49ers vs Cardinals Prediction & Betting Tips

Free San Francisco 49ers vs Arizona Cardinals prediction. 03:15 Kick-Off, Tuesday 22 November at Estadio Azteca. NFL betting tips and the latest American Football odds.

San Francisco 49ers

@

Arizona Cardinals

The Arizona Cardinals look easy to back at 1.90 considering they’ve been given a spread of +8. This looks a good number when squaring off against the San Francisco 49ers.

Knowing the players that are injured give us a helping hand when putting together American Football recommendations. Once we’ve also looked at the form guide, we use the available stats and make predictions.

Key 49ers vs Cardinals stats:

  • The +8 line has been covered by Cardinals in 14 of their last 20 games.
  • The -8 line hasn’t been covered by 49ers in 6 of their last 10 games.
  • The -8 line hasn’t been covered by 49ers in 12 of their last 20 games.
  • The +8 line has been covered by Cardinals in 4 consecutive games against 49ers.

Our best wager is for the dogs to cover the spread. +8 at odds of 1.90 look more than generous and we’re happy to back this NFL pick.

There’s an opportunity to secure bigger odds and this can be achieved by moving the line. Squeeze more juice from your pick by taking an alternative wagering view.

Last Games & H2H

Cardinals triumphed in their last game. It was on the road where Rams were beaten 27-17 at SoFi Stadium. Cardinals gained a total of 298 yards, comprising 220 passing and 78 rushing yards. They scored 2 rushing and 1 passing touchdown. 3 TD’s in total.

49ers won their previous game, beating Chargers at home. It was a 22-16 win at Levi's Stadium. 49ers enjoyed a gain of 230 passing and 157 rushing yards. This amounts to a total of 387 yards. They scored 2 TD’s. Both touchdowns were rushing TD’s.

The last encounter between Cardinals and 49ers saw the former win. It was a 31-17 scoreline at Levi's Stadium. The past 6 H2H clashes have seen both teams record three wins.

49ers vs Cardinals Betting Tips

Cardinals +8 @ 1.90 Bet Now bet365 logo
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Published 15:18, 19 November 2022

Bet Builder Tips

Spread Cardinals +8
Totals Over 43.5
First Score Method Touchdown

Cardinals vs 49ers bet builder tips: Get in the game with a same game parlay. Our picks are Cardinals to cover the +8 spread, over 43.5 on the total and Touchdown as first score method.

We recommend a bet builder as it’s an exciting way of wagering on a single event. Many bettors like to create a personalised bet which reflects their predictions for how a game is going to play out.

T&C apply. Gamble responsibly 18+

Betting Odds

49ers are regarded as having a 82% chance of winning this NFL game according to the latest betting odds. The gambling operators have priced them up at 1.22. The market suggests that Cardinals are least likely to win at 4.50.

9.5 is the spread and 43 is the total points line. Having a wager on totals is one of the most popular American Football markets. If you're keen on Over 43, this selection is available at 1.90.

49ers are favorites to win the Race to 15 Points market at odds of 1.30 although there’s the option to back neither side to make this total at 11.00.

There are hundreds of markets when it comes to wagering on the National Football League and we recommend visiting the premier betting sites to find the bet that matches your view on the contest.

Player Props

Prop betting is very popular, with bettors looking to wager on player props such as First Touchdown Scorer, Player Passing Attempts, Passing Yards, Interceptions and Kicking Points. The gambling sites will provide lots of options.

Those interested in favorite Christian McCaffrey (49ers) to score the first touchdown are able to get 4.50. If the Anytime TD angle makes appeal, then this is 1.66.

Christian McCaffrey (49ers)
First TD
4.50
Anytime TD
1.66
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Deebo Samuel (49ers)
First TD
8.00
Anytime TD
2.30
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James Conner (Cardinals)
First TD
9.00
Anytime TD
2.40
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Elijah Mitchell (49ers)
First TD
9.00
Anytime TD
2.50
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DeAndre Hopkins (Cardinals)
First TD
11.00
Anytime TD
2.75
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Brandon Aiyuk (49ers)
First TD
11.00
Anytime TD
2.87
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Micro Betting

It’s possible to use stats to your advantage when it comes to NFL micro betting markets, especially if you’re predicting outcomes such as the Next Drive Result. Check out the live player, score and team props and see if you can find an angle.

Game Stats

Latest regular season and play-off games stats.

