palmer (Bills)

Over 26.5

-112

Under 26.5

-112

Dawson Knox (Bills)

Over 24.5

-112

Under 24.5

-112

Sterling Shepard (Buccaneers)

Over 19.5

-112

Under 19.5

-112

Rachaad White (Buccaneers)

Over 15.5

-112

Under 15.5

-112

James Cook (Bills)

Over 11.5

-112

Under 11.5

-112

Rushing Yards

James Cook (Bills)

Over 81.5

-112

Under 81.5

-112

Rachaad White (Buccaneers)

Over 43.5

-112

Under 43.5

-112

Sean Tucker (Buccaneers)

Over 41.5

-112

Under 41.5

-112

Josh Allen (Bills)

Over 33.5

-112

Under 33.5

-112

Baker Mayfield (Buccaneers)

Over 11.5

-112

Under 11.5

-112

Passing Yards

Josh Allen (Bills)

Over 216.5

-112

Under 216.5

-112

Baker Mayfield (Buccaneers)

Over 203.5

-112

Under 203.5

-112

It’s good to consider all wagering options when it comes to NFL and micro betting can be an exciting way to get involved in the action. When everything goes in-game, consider whether a player will make or miss a field goal.

Bills Have Won Nine of Their Last Ten Home Games

The Bills have a 9-1 record in their last 10 home games, scoring 30.80 points per contest and conceding 20.10.

The Bucs have seven wins and three losses in the last 10 games away from home, putting up 25.70 points on average and giving up 20.40.

The Bills defeated the Bucs 24-18 the last time they played at Highmark Stadium.

Last 10 Games		W-L	P	PF	PA	O47.5	U47.5
Bills Home Stats		9-1	50.90	30.80	20.10	6	4
Buccaneers Away Stats		7-3	46.10	25.70	20.40	5	5

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O47.5 = Games Over 47.5 Points
• U47.5 = Games Under 47.5 Points

Latest regular season and playoff games stats.

Tampa Bay Buccaneers Stats

Buffalo Bills Stats

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 7 wins and 3 defeats in the last 10 games on the road

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 9 wins and 1 defeat in the last 10 home games

Point Spread

• +5.5 Betting Line: Have covered the spread in 8 of the last 10 games
• +5.5 Betting Line on the Road: Have covered the spread in 8 of the last 10 games on the road

Point Spread

• -5.5 Betting Line: Have covered the spread in 5 of the last 10 games
• -5.5 Betting Line at Home: Have covered the spread in 6 of the last 10 home games

Total Points

• Game Totals: An average of 46.90 pts in the previous 10 games
• Game Totals on the Road: An average of 46.10 pts in the previous 10 games on the road
• Over 47.5: Covered in 5 of the previous 10 games
• Over 47.5 on the Road: Covered in 5 of the previous 10 games on the road
• Team Totals: Have scored an average of 24.00 pts and allowed 22.90 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 25.70 pts and allowed 20.40 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 50.60 pts in the previous 10 games
• Game Totals at Home: An average of 50.90 pts in the previous 10 home games
• Over 47.5: Covered in 6 of the previous 10 games
• Over 47.5 at Home: Covered in 6 of the previous 10 home games
• Team Totals: Have scored an average of 27.70 pts and allowed 22.90 pts in the last 10 games
• Team Totals at Home: Have scored an average of 30.80 pts and allowed 20.10 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 323.90 Yds. Allowed 339.00 Yds
• Rushing Yards: Gained 99.90 Yds. Allowed 102.30 Yds
• Passing Yards: Gained 224.00 Yds. Allowed 236.70 Yds
• Total Touchdowns: Scored 2.60 TD. Allowed 2.60 TD
• Rushing Touchdowns: Scored 0.60 TD. Allowed 1.00 TD
• Passing Touchdowns: Scored 1.90 TD. Allowed 1.40 TD
• Total 1st Downs: Picked up 19.40. Allowed 18.80
• Total Turnovers: Committed 0.60. Committed by opponents 1.30
• Total Penalties: Committed 6.30. Committed by opponents 7.00
• Penalty Yards: Lost 50.20 Yds. Gained 56.30 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 383.40 Yds. Allowed 322.90 Yds
• Rushing Yards: Gained 152.60 Yds. Allowed 146.30 Yds
• Passing Yards: Gained 230.80 Yds. Allowed 176.60 Yds
• Total Touchdowns: Scored 3.50 TD. Allowed 2.70 TD
• Rushing Touchdowns: Scored 1.80 TD. Allowed 1.70 TD
• Passing Touchdowns: Scored 1.70 TD. Allowed 0.90 TD
• Total 1st Downs: Picked up 22.70. Allowed 19.60
• Total Turnovers: Committed 0.90. Committed by opponents 1.20
• Total Penalties: Committed 6.70. Committed by opponents 5.30
• Penalty Yards: Lost 56.60 Yds. Gained 41.30 Yds

Last 10 Games on the Road

• Total Yards: Gained 360.50 Yds. Allowed 326.00 Yds
• Rushing Yards: Gained 129.90 Yds. Allowed 82.80 Yds
• Passing Yards: Gained 230.60 Yds. Allowed 243.20 Yds
• Total Touchdowns: Scored 2.90 TD. Allowed 2.30 TD
• Rushing Touchdowns: Scored 1.10 TD. Allowed 0.90 TD
• Passing Touchdowns: Scored 1.80 TD. Allowed 1.40 TD
• Total 1st Downs: Picked up 21.20. Allowed 18.90
• Total Turnovers: Committed 1.00. Committed by opponents 1.30
• Total Penalties: Committed 5.70. Committed by opponents 6.10
• Penalty Yards: Lost 46.50 Yds. Gained 47.00 Yds

Last 10 Home Games

• Total Yards: Gained 376.80 Yds. Allowed 318.90 Yds
• Rushing Yards: Gained 153.50 Yds. Allowed 135.30 Yds
• Passing Yards: Gained 223.30 Yds. Allowed 183.60 Yds
• Total Touchdowns: Scored 3.80 TD. Allowed 2.40 TD
• Rushing Touchdowns: Scored 1.90 TD. Allowed 1.20 TD
• Passing Touchdowns: Scored 1.80 TD. Allowed 1.20 TD
• Total 1st Downs: Picked up 22.80. Allowed 19.60
• Total Turnovers: Committed 0.50. Committed by opponents 1.70
• Total Penalties: Committed 6.70. Committed by opponents 5.90
• Penalty Yards: Lost 48.60 Yds. Gained 50.10 Yds

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