DePaul vs St. John's Prediction, Picks & Odds | 16 Dec 2025

College Basketball Betting Preview: DePaul vs St. John's

The DePaul Blue Demons square off against the St. John's Red Storm, with tip-off scheduled for 19:00 on Tuesday, December 16.

There are odds of -120 that St. John's cover the -18.5 line when they face DePaul. We think this is a great spread for this betting prediction where there is lots of of value available.

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DePaul Blue Demons won their previous game by a 61-58 scoreline. It was on the road against Wichita State Shockers.

St. John's Red Storm were winners last time out. It was a 91-64 home victory against Iona Gaels.

Head-to-Head Statistics

It was St. John's who came out on top when they last played DePaul. A 82-58 win was recorded. St. John's have beaten DePaul in the past seven meetings. They’ve also claimed 8 victories in the past 10 head-to-head matchups.

NCAAB	Overall	PF	PA	N. Pts	Home	Away	Strk
DePaul	8-3	851	746	105	7-3	1-0	3W
St. John's	6-3	800	657	143	5-2	1-1	2W

View Full Standings

DePaul vs St. John's Prediction & Picks

Prepare for DePaul vs St. John's with our expert betting guide featuring a trusted match prediction, a correct score recommendation and a well-crafted bet builder.

Game Prediction

Our wager is the big favorites against the spread. Back St. John's off -18.5 at odds of -120 and be confident that the market leaders can cover the line in this college contest.

The college hoops handicappers at Sportsgambler.com always keep close tabs on team news as it develops. We also rely on recent form and key stats to help shape our basketball picks and guide the final call.

Key DePaul vs St. John's stats:

• The -18.5 line has been covered by St. John's in 3 of their last 5 games at home.
• The -18.5 line has been covered by St. John's in 4 consecutive games against DePaul.

St. John's -18.5 Probability

The best betting apps make it a 54.6% chance that our pick is settled as a winner. However, our analysts have this number closer to 60% based on their in-depth research. This is why we can recommend this college basketball wager.

There are many ways to back St. John's and that includes Winning Margin. Choose from a wide range of fixed intervals and get rewarded if you’re on the money.

Before placing a wager, see what betting offers are on the table. Our in-depth guide lists the top welcome bonuses right now.

Our Game Prediction

St. John's -18.5 @ -120 Bet Now

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Correct Score Prediction

DePaul 62 - 84 St. John's

For those wanting a big return from a small stake, consider the correct score lines. For example, St. John's can be backed to win 84-62 at huge betting odds.

DePaul vs St. John's Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the above betting predictions.

St. John's are strong -5000 favorites to win this college game according to the Moneyline betting odds. The sportsbooks give them a 98% chance of claiming victory. DePaul are the underdogs at +1600 and they’re regarded as least likely to win.

19.5 is where the spread lies, with total points being 152.5 right now. Basketball bettors love the chance to get an alternative angle by going for a Total wager. If you want to bet Under 152.5, there are odds of -102.

Whether you’re betting pre-game or in-game, the top basketball sportsbooks serve up a wide range of team props and game lines to choose from. The options are nearly endless, and it’s great to have so much variety.

Moneyline

DePaul

+1600

St. John's

-5000

Point Spread

DePaul +19.5

-110

St. John's -19.5

-110

Total Points

Under 152.5

-102

Over 152.5

-120

Prop betting is very popular, with bettors looking to wager on player props such as Points, Assists, Rebounds, Steals and Three-Pointers. It’s a great way of betting on individual player performance and the gambling sites will provide lots of options.

An increasing number of bettors are now enjoying micro betting on college basketball and it’s something which is available on an in-game basis. Wait for the action to start and then wager on something specific to happen.

Latest regular season and playoff games stats.

DePaul Stats

St. John's Stats

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 3 wins and 7 defeats in the last 10 games on the road

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 7 wins and 3 defeats in the last 10 home games

Point Spread

• +18.5 Betting Line: Have covered the spread in 9 of the last 10 games
• +18.5 Betting Line on the Road: Have covered the spread in 9 of the last 10 games on the road

Point Spread

• -18.5 Betting Line: Have covered the spread in 4 of the last 10 games
• -18.5 Betting Line at Home: Have covered the spread in 5 of the last 10 home games

Total Points

• Game Totals: An average of 144.30 pts in the previous 10 games
• Game Totals on the Road: An average of 143.10 pts in the previous 10 games on the road
• Over 152.5: Covered in 4 of the previous 10 games
• Over 152.5 on the Road: Covered in 4 of the previous 10 games on the road
• Team Totals: Have scored an average of 75.90 pts and allowed 68.40 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 67.50 pts and allowed 75.60 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 159.80 pts in the previous 10 games
• Game Totals at Home: An average of 154.60 pts in the previous 10 home games
• Over 152.5: Covered in 7 of the previous 10 games
• Over 152.5 at Home: Covered in 5 of the previous 10 home games
• Team Totals: Have scored an average of 86.60 pts and allowed 73.20 pts in the last 10 games
• Team Totals at Home: Have scored an average of 86.10 pts and allowed 68.50 pts in the last 10 home games

NCAAB Table Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Big East	Overall	PF	PA	N. Pts	Home	Away	Strk
UConn	10-1	869	680	189	7-1	3-0	6W
Seton Hall	10-1	842	678	164	7-0	3-1	4W
Butler	8-2	901	760	141	8-1	0-1	1W
Villanova	8-2	804	681	123	7-0	1-2	1W
DePaul	8-3	851	746	105	7-3	1-0	3W
Xavier	8-3	862	786	76	8-2	0-1	5W
Georgetown	7-3	782	741	41	6-1	1-2	1W
St. John's	6-3	800	657	143	5-2	1-1	2W
Providence	7-5	1100	1016	84	6-1	1-4	1L
Creighton	5-5	746	726	20	5-1	0-4	2L
Marquette	5-6	868	843	25	5-3	0-3	2L

• Overall = Overall Wins-Losses
• PF = Total Points For
• PA = Total Points Against
• N. Pts = Point Differential
• Home = Home Record
• Away = Away Record
• Strk = Current Streak

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