Eastern Illinois vs Southern Indiana Prediction, Picks & Odds | 22 Jan 2026

College Basketball Betting Preview: Eastern Illinois vs Southern Indiana

The Eastern Illinois Panthers go up against the Southern Indiana Screaming Eagles, with tip-off scheduled for 21:30 on Thursday, January 22.

Our best bet is Eastern Illinois to cover the spread. +2.5 at odds of -112 look more than generous and we’re happy to back them with this advantage against Southern Indiana.

Eastern Illinois Panthers claimed a victory in their previous game. A 105-49 home win occurred against Blackburn Beavers.

Southern Indiana Screaming Eagles lost on the road in their last game. Tennessee State Tigers won 73-67.

Head-to-Head Statistics

Eastern Illinois triumphed 63-54 when they last played Southern Indiana. The previous 5 games featuring these teams have resulted in three Eastern Illinois victories.

NCAAB	Overall	PF	PA	N. Pts	Home	Away	Strk
Eastern Illinois	13-20	2214	2321	-107	9-6	4-14	1L
Southern Indiana	7-23	2062	2212	-150	3-10	4-13	2L

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Eastern Illinois vs Southern Indiana Prediction & Picks

Step into Eastern Illinois vs Southern Indiana with confidence, armed with our expert match prediction, likely scoreline and a custom-built bet builder for maximum value.

Game Prediction

We wouldn’t be surprised to see the Eastern Illinois triumph in this college matchup. In terms of landing extra value, it makes sense to take +2.5 when it comes to the spread at -112.

The formbook is always a smart starting point when making basketball predictions. Up-to-date college hoops team news is just as important, while the stats we provide often reveal valuable insights.

Key Eastern Illinois vs Southern Indiana stats:

• The +2.5 line has been covered by Eastern Illinois in 4 of their last 5 games.
• The +2.5 line has been covered by Eastern Illinois in 6 of their last 10 games.
• The -2.5 line hasn’t been covered by USI in 4 consecutive games at home.
• The -2.5 line hasn’t been covered by USI in 9 of their last 10 games.
• The -2.5 line hasn’t been covered by USI in 16 of their last 20 games.
• The -2.5 line hasn’t been covered by USI in 3 of their last 5 games against Eastern Illinois.

Eastern Illinois +2.5 Probability

Based on the latest odds from the top sportsbooks, our pick carries a 52.9% chance of winning. In our opinion, there’s actually a probability of success between 55-60%. That means we’re regarding it as a value bet.

There’s an opportunity to secure bigger odds and this can be achieved by moving the line. Squeeze more juice from your pick by taking an alternative wagering view.

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Our Game Prediction

Eastern Illinois +2.5 @ -112 Bet Now

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Correct Score Prediction

Eastern Illinois 72 - 68 Southern Indiana

There are massive odds on offer when it comes to Eastern Illinois landing a 72-68 win. A close game is anticipated between two evenly-matched teams.

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Eastern Illinois vs Southern Indiana Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

At betting odds of -159 with the sportsbooks, Southern Indiana are regarded as 61% likely to win this college game. The market suggests that Eastern Illinois are least likely to win at +126.

The spread is currently 2.5, with the total points line at 135.5. There are many ways to bet on basketball including the Totals. There’s an opportunity to bet Over 135.5 at -115.

Consider every angle when placing your college hoops bets. The top basketball betting sites offer a huge selection of game lines and team props, and it’s all about finding a wager that fits your prediction of the game.

Moneyline

Eastern Illinois

+126

USI

-159

Point Spread

Eastern Illinois +2.5

-106

USI -2.5

-114

Total Points

Under 135.5

-105

Over 135.5

-115

We’re fond of player props as an alternative to betting on the game result. The gambling sites will have Points, Assists, Three-Pointers, Rebounds and Steals among the choices and you can take a particular view.

Micro betting is an exciting way to wager on college basketball. There are many live lines and it’s a simple case of predicting what is going to happen. Next Field Goal, where you select if the shot will be a two or three-pointer are among the options.

Latest regular season and playoff games stats.

Eastern Illinois Stats

Southern Indiana Stats

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 1 win and 9 defeats in the last 10 games on the road

Moneyline

• 1 win and 9 defeats in the last 10 games
• 3 wins and 7 defeats in the last 10 home games

Point Spread

• +2.5 Betting Line: Have covered the spread in 6 of the last 10 games
• +2.5 Betting Line on the Road: Have covered the spread in 1 of the last 10 games on the road

Point Spread

• -2.5 Betting Line: Have covered the spread in 1 of the last 10 games
• -2.5 Betting Line at Home: Have covered the spread in 3 of the last 10 home games

Total Points

• Game Totals: An average of 137.70 pts in the previous 10 games
• Game Totals on the Road: An average of 137.90 pts in the previous 10 games on the road
• Over 134.5: Covered in 5 of the previous 10 games
• Over 134.5 on the Road: Covered in 5 of the previous 10 games on the road
• Team Totals: Have scored an average of 72.90 pts and allowed 64.80 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 59.90 pts and allowed 78.00 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 139.10 pts in the previous 10 games
• Game Totals at Home: An average of 144.10 pts in the previous 10 home games
• Over 134.5: Covered in 5 of the previous 10 games
• Over 134.5 at Home: Covered in 7 of the previous 10 home games
• Team Totals: Have scored an average of 65.70 pts and allowed 73.40 pts in the last 10 games
• Team Totals at Home: Have scored an average of 72.30 pts and allowed 71.80 pts in the last 10 home games

NCAAB Table Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Ohio Valley	Overall	PF	PA	N. Pts	Home	Away	Strk
Tennessee State	23-9	2577	2347	230	13-2	10-7	6W
UT Martin	22-11	2305	2086	219	13-3	9-8	1L
Morehead State	20-13	2484	2466	18	12-2	8-11	1L
Southeast Missouri	20-13	2460	2331	129	11-5	9-8	1L
SIU Edwardsville	19-13	2271	2070	201	10-6	9-7	1L
Lindenwood	18-15	2566	2398	168	10-5	8-10	1L
Tennessee Tech	13-18	2272	2308	-36	8-6	5-12	2L
Eastern Illinois	13-20	2214	2321	-107	9-6	4-14	1L
Little Rock	12-20	2257	2372	-115	7-6	5-14	1L
Southern Indiana	7-23	2062	2212	-150	3-10	4-13	2L
Western Illinois	4-26	1933	2334	-401	3-11	1-15	5L

• Overall = Overall Wins-Losses
• PF = Total Points For
• PA = Total Points Against
• N. Pts = Point Differential
• Home = Home Record
• Away = Away Record
• Strk = Current Streak

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