Arizona Cardinals logo Arizona Cardinals Stats

San Francisco 49ers logo San Francisco 49ers Stats

Money Line

  • 4 wins and 6 defeats in the last 10 games
  • 1 win and 9 defeats in the last 10 home games

Money Line

  • 5 wins and 5 defeats in the last 10 games
  • 5 wins and 5 defeats in the last 10 games on the road

Points Spread

Points Spread

Total Points

Total Points

Game Stats

Last 10 Games

Game Stats

Last 10 Games
Last 10 Home Games
Last 10 Games on the Road

Team News

San Francisco 49ers @ Arizona Cardinals Lineups

Arizona Cardinals

Manager:
Kliff Kingsbury
5
Matt Prater
14
Andy Lee
19
Trace McSorley
21
Trayvon Mullen
23
Corey Clement
28
Charles Washington
30
Keaontay Ingram
31
Chris Banjo
35
Christian Matthew
41
Myjai Sanders
44
Markus Golden
45
Dennis Gardeck
46
Aaron Brewer
47
Ezekiel Turner
56
Ben Niemann
57
Kamu Grugier-Hill
64
Sean Harlow
66
Wyatt Davis
72
Cody Ford
81
Robbie Anderson
83
Greg Dortch
87
Maxx Williams
89
Stephen Anderson
91
Michael Dogbe
97
Cameron Thomas
98
Trysten Hill

San Francisco 49ers

Manager:
Kyle Shanahan
3
Ray-Ray McCloud
6
Danny Gray
9
Robbie Gould
13
Brock Purdy
15
Jauan Jennings
18
Mitch Wishnowsky
20
Ambry Thomas
24
Jordan Ponchez-Mason
25
Elijah Mitchell
26
Samuel Womack
30
George Odum
33
Tarvarius Moore
45
Demetrius Flannigan-Fowles
46
Taybor Pepper
48
Oren Burks
51
Azeez Al-Shaair
60
Daniel Brunskill
68
Colton McKivitz
75
Jordan Willis
76
Jaylon Moore
81
Tyler Kroft
82
Ross Dwelley
89
Charlie Woerner
92
Kerry Hyder Jr.
95
Drake Jackson
96
T.Y. McGill

Arizona Cardinals Substitutes

  • 3 Budda Baker
  • 4 Rondale Moore
  • 6 James Conner
  • 9 Isaiah Simmons
  • 10 DeAndre Hopkins
  • 12 Colt McCoy
  • 18 A.J. Green
  • 20 Marco Wilson
  • 25 Zaven Collins
  • 33 Antonio Hamilton
  • 34 Jalen Thompson
  • 51 Tanner Vallejo
  • 53 Billy Price
  • 54 Lecitus Smith
  • 65 Rashaad Coward
  • 68 Kelvin Beachum
  • 79 Josh Jones
  • 85 Trey McBride
  • 93 Jonathan Ledbetter
  • 94 Zach Allen
  • 95 Leki Fotu
  • 99 J.J. Watt

San Francisco 49ers Substitutes

  • 1 Jimmie Ward
  • 7 Charvarius Ward
  • 10 Jimmy Garoppolo
  • 11 Brandon Aiyuk
  • 19 Deebo Samuel
  • 23 Christian McCaffrey
  • 29 Talanoa Hufanga
  • 31 Tashaun Gipson
  • 38 Deommodore Lenoir
  • 44 Kyle Juszczyk
  • 54 Fred Warner
  • 57 Dre Greenlaw
  • 64 Jake Brendel
  • 65 Aaron Banks
  • 69 Mike McGlinchey
  • 71 Trent Williams
  • 74 Spencer Burford
  • 85 George Kittle
  • 90 Kevin Givens
  • 94 Charles Omenihu
  • 97 Nick Bosa
  • 98 Hassan Ridgeway

Arizona Cardinals Injuries

Type
Name
Info
Budda Baker
Ankle
Marquise Brown
Foot
Tae Daley
Undisclosed
Zach Ertz
Knee
Max Garcia
Shoulder
Marquis Hayes
Knee
Will Hernandez
Chest
DeAndre Hopkins
Hamstring
Rodney Hudson
Knee
D.J. Humphries
Back
Rashard Lawrence
Shoulder
Joshua Miles
Undisclosed
Byron Murphy
Back
Kyler Murray
Hamstring
Justin Pugh
Knee
Nick Vigil
Hamstring
Jonathan Ward
Hamstring
Antoine Wesley
Quadriceps
Darrel Williams
Hip

San Francisco 49ers Injuries

Type
Name
Info
Arik Armstead
Foot
Kalia Davis
Undisclosed
Samson Ebukam
Quadriceps
Maurice Hurst
Biceps
Javon Kinlaw
Knee
Trey Lance
Ankle
Jordan Matthews
Knee - ACL
Emmanuel Moseley
Knee - ACL
Jason Verrett
Achilles

