Duke vs Michigan State Prediction, Picks & Odds | 06 Dec 2025

College Basketball Betting Preview: Duke vs Michigan State

The Duke Blue Devils square off against the Michigan State Spartans, with tip-off scheduled for 12:00 on Saturday, December 6.

The Overs is sticking out like a sore thumb considering the line for Duke and Michigan State is set at 138.5. We’re expecting a bigger total and -110 is available.

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Duke Blue Devils previous game saw them claim a 67-66 home win over Florida Gators.

Michigan State Spartans won their last game which was at home. It was a 71-52 triumph against Iowa Hawkeyes.

Head-to-Head Statistics

Duke have won both of the most recent meetings against Michigan State. At home, they triumphed 81-76 before a 74-65 win on the road. The past 5 H2H games have seen Duke land three wins.

NCAAB	Overall	PF	PA	N. Pts	Home	Away	Strk
Michigan State	8-0	629	483	146	6-0	2-0	8W
Duke	9-0	802	536	266	7-0	2-0	9W

View Full Standings

Duke vs Michigan State Prediction & Picks

Get ahead of the game with our Duke vs Michigan State betting rundown, featuring our trusted match prediction, most likely correct score outcome and a fully loaded bet builder.

Game Prediction

We think that 138.5 is a more than generous total for Over backers in this college showdown. Take the -110 that we see the teams combine to good effect.

Getting the lowdown on injuries and analyzing the form guide are key steps before making basketball predictions. We also put strong emphasis on stats, where a data-led approach often leads to smarter college hoops picks.

Key Duke vs Michigan State stats:

• The 138.5 line has been covered in the last 7 Duke games on the road.
• The 138.5 line has been covered in 8 of the last 10 Duke games on the road.
• The 138.5 line has been covered in 16 of the last 20 Duke games.
• The 138.5 line has been covered in 6 of the last 10 MSU games.
• The 138.5 line has been covered in 3 of the last 5 MSU games.
• The 138.5 line has been covered in the last 4 games between these teams.

Over 138.5 Probability

The latest odds at the best betting apps suggest our pick carries a 52.4% chance of winning. After careful examination, our analysts have this probability somewhere between 55-60%. The bet can be recommended for this precise reason.

There are ways to increase the odds if you’re wanting to bet on Overs and one of them is wagering on the Match Result & Total lines where you also predict a team to win.

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Our Game Prediction

Over 138.5 Points @ -110 Bet Now

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Correct Score Prediction

Duke 73 - 72 Michigan State

There’s every chance that this is going to be a close game and we’ll have a play on Duke enjoying a 73-72 winning scoreline. Hopefully this can go close.

Duke vs Michigan State Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the above betting predictions.

The betting odds about Michigan State winning is -111, with Duke priced up at -108 to achieve victory. This means the top sportsbooks give the road team a 52% chance of winning.

There is a spread of 1.5 and total points has a line of 138.5. A Total wager relates to the number of points that will be scored overall. There’s an opportunity to bet Over 138.5 at -110.

If you’re planning to place a bet on a college hoops matchup, visit the top basketball betting sites and check out the many available game lines and team props. Find the lines which are the most attractive.

Moneyline

Duke

-108

MSU

-111

Point Spread

Duke +1.5

-128

MSU -1.5

+104

Total Points

Under 138.5

-110

Over 138.5

-110

If you’re looking for an alternative to the main game lines, check out the player props instead. It’s great to wager on Total Points, Three-Pointers, Assists, Steals, Blocks and Rebounds as potential options.

Micro betting provides a rollercoaster ride for college basketball bettors. It can be great to enjoy the live lines, with the opportunity to bet on the Next Field Goal. Watch the live action before deciding which way to go.

Latest regular season and playoff games stats.

