Louisville vs Cincinnati Prediction, Picks & Odds | 21 Nov 2025

College Basketball Betting Preview: Louisville vs Cincinnati

The Louisville Cardinals go up against the Cincinnati Bearcats, with tip-off scheduled for 18:30 on Friday, November 21.

We’re not sure that Louisville and Cincinnati will reach a certain points threshold. Our prediction is to take the -110 that there are Under 162.5 points.

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Louisville Cardinals previous game saw them claim a 106-81 home win over Ohio Bobcats.

Cincinnati Bearcats won their last game which was at home. It was a 72-55 triumph against Mount St. Mary's Mountaineers.

Head-to-Head Statistics

Cincinnati won the last matchup between the pair. Enjoying a 81-62 triumph when facing Louisville.

NCAAB	Overall	PF	PA	N. Pts	Home	Away	Strk
Cincinnati	4-0	314	244	70	4-0	0-0	4W
Louisville	4-0	412	284	128	4-0	0-0	4W

View Full Standings

Louisville vs Cincinnati Prediction & Picks

Make the most of Louisville vs Cincinnati with our betting analysis that includes an expert match prediction, expected scoreline and a hand-picked bet builder designed for value.

Game Prediction

There are good reasons for anticipating that the points tally will be lower than the line in this college showdown. If you agree with our pick of Under 162.5, you will find -110 available.

Injuries can influence the outcome and our college basketball handicappers factor that in alongside the latest form guide. We apply the same approach to the stats to build the clearest picture of how the game might unfold.

Key Louisville vs Cincinnati stats:

• The 162.5 line hasn’t been covered in the last 6 Louisville games on the road.
• The 162.5 line hasn’t been covered in 9 of the last 10 Louisville games on the road.
• The 162.5 line hasn’t been covered in 13 of the last 19 Louisville games on the road.
• The 162.5 line hasn’t been covered in the last 4 Cincinnati games.
• The 162.5 line hasn’t been covered in 19 of the last 20 Cincinnati games at home.
• The 162.5 line hasn’t been covered in 9 of the last 10 Cincinnati games.

Under 162.5 Probability

The best sportsbooks are estimating that there is a 52.4% likelihood of this pick delivering a return. Taking all factors into consideration, our experts think there’s a stronger chance of success and have a probability interval between 55-60%. This is why we regard this as a value bet.

If you’re wanting bigger odds for your Under wager, then there’s a way of changing the line and shooting for a lower points total in the hope of a better return.

Don’t miss your chance to claim the best betting offers, free bets, and bonuses with the help of our smart bonus guide.

Our Game Prediction

Under 162.5 Points @ -110 Bet Now

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Correct Score Prediction

Louisville 82 - 77 Cincinnati

There is a speculative wager that can be enjoyed on Louisville when it comes to the correct score lines. Taking them to win 82-77 should provide some entertainment.

Louisville vs Cincinnati Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the above betting predictions.

The sportsbooks are taking no chances with their Moneyline odds of -526 about Louisville which reflects they have a 84% chance of winning this college game. Cincinnati are the underdogs at +385 and they’re regarded as least likely to win.

9.5 is the spread and 164.5 is the total points line. A Total bet is always available and can often provide value selections. Those who wager Under 164.5 can get -110.

If you’re planning to place a bet on a college basketball matchup, head to the top betting apps and explore the wide range of team props and game lines. Look for the lines that offer the most value.

Moneyline

Louisville

-526

Cincinnati

+385

Point Spread

Louisville -9.5

-102

Cincinnati +9.5

-120

Total Points

Under 164.5

-110

Over 164.5

-110

Should you be more interested in a specific individual who is competing, check out the gambling sites’ prop bets where you can pick out player lines that focus on performance rather than the game result.

It’s good to consider all wagering options when it comes to college basketball and micro betting can be an exciting way to get involved in the action. When everything goes in-game, consider whether the next shot will be a Two or a Three-pointer.

Latest regular season and playoff games stats.

