América vs Santos Laguna Prediction, Betting Tips, Lineups & Odds | 04 Oct 2025

Liga MX Betting Preview: América vs Santos Laguna

América host Santos Laguna in this Liga MX fixture at Estadio Azteca, with kick-off set for 23:05 on Saturday 4 October. Our betting preview features expert predictions, betting tips, the latest odds, H2H stats, team news and both predicted and confirmed lineups.

Back the Favourites For a Convincing Win

América can be backed at -2 on the Asian Handicap in the knowledge that we get our stake returned if they beat Santos Laguna by two goals. A bigger win lands a full return at attractive betting odds of -116.

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Teams’ Previous H2H Saw 4-1 América Victory

Club América have enjoyed back-to-back Liga MX victories, most recently beating Pumas UNAM 4-1. It was a home win at Estadio Azteca. Andre Jardine's team enjoyed 55% possession and had twelve shots on target, while Alex Zendejas grabbed two goals, with Alvaro Angulo (own goal) and Jose Zuniga getting one.

Santos Laguna were defeated in their previous game. On their travels, they suffered a 1-0 loss against Monterrey at Estadio BBVA. Los Guerreros finished with just 33% possession and had two shots on goal.

Head-to-Head Statistics

América have claimed back-to-back wins over Santos. Away at Estadio Nuevo Corona, the most recent scoreline was 4-1 which came after a 3-0 home win at Estadio Azteca. There have been four draws in the previous 10 H2H meetings along with six América victories.

Liga MX		G	W	D	L	GF	GA	GD	GD	P
3	América	11	7	3	1	23	11	12	23:11	24
13	Santos Laguna	11	3	1	7	13	18	-5	13:18	10

View Full Table

7 wins, 1 loss and 2 draws, averaging 2.2 goals from 5.6 shots on goal and 11.3 attempts. Club América have had 58.9% possession and 7.3 corners per match. On average, the opposition have scored 1.0 goals from 2.9 shots on goal and 5.6 attempts, while being awarded 3.6 corners.

Top goalscorer Alex Zendejas has found the net 4 times, Brian Rodriguez 3, with Jose Zuniga and two other players on 2. Alexis Gutierrez, Brian Rodriguez and Alex Zendejas are the leading assists makers with 2.

Santos have 2 victories, 7 defeats and 1 draw, with an average of 3.4 shots on goal, 6.4 attempts and 1.0 goals. Francisco Rodriguez's men average 43.2% possession, 4.4 corners taken and 6.2 corners against them, while 1.8 goals have been conceded from 13.1 attempts and 5.8 shots on goal.

Cristian Dajome is top of the team’s scoring charts with 3, while Jesus Ocejo and Bruno Barticciotto have 2. Jose Abella has been the top assist maker with 2 in the last 10 games.

Predicted & Confirmed Lineups

América predicted lineup (4-2-3-1): Luis Malagón (GK), Israel Reyes Romero, Sebastián Cáceres, Ramón Juárez, Cristian Borja, Kevin Alvarez, Álvaro Fidalgo, Alexis Gutiérrez, Alejandro Zendejas, Allan Saint-Maximin, José Zúñiga.

Santos Laguna predicted lineup (4-3-3): Carlos Acevedo Lopez (GK), José Javier Abella, Óscar Haret Ortega, Jonathan Pérez, Bruno Amione, Javier Güemez, Aldo López Vargas, Salvador Mariscal, Ramiro Sordo, Bruno Barticciotto, Cristian Dájome.

América vs Santos Laguna Prediction & Betting Tips

Take on América vs Santos Laguna with our in-depth betting analysis, featuring an expert match prediction, scoreline advice, corners market insight, key player props and a value-driven bet builder.

Match Prediction

We think América can land a big win in this Liga MX match. That leads us to back the favourites -2 at odds of -116 which looks like a value proposition. They should be able to score some goals.

Our Liga MX experts like to go through the form guide, with injuries and suspensions also having a bearing on the match. Before making our football predictions, we combine this information with the latest numbers.

