Indiana State vs Southern Illinois Prediction, Picks & Odds | 25 Feb 2026

College Basketball Betting Preview: Indiana State vs Southern Illinois

The Indiana State Sycamores battle the Southern Illinois Salukis, with tip-off scheduled for 20:00 on Wednesday, February 25.

Southern Illinois should be taken against the spread at -8.5 with our prediction being for the favorites to achieve a comfortable margin of victory over Indiana State. Back them at the odds of -120 that are available.

Indiana State Sycamores were defeated in their previous game. On the road, they suffered a 87-70 reverse against Belmont Bruins.

Southern Illinois Salukis got the win in their last game. A 59-57 triumph occurred on the road when meeting Northern Iowa Panthers.

Head-to-Head Statistics

Southern Illinois have won two on the spin against Indiana State. They won 86-85 at home and 80-65 on the road. Southern Illinois have triumphed in six of the previous 10 clashes between these teams.

NCAAB	Overall	PF	PA	N. Pts	Home	Away	Strk
Southern Illinois	14-15	2126	2037	89	7-7	7-8	2W
Indiana State	10-19	2158	2191	-33	7-7	3-12	5L

View Full Standings

Indiana State vs Southern Illinois Prediction & Picks

We dive into the top Indiana State vs Southern Illinois betting angles, including our main match prediction, best correct score play and a bet builder tailored for value.

Game Prediction

There’s a generous line of -8.5 when it comes to Southern Illinois for this college contest. The -120 that they cover the spread has plenty of juice and our pick is that the favorites will make it happen.

It’s important to know which players are unavailable for the upcoming college hoops action along with the current form of each team. If you're after stats, you're in the right place because they form the foundation of our basketball predictions.

Key Indiana State vs Southern Illinois stats:

• The +8.5 line hasn’t been covered by Indiana State in 3 of their last 5 games.
• The +8.5 line hasn’t been covered by Indiana State in 2 consecutive games.

Southern Illinois -8.5 Probability

The best sportsbooks are estimating that there is a 54.6% likelihood of this pick delivering a return. However, our research has found that the actual probability is closer to 60%. It’s why we think it’s worth placing this college basketball bet.

There are several alternatives to the spread and we particularly like the Winning Margin lines. It’s great whether you’re expecting things to be close or comprehensive.

Check out the most rewarding betting offers in our in-depth guide before your next wager. The best bonuses and free bets await.

Our Game Prediction

Southern Illinois -8.5 @ -120 Bet Now

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Correct Score Prediction

Indiana State 64 - 77 Southern Illinois

Should you want to go for a selection at massive odds, head to the correct score lines where Southern Illinois can be backed speculatively to achieve a 77-64 victory.

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Indiana State vs Southern Illinois Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

Southern Illinois are strong -526 favorites to win this college game according to the Moneyline betting odds. The sportsbooks give them a 84% chance of claiming victory. The market suggests that Indiana State are least likely to win at +385.

8.5 is where the spread lies, with total points being 146.5 right now. A bet on the Totals allows fans to use the latest basketball data to good effect. Those expecting a low total can back Under 146.5 at -110.

The good news is that you’ll find a strong selection of game lines and team props for most college contests. The best basketball betting sites provide a wide range of pre-game and in-game wagering options.

Moneyline

IN State

+385

Southern Illinois

-526

Point Spread

IN State +8.5

-102

Southern Illinois -8.5

-120

Total Points

Under 146.5

-110

Over 146.5

-110

Prop betting is very popular, with bettors looking to wager on player props such as Points, Assists, Rebounds, Steals and Three-Pointers. It’s a great way of betting on individual player performance and the gambling sites will provide lots of options.

It’s possible to use stats to your advantage when it comes to college basketball micro betting, especially if you’re predicting outcomes such as the Next Field Goal. Check out the live player, score and team props to see if you can find an angle.

Latest regular season and playoff games stats.

Indiana State Stats

Southern Illinois Stats

Moneyline

• 1 win and 9 defeats in the last 10 games
• 2 wins and 8 defeats in the last 10 games on the road

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 home games

Point Spread

• +8.5 Betting Line: Have covered the spread in 6 of the last 10 games
• +8.5 Betting Line on the Road: Have covered the spread in 7 of the last 10 games on the road

Point Spread

• -8.5 Betting Line: Have covered the spread in 3 of the last 10 games
• -8.5 Betting Line at Home: Have covered the spread in 3 of the last 10 home games

Total Points

• Game Totals: An average of 146.60 pts in the previous 10 games
• Game Totals on the Road: An average of 148.90 pts in the previous 10 games on the road
• Over 145.5: Covered in 6 of the previous 10 games
• Over 145.5 on the Road: Covered in 7 of the previous 10 games on the road
• Team Totals: Have scored an average of 70.20 pts and allowed 76.40 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 72.50 pts and allowed 76.40 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 132.10 pts in the previous 10 games
• Game Totals at Home: An average of 141.20 pts in the previous 10 home games
• Over 145.5: Covered in 2 of the previous 10 games
• Over 145.5 at Home: Covered in 3 of the previous 10 home games
• Team Totals: Have scored an average of 68.00 pts and allowed 64.10 pts in the last 10 games
• Team Totals at Home: Have scored an average of 72.50 pts and allowed 68.70 pts in the last 10 home games

NCAAB Table Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Missouri Valley	Overall	PF	PA	N. Pts	Home	Away	Strk
Belmont	25-4	2433	2102	331	14-2	11-2	3W
Murray State	20-10	2510	2379	131	14-3	6-7	1W
Bradley	19-11	2314	2187	127	15-3	4-8	1L
Northern Iowa	18-11	2004	1771	233	12-4	6-7	1L
Illinois State	18-11	2200	1973	227	14-3	4-8	1L
UIC	17-13	2271	2086	185	10-6	7-7	1W
Valparaiso	15-13	1978	1997	-19	11-4	4-9	3W
Southern Illinois	14-15	2126	2037	89	7-7	7-8	2W
Drake	12-17	2210	2181	29	7-11	5-6	7L
Indiana State	10-19	2158	2191	-33	7-7	3-12	5L
Evansville	6-22	1873	2121	-248	4-11	2-11	3L

• Overall = Overall Wins-Losses
• PF = Total Points For
• PA = Total Points Against
• N. Pts = Point Differential
• Home = Home Record
• Away = Away Record
• Strk = Current Streak

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