Louisville Stats

Cincinnati Stats

Moneyline

• 8 wins and 2 defeats in the last 10 games
• 8 wins and 2 defeats in the last 10 games on the road

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 8 wins and 2 defeats in the last 10 home games

Point Spread

• -9.5 Betting Line: Have covered the spread in 5 of the last 10 games
• -9.5 Betting Line on the Road: Have covered the spread in 6 of the last 10 games on the road

Point Spread

• +9.5 Betting Line: Have covered the spread in 8 of the last 10 games
• +9.5 Betting Line at Home: Have covered the spread in the last 10 home games

Total Points

• Game Totals: An average of 156.10 pts in the previous 10 games
• Game Totals on the Road: An average of 145.00 pts in the previous 10 games on the road
• Over 162.5: Covered in 4 of the previous 10 games
• Over 162.5 on the Road: Covered in 1 of the previous 10 games on the road
• Team Totals: Have scored an average of 85.30 pts and allowed 70.80 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 78.80 pts and allowed 66.20 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 140.50 pts in the previous 10 games
• Game Totals at Home: An average of 140.70 pts in the previous 10 home games
• Over 162.5: Covered in 1 of the previous 10 games
• Over 162.5 at Home: Covered in 1 of the previous 10 home games
• Team Totals: Have scored an average of 73.60 pts and allowed 66.90 pts in the last 10 games
• Team Totals at Home: Have scored an average of 75.50 pts and allowed 65.20 pts in the last 10 home games

NCAAB Table Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Big 12	Overall	PF	PA	N. Pts	Home	Away	Strk
Iowa State	4-0	382	249	133	3-0	1-0	4W
Houston	5-0	382	267	115	4-0	1-0	5W
Oklahoma State	5-0	464	365	99	5-0	0-0	5W
West Virginia	5-0	364	274	90	5-0	0-0	5W
Kansas State	5-0	472	391	81	5-0	0-0	5W
Arizona	5-0	410	335	75	3-0	2-0	5W
Cincinnati	4-0	314	244	70	4-0	0-0	4W
Colorado	4-0	377	329	48	4-0	0-0	4W
Baylor	3-0	268	231	37	3-0	0-0	3W
UCF	5-1	522	467	55	4-1	1-0	4W
Utah	5-1	518	481	37	5-1	0-0	1L
Texas Tech	4-1	437	364	73	4-0	0-1	2W
BYU	3-1	338	273	65	3-1	0-0	1L
Arizona State	3-1	302	269	33	3-1	0-0	1W
TCU	3-2	400	318	82	3-2	0-0	1W
Kansas	3-2	387	319	68	3-0	0-2	1L

Atlantic Coast	Overall	PF	PA	N. Pts	Home	Away	Strk
Duke	5-0	462	301	161	4-0	1-0	5W
NC State	4-0	403	279	124	4-0	0-0	4W
North Carolina	5-0	440	316	124	5-0	0-0	5W
Virginia	4-0	363	246	117	4-0	0-0	4W
Syracuse	4-0	326	213	113	3-0	1-0	4W
Virginia Tech	5-0	461	364	97	5-0	0-0	5W
SMU	5-0	460	370	90	5-0	0-0	5W
Stanford	4-0	350	281	69	4-0	0-0	4W
Louisville	4-0	412	284	128	4-0	0-0	4W
California	4-1	420	348	72	4-0	0-1	1W
Georgia Tech	4-1	355	315	40	4-0	0-1	1W
Clemson	4-1	423	293	130	4-0	0-1	1W
Notre Dame	4-1	418	338	80	4-0	0-1	1W
Miami	4-1	456	345	111	4-0	0-1	1W
Florida State	3-1	372	291	81	3-0	0-1	1W
Pittsburgh	4-2	430	383	47	4-0	0-2	1L
Wake Forest	3-2	445	383	62	3-0	0-2	1L
Boston College	3-2	352	313	39	2-1	1-1	2W

• Overall = Overall Wins-Losses
• PF = Total Points For
• PA = Total Points Against
• N. Pts = Point Differential
• Home = Home Record
• Away = Away Record
• Strk = Current Streak

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