Louisiana vs Santa Clara Prediction, Picks & Odds | 21 Nov 2025

College Basketball Betting Preview: Louisiana vs Santa Clara

The Louisiana Ragin' Cajuns square off against the Santa Clara Broncos, with tip-off scheduled for 22:00 on Friday, November 21.

Our prediction is that Santa Clara will beat Louisiana by a significant margin. With this in mind, let’s go for them on the spread at -19.5 which is currently available at odds of -110.

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Louisiana Ragin' Cajuns suffered a defeat in their previous game. A 93-66 scoreline occurred on the road against Stanford Cardinal.

Santa Clara Broncos won their last game, beating Idaho State Bengals at home. It was a 64-55 win.

NCAAB	Overall	PF	PA	N. Pts	Home	Away	Strk
Santa Clara	5-0	411	326	85	4-0	1-0	5W
Louisiana	1-4	312	374	-62	1-1	0-3	3L

View Full Standings

Louisiana vs Santa Clara Prediction & Picks

Step into Louisiana vs Santa Clara with confidence, armed with our expert match prediction, likely scoreline and a custom-built bet builder for maximum value.

Game Prediction

If you agree with our prediction that Santa Clara can be superior in this college contest, you can get -110 for this selection against the spread. The favorites should be capable of covering the -19.5 line.

We keep a close eye on team news and our college basketball handicappers stay sharp by tracking the latest form and lineups. You’ll also find a full set of stats that offer valuable insight and help shape smarter predictions ahead of the action.

Key Louisiana vs Santa Clara stats:

• The +19.5 line hasn’t been covered by Louisiana in 3 of their last 5 games on the road.
• The +19.5 line hasn’t been covered by Louisiana in 2 consecutive games.

Santa Clara -19.5 Probability

According to the best betting apps, our pick has a 52.4% chance of delivering a return. Taking all factors into consideration, our cappers think there’s a stronger chance of success and estimate the probability to be closer to 60%. The bet can be recommended for this precise reason.

There are many ways to back Santa Clara and that includes Winning Margin. Choose from a wide range of fixed intervals and get rewarded if you’re on the money.

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Our Game Prediction

Santa Clara -19.5 @ -110 Bet Now

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Correct Score Prediction

Louisiana 62 - 85 Santa Clara

If you want to take a chance on a correct score, then Santa Clara to enjoy a 85-62 win could be along the right lines. There are enormous odds for this particular outcome.

Louisiana vs Santa Clara Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the above betting predictions.

With an estimated 98% chance of winning, the sportsbooks are taking no chances with their -5000 betting odds about Santa Clara triumphing in this college game. At +1600, Louisiana are regarded as having a lower probability of winning.

The current spread is 19.5 and total points is 141.5. There are many ways to bet on basketball including the Totals. If you want to wager Over 141.5, there are odds of -110.

Whether you’re betting pre-game or in-game, the top basketball sportsbooks serve up a wide range of team props and game lines to choose from. The options are nearly endless, and it’s great to have so much variety.

Moneyline

Louisiana

+1600

Santa Clara

-5000

Point Spread

Louisiana +19.5

-110

Santa Clara -19.5

-110

Total Points

Under 141.5

-110

Over 141.5

-110

There is regularly betting value to be found from wagering on the player props with the best online gambling sites. You can find lots of ways to back for or against a specific player lining up for one of the two teams.

Micro betting is something that’s really popular with bettors, with college basketball fans essentially being able to wager in-game when it comes to score, player and team props. Check out the two-way lines where you can bet whether the next shot will be a Two-pointer or a Three-pointer.

Latest regular season and playoff games stats.

Louisiana Stats

Santa Clara Stats

Moneyline

• 3 wins and 7 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 games on the road

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 7 wins and 3 defeats in the last 10 home games

Point Spread

• +19.5 Betting Line: Have covered the spread in 7 of the last 10 games
• +19.5 Betting Line on the Road: Have covered the spread in 7 of the last 10 games on the road

Point Spread

• -19.5 Betting Line: Have covered the spread in 3 of the last 10 games
• -19.5 Betting Line at Home: Have covered the spread in 3 of the last 10 home games

Total Points

• Game Totals: An average of 132.00 pts in the previous 10 games
• Game Totals on the Road: An average of 136.00 pts in the previous 10 games on the road
• Over 141.5: Covered in 4 of the previous 10 games
• Over 141.5 on the Road: Covered in 3 of the previous 10 games on the road
• Team Totals: Have scored an average of 60.20 pts and allowed 71.80 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 63.50 pts and allowed 72.50 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 156.00 pts in the previous 10 games
• Game Totals at Home: An average of 154.20 pts in the previous 10 home games
• Over 141.5: Covered in 8 of the previous 10 games
• Over 141.5 at Home: Covered in 7 of the previous 10 home games
• Team Totals: Have scored an average of 84.50 pts and allowed 71.50 pts in the last 10 games
• Team Totals at Home: Have scored an average of 83.00 pts and allowed 71.20 pts in the last 10 home games

NCAAB Table Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

West Coast	Overall	PF	PA	N. Pts	Home	Away	Strk
Gonzaga	5-0	470	289	181	4-0	1-0	5W
Loyola Marymount	6-0	524	383	141	4-0	2-0	6W
Saint Mary's	5-0	426	305	121	5-0	0-0	5W
Santa Clara	5-0	411	326	85	4-0	1-0	5W
San Francisco	4-1	407	327	80	4-0	0-1	3W
Seattle	3-1	332	287	45	3-1	0-0	2W
San Diego	3-1	312	272	40	3-1	0-0	2W
Portland	3-1	326	313	13	3-0	0-1	1L
Oregon State	3-1	284	289	-5	3-0	0-1	1L
Pepperdine	3-2	435	397	38	3-1	0-1	1W
Pacific	3-2	373	355	18	2-0	1-2	1L
Washington State	2-3	398	394	4	2-2	0-1	1W

Sun Belt	Overall	PF	PA	N. Pts	Home	Away	Strk
South Alabama	6-0	460	385	75	3-0	3-0	6W
Marshall	4-1	435	408	27	2-0	2-1	1W
Texas State	4-2	453	402	51	4-0	0-2	3W
Appalachian State	3-2	372	334	38	2-0	1-2	1W
Georgia Southern	3-2	441	423	18	2-0	1-2	1L
Arkansas State	3-2	407	412	-5	1-0	2-2	1L
Troy	4-3	650	596	54	1-0	3-3	1L
Coastal Carolina	2-2	331	260	71	2-0	0-2	1L
James Madison	3-3	457	456	1	3-0	0-3	1W
Southern Miss	2-3	403	359	44	2-0	0-3	1W
Old Dominion	2-3	367	392	-25	2-0	0-3	2L
Georgia State	1-4	326	339	-13	1-1	0-3	1L
UL Monroe	1-4	362	394	-32	1-1	0-3	2L
Louisiana	1-4	312	374	-62	1-1	0-3	3L

• Overall = Overall Wins-Losses
• PF = Total Points For
• PA = Total Points Against
• N. Pts = Point Differential
• Home = Home Record
• Away = Away Record
• Strk = Current Streak

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