Key América vs Santos Laguna league stats:

• The -2 line has been covered by América in 2 consecutive games against Santos.

América -2 Probability

The best football betting sites make it a 53.8% chance that our pick is settled as a winner. However, we have this number closer to 60% based on our in-depth research. This bet can therefore be backed with confidence.

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Our Match Prediction

América Asian Hcp -2 @ -116 Watch Live Bet Now

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Correct Score Prediction

América 3 - 0 Santos

A 3-0 win in favor of América is available at odds of +575. Take a chance on the correct score and get rewarded for predicting the right scoreline.

Player Prop Picks

Top Pick: Bruno Barticciotto Over 0.5 Shots On Target -118

Bruno Barticciotto (Santos) is available at -118 to finish with at least one shot on goal. Those wanting to back him should certainly look at the Shots on Target betting odds available.

Latest Bruno Barticciotto Player Prop Odds

Goalscorer

Anytime

+370

First

+1200

Shots On Target

Over 0.5

-118

Under 0.5

-147

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Allan Saint-Maximin to Score +250

Allan Saint-Maximin (América) has racked up two goals in his past six Liga MX games. We’re happy to take the +250 for this Anytime Goalscorer bet as there’s value in the odds that he finds the net at least once.

Latest Allan Saint-Maximin Player Prop Odds

Goalscorer

Anytime

+250

First

+850

Shots On Target

Over 0.5

-147

Under 0.5

-103

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Corners Prediction

América Over 7.5 Corners +110

The 7.5 corners line has been covered by América in their past four home games. There’s everything to like about the América Team Corners line which looks low and we’d expect them to go over at +110.

League Games

League Games

Last 10 Total For Against

Last 10 at Home Total For Against

Last 10 Away Total For Against

América

Total

10.90 7.30 3.60

Home

9.70 6.70 3.00

Away

8.60 4.60 4.00

Santos

Total

10.60 4.40 6.20

Home

9.60 4.60 5.00

Away

10.80 4.20 6.60

Latest Corner Odds

Total Corners

Over 10.5

-118

Under 10.5

-127

América Corners

Over 7.5

+110

Under 7.5

-150

Santos Corners

Over 2.5

-175

Under 2.5

+125

Most Corners

1

-526

X

+850

2

+450

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América vs Santos Laguna Odds

The odds are updated on a frequent basis. You might therefore find that they are different to the ones listed for the above betting predictions.

Bookies Have América as Massive Favourites

Club América are overwhelming -588 favourites to win this Liga MX clash based on the latest betting odds. The bookmakers afford them a 85% probability of claiming the spoils. Santos Laguna are an outside chance to get the job done and you can now back them at +1200.

There’s sometimes a case for betting on the Half-Time Result market, with América available at -200 and Santos at +750. The third option is the draw which is priced at +205.

The Over 2.5 pick is trading as the favourite when it comes to betting on Total Goals. A different angle is going for a BTTS wager and there’s -139 available for Both Teams to Score No.

All of the Liga MX games see the top betting sites go to town with their service. Bettors can find the best approach from the hundreds of markets which are presented to them each time.

Full-Time Result

1

-588

X

+600

2

+1200

Half-Time Result

1

-200

X

+205

2

+750

Draw No Bet

1

-2000

2

+750

Asian Handicap

1 Hcp -2

-116

2 Hcp +2

-109

Total Goals

Under 2.5

+185

Over 2.5

-263

Both Teams to Score

Yes

-103

No

-139

Rodrigo Aguirre Favourite to Be First Goalscorer

Rodrigo Aguirre is the favourite to be First Goalscorer at +370. If you’re interested in backing him to find the net at anytime, then the price is +110.

