Titans vs 49ers Prediction, Picks & Odds | 14 Dec 2025

NFL Betting Preview: Titans vs Niners

The Tennessee Titans square off against the San Francisco 49ers at Levi's Stadium, with kickoff scheduled for 16:25 on Sunday, December 14.

The Titans can avoid a big loss against the Niners, with bettors able to back them against the spread. The underdogs should be able to cover +12.5 which have been made available at -105.

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Tennessee Titans triumphed in their previous game. It was on the road where Cleveland Browns were beaten 31-29 at Huntington Bank Field. The Titans put up 292 yards, split between 108 passing and 184 rushing yards. The offense moved the chains 13 times and struck for 4 touchdowns.

San Francisco 49ers won their last game 26-8, making it three on the bounce. This was a road victory at Huntington Bank Field against Cleveland Browns. The 49ers generated 246 yards, including 161 passing and 85 rushing yards. They picked up 18 first downs and scored 3 touchdowns, split between one passing and 2 rushing TD's.

Head-to-Head Statistics

The Titans won the last matchup between the pair. Enjoying a 20-17 triumph when facing the Niners at Nissan Stadium.

Quarterbacks

Cam Ward

200.5 Passing Yards

Over -112

Under -112

Brock Purdy

242.5 Passing Yards

Over -112

Under -112

Titans vs 49ers Prediction & Picks

Join us as we dissect the best Titans vs 49ers betting tips — from our expert match prediction and correct score advice to top player prop insights and a ready-made bet builder.

Game Prediction

Let’s take a chance on the Titans and wager the underdogs with a +12.5 points start. They should be able to cover the line in this NFL showdown at odds of -105.

The NFL handicappers at Sportsgambler.com always keep close tabs on team news as it develops. We also rely on recent form and key stats to help shape our predictions and guide the final call.

Key Titans vs 49ers stats:

• The +12.5 line has been covered by Titans in 4 of their last 5 games.
• The +12.5 line has been covered by Titans in 7 of their last 10 games on the road.
• The -12.5 line hasn’t been covered by 49ers in 7 consecutive games at home.
• The -12.5 line hasn’t been covered by 49ers in 9 of their last 10 games at home.
• The -12.5 line hasn’t been covered by 49ers in 11 of their last 13 games this season.

Titans +12.5 Probability

According to the best NFL sportsbooks, our pick has a 51.3% chance of winning. Based on our cappers in-depth research, we calculate the actual probability to be closer to 60%. This bet can therefore be backed with confidence.

There are several alternatives to the spread and we particularly like the Winning Margin lines. It’s great whether you’re expecting things to be close or comprehensive.

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Our Game Prediction

Titans +12.5 @ -105 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (22:25, 12 December 2025). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Jauan Jennings Anytime TD +185

Jauan Jennings (Niners) can be backed at +185 to hit the end zone. We’re happy to take the odds that he’ll score at least one touchdown in the Anytime Touchdown Scorer market.

Latest Jauan Jennings Player Prop Odds

Touchdown

Anytime

+170

First

+750

Receiving Yards

Over 47.5

-112

Under 47.5

-112

---

Christian McCaffrey Under 70.5 Rushing Yards -114

The odds for Christian McCaffrey (Titans) to finish with fewer than 70.5 rushing yards stand at -114. Considering all factors, we’re confident he’ll fall short of the Player Rushing Yards line.

Latest Christian McCaffrey Player Prop Odds

Touchdown

Anytime

-263

First

+240

Receiving Yards

Over 40.5

-112

Under 40.5

-112

Rushing Yards

Over 64.5

-112

Under 64.5

-112

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Titans 21 - 31 49ers

Should you want to go for a selection at huge odds, head to the correct score lines where the 49ers can be backed speculatively to achieve a 31-21 victory.

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Titans vs 49ers Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

The latest Moneyline betting odds give San Francisco 49ers a 76% chance of winning this game which means they’re overwhelming -323 favorites with the sportsbooks. For those wanting to oppose the market leader, you can get +260 about Tennessee Titans.

The spread is 7.5 and the total points line is currently 45.5. There are many ways to bet on the NFL including the Totals. If you want to bet Under 45.5, there are odds of -110.

If you’re betting on the National Football League, we recommend visiting the top betting apps and scanning through the many team props and game lines. There’s the opportunity to wager pre-game and in-game.

Moneyline

Titans

+260

49ers

-323

Point Spread

Titans +7.5

-110

49ers -7.5

-110

Total Points

Under 45.5

-110

Over 45.5

-110

The First Touchdown Scorer favorite is Christian McCaffrey at +240. Similar odds can be found if you’re interested in this player to register the final TD.

