Cincinnati vs Clemson Prediction, Picks & Odds | 21 Dec 2025

College Basketball Betting Preview: Cincinnati vs Clemson

The Cincinnati Bearcats go up against the Clemson Tigers, with tip-off scheduled for 15:00 on Sunday, December 21.

Clemson should secure a comfortable win and a bet on the spread could be the best way forward. Back this selection off -6.5 to cover the line against Cincinnati at odds of -105.

Feeling good about our ATS pick? Get the full lowdown in our in-depth BetMGM review, then grab the exclusive promo code as you prep your next move.

Cincinnati Bearcats claimed a victory in their previous game. A 88-51 home win occurred against Alabama State.

Clemson Tigers won their last game which was at home. It was a 68-61 triumph against South Carolina Gamecocks.

NCAAB	Overall	PF	PA	N. Pts	Home	Away	Strk
Clemson	9-3	968	791	177	8-0	1-3	2W
Cincinnati	7-4	831	721	110	7-2	0-2	1W

View Full Standings

Cincinnati vs Clemson Prediction & Picks

Take on Cincinnati vs Clemson with our in-depth betting analysis, featuring an expert match prediction, scoreline advice and a value-driven bet builder. Scroll down for the full breakdown.

Game Prediction

It’s awesome to see Clemson given a -6.5 line on the spread at odds of -105 as we’re expecting a bigger margin of victory in this college contest.

Recent form is always part of the equation and we combine it with team news as soon as it’s available. To deliver expert basketball predictions, our handicappers also analyze the latest college hoops stats to ensure we’re working with the best information possible.

Key Cincinnati vs Clemson stats:

• The -6.5 line has been covered by Clemson in 4 of their last 5 games at home.
• The -6.5 line has been covered by Clemson in 15 of their last 20 games at home.
• The -6.5 line has been covered by Clemson in 3 consecutive games at home.
• The +6.5 line hasn’t been covered by Cincinnati in 3 of their last 5 games on the road.

Clemson -6.5 Probability

According to the top sportsbooks, our pick has a 51.3% chance of winning. In the opinion of our analysts, there’s actually a probability of success closer to 60%. It is therefore regarded as a value bet.

If you’re in pursuit of bigger odds, then a Bet Builder could be the way forward. Take Clemson to cover the line with additional selections until you’re satisfied with the price.

Before placing your bets, take advantage of our guide packed with up-to-date free bets and the latest bonus offers.

Our Game Prediction

Clemson -6.5 @ -105 Bet Now

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Correct Score Prediction

Cincinnati 68 - 79 Clemson

For those looking to get more bang for their buck, consider a correct score wager on Clemson. Backing them to win 79-68 means you can land a potential monster return.

Cincinnati vs Clemson Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the above betting predictions.

With the sportsbooks giving them a 74% probability of winning this college game, Clemson might be a popular parlay pick. That is reflected in their -286 Moneyline betting odds. Cincinnati are regarded as a long shot to win and you can currently back them at +230.

The spread currently stands at 5.5 and the total points line is 139.5. There is no denying the popularity of betting on the Totals. If you want to wager Over 139.5, there are odds of -110.

Whether you’re betting pre-game or in-game, the top basketball sportsbooks serve up a wide range of team props and game lines to choose from. The options are nearly endless, and it’s great to have so much variety.

Moneyline

Cincinnati

+230

Clemson

-286

Point Spread

Cincinnati +5.5

-102

Clemson -5.5

-120

Total Points

Under 139.5

-110

Over 139.5

-110

The gambling sites also allow you to place player prop bets such as Points, Assists, Steals and Rebounds. This means you can focus on an individual player’s performance rather than wager on the actual outcome of the game in question.

Among the various options for wagering on college basketball, you will find that micro betting is provided. It focuses on short-term in-game outcomes such as Next Field Goal, where you select if the shot will be a two or three-pointer.

Latest regular season and playoff games stats.