Rodrigo Aguirre (América)

First

+110

Anytime

+370

Patricio Salas (América)

First

+150

Anytime

+475

Paul Brian Rodríguez (América)

First

+170

Anytime

+510

Álex Zendejas (América)

First

+190

Anytime

+600

Javairô Dilrosun (América)

First

+210

Anytime

+700

Allan Saint-Maximin (América)

First

+250

Anytime

+850

Erick Sanchez (América)

First

+300

Anytime

+950

Álvaro Fidalgo (América)

First

+300

Anytime

+1000

Aarón Arredondo (América)

First

+320

Anytime

+950

Bruno Barticciotto (Santos)

First

+370

Anytime

+1200

Jonathan dos Santos (América)

First

+450

Anytime

+1300

Ramiro Sordo (Santos)

First

+480

Anytime

+1400

Israel Reyes (América)

First

+500

Anytime

+1600

Kevin Alvarez (América)

First

+550

Anytime

+1700

Miguel Vazquez (América)

First

+600

Anytime

+2000

Jordan Carrillo (Santos)

First

+650

Anytime

+1900

Fran Villalba (Santos)

First

+700

Anytime

+2000

Cristián Borja (América)

First

+700

Anytime

+2200

Diego Javier Medina Vázquez (Santos)

First

+750

Anytime

+2200

Ronaldo Prieto (Santos)

First

+800

Anytime

+2200

Paul Brian Rodríguez (América)

Over 0.5

-263

Under 0.5

+160

Álex Zendejas (América)

Over 0.5

-213

Under 0.5

+133

Javairô Dilrosun (América)

Over 0.5

-167

Under 0.5

+105

Allan Saint-Maximin (América)

Over 0.5

-147

Under 0.5

-103

Bruno Barticciotto (Santos)

Over 0.5

-118

Under 0.5

-147

Rodrigo Aguirre (América)

Over 1.5

-116

Under 1.5

-149

Erick Sanchez (América)

Over 0.5

-109

Under 0.5

-147

Álvaro Fidalgo (América)

Over 0.5

-105

Under 0.5

-152

Aarón Arredondo (América)

Over 0.5

+105

Under 0.5

-167

Ramiro Sordo (Santos)

Over 0.5

+128

Under 0.5

-204

Patricio Salas (América)

Over 1.5

+132

Under 1.5

-238

Jonathan dos Santos (América)

Over 0.5

+160

Under 0.5

-278

Jordan Carrillo (Santos)

Over 0.5

+170

Under 0.5

-286

Israel Reyes (América)

Over 0.5

+185

Under 0.5

-313

Kevin Alvarez (América)

Over 0.5

+190

Under 0.5

-333

Fran Villalba (Santos)

Over 0.5

+195

Under 0.5

-333

Miguel Vazquez (América)

Over 0.5

+220

Under 0.5

-417

Diego Javier Medina Vázquez (Santos)

Over 0.5

+230

Under 0.5

-435

Ronaldo Prieto (Santos)

Over 0.5

+240

Under 0.5

-455

Cristián Borja (América)

Over 0.5

+290

Under 0.5

-588

América Bidding to Continue Strong Home Form

América have clocked up seven wins, two draws and one defeat in the past 10 home games, recording an average of 2.00 goals per match and conceding 0.50.

Santos Laguna have not won in the past ten away matches. Los Guerreros have finished with eight defeats and two draws in the last 10 away matches, recording an average of 0.90 goals per game and conceding 2.10.

The most recent Estadio Azteca meeting saw América claim a 3-0 win over Santos. The past 6 H2H meetings at Estadio Azteca have involved four América victories, a single draw and one Santos win.

Last 10 League Games		W-D-L	G	GF	GA	O2.5	U2.5	B-Y	B-No
América Home Stats		7-2-1	2.50	2.00	0.50	5	5	4	6
Santos Laguna Away Stats		0-2-8	3.00	0.90	2.10	6	4	6	4

• W-D-L = Wins-Draws-Losses
• G = Avg. Goals
• GF = Avg. Goals For
• GA = Avg. Goals Against
• O2.5 = Matches Over 2.5 Goals
• U2.5 = Matches Under 2.5 Goals
• B-Y = Matches BTTS Yes
• B-No = Matches BTTS No

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América vs Santos Laguna Lineups & Team News

Before placing any bets on América vs Santos, check the team news first. We’ll share both predicted and confirmed lineups for the Liga MX along with the latest injury news.

América Team Page Santos Laguna Team Page