Touchdown

Christian McCaffrey (49ers)

First TD

+240

Anytime TD

-263

George Kittle (49ers)

First TD

+500

Anytime TD

+115

Jauan Jennings (49ers)

First TD

+750

Anytime TD

+170

Ricky Pearsall (49ers)

First TD

+1200

Anytime TD

+270

Tony Pollard (Titans)

First TD

+1400

Anytime TD

+270

Brian Robinson Jr. (49ers)

First TD

+1600

Anytime TD

+270

Tyjae Spears (Titans)

First TD

+1800

Anytime TD

+260

Elic Ayomanor (Titans)

First TD

+2000

Anytime TD

+330

Demarcus Robinson (49ers)

First TD

+2000

Anytime TD

+500

Chimere Dike (Titans)

First TD

+2200

Anytime TD

+360

Gunnar Helm (Titans)

First TD

+2700

Anytime TD

+500

Chigoziem Okonkwo (Titans)

First TD

+3000

Anytime TD

+550

Van Jefferson (Titans)

First TD

+3000

Anytime TD

+650

Brock Purdy (49ers)

First TD

+3000

Anytime TD

+700

Luke Farrell (49ers)

First TD

+5000

Anytime TD

+700

Cam Ward (Titans)

First TD

+5000

Anytime TD

+1100

Kyle Juszczyk (49ers)

First TD

+6500

Anytime TD

+850

Kendrick Bourne (49ers)

First TD

+10000

Anytime TD

+1400

Skyy Moore (49ers)

First TD

+10000

Anytime TD

+1800

Jordan Watkins (49ers)

First TD

+10000

Anytime TD

+1800

Jake Tonges (49ers)

First TD

+10000

Anytime TD

+1600

James Proche II (Titans)

First TD

+10000

Anytime TD

+2700

Isaac Guerendo (49ers)

First TD

+10000

Anytime TD

+2000

David Martin-Robinson (Titans)

First TD

+10000

Anytime TD

+4000

Julius Chestnut (Titans)

First TD

+10000

Anytime TD

+4000

Mason Kinsey (Titans)

First TD

+10000

Anytime TD

+4500

Kalel Mullings (Titans)

First TD

+10000

Anytime TD

+7000

James Jordan (49ers)

First TD

+10000

Anytime TD

+2000

Receiving Yards

George Kittle (49ers)

Over 61.5

-112

Under 61.5

-112

Jauan Jennings (49ers)

Over 47.5

-112

Under 47.5

-112

Christian McCaffrey (49ers)

Over 40.5

-112

Under 40.5

-112

Ricky Pearsall (49ers)

Over 37.5

-112

Under 37.5

-112

Elic Ayomanor (Titans)

Over 31.5

-112

Under 31.5

-112

Chimere Dike (Titans)

Over 30.5

-112

Under 30.5

-112

Chigoziem Okonkwo (Titans)

Over 27.5

-112

Under 27.5

-112

Gunnar Helm (Titans)

Over 24.5

-112

Under 24.5

-112

Tyjae Spears (Titans)

Over 21.5

-112

Under 21.5

-112

Van Jefferson (Titans)

Over 21.5

-112

Under 21.5

-112

Demarcus Robinson (49ers)

Over 10.5

-112

Under 10.5

-112

Tony Pollard (Titans)

Over 8.5

-112

Under 8.5

-112

Rushing Yards

Christian McCaffrey (49ers)

Over 64.5

-112

Under 64.5

-112

Tony Pollard (Titans)

Over 49.5

-112

Under 49.5

-112

Brian Robinson Jr. (49ers)

Over 29.5

-112

Under 29.5

-112

Tyjae Spears (Titans)

Over 16.5

-112

Under 16.5

-112

Cam Ward (Titans)

Over 8.5

-112

Under 8.5

-112

Brock Purdy (49ers)

Over 7.5

-127

Under 7.5

-102

Passing Yards

Brock Purdy (49ers)

Over 242.5

-112

Under 242.5

-112

Cam Ward (Titans)

Over 200.5

-112

Under 200.5

-112

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Niners Own Five Wins From Last Ten at Home

The Niners have five wins and five losses in the last 10 games at home, scoring 22.80 points per matchup and conceding 21.10.

The Titans own a 3-7 mark in their past 10 road games, posting 18.30 points per contest while yielding 28.10.

Last 10 Games		W-L	P	PF	PA	O44.5	U44.5
49ers Home Stats		5-5	43.90	22.80	21.10	5	5
Titans Away Stats		3-7	46.40	18.30	28.10	5	5

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O44.5 = Games Over 44.5 Points
• U44.5 = Games Under 44.5 Points

Latest regular season and playoff games stats.