Previous Arizona Cardinals Lineups

13 Nov NFL
Cardinals 27-17 Rams
06 Nov NFL
Seahawks 31-21 Cardinals
30 Oct NFL
Cardinals 26-34 Vikings

Previous San Francisco 49ers Lineups

14 Nov NFL
Chargers 16-22 49ers
30 Oct NFL
49ers 31-14 Rams
23 Oct NFL
Chiefs 44-23 49ers

NFL Standings Select Season

AFC East W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Bills 9 3 0 0.750 333 209 124 4-1-0 5-2-0 1-2-0 6-2-0 3-2-0 3W
Dolphins 8 3 0 0.727 282 256 26 5-1-0 3-2-0 2-1-0 6-2-0 5-0-0 5W
Jets 7 4 0 0.636 230 196 34 3-3-0 4-1-0 2-2-0 5-4-0 3-2-0 1W
Patriots 6 6 0 0.500 249 226 23 3-3-0 3-3-0 2-2-0 5-3-0 3-2-0 2L
AFC North W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Ravens 7 4 0 0.636 275 227 48 3-2-0 4-2-0 2-0-0 4-3-0 4-1-0 1L
Bengals 7 4 0 0.636 285 231 54 3-1-0 4-3-0 1-3-0 4-3-0 4-1-0 3W
Browns 4 7 0 0.364 263 286 -23 3-3-0 1-4-0 2-1-0 2-6-0 2-3-0 1W
Steelers 4 7 0 0.364 194 261 -67 2-3-0 2-4-0 1-2-0 2-6-0 2-3-0 1W
AFC South W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Titans 7 4 0 0.636 209 205 4 3-2-0 4-2-0 3-0-0 5-3-0 3-2-0 1L
Colts 4 7 1 0.333 190 244 -54 2-4-0 2-3-1 1-3-1 4-5-1 1-4-0 2L
Jaguars 4 7 0 0.364 244 232 12 3-3-0 1-4-0 1-2-0 4-4-0 2-3-0 1W
Texans 1 9 1 0.091 174 260 -86 0-4-1 1-5-0 1-1-1 1-5-1 0-5-0 6L
AFC West W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Chiefs 9 2 0 0.818 326 243 83 5-1-0 4-1-0 3-0-0 5-2-0 5-0-0 5W
Chargers 6 5 0 0.545 252 282 -30 2-3-0 4-2-0 2-2-0 4-3-0 2-3-0 1W
Raiders 4 7 0 0.364 265 276 -11 2-2-0 2-5-0 2-2-0 3-5-0 2-3-0 2W
Broncos 3 8 0 0.273 157 194 -37 2-3-0 1-5-0 0-3-0 2-6-0 1-4-0 3L
NFC East W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Eagles 10 1 0 0.909 303 216 87 5-1-0 5-0-0 2-1-0 6-1-0 4-1-0 2W
Cowboys 8 3 0 0.727 279 187 92 5-1-0 3-2-0 3-1-0 7-3-0 4-1-0 2W
Giants 7 4 0 0.636 225 232 -7 4-2-0 3-2-0 0-2-0 3-4-0 2-3-0 2L
Commanders 7 5 0 0.583 233 236 -3 3-3-0 4-2-0 1-2-0 4-4-0 4-1-0 3W
NFC North W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Vikings 9 2 0 0.818 262 257 5 5-1-0 4-1-0 3-0-0 6-2-0 4-1-0 1W
Lions 4 7 0 0.364 275 310 -35 2-4-0 2-3-0 2-1-0 4-4-0 3-2-0 1L
Packers 4 8 0 0.333 235 283 -48 3-3-0 1-5-0 1-2-0 3-5-0 1-4-0 2L
Bears 3 9 0 0.250 251 305 -54 2-3-0 1-6-0 0-3-0 1-7-0 0-5-0 5L
NFC South W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Buccaneers 5 6 0 0.455 200 203 -3 3-3-0 2-3-0 2-1-0 5-2-0 2-3-0 1L
Falcons 5 7 0 0.417 272 293 -21 4-2-0 1-5-0 1-3-0 4-5-0 2-3-0 1L
