Titans vs Cardinals Prediction, Picks & Odds | 05 Oct 2025

NFL Betting Preview: Titans vs Cardinals

The Tennessee Titans go up against the Arizona Cardinals in this NFL Week 5 matchup at State Farm Stadium, with kickoff scheduled for 16:05 on Sunday, October 5. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

You can get -102 that there are Over 41.5 points and there’s lots of juice in those odds. The Cardinals and the Titans should be able to keep the score ticking for our prediction to win.

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Tennessee Titans were beaten in their previous four games and the latest was on the road at NRG Stadium. Houston Texans claimed a 26-0 win. The Titans put up 175 total yards, made up of 93 through the air and 82 on the ground. They converted for 10 first downs and allowed 20.

Arizona Cardinals were defeated last time, making it back-to-back losses. State Farm Stadium saw them beaten 23-20 at home to Seattle Seahawks. The Cardinals finished with 253 yards, including 164 passing and 89 rushing yards. The offense converted for 18 first downs and scored 2 touchdowns, both through the air.

Head-to-Head Statistics

The scoreline was 38-13 in favor of the Cardinals when they last played the Titans, with the matchup taking place at Nissan Stadium.

Quarterbacks

Cam Ward

179.5 Passing Yards

Over -112

Under -112

Kyler Murray

220.5 Passing Yards

Over -112

Under -112

Titans vs Cardinals Prediction & Picks

Our Titans vs Cardinals betting tips provide expert coverage of all major angles, including our main match prediction, top player prop picks, correct score recommendation and best bet builder insights.

Game Prediction

We’re predicting that the two teams will produce a significant combined points total in this NFL matchup. Therefore, our pick is to take the -102 that there are Over 41.5 points.

The NFL handicappers at Sportsgambler.com stay on top of injuries and team form that could impact the outcome. We also leave no stone unturned when analyzing the latest stats to support every prediction.

Key Titans vs Cardinals stats:

• The 41.5 line has been covered in 7 of the last 10 Titans games on the road.
• The 41.5 line has been covered in 11 of the last 20 Titans games.
• The 41.5 line has been covered in the last 5 Cardinals games at home.
• The 41.5 line has been covered in 7 of the last 10 Cardinals games.
• The 41.5 line has been covered in 14 of the last 20 Cardinals games at home.

Over 41.5 Probability

According to the top sportsbooks, there’s a 50.5% likelihood of our pick landing a return. Taking all factors into consideration, our analysts think there’s a stronger chance of success and have a probability interval between 55-60%. This is why we can recommend this wager.

There’s a chance to secure larger odds when you bet on the Totals. The sportsbooks allow you to move the line for an Over pick until you’re happy with the potential return.

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Our Game Prediction

Over 41.5 Points @ -102 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (22:26, 03 October 2025). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Kyler Murray Over 219.5 Passing Yards -114

You can back Kyler Murray (Cardinals) at -114 to accumulate over 219.5 passing yards. We can back him in the QB Passing Yards market and hope the Over hits.

Latest Kyler Murray Player Prop Odds

Touchdown

Anytime

+230

First

+1000

Passing Yards

Over 220.5

-112

Under 220.5

-112

Rushing Yards

Over 30.5

-112

Under 30.5

-112

---

Michael Carter Over 46.5 Rushing Yards -114

The odds for Michael Carter (Titans) to exceed 46.5 rushing yards stand at -114. We're confident in him covering the Player Rushing Yards line and hitting our Over bet.

Latest Michael Carter Player Prop Odds

Touchdown

Anytime

+145

First

+700

Receiving Yards

Over 10.5

-112

Under 10.5

-112

Rushing Yards

Over 42.5

-112

Under 42.5

-112

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Titans 14 - 30 Cardinals

Correct score betting might be tough to predict but there’s a huge potential return if you get it right. We’ll try the Cardinals to achieve a 30-14 victory at monster odds.

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Titans vs Cardinals Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

According to the Moneyline betting odds, Arizona Cardinals are red-hot -238 favorites with the sportsbooks and that means a 70% chance of winning this game. At +195, Tennessee Titans are regarded as having a lower probability of winning.

There is a spread of 5.5 and total points has a line of 46.5. There are many ways to bet on the NFL including the Totals. If you want to back Over 46.5, it’s -110.

Consider every angle when placing your National Football League wagers. The top betting apps have a huge selection of game lines and team props and it’s all about finding a bet which matches your prediction of the game.

Moneyline

Titans

+195

Cardinals

-238

Point Spread

Titans +5.5

-110

Cardinals -5.5

-110

Total Points

Under 46.5

-110

Over 46.5

-110

Favorite Trey McBride is now available at +600 to be the First Touchdown Scorer. You will find similar odds apply when it comes to him scoring the last TD.