Tennessee Titans Stats

San Francisco 49ers Stats

Moneyline

• 2 wins and 8 defeats in the last 10 games
• 3 wins and 7 defeats in the last 10 games on the road

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 5 wins and 5 defeats in the last 10 home games

Point Spread

• +12.5 Betting Line: Have covered the spread in 6 of the last 10 games
• +12.5 Betting Line on the Road: Have covered the spread in 7 of the last 10 games on the road

Point Spread

• -12.5 Betting Line: Have covered the spread in 2 of the last 10 games
• -12.5 Betting Line at Home: Have covered the spread in 1 of the last 10 home games

Total Points

• Game Totals: An average of 41.30 pts in the previous 10 games
• Game Totals on the Road: An average of 46.40 pts in the previous 10 games on the road
• Over 44.5: Covered in 4 of the previous 10 games
• Over 44.5 on the Road: Covered in 5 of the previous 10 games on the road
• Team Totals: Have scored an average of 15.00 pts and allowed 26.30 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 18.30 pts and allowed 28.10 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 46.80 pts in the previous 10 games
• Game Totals at Home: An average of 43.90 pts in the previous 10 home games
• Over 44.5: Covered in 6 of the previous 10 games
• Over 44.5 at Home: Covered in 5 of the previous 10 home games
• Team Totals: Have scored an average of 24.80 pts and allowed 22.00 pts in the last 10 games
• Team Totals at Home: Have scored an average of 22.80 pts and allowed 21.10 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 253.40 Yds. Allowed 344.10 Yds
• Rushing Yards: Gained 83.80 Yds. Allowed 115.50 Yds
• Passing Yards: Gained 169.60 Yds. Allowed 228.60 Yds
• Total Touchdowns: Scored 1.60 TD. Allowed 3.10 TD
• Rushing Touchdowns: Scored 0.50 TD. Allowed 1.20 TD
• Passing Touchdowns: Scored 0.70 TD. Allowed 1.80 TD
• Total 1st Downs: Picked up 14.70. Allowed 19.70
• Total Turnovers: Committed 1.30. Committed by opponents 0.70
• Total Penalties: Committed 7.00. Committed by opponents 6.70
• Penalty Yards: Lost 50.90 Yds. Gained 48.20 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 334.60 Yds. Allowed 356.80 Yds
• Rushing Yards: Gained 100.60 Yds. Allowed 103.80 Yds
• Passing Yards: Gained 234.00 Yds. Allowed 253.00 Yds
• Total Touchdowns: Scored 2.70 TD. Allowed 2.70 TD
• Rushing Touchdowns: Scored 1.10 TD. Allowed 0.70 TD
• Passing Touchdowns: Scored 1.60 TD. Allowed 1.90 TD
• Total 1st Downs: Picked up 21.50. Allowed 20.70
• Total Turnovers: Committed 1.40. Committed by opponents 1.10
• Total Penalties: Committed 4.80. Committed by opponents 6.70
• Penalty Yards: Lost 32.90 Yds. Gained 46.30 Yds

Last 10 Games on the Road

• Total Yards: Gained 275.10 Yds. Allowed 356.40 Yds
• Rushing Yards: Gained 98.40 Yds. Allowed 150.50 Yds
• Passing Yards: Gained 176.70 Yds. Allowed 205.90 Yds
• Total Touchdowns: Scored 1.90 TD. Allowed 3.50 TD
• Rushing Touchdowns: Scored 0.70 TD. Allowed 1.60 TD
• Passing Touchdowns: Scored 1.10 TD. Allowed 1.80 TD
• Total 1st Downs: Picked up 15.70. Allowed 19.30
• Total Turnovers: Committed 1.90. Committed by opponents 1.40
• Total Penalties: Committed 7.10. Committed by opponents 6.80
• Penalty Yards: Lost 55.10 Yds. Gained 50.90 Yds

Last 10 Home Games

• Total Yards: Gained 366.50 Yds. Allowed 299.20 Yds
• Rushing Yards: Gained 117.40 Yds. Allowed 102.60 Yds
• Passing Yards: Gained 249.10 Yds. Allowed 196.60 Yds
• Total Touchdowns: Scored 2.60 TD. Allowed 2.40 TD
• Rushing Touchdowns: Scored 1.20 TD. Allowed 0.80 TD
• Passing Touchdowns: Scored 1.40 TD. Allowed 1.50 TD
• Total 1st Downs: Picked up 21.30. Allowed 18.40
• Total Turnovers: Committed 1.70. Committed by opponents 0.70
• Total Penalties: Committed 5.50. Committed by opponents 5.00
• Penalty Yards: Lost 41.20 Yds. Gained 37.00 Yds

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