Panthers 4 8 0 0.333 230 266 -36 4-3-0 0-5-0 3-1-0 3-5-0 2-3-0 1W
Saints 4 8 0 0.333 249 280 -31 3-4-0 1-4-0 1-2-0 3-5-0 2-3-0 1L
NFC West W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
49ers 7 4 0 0.636 249 173 76 4-1-0 3-3-0 4-0-0 6-2-0 4-1-0 4W
Seahawks 6 5 0 0.545 291 281 10 3-2-0 3-3-0 2-1-0 4-4-0 3-2-0 2L
Cardinals 4 8 0 0.333 264 321 -57 1-6-0 3-2-0 1-4-0 3-6-0 1-4-0 2L
Rams 3 8 0 0.273 178 253 -75 2-4-0 1-4-0 1-3-0 3-6-0 0-5-0 5L
AFC Conference W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Chiefs 9 2 0 0.818 326 243 83 5-1-0 4-1-0 3-0-0 5-2-0 5-0-0 5W
Titans 7 4 0 0.636 209 205 4 3-2-0 4-2-0 3-0-0 5-3-0 3-2-0 1L
Dolphins 8 3 0 0.727 282 256 26 5-1-0 3-2-0 2-1-0 6-2-0 5-0-0 5W
Ravens 7 4 0 0.636 275 227 48 3-2-0 4-2-0 2-0-0 4-3-0 4-1-0 1L
Bills 9 3 0 0.750 333 209 124 4-1-0 5-2-0 1-2-0 6-2-0 3-2-0 3W
Bengals 7 4 0 0.636 285 231 54 3-1-0 4-3-0 1-3-0 4-3-0 4-1-0 3W
Jets 7 4 0 0.636 230 196 34 3-3-0 4-1-0 2-2-0 5-4-0 3-2-0 1W
Patriots 6 6 0 0.500 249 226 23 3-3-0 3-3-0 2-2-0 5-3-0 3-2-0 2L
Chargers 6 5 0 0.545 252 282 -30 2-3-0 4-2-0 2-2-0 4-3-0 2-3-0 1W
Colts 4 7 1 0.333 190 244 -54 2-4-0 2-3-1 1-3-1 4-5-1 1-4-0 2L
Jaguars 4 7 0 0.364 244 232 12 3-3-0 1-4-0 1-2-0 4-4-0 2-3-0 1W
Raiders 4 7 0 0.364 265 276 -11 2-2-0 2-5-0 2-2-0 3-5-0 2-3-0 2W
Browns 4 7 0 0.364 263 286 -23 3-3-0 1-4-0 2-1-0 2-6-0 2-3-0 1W
Steelers 4 7 0 0.364 194 261 -67 2-3-0 2-4-0 1-2-0 2-6-0 2-3-0 1W
Broncos 3 8 0 0.273 157 194 -37 2-3-0 1-5-0 0-3-0 2-6-0 1-4-0 3L
Texans 1 9 1 0.091 174 260 -86 0-4-1 1-5-0 1-1-1 1-5-1 0-5-0 6L
NFC Conference W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Eagles 10 1 0 0.909 303 216 87 5-1-0 5-0-0 2-1-0 6-1-0 4-1-0 2W
Vikings 9 2 0 0.818 262 257 5 5-1-0 4-1-0 3-0-0 6-2-0 4-1-0 1W
49ers 7 4 0 0.636 249 173 76 4-1-0 3-3-0 4-0-0 6-2-0 4-1-0 4W
Buccaneers 5 6 0 0.455 200 203 -3 3-3-0 2-3-0 2-1-0 5-2-0 2-3-0 1L
Cowboys 8 3 0 0.727 279 187 92 5-1-0 3-2-0 3-1-0 7-3-0 4-1-0 2W
Giants 7 4 0 0.636 225 232 -7 4-2-0 3-2-0 0-2-0 3-4-0 2-3-0 2L
Commanders 7 5 0 0.583 233 236 -3 3-3-0 4-2-0 1-2-0 4-4-0 4-1-0 3W
Seahawks 6 5 0 0.545 291 281 10 3-2-0 3-3-0 2-1-0 4-4-0 3-2-0 2L
Falcons 5 7 0 0.417 272 293 -21 4-2-0 1-5-0 1-3-0 4-5-0 2-3-0 1L
Lions 4 7 0 0.364 275 310 -35 2-4-0 2-3-0 2-1-0 4-4-0 3-2-0 1L
Packers 4 8 0 0.333 235 283 -48 3-3-0 1-5-0 1-2-0 3-5-0 1-4-0 2L
Panthers 4 8 0 0.333 230 266 -36 4-3-0 0-5-0 3-1-0 3-5-0 2-3-0 1W