Duke Stats

Michigan State Stats

Moneyline

• 9 wins and 1 defeat in the last 10 games
• 9 wins and 1 defeat in the last 10 games on the road

Moneyline

• 9 wins and 1 defeat in the last 10 games
• 9 wins and 1 defeat in the last 10 home games

Point Spread

• +1.5 Betting Line: Have covered the spread in 9 of the last 10 games
• +1.5 Betting Line on the Road: Have covered the spread in 9 of the last 10 games on the road

Point Spread

• -1.5 Betting Line: Have covered the spread in 9 of the last 10 games
• -1.5 Betting Line at Home: Have covered the spread in 9 of the last 10 home games

Total Points

• Game Totals: An average of 147.50 pts in the previous 10 games
• Game Totals on the Road: An average of 150.60 pts in the previous 10 games on the road
• Over 138.5: Covered in 7 of the previous 10 games
• Over 138.5 on the Road: Covered in 8 of the previous 10 games on the road
• Team Totals: Have scored an average of 86.90 pts and allowed 60.60 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 86.80 pts and allowed 63.80 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 138.90 pts in the previous 10 games
• Game Totals at Home: An average of 139.50 pts in the previous 10 home games
• Over 138.5: Covered in 6 of the previous 10 games
• Over 138.5 at Home: Covered in 6 of the previous 10 home games
• Team Totals: Have scored an average of 76.60 pts and allowed 62.30 pts in the last 10 games
• Team Totals at Home: Have scored an average of 76.20 pts and allowed 63.30 pts in the last 10 home games

NCAAB Table Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Big Ten	Overall	PF	PA	N. Pts	Home	Away	Strk
Michigan State	8-0	629	483	146	6-0	2-0	8W
USC	8-0	725	620	105	5-0	3-0	8W
Purdue	8-0	709	541	168	6-0	2-0	8W
Michigan	7-0	656	473	183	5-0	2-0	7W
Nebraska	8-0	678	561	117	8-0	0-0	8W
Penn State	8-1	748	630	118	7-1	1-0	3W
Indiana	7-1	691	510	181	7-0	0-1	1L
Iowa	7-1	636	499	137	6-0	1-1	1L
Ohio State	6-1	621	471	150	6-0	0-1	1L
UCLA	6-2	621	522	99	5-1	1-1	1W
Wisconsin	6-2	695	588	107	5-0	1-2	1W
Illinois	6-2	723	562	161	6-2	0-0	1L
Maryland	6-3	707	702	5	5-1	1-2	1W
Northwestern	5-3	648	572	76	4-2	1-1	2L
Washington	5-3	658	589	69	3-1	2-2	2L
Minnesota	5-4	661	611	50	5-3	0-1	1W
Rutgers	5-4	639	622	17	5-2	0-2	1L
Oregon	4-4	593	605	-12	4-3	0-1	4L

Atlantic Coast	Overall	PF	PA	N. Pts	Home	Away	Strk
Duke	9-0	802	536	266	7-0	2-0	9W
SMU	8-1	805	680	125	7-0	1-1	1L
Louisville	7-1	757	530	227	6-0	1-1	1L
Virginia	7-1	701	542	159	5-0	2-1	2W
North Carolina	7-1	650	524	126	6-0	1-1	1W
California	7-1	670	559	111	7-0	0-1	4W
Stanford	7-1	663	575	88	5-1	2-0	3W
Virginia Tech	7-2	747	674	73	5-0	2-2	1W
Clemson	7-2	766	600	166	6-0	1-2	1L
Miami	7-2	768	589	179	5-1	2-1	2W
Wake Forest	6-3	767	661	106	5-1	1-2	1L
Notre Dame	6-3	679	609	70	6-0	0-3	1W
NC State	5-3	728	619	109	4-1	1-2	2L
Syracuse	5-3	586	517	69	4-0	1-3	1W
Florida State	5-3	691	624	67	5-2	0-1	2L
Pittsburgh	5-4	645	613	32	5-2	0-2	1L
Georgia Tech	5-4	645	625	20	5-2	0-2	3L
Boston College	4-5	633	603	30	3-4	1-1	1L

• Overall = Overall Wins-Losses
• PF = Total Points For
• PA = Total Points Against
• N. Pts = Point Differential
• Home = Home Record
• Away = Away Record
• Strk = Current Streak

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