Touchdown

Trey McBride (Cardinals)

First TD

+600

Anytime TD

+125

Tony Pollard (Titans)

First TD

+700

Anytime TD

+135

Michael Carter (Cardinals)

First TD

+700

Anytime TD

+145

Marvin Harrison Jr. (Cardinals)

First TD

+700

Anytime TD

+150

Kyler Murray (Cardinals)

First TD

+1000

Anytime TD

+230

Emari Demercado (Cardinals)

First TD

+1200

Anytime TD

+260

Michael Wilson (Cardinals)

First TD

+1300

Anytime TD

+310

Bam Knight (Cardinals)

First TD

+1700

Anytime TD

+410

Elic Ayomanor (Titans)

First TD

+1900

Anytime TD

+400

Tyjae Spears (Titans)

First TD

+2000

Anytime TD

+440

Calvin Ridley (Titans)

First TD

+2000

Anytime TD

+490

Greg Dortch (Cardinals)

First TD

+2200

Anytime TD

+600

Chigoziem Okonkwo (Titans)

First TD

+3000

Anytime TD

+650

Zay Jones (Cardinals)

First TD

+3000

Anytime TD

+750

Cam Ward (Titans)

First TD

+3500

Anytime TD

+850

Tyler Lockett (Titans)

First TD

+3500

Anytime TD

+850

Chimere Dike (Titans)

First TD

+4000

Anytime TD

+750

Gunnar Helm (Titans)

First TD

+4500

Anytime TD

+1100

Elijah Higgins (Cardinals)

First TD

+8000

Anytime TD

+2000

Van Jefferson (Titans)

First TD

+8000

Anytime TD

+1600

Julius Chestnut (Titans)

First TD

+10000

Anytime TD

+3000

Tip Reiman (Cardinals)

First TD

+10000

Anytime TD

+2200

James Proche II (Titans)

First TD

+10000

Anytime TD

+2700

Travis Vokolek (Cardinals)

First TD

+10000

Anytime TD

+3000

David Martin-Robinson (Titans)

First TD

+10000

Anytime TD

+4500

Simi Fehoko (Cardinals)

First TD

+10000

Anytime TD

+4000

Receiving Yards

Trey McBride (Cardinals)

Over 59.5

-112

Under 59.5

-112

Marvin Harrison Jr. (Cardinals)

Over 54.5

-112

Under 54.5

-112

Elic Ayomanor (Titans)

Over 37.5

-112

Under 37.5

-112

Calvin Ridley (Titans)

Over 29.5

-112

Under 29.5

-112

Michael Wilson (Cardinals)

Over 23.5

-112

Under 23.5

-112

Chigoziem Okonkwo (Titans)

Over 23.5

-112

Under 23.5

-112

Tyler Lockett (Titans)

Over 14.5

-112

Under 14.5

-112

Gunnar Helm (Titans)

Over 13.5

-112

Under 13.5

-112

Emari Demercado (Cardinals)

Over 12.5

-112

Under 12.5

-112

Michael Carter (Cardinals)

Over 10.5

-112

Under 10.5

-112

Tony Pollard (Titans)

Over 9.5

-112

Under 9.5

-112

Zay Jones (Cardinals)

Over 9.5

-112

Under 9.5

-112

Greg Dortch (Cardinals)

Over 8.5

-112

Under 8.5

-112

Rushing Yards

Tony Pollard (Titans)

Over 55.5

-112

Under 55.5

-112

Michael Carter (Cardinals)

Over 42.5

-112

Under 42.5

-112

Kyler Murray (Cardinals)

Over 30.5

-112

Under 30.5

-112

Tyjae Spears (Titans)

Over 18.5

-112

Under 18.5

-112

Emari Demercado (Cardinals)

Over 17.5

-112

Under 17.5

-112

Cam Ward (Titans)

Over 10.5

-112

Under 10.5

-112

Passing Yards

Kyler Murray (Cardinals)

Over 220.5

-112

Under 220.5

-112

Cam Ward (Titans)

Over 179.5

-112

Under 179.5

-112

It’s possible to use stats to your advantage when it comes to NFL micro betting, especially if you’re predicting outcomes such as the Next Drive Result. Check out the live team, score and player props and see if you can find an angle.

Cardinals Own Six Wins From Last Ten at Home

The Cardinals own a 6-4 mark in their past 10 home games, averaging 24.60 points on offense and surrendering 20.80 on defense.

The Titans have dropped five road games in a row. They have two wins and eight losses in the last 10 games on the road, averaging 17.80 points scored and 29.80 points allowed.

Last 10 Games		W-L	P	PF	PA	O41.5	U41.5
Cardinals Home Stats		6-4	45.40	24.60	20.80	6	4
Titans Away Stats		2-8	47.60	17.80	29.80	7	3

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O41.5 = Games Over 41.5 Points
• U41.5 = Games Under 41.5 Points

Latest regular season and playoff games stats.