Cincinnati Stats

Clemson Stats

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 2 wins and 8 defeats in the last 10 games on the road

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 9 wins and 1 defeat in the last 10 home games

Point Spread

• +6.5 Betting Line: Have covered the spread in 7 of the last 10 games
• +6.5 Betting Line on the Road: Have covered the spread in 5 of the last 10 games on the road

Point Spread

• -6.5 Betting Line: Have covered the spread in 5 of the last 10 games
• -6.5 Betting Line at Home: Have covered the spread in 7 of the last 10 home games

Total Points

• Game Totals: An average of 139.50 pts in the previous 10 games
• Game Totals on the Road: An average of 145.40 pts in the previous 10 games on the road
• Over 139.5: Covered in 3 of the previous 10 games
• Over 139.5 on the Road: Covered in 6 of the previous 10 games on the road
• Team Totals: Have scored an average of 73.70 pts and allowed 65.80 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 70.10 pts and allowed 75.30 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 147.70 pts in the previous 10 games
• Game Totals at Home: An average of 135.70 pts in the previous 10 home games
• Over 139.5: Covered in 5 of the previous 10 games
• Over 139.5 at Home: Covered in 3 of the previous 10 home games
• Team Totals: Have scored an average of 78.30 pts and allowed 69.40 pts in the last 10 games
• Team Totals at Home: Have scored an average of 77.30 pts and allowed 58.40 pts in the last 10 home games

NCAAB Table Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Atlantic Coast	Overall	PF	PA	N. Pts	Home	Away	Strk
Duke	11-0	965	669	296	8-0	3-0	11W
North Carolina	11-1	959	775	184	9-0	2-1	5W
California	11-1	1006	811	195	11-0	0-1	8W
Virginia	10-1	951	747	204	8-0	2-1	5W
Virginia Tech	11-2	1080	944	136	9-0	2-2	5W
Louisville	10-2	1099	818	281	8-0	2-2	1W
Miami	10-2	1058	813	245	8-1	2-1	5W
Stanford	10-2	976	860	116	6-2	4-0	3W
SMU	9-2	975	849	126	8-0	1-2	1L
Notre Dame	9-3	928	817	111	8-0	1-3	4W
Clemson	9-3	968	791	177	8-0	1-3	2W
Wake Forest	9-3	1024	868	156	7-1	2-2	3W
NC State	8-4	1072	876	196	7-2	1-2	1W
Syracuse	8-4	893	795	98	7-1	1-3	2W
Georgia Tech	8-4	906	849	57	8-2	0-2	3W
Florida State	6-6	1018	955	63	6-3	0-3	1W
Pittsburgh	6-6	882	835	47	6-3	0-3	1W
Boston College	5-6	774	742	32	4-5	1-1	1L

Big 12	Overall	PF	PA	N. Pts	Home	Away	Strk
Iowa State	11-0	995	696	299	8-0	3-0	11W
Arizona	10-0	900	674	226	7-0	3-0	10W
BYU	11-1	1027	785	242	9-1	2-0	8W
Houston	11-1	954	720	234	9-1	2-0	5W
Oklahoma State	10-1	989	852	137	8-0	2-1	1W
UCF	9-1	873	739	134	8-1	1-0	8W
Colorado	10-2	1036	920	116	10-1	0-1	1L
Baylor	8-2	912	771	141	7-1	1-1	2W
Kansas	9-3	896	762	134	7-1	2-2	3W
Arizona State	9-3	965	900	65	6-2	3-1	1L
TCU	8-3	849	721	128	6-3	2-0	3W
Texas Tech	8-3	920	813	107	7-1	1-2	1W
West Virginia	8-4	904	731	173	8-2	0-2	1L
Kansas State	8-4	1056	924	132	7-2	1-2	3W
Utah	8-4	989	946	43	8-1	0-3	1W
Cincinnati	7-4	831	721	110	7-2	0-2	1W

• Overall = Overall Wins-Losses
• PF = Total Points For
• PA = Total Points Against
• N. Pts = Point Differential
• Home = Home Record
• Away = Away Record
• Strk = Current Streak

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