Cardinals 4 8 0 0.333 264 321 -57 1-6-0 3-2-0 1-4-0 3-6-0 1-4-0 2L
Saints 4 8 0 0.333 249 280 -31 3-4-0 1-4-0 1-2-0 3-5-0 2-3-0 1L
Rams 3 8 0 0.273 178 253 -75 2-4-0 1-4-0 1-3-0 3-6-0 0-5-0 5L
Bears 3 9 0 0.250 251 305 -54 2-3-0 1-6-0 0-3-0 1-7-0 0-5-0 5L
NFL Team W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Eagles 10 1 0 0.909 303 216 87 5-1-0 5-0-0 2-1-0 6-1-0 4-1-0 2W
Chiefs 9 2 0 0.818 326 243 83 5-1-0 4-1-0 3-0-0 5-2-0 5-0-0 5W
Vikings 9 2 0 0.818 262 257 5 5-1-0 4-1-0 3-0-0 6-2-0 4-1-0 1W
Bills 9 3 0 0.750 333 209 124 4-1-0 5-2-0 1-2-0 6-2-0 3-2-0 3W
Cowboys 8 3 0 0.727 279 187 92 5-1-0 3-2-0 3-1-0 7-3-0 4-1-0 2W
Dolphins 8 3 0 0.727 282 256 26 5-1-0 3-2-0 2-1-0 6-2-0 5-0-0 5W
Ravens 7 4 0 0.636 275 227 48 3-2-0 4-2-0 2-0-0 4-3-0 4-1-0 1L
Bengals 7 4 0 0.636 285 231 54 3-1-0 4-3-0 1-3-0 4-3-0 4-1-0 3W
Giants 7 4 0 0.636 225 232 -7 4-2-0 3-2-0 0-2-0 3-4-0 2-3-0 2L
Jets 7 4 0 0.636 230 196 34 3-3-0 4-1-0 2-2-0 5-4-0 3-2-0 1W
49ers 7 4 0 0.636 249 173 76 4-1-0 3-3-0 4-0-0 6-2-0 4-1-0 4W
Titans 7 4 0 0.636 209 205 4 3-2-0 4-2-0 3-0-0 5-3-0 3-2-0 1L
Commanders 7 5 0 0.583 233 236 -3 3-3-0 4-2-0 1-2-0 4-4-0 4-1-0 3W
Chargers 6 5 0 0.545 252 282 -30 2-3-0 4-2-0 2-2-0 4-3-0 2-3-0 1W
Seahawks 6 5 0 0.545 291 281 10 3-2-0 3-3-0 2-1-0 4-4-0 3-2-0 2L
Patriots 6 6 0 0.500 249 226 23 3-3-0 3-3-0 2-2-0 5-3-0 3-2-0 2L
Buccaneers 5 6 0 0.455 200 203 -3 3-3-0 2-3-0 2-1-0 5-2-0 2-3-0 1L
Falcons 5 7 0 0.417 272 293 -21 4-2-0 1-5-0 1-3-0 4-5-0 2-3-0 1L
Colts 4 7 1 0.333 190 244 -54 2-4-0 2-3-1 1-3-1 4-5-1 1-4-0 2L
Browns 4 7 0 0.364 263 286 -23 3-3-0 1-4-0 2-1-0 2-6-0 2-3-0 1W
Lions 4 7 0 0.364 275 310 -35 2-4-0 2-3-0 2-1-0 4-4-0 3-2-0 1L
Jaguars 4 7 0 0.364 244 232 12 3-3-0 1-4-0 1-2-0 4-4-0 2-3-0 1W
Raiders 4 7 0 0.364 265 276 -11 2-2-0 2-5-0 2-2-0 3-5-0 2-3-0 2W
Steelers 4 7 0 0.364 194 261 -67 2-3-0 2-4-0 1-2-0 2-6-0 2-3-0 1W
Cardinals 4 8 0 0.333 264 321 -57 1-6-0 3-2-0 1-4-0 3-6-0 1-4-0 2L
Panthers 4 8 0 0.333 230 266 -36 4-3-0 0-5-0 3-1-0 3-5-0 2-3-0 1W
Packers 4 8 0 0.333 235 283 -48 3-3-0 1-5-0 1-2-0 3-5-0 1-4-0 2L
Saints 4 8 0 0.333 249 280 -31 3-4-0 1-4-0 1-2-0 3-5-0 2-3-0 1L
Broncos 3 8 0 0.273 157 194 -37 2-3-0 1-5-0 0-3-0 2-6-0 1-4-0 3L
Rams 3 8 0 0.273 178 253 -75 2-4-0 1-4-0 1-3-0 3-6-0 0-5-0 5L
Bears 3 9 0 0.250 251 305 -54 2-3-0 1-6-0 0-3-0 1-7-0 0-5-0 5L
Texans 1 9 1 0.091 174 260 -86 0-4-1 1-5-0 1-1-1 1-5-1 0-5-0 6L