Tennessee Titans Stats

Arizona Cardinals Stats

Moneyline

• 0 wins and 10 defeats in the last 10 games
• 2 wins and 8 defeats in the last 10 games on the road

Moneyline

• 4 wins and 6 defeats in the last 10 games
• 6 wins and 4 defeats in the last 10 home games

Point Spread

• +8.5 Betting Line: Have covered the spread in 4 of the last 10 games
• +8.5 Betting Line on the Road: Have covered the spread in 5 of the last 10 games on the road

Point Spread

• -8.5 Betting Line: Have covered the spread in 2 of the last 10 games
• -8.5 Betting Line at Home: Have covered the spread in 4 of the last 10 home games

Total Points

• Game Totals: An average of 45.00 pts in the previous 10 games
• Game Totals on the Road: An average of 47.60 pts in the previous 10 games on the road
• Over 41.5: Covered in 5 of the previous 10 games
• Over 41.5 on the Road: Covered in 7 of the previous 10 games on the road
• Team Totals: Have scored an average of 16.00 pts and allowed 29.00 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 17.80 pts and allowed 29.80 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 45.50 pts in the previous 10 games
• Game Totals at Home: An average of 45.40 pts in the previous 10 home games
• Over 41.5: Covered in 7 of the previous 10 games
• Over 41.5 at Home: Covered in 6 of the previous 10 home games
• Team Totals: Have scored an average of 23.80 pts and allowed 21.70 pts in the last 10 games
• Team Totals at Home: Have scored an average of 24.60 pts and allowed 20.80 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 269.10 Yds. Allowed 372.40 Yds
• Rushing Yards: Gained 90.10 Yds. Allowed 166.80 Yds
• Passing Yards: Gained 179.00 Yds. Allowed 205.60 Yds
• Total Touchdowns: Scored 1.50 TD. Allowed 3.60 TD
• Rushing Touchdowns: Scored 0.50 TD. Allowed 1.70 TD
• Passing Touchdowns: Scored 1.00 TD. Allowed 1.60 TD
• Total 1st Downs: Picked up 16.50. Allowed 20.80
• Total Turnovers: Committed 1.80. Committed by opponents 1.40
• Total Penalties: Committed 7.90. Committed by opponents 6.60
• Penalty Yards: Lost 66.10 Yds. Gained 52.40 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 340.70 Yds. Allowed 343.20 Yds
• Rushing Yards: Gained 131.40 Yds. Allowed 113.70 Yds
• Passing Yards: Gained 209.30 Yds. Allowed 229.50 Yds
• Total Touchdowns: Scored 2.40 TD. Allowed 2.30 TD
• Rushing Touchdowns: Scored 0.70 TD. Allowed 1.00 TD
• Passing Touchdowns: Scored 1.50 TD. Allowed 1.30 TD
• Total 1st Downs: Picked up 20.80. Allowed 19.80
• Total Turnovers: Committed 1.10. Committed by opponents 0.90
• Total Penalties: Committed 7.20. Committed by opponents 7.60
• Penalty Yards: Lost 54.60 Yds. Gained 67.30 Yds

Last 10 Games on the Road

• Total Yards: Gained 279.80 Yds. Allowed 325.30 Yds
• Rushing Yards: Gained 105.90 Yds. Allowed 153.30 Yds
• Passing Yards: Gained 173.90 Yds. Allowed 172.00 Yds
• Total Touchdowns: Scored 1.70 TD. Allowed 3.60 TD
• Rushing Touchdowns: Scored 0.60 TD. Allowed 1.60 TD
• Passing Touchdowns: Scored 1.10 TD. Allowed 1.80 TD
• Total 1st Downs: Picked up 16.50. Allowed 18.90
• Total Turnovers: Committed 1.90. Committed by opponents 0.90
• Total Penalties: Committed 7.70. Committed by opponents 6.70
• Penalty Yards: Lost 61.20 Yds. Gained 55.00 Yds

Last 10 Home Games

• Total Yards: Gained 334.30 Yds. Allowed 355.70 Yds
• Rushing Yards: Gained 140.50 Yds. Allowed 124.50 Yds
• Passing Yards: Gained 193.80 Yds. Allowed 231.20 Yds
• Total Touchdowns: Scored 2.90 TD. Allowed 2.10 TD
• Rushing Touchdowns: Scored 1.30 TD. Allowed 1.00 TD
• Passing Touchdowns: Scored 1.30 TD. Allowed 1.10 TD
• Total 1st Downs: Picked up 20.40. Allowed 21.20
• Total Turnovers: Committed 1.00. Committed by opponents 1.20
• Total Penalties: Committed 4.80. Committed by opponents 6.70
• Penalty Yards: Lost 43.10 Yds. Gained 59.20 Yds

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