Siena vs Indiana Prediction, Picks & Odds | 22 Dec 2025

College Basketball Betting Preview: Siena vs Indiana

The Siena Saints go up against the Indiana Hoosiers, with tip-off scheduled for 18:00 on Monday, December 22.

There’s a case to be made for Indiana on the spread when they face Siena. Our prediction is that the betting favorites can cover the -23.5 line at odds of -110 considering they should be superior.

Backing our spread pick? Don’t forget to check out our exclusive BetMGM promo code and full site review before locking in your selection.

Siena Saints lost on the road in their previous game. Vermont Catamounts won 83-69.

Indiana Hoosiers were winners last time out. It was a 78-58 home victory against Chicago State Cougars.

NCAAB	Overall	PF	PA	N. Pts	Home	Away	Strk
Indiana	9-3	1020	799	221	9-1	0-2	1W
Siena	9-3	844	758	86	4-1	5-2	1L

View Full Standings

Siena vs Indiana Prediction & Picks

Explore our top Siena vs Indiana betting tips, including an expert match prediction, correct score forecast and a bet builder ready to use. Each section below offers expert insight into the key betting angles.

Game Prediction

We’d be surprised if Indiana don’t exceed a -23.5 spread in this college showdown. That is why the bet has to be the big favorites to cover the line at -110.

The basketball picks at Sportsgambler.com are always guided by the latest team news, injury updates and overall form. Once we've reviewed that, we dive into the most relevant stats to confidently recommend every college hoops pick.

Key Siena vs Indiana stats:

• The -23.5 line has been covered by Indiana in 4 of their last 10 games at home.

Indiana -23.5 Probability

The top betting sites are estimating that there is a 52.4% likelihood of this pick winning. However, our cappers in-depth research has found that the actual probability is closer to 60%. This college basketball bet can therefore be backed with confidence.

If you want to pimp the odds about Indiana covering the line, you might consider going down the Bet Builder route and combine this prediction with other selections.

Elevate your wagering experience with the latest free bets, promos and top betting offers listed in our comprehensive bonus guide.

Our Game Prediction

Indiana -23.5 @ -110 Bet Now

BetMGM Promo Up To $1500 in Bonus Bets Get Bonus T&C apply. Gamble responsibly 18+

Gamble responsibly 18+. All odds are correct at time of publishing and are subject to change. To use the Bookmaker Live Streaming services you will need to be logged in and have a funded account or to have placed a bet in the last 24 hours. Geo-restrictions apply.

Correct Score Prediction

Siena 61 - 88 Indiana

There’s the chance to land huge betting odds when it comes to the Hoosiers winning on the correct score lines. We’ll try a 88-61 victory in their favor and this should be in the right ball park.

Siena vs Indiana Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the above betting predictions.

Indiana have short betting odds and they’re overwhelming -10000 favorites for this college game. This means the sportsbooks give them a 99% chance of winning. Siena are regarded as a long shot to win and you can currently back them at +2400.

23.5 is the spread and 143.5 is the total points line. A bet on the Totals allows fans to use the latest basketball data to good effect. If you want to wager Over 143.5, there are odds of -110.

The best betting apps provide a wide range of team props and game lines for most college basketball matchups. Be sure to explore all the available options before placing your bet.

Moneyline

Siena

+2400

Indiana

-10000

Point Spread

Siena +23.5

-110

Indiana -23.5

-110

Total Points

Under 143.5

-110

Over 143.5

-110

We’re fond of player props as an alternative to betting on the game result. The gambling sites will have Points, Assists, Three-Pointers, Rebounds and Steals among the choices and you can take a particular view.

An increasing number of bettors are now enjoying micro betting on college basketball and it’s something which is available on an in-game basis. Wait for the action to start and then wager on something specific to happen.

Latest regular season and playoff games stats.

Siena Stats

Indiana Stats

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 5 wins and 5 defeats in the last 10 games on the road

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 9 wins and 1 defeat in the last 10 home games

Point Spread

• +23.5 Betting Line: Have covered the spread in the last 10 games
• +23.5 Betting Line on the Road: Have covered the spread in the last 10 games on the road

Point Spread

• -23.5 Betting Line: Have covered the spread in 3 of the last 10 games
• -23.5 Betting Line at Home: Have covered the spread in 4 of the last 10 home games

Total Points

• Game Totals: An average of 134.60 pts in the previous 10 games
• Game Totals on the Road: An average of 137.60 pts in the previous 10 games on the road
• Over 143.5: Covered in 1 of the previous 10 games
• Over 143.5 on the Road: Covered in 4 of the previous 10 games on the road
• Team Totals: Have scored an average of 70.00 pts and allowed 64.60 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 68.40 pts and allowed 69.20 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 149.30 pts in the previous 10 games
• Game Totals at Home: An average of 155.00 pts in the previous 10 home games
• Over 143.5: Covered in 5 of the previous 10 games
• Over 143.5 at Home: Covered in 7 of the previous 10 home games
• Team Totals: Have scored an average of 82.20 pts and allowed 67.10 pts in the last 10 games
• Team Totals at Home: Have scored an average of 89.60 pts and allowed 65.40 pts in the last 10 home games

NCAAB Table Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Big Ten	Overall	PF	PA	N. Pts	Home	Away	Strk
Michigan	11-0	1049	727	322	8-0	3-0	11W
Nebraska	12-0	1000	806	194	11-0	1-0	12W
USC	12-1	1162	979	183	8-1	4-0	4W
Purdue	11-1	1019	798	221	9-1	2-0	3W
Michigan State	11-1	936	760	176	8-1	3-0	3W
Iowa	10-2	966	719	247	9-0	1-2	2W
UCLA	9-3	965	831	134	8-1	1-2	2W
Indiana	9-3	1020	799	221	9-1	0-2	1W
Ohio State	8-3	946	800	146	6-2	2-1	1L
Illinois	8-3	966	787	179	6-3	2-0	1L
Penn State	8-4	938	899	39	7-3	1-1	3L
Washington	7-4	913	804	109	4-1	3-3	1L
Wisconsin	7-4	917	830	87	6-0	1-4	2L
Northwestern	7-5	967	842	125	6-3	1-2	1L
Minnesota	6-5	807	749	58	6-3	0-2	1W
Oregon	6-6	936	901	35	6-3	0-3	1L
Maryland	6-6	926	966	-40	5-2	1-4	3L
Rutgers	6-6	828	873	-45	6-2	0-4	1W

Metro Atlantic Athletic	Overall	PF	PA	N. Pts	Home	Away	Strk
Siena	9-3	844	758	86	4-1	5-2	1L
Marist	8-3	810	695	115	6-1	2-2	1W
Quinnipiac	9-4	1024	955	69	5-1	4-3	1L
Iona	9-4	1046	1020	26	4-2	5-2	1W
Fairfield	7-5	891	900	-9	4-1	3-4	2W
Merrimack	6-7	842	936	-94	3-1	3-6	1L
Saint Peter's	4-5	611	648	-37	4-1	0-4	1L
Sacred Heart	5-7	939	937	2	3-1	2-6	1W
Canisius	5-7	722	810	-88	4-1	1-6	1L
Manhattan	5-8	1016	1084	-68	4-2	1-6	1W
Mount St. Mary's	4-9	891	988	-97	2-2	2-7	1W
Niagara	3-9	753	900	-147	2-1	1-8	1W
Rider	1-9	586	736	-150	1-2	0-7	7L

• Overall = Overall Wins-Losses
• PF = Total Points For
• PA = Total Points Against
• N. Pts = Point Differential
• Home = Home Record
• Away = Away Record
• Strk = Current Streak

Top Basketball Pages