Eastern Illinois vs SIU Edwardsville Prediction, Picks & Odds | 04 Mar 2026

College Basketball Betting Preview: Eastern Illinois vs SIU Edwardsville

The Eastern Illinois Panthers square off against the SIU Edwardsville Cougars, with tip-off scheduled for 19:00 on Wednesday, March 4.

It’s awesome to see SIUE with a -5.5 line on the spread at odds of -110 as we’re expecting a bigger margin of victory against Eastern Illinois.

SIUE Are 7 From 10 on the Head-to-Head

The last meeting between SIU Edwardsville Cougars and Eastern Illinois Panthers was on Saturday, with SIUE registering a 77-50 win. The past 10 games between the teams have seen SIUE win seven times.

NCAAB	Overall	PF	PA	N. Pts	Home	Away	Strk
SIU Edwardsville	19-12	2200	1993	207	10-5	9-7	2W
Eastern Illinois	12-19	2074	2184	-110	9-6	3-13	1L

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Eastern Illinois vs SIU Edwardsville Prediction & Picks

We dive into the best Eastern Illinois vs SIU Edwardsville betting angles, including a key match prediction, our correct score forecast and a value-focused bet builder. Read on for the full breakdown.

Game Prediction

Get with the favorites with a -5.5 spread. We like this bet and are backing SIUE at odds of -110 to enjoy a solid win in this college showdown.

The basketball picks at Sportsgambler.com are always guided by the latest team news, injury updates and overall form. Once we've reviewed that, we dive into the most relevant stats to confidently recommend every college hoops pick.

Key Eastern Illinois vs SIU Edwardsville stats:

• The -5.5 line has been covered by SIUE in 6 of their last 10 games.
• The -5.5 line has been covered by SIUE in 3 of their last 5 games at home.
• The -5.5 line has been covered by SIUE in 2 consecutive games.
• The +5.5 line hasn’t been covered by Eastern Illinois in 3 of their last 5 games on the road.
• The +5.5 line hasn’t been covered by Eastern Illinois in 11 of their last 20 games on the road.
• The -5.5 line has been covered by SIUE in 6 of their last 10 games against Eastern Illinois.

SIUE -5.5 Probability

The best betting sites make it a 52.4% chance that our pick will deliver a return. However, our cappers have this figure between 55-60% based on their in-depth research. This college basketball wager can therefore be backed with confidence.

If you want to pimp the odds about SIUE covering the line, you might consider going down the Bet Builder route and combine this prediction with other selections.

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Our Game Prediction

SIUE -5.5 @ -110 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Mar 4, 11:02). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Eastern Illinois 63 - 71 SIUE

We’re going for the Cougars to win by a 71-63 scoreline, something which is available at huge odds. This speculative wager can provide a big return for a small stake.

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Eastern Illinois vs SIU Edwardsville Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

The sportsbooks have SIU Edwardsville at -250 when it comes to the Moneyline betting, implying the favorites are 71% likely to win this game according to the latest odds. If you’re looking for an alternative angle, Eastern Illinois are trading at +198.

The spread is currently 4.5, with the total points line at 127.5. Having a wager on the Totals is one of the most popular basketball bets. If you want to wager Over 127.5, there are odds of -110.

The good news is that you can access a wide range of team props and game lines for most college basketball contests. The best betting apps have a huge range of pre-game and in-game wagering options.

Moneyline

Eastern Illinois

+198

SIUE

-250

Point Spread

Eastern Illinois +4.5

-102

SIUE -4.5

-120

Total Points

Under 127.5

-110

Over 127.5

-110

If you’re looking for an alternative to the main game lines, check out the player props instead. It’s great to wager on Total Points, Three-Pointers, Assists, Steals, Blocks and Rebounds as potential options.

There are always opportunities to enjoy college basketball micro betting. It’s generally the case that you will find player and team props in-game and bettors can use their insight to wager on outcomes such as if the next shot will be a Two or Three-Pointer.

Latest regular season and playoff games stats.

Eastern Illinois Stats

SIU Edwardsville Stats

Moneyline

• 3 wins and 7 defeats in the last 10 games
• 3 wins and 7 defeats in the last 10 games on the road

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 7 wins and 3 defeats in the last 10 home games

Point Spread

• +5.5 Betting Line: Have covered the spread in 5 of the last 10 games
• +5.5 Betting Line on the Road: Have covered the spread in 5 of the last 10 games on the road

Point Spread

• -5.5 Betting Line: Have covered the spread in 6 of the last 10 games
• -5.5 Betting Line at Home: Have covered the spread in 4 of the last 10 home games

Total Points

• Game Totals: An average of 138.40 pts in the previous 10 games
• Game Totals on the Road: An average of 131.40 pts in the previous 10 games on the road
• Over 127.5: Covered in 8 of the previous 10 games
• Over 127.5 on the Road: Covered in 5 of the previous 10 games on the road
• Team Totals: Have scored an average of 66.20 pts and allowed 72.20 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 62.90 pts and allowed 68.50 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 129.30 pts in the previous 10 games
• Game Totals at Home: An average of 131.80 pts in the previous 10 home games
• Over 127.5: Covered in 6 of the previous 10 games
• Over 127.5 at Home: Covered in 6 of the previous 10 home games
• Team Totals: Have scored an average of 67.10 pts and allowed 62.20 pts in the last 10 games
• Team Totals at Home: Have scored an average of 69.70 pts and allowed 62.10 pts in the last 10 home games

NCAAB Table Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Ohio Valley	Overall	PF	PA	N. Pts	Home	Away	Strk
Tennessee State	21-9	2416	2225	191	11-2	10-7	4W
UT Martin	21-10	2184	1955	229	12-3	9-7	1L
Morehead State	19-12	2351	2312	39	11-2	8-10	7W
Southeast Missouri	19-12	2331	2199	132	10-5	9-7	1W
SIU Edwardsville	19-12	2200	1993	207	10-5	9-7	2W
Lindenwood	17-14	2428	2268	160	9-5	8-9	1W
Tennessee Tech	13-18	2272	2308	-36	8-6	5-12	2L
Little Rock	12-19	2195	2300	-105	7-6	5-13	1W
Eastern Illinois	12-19	2074	2184	-110	9-6	3-13	1L
Southern Indiana	7-23	2062	2212	-150	3-10	4-13	2L
Western Illinois	4-26	1933	2334	-401	3-11	1-15	5L

• Overall = Overall Wins-Losses
• PF = Total Points For
• PA = Total Points Against
• N. Pts = Point Differential
• Home = Home Record
• Away = Away Record
• Strk = Current Streak

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